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Conserved domains on  [gi|211063455|ref|NP_571156|]
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cadherin-2 precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-365 3.93e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 260 NGTVDEGAKPGTFVMTVTSQDKDDPNtaNGMLRYKILSQTPespsSNMFTINNKTGkIITVAAGLDREKVPQYTLIIQAT 339
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 211063455 340 DMEGNPtygLSNTATAVIRLLDVNDN 365
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 830-889 1.23e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.23e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  830 ADTDPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYG 889
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-117 4.34e-26

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 102.36  E-value: 4.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455    27 CQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPaDFRIDADGTVMAARTLQLTDRKgQSLEIKAKDen 106
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEK-KSFTVLAWD-- 76

                           90
                   ....*....|.
gi 211063455   107 SQEQWMVHINF 117
Cdd:smart01055  77 SQGQEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-588 8.12e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 490 QIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLY-DPANWLEIDPNNGRISTIAVLDREspyvKNNLYNATFMASDNG 568
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 211063455 569 VPRASGTGTLQIYLLDINDN 588
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-480 1.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 373 TFHGEVPEN-RVNVIVTNLTVTDKDEPgtPAWNAVYRIISGDPTGRFSIptDPVTneGLVTVVKPVDFEMNRSFMLTVVA 451
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 211063455 452 -DNEVPlasgihrTRQSTATVSIRVIDVNE 480
Cdd:cd11304   75 tDGGGP-------PLSSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 8.02e-19

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 82.39  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 150 IPPVNVLENSRKqfPEELVKIQSDKDKSNTLRYSVTGPGADQnPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:cd00031    1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 211063455 230 NGNQMENPIDIIINVIDMNDN 250
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
595-688 6.97e-11

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 6.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  595 QEAEVCE--RPEPNAINITAVDGDLNPNAGPYAFELPNRPSDirrNWTLTRISGDhaqLSLK--ISYLESGIYELPISIT 670
Cdd:pfam00028   1 YSASVPEnaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 211063455  671 DSGNLPMSNTTYLRIKVC 688
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-365 3.93e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 260 NGTVDEGAKPGTFVMTVTSQDKDDPNtaNGMLRYKILSQTPespsSNMFTINNKTGkIITVAAGLDREKVPQYTLIIQAT 339
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 211063455 340 DMEGNPtygLSNTATAVIRLLDVNDN 365
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 830-889 1.23e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.23e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  830 ADTDPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYG 889
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-117 4.34e-26

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 102.36  E-value: 4.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455    27 CQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPaDFRIDADGTVMAARTLQLTDRKgQSLEIKAKDen 106
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEK-KSFTVLAWD-- 76

                           90
                   ....*....|.
gi 211063455   107 SQEQWMVHINF 117
Cdd:smart01055  77 SQGQEKKEIKV 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-367 5.78e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   280 DKDDPntANGMLRYKILSQTPEspssNMFTINNKTGkIITVAAGLDREKVPQYTLIIQATDMEGNPtygLSNTATAVIRL 359
Cdd:smart00112   4 DADSG--ENGKVTYSILSGNDD----GLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTITV 73


                   ....*...
gi 211063455   360 LDVNDNAP 367
Cdd:smart00112  74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-588 8.12e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 490 QIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLY-DPANWLEIDPNNGRISTIAVLDREspyvKNNLYNATFMASDNG 568
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 211063455 569 VPRASGTGTLQIYLLDINDN 588
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
260-360 3.08e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 3.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  260 NGTVDEGAKPGTFVMTVTSQDKDDPntANGMLRYKILSQtpesPSSNMFTINNKTGkIITVAAGLDREKVPQYTLIIQAT 339
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTG-DISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 211063455  340 DmegNPTYGLSNTATAVIRLL 360
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-480 1.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 373 TFHGEVPEN-RVNVIVTNLTVTDKDEPgtPAWNAVYRIISGDPTGRFSIptDPVTneGLVTVVKPVDFEMNRSFMLTVVA 451
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 211063455 452 -DNEVPlasgihrTRQSTATVSIRVIDVNE 480
Cdd:cd11304   75 tDGGGP-------PLSSTATVTITVLDVND 97
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-116 3.92e-19

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 82.76  E-value: 3.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   26 PCQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPaDFRIDADGTVMAARTLQLTDRKgQSLEIKAKDE 105
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQ-TSFLVHAWDS 78

                          90
                  ....*....|.
gi 211063455  106 NSQEQWMVHIN 116
Cdd:pfam08758  79 HGEKMASVKVT 89
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 8.02e-19

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 82.39  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 150 IPPVNVLENSRKqfPEELVKIQSDKDKSNTLRYSVTGPGADQnPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:cd00031    1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 211063455 230 NGNQMENPIDIIINVIDMNDN 250
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
490-583 1.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  490 QIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLYD-PANWLEIDPNNGRISTIAVLDRESpyvkNNLYNATFMASDNG 568
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 211063455  569 VPRASGTGTLQIYLL 583
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 507-590 2.61e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   507 TAHDPDRYMQQTISYSKLY-DPANWLEIDPNNGRISTIAVLDREspyvKNNLYNATFMASDNGVPRASGTGTLQIYLLDI 585
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 211063455   586 NDNAP 590
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 172-252 2.34e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.34e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   172 SDKDKSNTLRYSVTGpgadQNPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDINGNQMENPIDIIINVIDMNDNR 251
Cdd:smart00112   5 ADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 211063455   252 P 252
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
374-476 1.46e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  374 FHGEVPEN-RVNVIVTNLTVTDKDEPgtPAWNAVYRIISGDPTGRFSIPTDPvtneGLVTVVKPVDFEMNRSFMLTVVAD 452
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 211063455  453 NEVPlasgihRTRQSTATVSIRVI 476
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-482 6.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 6.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   391 TVTDKDEPgtPAWNAVYRIISGDPTGRFSIptDPVTneGLVTVVKPVDFEMNRSFMLTVVA-DNEVPLASgihrtrqSTA 469
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEAtDGGGPPLS-------STA 67

                           90
                   ....*....|...
gi 211063455   470 TVSIRVIDVNESP 482
Cdd:smart00112  68 TVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
151-245 1.13e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  151 PPVNVLENSR-KQFPEELVKIQSDKDKSNTLRYSVTGPGADQNptglFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 211063455  230 NGNQMENPIDIIINVI 245
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
595-688 6.97e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 6.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  595 QEAEVCE--RPEPNAINITAVDGDLNPNAGPYAFELPNRPSDirrNWTLTRISGDhaqLSLK--ISYLESGIYELPISIT 670
Cdd:pfam00028   1 YSASVPEnaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 211063455  671 DSGNLPMSNTTYLRIKVC 688
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-688 1.31e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 594 PQEAEVCERPEPNA--INITAVDGDLNPNaGPYAFELPNRPSDirrnwTLTRISGDHAQLSLK--ISYLESGIYELPISI 669
Cdd:cd11304    1 SYEVSVPENAPPGTvvLTVSATDPDSGEN-GEVTYSIVSGNED-----GLFSIDPSTGEITTAkpLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 211063455 670 TDSGNLPMSNTTYLRIKVC 688
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-365 3.93e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 260 NGTVDEGAKPGTFVMTVTSQDKDDPNtaNGMLRYKILSQTPespsSNMFTINNKTGkIITVAAGLDREKVPQYTLIIQAT 339
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 211063455 340 DMEGNPtygLSNTATAVIRLLDVNDN 365
Cdd:cd11304   76 DGGGPP---LSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 830-889 1.23e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.23e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  830 ADTDPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYG 889
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-117 4.34e-26

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 102.36  E-value: 4.34e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455    27 CQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPaDFRIDADGTVMAARTLQLTDRKgQSLEIKAKDen 106
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDP-DFRVLEDGTVYATRPVSLSSEK-KSFTVLAWD-- 76

                           90
                   ....*....|.
gi 211063455   107 SQEQWMVHINF 117
Cdd:smart01055  77 SQGQEKKEIKV 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 280-367 5.78e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 5.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   280 DKDDPntANGMLRYKILSQTPEspssNMFTINNKTGkIITVAAGLDREKVPQYTLIIQATDMEGNPtygLSNTATAVIRL 359
Cdd:smart00112   4 DADSG--ENGKVTYSILSGNDD----GLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTITV 73


                   ....*...
gi 211063455   360 LDVNDNAP 367
Cdd:smart00112  74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-588 8.12e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 8.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 490 QIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLY-DPANWLEIDPNNGRISTIAVLDREspyvKNNLYNATFMASDNG 568
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 211063455 569 VPRASGTGTLQIYLLDINDN 588
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
260-360 3.08e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 3.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  260 NGTVDEGAKPGTFVMTVTSQDKDDPntANGMLRYKILSQtpesPSSNMFTINNKTGkIITVAAGLDREKVPQYTLIIQAT 339
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTG-DISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 211063455  340 DmegNPTYGLSNTATAVIRLL 360
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-480 1.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 373 TFHGEVPEN-RVNVIVTNLTVTDKDEPgtPAWNAVYRIISGDPTGRFSIptDPVTneGLVTVVKPVDFEMNRSFMLTVVA 451
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 211063455 452 -DNEVPlasgihrTRQSTATVSIRVIDVNE 480
Cdd:cd11304   75 tDGGGP-------PLSSTATVTITVLDVND 97
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 26-116 3.92e-19

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 82.76  E-value: 3.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   26 PCQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPaDFRIDADGTVMAARTLQLTDRKgQSLEIKAKDE 105
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDP-RFKVNTDGTVTAKRPVTLHGRQ-TSFLVHAWDS 78

                          90
                  ....*....|.
gi 211063455  106 NSQEQWMVHIN 116
Cdd:pfam08758  79 HGEKMASVKVT 89
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 150-250 8.02e-19

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 82.39  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 150 IPPVNVLENSRKqfPEELVKIQSDKDKSNTLRYSVTGPGADQnPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:cd00031    1 IPDGSAVEGRSR--GSFRVSIPTDLIASSGEIIKISAAGKEA-LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                         90       100
                 ....*....|....*....|.
gi 211063455 230 NGNQMENPIDIIINVIDMNDN 250
Cdd:cd00031   78 GANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
490-583 1.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  490 QIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLYD-PANWLEIDPNNGRISTIAVLDRESpyvkNNLYNATFMASDNG 568
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 211063455  569 VPRASGTGTLQIYLL 583
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 507-590 2.61e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   507 TAHDPDRYMQQTISYSKLY-DPANWLEIDPNNGRISTIAVLDREspyvKNNLYNATFMASDNGVPRASGTGTLQIYLLDI 585
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 211063455   586 NDNAP 590
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-250 2.89e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 2.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 153 VNVLENSRKqfPEELVKIQ-SDKDKSN--TLRYSVTGPgadqNPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSaTDPDSGEngEVTYSIVSG----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 211063455 230 NGNQMENPIDIIINVIDMNDN 250
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 172-252 2.34e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.34e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   172 SDKDKSNTLRYSVTGpgadQNPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDINGNQMENPIDIIINVIDMNDNR 251
Cdd:smart00112   5 ADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 211063455   252 P 252
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
374-476 1.46e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  374 FHGEVPEN-RVNVIVTNLTVTDKDEPgtPAWNAVYRIISGDPTGRFSIPTDPvtneGLVTVVKPVDFEMNRSFMLTVVAD 452
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 211063455  453 NEVPlasgihRTRQSTATVSIRVI 476
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-482 6.21e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 6.21e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455   391 TVTDKDEPgtPAWNAVYRIISGDPTGRFSIptDPVTneGLVTVVKPVDFEMNRSFMLTVVA-DNEVPLASgihrtrqSTA 469
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEAtDGGGPPLS-------STA 67

                           90
                   ....*....|...
gi 211063455   470 TVSIRVIDVNESP 482
Cdd:smart00112  68 TVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
151-245 1.13e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  151 PPVNVLENSR-KQFPEELVKIQSDKDKSNTLRYSVTGPGADQNptglFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDI 229
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN----FRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 211063455  230 NGNQMENPIDIIINVI 245
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
595-688 6.97e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 6.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455  595 QEAEVCE--RPEPNAINITAVDGDLNPNAGPYAFELPNRPSDirrNWTLTRISGDhaqLSLK--ISYLESGIYELPISIT 670
Cdd:pfam00028   1 YSASVPEnaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 211063455  671 DSGNLPMSNTTYLRIKVC 688
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-688 1.31e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.92  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211063455 594 PQEAEVCERPEPNA--INITAVDGDLNPNaGPYAFELPNRPSDirrnwTLTRISGDHAQLSLK--ISYLESGIYELPISI 669
Cdd:cd11304    1 SYEVSVPENAPPGTvvLTVSATDPDSGEN-GEVTYSIVSGNED-----GLFSIDPSTGEITTAkpLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 211063455 670 TDSGNLPMSNTTYLRIKVC 688
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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