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Conserved domains on  [gi|51479177|ref|NP_077313|]
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iroquois-class homeodomain protein IRX-1 [Homo sapiens]

Protein Classification

iroquois-class homeodomain protein( domain architecture ID 11160563)

iroquois-class homeodomain protein plays numerous roles in early embryo patterning

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 146-184 2.29e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.29e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51479177   146 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 184
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
313-326 3.06e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


:

Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.06e-03
                           10
                   ....*....|....
gi 51479177    313 KPKIWSLAETATSP 326
Cdd:smart00548   5 KPKIWSLADTATSS 18
DNA_pol_phi super family cl47903
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 195-248 5.64e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


The actual alignment was detected with superfamily member pfam04931:

Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.14  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 51479177   195 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDK-IDEHDGDQSNEDDEDK 248
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDE 679
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 146-184 2.29e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.29e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51479177   146 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 184
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 135-189 1.98e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 1.98e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 51479177 135 TRESTSTLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 189
Cdd:cd00086   8 TPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 135-186 5.52e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 57.65  E-value: 5.52e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 51479177    135 TRESTSTLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 186
Cdd:smart00389   9 TPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
127-190 2.70e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.35  E-value: 2.70e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51479177 127 DPGRPKN--ATRESTSTLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 190
Cdd:COG5576  49 SPPKSKRrrTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
313-326 3.06e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.06e-03
                           10
                   ....*....|....
gi 51479177    313 KPKIWSLAETATSP 326
Cdd:smart00548   5 KPKIWSLADTATSS 18
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 195-248 5.64e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.14  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 51479177   195 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDK-IDEHDGDQSNEDDEDK 248
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDE 679
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 146-184 2.29e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.29e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 51479177   146 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 184
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 135-189 1.98e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 61.88  E-value: 1.98e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 51479177 135 TRESTSTLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 189
Cdd:cd00086   8 TPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 135-186 5.52e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 57.65  E-value: 5.52e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 51479177    135 TRESTSTLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 186
Cdd:smart00389   9 TPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
135-187 7.06e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.26  E-value: 7.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 51479177   135 TRESTSTLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK 187
Cdd:pfam00046   8 TPEQLEELEK---EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
127-190 2.70e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 44.35  E-value: 2.70e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51479177 127 DPGRPKN--ATRESTSTLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 190
Cdd:COG5576  49 SPPKSKRrrTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
313-326 3.06e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.06e-03
                           10
                   ....*....|....
gi 51479177    313 KPKIWSLAETATSP 326
Cdd:smart00548   5 KPKIWSLADTATSS 18
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 195-248 5.64e-03

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 39.14  E-value: 5.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 51479177   195 ARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDK-IDEHDGDQSNEDDEDK 248
Cdd:pfam04931 625 ARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEdDDEDDDDEDEEDDDDE 679
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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