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Conserved domains on  [gi|158533984|ref|NP_076392|]
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lipase member M precursor [Mus musculus]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
50-408 1.77e-57

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.54  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  50 SEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEgSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 130 GNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQKKVYYVGYSQGTTMGFIAFsTMPELAHKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 210 FALAPIATVKYARSPGTK---FLLLPDMMIKVlfgrqeFLYQTRFFRQLFIYLcgqmiLDQICSNIIL---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHLDQMVVAM------GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 284 --MNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSeTKNQEKCNQPTPIRYKVRDMMVPTAMWT--GGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGL 338
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 158533984 360 SNPDDVKTLLSEVTN---LIYHKNipeWAHVDFIWGLDAPQRVYNEIIHLMK 408
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
50-408 1.77e-57

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.54  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  50 SEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEgSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 130 GNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQKKVYYVGYSQGTTMGFIAFsTMPELAHKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 210 FALAPIATVKYARSPGTK---FLLLPDMMIKVlfgrqeFLYQTRFFRQLFIYLcgqmiLDQICSNIIL---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHLDQMVVAM------GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 284 --MNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSeTKNQEKCNQPTPIRYKVRDMMVPTAMWT--GGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGL 338
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 158533984 360 SNPDDVKTLLSEVTN---LIYHKNipeWAHVDFIWGLDAPQRVYNEIIHLMK 408
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
49-111 2.24e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 106.08  E-value: 2.24e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 158533984   49 VSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNL 111
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
59-214 2.04e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 51.54  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  59 PSEEYEVATEDGYILsvnripRGQTRLKKEGSRPVVLLQHGLLGDASNWisnlpnNSLGFILADAGFDVWMGNSRGNTWS 138
Cdd:COG2267    2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGRS 69
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 158533984 139 RKHKTLsidqdefwAFSYDEMARfDLPAVINFILQKTGQkKVYYVGYSQGttmGFIAFSTMPELAHKIKMYFALAP 214
Cdd:COG2267   70 DGPRGH--------VDSFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAP 132
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
50-408 1.77e-57

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 193.54  E-value: 1.77e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  50 SEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEgSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 130 GNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQKKVYYVGYSQGTTMGFIAFsTMPELAHKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 210 FALAPIATVKYARSPGTK---FLLLPDMMIKVlfgrqeFLYQTRFFRQLFIYLcgqmiLDQICSNIIL---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHLDQMVVAM------GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 284 --MNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWGSeTKNQEKCNQPTPIRYKVRDMMVPTAMWT--GGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGL 338
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 158533984 360 SNPDDVKTLLSEVTN---LIYHKNipeWAHVDFIWGLDAPQRVYNEIIHLMK 408
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMIQFFR 387
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
49-111 2.24e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 106.08  E-value: 2.24e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 158533984   49 VSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNL 111
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
92-392 5.60e-27

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 107.98  E-value: 5.60e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984   92 PVVLLQHGLLGDASNWISNLPNnslgfiLADAGFDVWMGNSRGNTWSRKHKTLSidqdefwAFSYDEMARFdlpavINFI 171
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  172 LQKTGQKKVYYVGYSQGTTMGFIAFSTMPElahKIKMYFALAPIatvkyarSPGTKFLLLPDMMIKVLFGRQEFLYQTRF 251
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  252 FRQLFIYLCGQMILDQICSNIILLLGGFntnNMNMSRANVYVAHTPAGTSVQNILHWSQAVNSGELRAFDWgsetknqek 331
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKALPLL---NKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158533984  332 cnqptpirykvrdmmvPTAMWTGGQDWLsNPDDVKTLLSEVTNLIYHKNIPEWAHVDFIWG 392
Cdd:pfam00561 201 ----------------PTLIIWGDQDPL-VPPQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
59-214 2.04e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 51.54  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  59 PSEEYEVATEDGYILsvnripRGQTRLKKEGSRPVVLLQHGLLGDASNWisnlpnNSLGFILADAGFDVWMGNSRGNTWS 138
Cdd:COG2267    2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGRS 69
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 158533984 139 RKHKTLsidqdefwAFSYDEMARfDLPAVINFILQKTGQkKVYYVGYSQGttmGFIAFSTMPELAHKIKMYFALAP 214
Cdd:COG2267   70 DGPRGH--------VDSFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAP 132
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
91-191 1.26e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 43.66  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  91 RPVVLLqHGLLGDASNWiSNLPNNslgfiLADAGFDVWmgnsrgntwsrkhkTLSIDQDefwAFSYDEMARfDLPAVINF 170
Cdd:COG1075    6 YPVVLV-HGLGGSAASW-APLAPR-----LRAAGYPVY--------------ALNYPST---NGSIEDSAE-QLAAFVDA 60
                         90       100
                 ....*....|....*....|.
gi 158533984 171 ILQKTGQKKVYYVGYSQGTTM 191
Cdd:COG1075   61 VLAATGAEKVDLVGHSMGGLV 81
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
86-216 2.09e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 42.70  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  86 KKEGSRPVVLLQHGllGDASNWISNLPNNSLgfiLADAGFDVWMGNSRGNTWSRKHktlsidqdefwaFSYDEMArfDLP 165
Cdd:COG1506   18 ADGKKYPVVVYVHG--GPGSRDDSFLPLAQA---LASRGYAVLAPDYRGYGESAGD------------WGGDEVD--DVL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 158533984 166 AVINFILQKTG--QKKVYYVGYSQGttmGFIAFSTMPELAHKIKMYFALAPIA 216
Cdd:COG1506   79 AAIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVS 128
YpfH COG0400
Predicted esterase [General function prediction only];
88-230 8.58e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 40.28  E-value: 8.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984  88 EGSRPVVLLQHGLLGDASNWIS---NLPNNSLGFILADAGFDVWMGnsrGNTWSRKHKTLSIDQDEFWAFSYDEMARFdl 164
Cdd:COG0400    2 GPAAPLVVLLHGYGGDEEDLLPlapELALPGAAVLAPRAPVPEGPG---GRAWFDLSFLEGREDEEGLAAAAEALAAF-- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984 165 pavINFILQKTG--QKKVYYVGYSQGTTM-------------GFIAFSTmpelahkikmYFALAPIATVKYARSPGTKFL 229
Cdd:COG0400   77 ---IDELEARYGidPERIVLAGFSQGAAMalslalrrpellaGVVALSG----------YLPGEEALPAPEAALAGTPVF 143

                 .
gi 158533984 230 L 230
Cdd:COG0400  144 L 144
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
91-207 2.48e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 39.12  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158533984   91 RPVVLLQHGLlGDASNWISNLpnnslGFILADAGFDVWM------GNSRGNTWsrkhktlsidqdefWAFSYDEMARfDL 164
Cdd:pfam12146   4 RAVVVLVHGL-GEHSGRYAHL-----ADALAAQGFAVYAydhrghGRSDGKRG--------------HVPSFDDYVD-DL 62
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 158533984  165 PAVINFILQKTGQKKVYYVGYSQGttmGFIAFSTMPELAHKIK 207
Cdd:pfam12146  63 DTFVDKIREEHPGLPLFLLGHSMG---GLIAALYALRYPDKVD 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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