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Conserved domains on  [gi|52317148|ref|NP_067467|]
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AP-3 complex subunit beta-2 [Mus musculus]

Protein Classification

AP-3 complex subunit beta( domain architecture ID 12024697)

AP-3 complex subunit beta is part of the non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590 1.49e-170

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


:

Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 511.01  E-value: 1.49e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148     34 SDYKRHDDLKEMLDTNKDS--LKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLS 111
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    112 ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLL 191
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    192 ADKTTLVAGSVVMAFEEVC---PERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPtqneslleenpeka 268
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    269 fygseedeakgpgseeaataalparkpyvmdpdhRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGV-IAKALVRL 347
Cdd:pfam01602  227 ----------------------------------KELLEDLLNLLQNSNNAVLYETANTIVHLAPAPELIVlAVNALGRL 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    348 LRSHSE-VQYVVLQNVATMSIKR-RGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSM-DKD 424
Cdd:pfam01602  273 LSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPD 352
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    425 FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASI 504
Cdd:pfam01602  353 FKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAA 432
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    505 LWLIGEYCEHVP--KIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTK--LLTQYVLSLAKYDQ-NYDIRDRA 579
Cdd:pfam01602  433 LWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETTqnLIIQLLLTLATQDSlDLEVRDRA 512
                          570
                   ....*....|.
gi 52317148    580 RFTRQLIVPSE 590
Cdd:pfam01602  513 VEYLRLLSLAD 523
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
804-947 1.43e-60

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


:

Pssm-ID: 464319  Cd Length: 148  Bit Score: 203.65  E-value: 1.43e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    804 KEISLLDLEDFTPPSVQPVSPPM-VVSTSLAADLEGLTLTDSSLVPSLLSPV-SSIGRQELLHRVAGEGLSVDYAFSRQP 881
Cdd:pfam14796    3 NEDLLLDLDDFSPSSPVMTPSLGgFLSPSLATDLEGLSLTDSSSAIEVVSPSfVPTKTHELLHRMTGEGLSVEYRFTRQP 82
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52317148    882 FSGDPHMVSLHIYFSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQ 947
Cdd:pfam14796   83 CIYSPKMVSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590 1.49e-170

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 511.01  E-value: 1.49e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148     34 SDYKRHDDLKEMLDTNKDS--LKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLS 111
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    112 ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLL 191
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    192 ADKTTLVAGSVVMAFEEVC---PERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPtqneslleenpeka 268
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    269 fygseedeakgpgseeaataalparkpyvmdpdhRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGV-IAKALVRL 347
Cdd:pfam01602  227 ----------------------------------KELLEDLLNLLQNSNNAVLYETANTIVHLAPAPELIVlAVNALGRL 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    348 LRSHSE-VQYVVLQNVATMSIKR-RGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSM-DKD 424
Cdd:pfam01602  273 LSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPD 352
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    425 FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASI 504
Cdd:pfam01602  353 FKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAA 432
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    505 LWLIGEYCEHVP--KIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTK--LLTQYVLSLAKYDQ-NYDIRDRA 579
Cdd:pfam01602  433 LWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETTqnLIIQLLLTLATQDSlDLEVRDRA 512
                          570
                   ....*....|.
gi 52317148    580 RFTRQLIVPSE 590
Cdd:pfam01602  513 VEYLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
46-608 2.39e-67

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 241.94  E-value: 2.39e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   46 LDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQL 125
Cdd:COG5096   28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  126 IRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQ--LIEVIEKLLADKTTLVAGSVV 203
Cdd:COG5096  108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHElgLIDILKELVADSDPIVIANAL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  204 MAFEEVCPERI-DLIHKNYRKLCNLliDVEEWGQVVIISMLTRYARTQFLSPTQneslleenpekafygseedeakgPGS 282
Cdd:COG5096  188 ASLAEIDPELAhGYSLEVILRIPQL--DLLSLSVSTEWLLLIILEVLTERVPTT-----------------------PDS 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  283 EEAATAALParkPYVMDPDHRLLLRNTKPLLQsrsAAVVMAVAQLYFHLAPKaevgviakaLVRLLRSHSEVQYVVLQNV 362
Cdd:COG5096  243 AEDFEERLS---PPLQHNNAEVLLIAVKVILR---LLVFLPSNNLFLISSPP---------LVTLLAKPESLIQYVLRRN 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  363 ATMSIKRRG-MFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYI--RSMDKDFVAATIQAIGRCATN 439
Cdd:COG5096  308 IQIDLEVCSkLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQILLELIYYIaeNHIDAEMVSEAIKALGDLASK 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  440 IGRVRDTCLNGLVQLLSN---RDELVVAE------------SVVVIKKLLQMQPAQHGEII-KHLAKLTDNIQVP----- 498
Cdd:COG5096  388 AESSVNDCISELLELLEGvwiRGSYIVQEvrivdcisviriSVLVLRILPNEYPKILLRGLyALEETLELQSREPraksv 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  499 MARASILWLIGEYCEHVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTN-SKQTKLLTQYVLSLAKYDQNY---- 573
Cdd:COG5096  468 TDKYLGAWLLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMSSVKLIANSiRKAKQCNSELDQDVLRRCFDYvlvp 547
                        570       580       590
                 ....*....|....*....|....*....|....*
gi 52317148  574 DIRDRARFTRQLIVPseqggALSRHAKKLFLAPKP 608
Cdd:COG5096  548 DLRDRARMYSRLLST-----PLPEFSDPILCEAKK 577
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
804-947 1.43e-60

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 203.65  E-value: 1.43e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    804 KEISLLDLEDFTPPSVQPVSPPM-VVSTSLAADLEGLTLTDSSLVPSLLSPV-SSIGRQELLHRVAGEGLSVDYAFSRQP 881
Cdd:pfam14796    3 NEDLLLDLDDFSPSSPVMTPSLGgFLSPSLATDLEGLSLTDSSSAIEVVSPSfVPTKTHELLHRMTGEGLSVEYRFTRQP 82
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52317148    882 FSGDPHMVSLHIYFSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQ 947
Cdd:pfam14796   83 CIYSPKMVSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
PTZ00429 PTZ00429
beta-adaptin; Provisional
41-579 5.49e-55

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 205.17  E-value: 5.49e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    41 DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLK 120
Cdd:PTZ00429   36 ELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPEKALLAVNTFLQDTT 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   121 DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYS------LDSDQKDQLIevieKLLADK 194
Cdd:PTZ00429  116 NSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFKKDLV----ELLNDN 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   195 TTLV---AGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTryartqflsptqneslleenpekafyg 271
Cdd:PTZ00429  192 NPVVasnAAAIVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLA--------------------------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   272 seedeAKGPGSEEAATAALParkpyvmdpdhRLLLRntkplLQSRSAAVVMAVAQLYFHLAPK------AEVGV-IAKAL 344
Cdd:PTZ00429  245 -----AQRPSDKESAETLLT-----------RVLPR-----MSHQNPAVVMGAIKVVANLASRcsqeliERCTVrVNTAL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   345 VRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKD 424
Cdd:PTZ00429  304 LTLSRRDAETQYIVCKNIHALLVIFPNLLRTNLDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMV 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   425 FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELvVAESVVVIKKLLQMQPAQ---HGEIIKHLAkltDNIQVPMAR 501
Cdd:PTZ00429  384 FVVEVVRAIASLAIKVDSVAPDCANLLLQIVDRRPEL-LPQVVTAAKDIVRKYPELlmlDTLVTDYGA---DEVVEEEAK 459
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52317148   502 ASILWLIGEYCEHVPKiAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVL-SLAKYDQNYDIRDRA 579
Cdd:PTZ00429  460 VSLLWMLGEYCDFIEN-GKDIIQRFIDTIMEHEQRVQLAILSAAVKMFLRDPQGMEPQLNRVLeTVTTHSDDPDVRDRA 537
 
Name Accession Description Interval E-value
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590 1.49e-170

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 511.01  E-value: 1.49e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148     34 SDYKRHDDLKEMLDTNKDS--LKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLS 111
Cdd:pfam01602    1 EEKRIQQELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    112 ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLL 191
Cdd:pfam01602   81 TNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    192 ADKTTLVAGSVVMAFEEVC---PERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPtqneslleenpeka 268
Cdd:pfam01602  161 SDKDPGVQSAAVALLYEICkndRLYLKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLDPLLP-------------- 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    269 fygseedeakgpgseeaataalparkpyvmdpdhRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGV-IAKALVRL 347
Cdd:pfam01602  227 ----------------------------------KELLEDLLNLLQNSNNAVLYETANTIVHLAPAPELIVlAVNALGRL 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    348 LRSHSE-VQYVVLQNVATMSIKR-RGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSM-DKD 424
Cdd:pfam01602  273 LSSPDEnLRYVALRNLNKIVMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIaDPD 352
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    425 FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASI 504
Cdd:pfam01602  353 FKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAA 432
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    505 LWLIGEYCEHVP--KIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTK--LLTQYVLSLAKYDQ-NYDIRDRA 579
Cdd:pfam01602  433 LWILGEYGELIPngSSPPDLLRSILEVFVLESAKVRAAALTALAKLGLTSPEETTqnLIIQLLLTLATQDSlDLEVRDRA 512
                          570
                   ....*....|.
gi 52317148    580 RFTRQLIVPSE 590
Cdd:pfam01602  513 VEYLRLLSLAD 523
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
46-608 2.39e-67

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 241.94  E-value: 2.39e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   46 LDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQL 125
Cdd:COG5096   28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  126 IRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQ--LIEVIEKLLADKTTLVAGSVV 203
Cdd:COG5096  108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYHElgLIDILKELVADSDPIVIANAL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  204 MAFEEVCPERI-DLIHKNYRKLCNLliDVEEWGQVVIISMLTRYARTQFLSPTQneslleenpekafygseedeakgPGS 282
Cdd:COG5096  188 ASLAEIDPELAhGYSLEVILRIPQL--DLLSLSVSTEWLLLIILEVLTERVPTT-----------------------PDS 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  283 EEAATAALParkPYVMDPDHRLLLRNTKPLLQsrsAAVVMAVAQLYFHLAPKaevgviakaLVRLLRSHSEVQYVVLQNV 362
Cdd:COG5096  243 AEDFEERLS---PPLQHNNAEVLLIAVKVILR---LLVFLPSNNLFLISSPP---------LVTLLAKPESLIQYVLRRN 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  363 ATMSIKRRG-MFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYI--RSMDKDFVAATIQAIGRCATN 439
Cdd:COG5096  308 IQIDLEVCSkLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQILLELIYYIaeNHIDAEMVSEAIKALGDLASK 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  440 IGRVRDTCLNGLVQLLSN---RDELVVAE------------SVVVIKKLLQMQPAQHGEII-KHLAKLTDNIQVP----- 498
Cdd:COG5096  388 AESSVNDCISELLELLEGvwiRGSYIVQEvrivdcisviriSVLVLRILPNEYPKILLRGLyALEETLELQSREPraksv 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  499 MARASILWLIGEYCEHVPKIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTN-SKQTKLLTQYVLSLAKYDQNY---- 573
Cdd:COG5096  468 TDKYLGAWLLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMSSVKLIANSiRKAKQCNSELDQDVLRRCFDYvlvp 547
                        570       580       590
                 ....*....|....*....|....*....|....*
gi 52317148  574 DIRDRARFTRQLIVPseqggALSRHAKKLFLAPKP 608
Cdd:COG5096  548 DLRDRARMYSRLLST-----PLPEFSDPILCEAKK 577
AP3B1_C pfam14796
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
804-947 1.43e-60

Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.


Pssm-ID: 464319  Cd Length: 148  Bit Score: 203.65  E-value: 1.43e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    804 KEISLLDLEDFTPPSVQPVSPPM-VVSTSLAADLEGLTLTDSSLVPSLLSPV-SSIGRQELLHRVAGEGLSVDYAFSRQP 881
Cdd:pfam14796    3 NEDLLLDLDDFSPSSPVMTPSLGgFLSPSLATDLEGLSLTDSSSAIEVVSPSfVPTKTHELLHRMTGEGLSVEYRFTRQP 82
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52317148    882 FSGDPHMVSLHIYFSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQ 947
Cdd:pfam14796   83 CIYSPKMVSVELTFTNTSDSEITNIHIGEKKLPAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
PTZ00429 PTZ00429
beta-adaptin; Provisional
41-579 5.49e-55

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 205.17  E-value: 5.49e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    41 DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLK 120
Cdd:PTZ00429   36 ELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPEKALLAVNTFLQDTT 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   121 DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYS------LDSDQKDQLIevieKLLADK 194
Cdd:PTZ00429  116 NSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFKKDLV----ELLNDN 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   195 TTLV---AGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTryartqflsptqneslleenpekafyg 271
Cdd:PTZ00429  192 NPVVasnAAAIVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLA--------------------------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   272 seedeAKGPGSEEAATAALParkpyvmdpdhRLLLRntkplLQSRSAAVVMAVAQLYFHLAPK------AEVGV-IAKAL 344
Cdd:PTZ00429  245 -----AQRPSDKESAETLLT-----------RVLPR-----MSHQNPAVVMGAIKVVANLASRcsqeliERCTVrVNTAL 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   345 VRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKD 424
Cdd:PTZ00429  304 LTLSRRDAETQYIVCKNIHALLVIFPNLLRTNLDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMV 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148   425 FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELvVAESVVVIKKLLQMQPAQ---HGEIIKHLAkltDNIQVPMAR 501
Cdd:PTZ00429  384 FVVEVVRAIASLAIKVDSVAPDCANLLLQIVDRRPEL-LPQVVTAAKDIVRKYPELlmlDTLVTDYGA---DEVVEEEAK 459
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52317148   502 ASILWLIGEYCEHVPKiAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVL-SLAKYDQNYDIRDRA 579
Cdd:PTZ00429  460 VSLLWMLGEYCDFIEN-GKDIIQRFIDTIMEHEQRVQLAILSAAVKMFLRDPQGMEPQLNRVLeTVTTHSDDPDVRDRA 537
Cnd1 pfam12717
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
125-246 4.83e-18

non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.


Pssm-ID: 463677 [Multi-domain]  Cd Length: 162  Bit Score: 82.51  E-value: 4.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148    125 LIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVM 204
Cdd:pfam12717    1 LIRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILPDMVKVKGFISELAKLLEDPNPMVVANALA 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 52317148    205 AFEEVCPERIDLI----HKNYRKLCNLLIDVEEWGQVVIISMLTRY 246
Cdd:pfam12717   81 ALTEISEKDPNAIynllPDIISKLSDALNECSEWGQIYILDFLASY 126
HEAT COG1413
HEAT repeat [General function prediction only];
111-214 2.40e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  111 SISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAASDMSPYVRKTAAHAIPKLYSldsdqkDQLIEVIEKL 190
Cdd:COG1413   17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGD------PEAVPALIAA 86
                         90       100
                 ....*....|....*....|....
gi 52317148  191 LADKTTLVAGSVVMAFEEVCPERI 214
Cdd:COG1413   87 LKDEDPEVRRAAAEALGRLGDPAA 110
HEAT COG1413
HEAT repeat [General function prediction only];
111-205 4.32e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.32  E-value: 4.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52317148  111 SISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAASDMSPYVRKTAAHAipkLYSLDSdqkDQLIEVIEKL 190
Cdd:COG1413   48 AVPALLEALKDPDPEVRAAAAEALGRIGDPEAVP----ALIAALKDEDPEVRRAAAEA---LGRLGD---PAAVPALLEA 117
                         90
                 ....*....|....*
gi 52317148  191 LADKTTLVAGSVVMA 205
Cdd:COG1413  118 LKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
111-169 1.49e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 52317148  111 SISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAASDMSPYVRKTAAHAI 169
Cdd:COG1413   79 AVPALIAALKDEDPEVRRAAAEALGRLGDPAAVP----ALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
119-195 3.07e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 3.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52317148    119 LKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAASDMSPYVRKTAAHAIPKLYSLDSdqkdqlIEVIEKLLADKT 195
Cdd:pfam13646    9 LRDPDPEVRAAAIRALGRIGDPEAVP----ALLELLKDEDPAVRRAAAEALGKIGDPEA------LPALLELLRDDD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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