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Conserved domains on  [gi|50428935|ref|NP_060644|]
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microtubule-associated protein 1S isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 484-899 7.15e-12

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 69.81  E-value: 7.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   484 REGLLATHPRPGQERPGVARKEPARAeaPRKTEKEAKTPRELKKDPKPSvSRTQPREVRRAASSVPNLKKTNAQAAPKPR 563
Cdd:PHA03307   39 SQGQLVSDSAELAAVTVVAGAAACDR--FEPPTGPPPGPGTEAPANESR-STPTWSLSTLAPASPAREGSPTPPGPSSPD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   564 KAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSlelgpiPAGEEKALELPLAASSIPRPRTPSPEs 643
Cdd:PHA03307  116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAV------ASDAASSRQAALPLSSPEETARAPSS- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   644 hrSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQvlpPSAPTSEAGLSLPLRG 723
Cdd:PHA03307  189 --PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC---GWGPENECPLPRPAPI 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   724 PRARRSASPHdvdlclvspcefEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLA 803
Cdd:PHA03307  264 TLPTRIWEAS------------GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   804 PGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAA 883
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                         410
                  ....*....|....*.
gi 50428935   884 AKTKGLAGGDRASRPL 899
Cdd:PHA03307  412 PRPSPLDAGAASGAFY 427
ComEC super family cl28169
DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily ...
 249-434 4.21e-05

DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG2333:

Pssm-ID: 441904 [Multi-domain]  Cd Length: 253  Bit Score: 46.39  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  249 GLGDAAFF-AVNGFTVLVNGGSNPKSSFWKLV-------RHLDRVDAVLVTHPGADSLPGLNSLLRRKlaersevaaggg 320
Cdd:COG2333    9 GQGDAILIrTPDGKTILIDTGPRPSFDAGERVvlpylraLGIRRLDLLVLTHPDADHIGGLAAVLEAF------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  321 swddRLRRLISPNlgvvffnaceaasrLARGEDEAELALSLLAQLGITPLPLSRGpvpakptvlfEKMGVGRLDMYVLHP 400
Cdd:COG2333   77 ----PVGRVLVSG--------------PPDTSETYERLLEALKEKGIPVRPCRAG----------DTWQLGGVRFEVLWP 128

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 50428935  401 PSAGAERTL---ASvCALLVWHPAgpgekvVRVLFPG 434
Cdd:COG2333  129 PEDLLEGSDennNS-LVLRLTYGG------FSFLLTG 158
PHA03381 super family cl31824
tegument protein VP22; Provisional
 858-960 1.10e-03

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.31  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   858 NVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAggdRASRPLSARSEPSEKGGRAPLSRKSSTPkTATRGPSGSASSRPG 937
Cdd:PHA03381   86 DPRPSRRPHAQPEASGPGPARGARGPAGSRGRG---RRAESPSPRDPPNPKGASAPRGRKSACA-DSAALLDAPAPAAPK 161

                          90       100
                  ....*....|....*....|...
gi 50428935   938 VSATPPKSPVYLDLAYLPSGSSA 960
Cdd:PHA03381  162 RQKTPAGLARKLHFSTAPTSPTA 184
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 484-899 7.15e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 69.81  E-value: 7.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   484 REGLLATHPRPGQERPGVARKEPARAeaPRKTEKEAKTPRELKKDPKPSvSRTQPREVRRAASSVPNLKKTNAQAAPKPR 563
Cdd:PHA03307   39 SQGQLVSDSAELAAVTVVAGAAACDR--FEPPTGPPPGPGTEAPANESR-STPTWSLSTLAPASPAREGSPTPPGPSSPD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   564 KAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSlelgpiPAGEEKALELPLAASSIPRPRTPSPEs 643
Cdd:PHA03307  116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAV------ASDAASSRQAALPLSSPEETARAPSS- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   644 hrSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQvlpPSAPTSEAGLSLPLRG 723
Cdd:PHA03307  189 --PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC---GWGPENECPLPRPAPI 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   724 PRARRSASPHdvdlclvspcefEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLA 803
Cdd:PHA03307  264 TLPTRIWEAS------------GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   804 PGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAA 883
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                         410
                  ....*....|....*.
gi 50428935   884 AKTKGLAGGDRASRPL 899
Cdd:PHA03307  412 PRPSPLDAGAASGAFY 427
ComEC COG2333
DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily ...
 249-434 4.21e-05

DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441904 [Multi-domain]  Cd Length: 253  Bit Score: 46.39  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  249 GLGDAAFF-AVNGFTVLVNGGSNPKSSFWKLV-------RHLDRVDAVLVTHPGADSLPGLNSLLRRKlaersevaaggg 320
Cdd:COG2333    9 GQGDAILIrTPDGKTILIDTGPRPSFDAGERVvlpylraLGIRRLDLLVLTHPDADHIGGLAAVLEAF------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  321 swddRLRRLISPNlgvvffnaceaasrLARGEDEAELALSLLAQLGITPLPLSRGpvpakptvlfEKMGVGRLDMYVLHP 400
Cdd:COG2333   77 ----PVGRVLVSG--------------PPDTSETYERLLEALKEKGIPVRPCRAG----------DTWQLGGVRFEVLWP 128

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 50428935  401 PSAGAERTL---ASvCALLVWHPAgpgekvVRVLFPG 434
Cdd:COG2333  129 PEDLLEGSDennNS-LVLRLTYGG------FSFLLTG 158
PHA03381 PHA03381
tegument protein VP22; Provisional
 858-960 1.10e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.31  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   858 NVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAggdRASRPLSARSEPSEKGGRAPLSRKSSTPkTATRGPSGSASSRPG 937
Cdd:PHA03381   86 DPRPSRRPHAQPEASGPGPARGARGPAGSRGRG---RRAESPSPRDPPNPKGASAPRGRKSACA-DSAALLDAPAPAAPK 161

                          90       100
                  ....*....|....*....|...
gi 50428935   938 VSATPPKSPVYLDLAYLPSGSSA 960
Cdd:PHA03381  162 RQKTPAGLARKLHFSTAPTSPTA 184
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 544-955 1.73e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    544 AASSVPNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSlelgPIPAG-EEK 622
Cdd:pfam05109  427 STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPS----PRDNGtESK 502

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    623 ALEL--PLAASSIPRPRTPSPeshrSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTevdeslsv 700
Cdd:pfam05109  503 APDMtsPTSAVTTPTPNATSP----TPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAT-------- 570

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    701 sfEQVLPPSAPTSEAGLSLPLRGPRARRSASPHdvdlCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAE 780
Cdd:pfam05109  571 --IPTLGKTSPTSAVTTPTPNATSPTVGETSPQ----ANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSM 644

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    781 ETPPTSVSESL-PTLSDSDP--VPLAPGAadsdEDTEGFGVPRHDPLPDP---LKVPPPLPDPSSICMVD-PEMLPPKTA 853
Cdd:pfam05109  645 SLRPSSISETLsPSTSDNSTshMPLLTSA----HPTGGENITQVTPASTSthhVSTSSPAPRPGTTSQASgPGNSSTSTK 720

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    854 RQTENVSR------TRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRG 927
Cdd:pfam05109  721 PGEVNVTKgtppknATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATTYLP 800

                          410       420
                   ....*....|....*....|....*...
gi 50428935    928 PSGSASSRPGVSATPPksPVYLDLAYLP 955
Cdd:pfam05109  801 PSTSSKLRPRWTFTSP--PVTTAQATVP 826
Lactamase_B_6 pfam16661
Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase ...
 258-304 7.51e-03

Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase superfamily.


Pssm-ID: 406948  Cd Length: 192  Bit Score: 38.73  E-value: 7.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 50428935    258 VNGFTVLVNGGSNPKSSFWKLV----RHLDRVDAVLVTHPGADSLPGLNSL 304
Cdd:pfam16661    4 FDNVRILLDPGWDGSFSYESDLkyleKILPEVDLILLSHPTLEHLGAYPLL 54
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 484-899 7.15e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 69.81  E-value: 7.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   484 REGLLATHPRPGQERPGVARKEPARAeaPRKTEKEAKTPRELKKDPKPSvSRTQPREVRRAASSVPNLKKTNAQAAPKPR 563
Cdd:PHA03307   39 SQGQLVSDSAELAAVTVVAGAAACDR--FEPPTGPPPGPGTEAPANESR-STPTWSLSTLAPASPAREGSPTPPGPSSPD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   564 KAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSlelgpiPAGEEKALELPLAASSIPRPRTPSPEs 643
Cdd:PHA03307  116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAV------ASDAASSRQAALPLSSPEETARAPSS- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   644 hrSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQvlpPSAPTSEAGLSLPLRG 723
Cdd:PHA03307  189 --PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC---GWGPENECPLPRPAPI 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   724 PRARRSASPHdvdlclvspcefEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLA 803
Cdd:PHA03307  264 TLPTRIWEAS------------GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   804 PGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAA 883
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                         410
                  ....*....|....*.
gi 50428935   884 AKTKGLAGGDRASRPL 899
Cdd:PHA03307  412 PRPSPLDAGAASGAFY 427
PHA03247 PHA03247
large tegument protein UL36; Provisional
 467-919 1.46e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   467 PGRAESKESVGSRDSSKREGLLATHPrPGQERPGVARKEPARAEAPRKTEKEAKTPRELKKDPKPSVSRTQPRevRRAAS 546
Cdd:PHA03247 2593 PQSARPRAPVDDRGDPRGPAPPSPLP-PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRP--RRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   547 SVPNLKKTNAQAAPKPRKAPSTshsgFPPVANGPRSPPSLRCGEASPPSAACGSP-----ASQLVATPSLELGPIPAGEE 621
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPT----VGSLTSLADPPPPPPTPEPAPHALVSATPlppgpAAARQASPALPAAPAPPAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   622 KALELPLAASSIPRPRTPSPESHRSPAegserlslsplRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTevdeslsvs 701
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPP-----------AAPAAGPPRRLTRPAVASLSESRESLPSPWDPA--------- 2805

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   702 feqvlPPSAPTSEAGLSLPLRGPRARRSASPhdvdlclvspcefehRKAVPMAPAPAsPGSSNDSSARSQERAGGLGAEE 781
Cdd:PHA03247 2806 -----DPPAAVLAPAAALPPAASPAGPLPPP---------------TSAQPTAPPPP-PGPPPPSLPLGGSVAPGGDVRR 2864

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   782 TPPTSVSESLPTLSDSDPVPLAPGAADSdEDTEGFGVPrhdplPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSR 861
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVRRLARPAVS-RSTESFALP-----PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   862 TRKPLARPNSRAAAPKATPVAAAKTKG------------LAGGDRASRPLSARSEPSEKGgrAPLSRKSS 919
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGalvpgrvavprfRVPQPAPSREAPASSTPPLTG--HSLSRVSS 3006
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 565-960 3.41e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 61.34  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   565 APSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESH 644
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   645 RSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEvGSPHSTEVDESLSVSFEQVLPPSAPTSEAglslPLRGP 724
Cdd:PHA03307  124 ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS-DAASSRQAALPLSSPEETARAPSSPPAEP----PPSTP 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   725 RARRSASPHDVDlclvSPCEFEHRKAVPMAP--APASPGSSNDSSARSQERAGGLGAEE-----------TPPTSVSESL 791
Cdd:PHA03307  199 PAAASPRPPRRS----SPISASASSPAPAPGrsAADDAGASSSDSSSSESSGCGWGPENecplprpapitLPTRIWEASG 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   792 PTLSDSDPVPLAPGAADSDEDtegfgvPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNS 871
Cdd:PHA03307  275 WNGPSSRPGPASSSSSPRERS------PSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   872 RAAAPKATPVAAaktkglaggDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLDL 951
Cdd:PHA03307  349 RSPSPSRPPPPA---------DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDA 419


                  ....*....
gi 50428935   952 AYLPSGSSA 960
Cdd:PHA03307  420 GAASGAFYA 428
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 455-826 6.83e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 6.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   455 REPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRP----GQERPGVARKEPARAEAPRKTEKEAKTPRELKKDPK 530
Cdd:PHA03307   82 NESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPppasPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   531 PSVSRTQPREVRRAASSVPNLKKT-NAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATP 609
Cdd:PHA03307  162 VASDAASSRQAALPLSSPEETARApSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSS 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   610 SLELGPIPAGEEKA-LELPLAASSIPRPRTPSPESHRSPAEGSERLSLSP-LRGGEAGPDASPTVTTPTVTTPSlpAEVG 687
Cdd:PHA03307  242 SESSGCGWGPENECpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPrERSPSPSPSSPGSGPAPSSPRAS--SSSS 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   688 SPHSTEVDESLSVSfeqvlPPSAPTSEAGLSLPLRGPRARRSASPHDVDlclvSPCEFEHRKAVPMAPApASPGSSNDSS 767
Cdd:PHA03307  320 SSRESSSSSTSSSS-----ESSRGAAVSPGPSPSRSPSPSRPPPPADPS----SPRKRPRPSRAPSSPA-ASAGRPTRRR 389

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 50428935   768 ARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPD 826
Cdd:PHA03307  390 ARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPPPP 448
PHA03247 PHA03247
large tegument protein UL36; Provisional
 474-966 7.04e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 7.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   474 ESVGSRDSSKREGLLATHPRPgqerPGVARKEPARAEAPRKTEKeAKTPRELKKD--PKPSVSRT---QPREVRRAASSV 548
Cdd:PHA03247 2541 EELASDDAGDPPPPLPPAAPP----AAPDRSVPPPRPAPRPSEP-AVTSRARRPDapPQSARPRApvdDRGDPRGPAPPS 2615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   549 PNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRC---GEASPPS-AACGSPASQLVATPSlelGPIPAGEEKAL 624
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDpapGRVSRPRrARRLGRAAQASSPPQ---RPRRRAARPTV 2692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   625 ElPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTvttptvttpslPAEVGSPHSTEVDESlsvsfeq 704
Cdd:PHA03247 2693 G-SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA-----------PAPPAVPAGPATPGG------- 2753

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   705 VLPPSAPTSEAGLSLPlRGPRARRSASPHDVDLCLVSPCEfEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPP 784
Cdd:PHA03247 2754 PARPARPPTTAGPPAP-APPAAPAAGPPRRLTRPAVASLS-ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   785 TSVSESLPTLSDSDPVP-------LAPGAADSDEDTEGFGV-----PRHDP---LPDPlkVPPPLPDPSSICMVDPEMLP 849
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPPslplggsVAPGGDVRRRPPSRSPAakpaaPARPPvrrLARP--AVSRSTESFALPPDQPERPP 2909

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   850 PKTARQTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRksstpktaTRGPS 929
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR--------FRVPQ 2981

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 50428935   930 gSASSRPgVSATPPKSPVYLDLAYLPSGSSAHLVDEE 966
Cdd:PHA03247 2982 -PAPSRE-APASSTPPLTGHSLSRVSSWASSLALHEE 3016
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 466-877 4.41e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 54.31  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   466 GPGRAESKEsvGSRDSSKREGLLATHPRPGQERPGVARKEP--ARAEAPRKTE---------KEAKTPRELKKDPKPSVS 534
Cdd:PTZ00449  523 APGDKEGEE--GEHEDSKESDEPKEGGKPGETKEGEVGKKPgpAKEHKPSKIPtlskkpefpKDPKHPKDPEEPKKPKRP 600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   535 RTQPREVRRAASSVPNLKKTnaqaaPKPRKAPSTSHSgfppvangPRSPPSlrcgeASPPSAACGSPASQLVATPSLELG 614
Cdd:PTZ00449  601 RSAQRPTRPKSPKLPELLDI-----PKSPKRPESPKS--------PKRPPP-----PQRPSSPERPEGPKIIKSPKPPKS 662

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   615 PIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTVTTPTvttpsLPAEVGSPHS--T 692
Cdd:PTZ00449  663 PKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPK-----LPRDEEFPFEpiG 737

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   693 EVDESLSVSFEQVLPPSAPTS---EAGLSLPLRGPRARRSASPhDVDLCLVSPCEFEHRKAVPMAPAPASPGsSNDSSAR 769
Cdd:PTZ00449  738 DPDAEQPDDIEFFTPPEEERTffhETPADTPLPDILAEEFKEE-DIHAETGEPDEAMKRPDSPSEHEDKPPG-DHPSLPK 815

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   770 SQERAGGLGAEETPPTSVSESLPTLSDSDPVPLAPGAADSDEDTegfgvPRHDPLPDPlKVPPPLPDPSSICMVDPEMLP 849
Cdd:PTZ00449  816 KRHRLDGLALSTTDLESDAGRIAKDASGKIVKLKRSKSFDDLTT-----VEEAEEMGA-EARKIVVDDDGTEADDEDTHP 889

                         410       420       430
                  ....*....|....*....|....*....|...
gi 50428935   850 PKTARQTEnvSRTRKPLARPN-----SRAAAPK 877
Cdd:PTZ00449  890 PEEKHKSE--VRRRRPPKKPSkpkkpSKPKKPK 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
 457-837 3.64e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   457 PVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPGVAR-KEPARAEAPRKTEKEAKTP--RELKKDPKPSV 533
Cdd:PHA03247 2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHAlvSATPLPPGPAA 2727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   534 SRTQPREVRRAASSVPNLKKTNAQAAPKPRKAPSTSHSgfPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSLEL 613
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   614 GPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTE 693
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   694 VDE-SLSVSFE-QVLPPSAPTseaglslPLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQ 771
Cdd:PHA03247 2886 LARpAVSRSTEsFALPPDQPE-------RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA 2958

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   772 ERAGGLGA-----------------------EETPPTSVSESLPTLS----------DSDPVPLA------------PGA 806
Cdd:PHA03247 2959 VPQPWLGAlvpgrvavprfrvpqpapsreapASSTPPLTGHSLSRVSswasslalheETDPPPVSlkqtlwppddteDSD 3038

                         410       420       430
                  ....*....|....*....|....*....|....
gi 50428935   807 ADS--DEDTEGFGVPRHDPLPDPLKVPPP-LPDP 837
Cdd:PHA03247 3039 ADSlfDSDSERSDLEALDPLPPEPHDPFAhEPDP 3072
ComEC COG2333
DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily ...
 249-434 4.21e-05

DNA uptake channel protein ComEC C-terminal domain, metallo-beta-lactamase superfamily [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441904 [Multi-domain]  Cd Length: 253  Bit Score: 46.39  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  249 GLGDAAFF-AVNGFTVLVNGGSNPKSSFWKLV-------RHLDRVDAVLVTHPGADSLPGLNSLLRRKlaersevaaggg 320
Cdd:COG2333    9 GQGDAILIrTPDGKTILIDTGPRPSFDAGERVvlpylraLGIRRLDLLVLTHPDADHIGGLAAVLEAF------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935  321 swddRLRRLISPNlgvvffnaceaasrLARGEDEAELALSLLAQLGITPLPLSRGpvpakptvlfEKMGVGRLDMYVLHP 400
Cdd:COG2333   77 ----PVGRVLVSG--------------PPDTSETYERLLEALKEKGIPVRPCRAG----------DTWQLGGVRFEVLWP 128

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 50428935  401 PSAGAERTL---ASvCALLVWHPAgpgekvVRVLFPG 434
Cdd:COG2333  129 PEDLLEGSDennNS-LVLRLTYGG------FSFLLTG 158
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
707-928 8.77e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 8.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   707 PPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTS 786
Cdd:PRK12323  375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   787 VSesLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPP---PLPDPSSICMVDPEMLPPKTARQTENVSRTR 863
Cdd:PRK12323  455 AA--APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPAQPDAAPAGWVAESIPDPATA 532

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50428935   864 KPLARPNSRAAAPKATPVAAAktkglaggDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRGP 928
Cdd:PRK12323  533 DPDDAFETLAPAPAAAPAPRA--------AAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 785-956 8.51e-04

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 42.95  E-value: 8.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   785 TSVSESLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDpssicmvDPEMLPPKTARQTENVSR--T 862
Cdd:PHA03325  266 SSLPTSAPKRRSRRAGAMRAAAGETADLADDDGSEHSDPEPLPASLPPPPVR-------RPRVKHPEAGKEEPDGARnaE 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   863 RKPLARPNSRAAAPKATPVAAAKTKGLAGGDRasrpLSARSEPSEKGGRAPLSRKSSTPKTATrgPSGSASSRPGVSATP 942
Cdd:PHA03325  339 AKEPAQPATSTSSKGSSSAQNKDSGSTGPGSS----LAAASSFLEDDDFGSPPLDLTTSLRHM--PSPSVTSAPEPPSIP 412

                         170
                  ....*....|....
gi 50428935   943 pkspvyldLAYLPS 956
Cdd:PHA03325  413 --------LTYLSD 418
PHA03381 PHA03381
tegument protein VP22; Provisional
 858-960 1.10e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.31  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   858 NVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAggdRASRPLSARSEPSEKGGRAPLSRKSSTPkTATRGPSGSASSRPG 937
Cdd:PHA03381   86 DPRPSRRPHAQPEASGPGPARGARGPAGSRGRG---RRAESPSPRDPPNPKGASAPRGRKSACA-DSAALLDAPAPAAPK 161

                          90       100
                  ....*....|....*....|...
gi 50428935   938 VSATPPKSPVYLDLAYLPSGSSA 960
Cdd:PHA03381  162 RQKTPAGLARKLHFSTAPTSPTA 184
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
584-813 1.25e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   584 PSLRCGEASPPSAACG---SPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLR 660
Cdd:PRK12323  365 PGQSGGGAGPATAAAApvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   661 GGEAGPDASptvttptvtTPSLPAEVGSPhstevdeslsvsfeQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLV 740
Cdd:PRK12323  445 GGAPAPAPA---------PAAAPAAAARP--------------AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEE 501

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50428935   741 SPCEFEHRKAVPMAPAPASPGS-SNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSDPVPLAPGAADSDEDT 813
Cdd:PRK12323  502 LPPEFASPAPAQPDAAPAGWVAeSIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 544-955 1.73e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    544 AASSVPNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSlelgPIPAG-EEK 622
Cdd:pfam05109  427 STTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPS----PRDNGtESK 502

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    623 ALEL--PLAASSIPRPRTPSPeshrSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTevdeslsv 700
Cdd:pfam05109  503 APDMtsPTSAVTTPTPNATSP----TPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNAT-------- 570

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    701 sfEQVLPPSAPTSEAGLSLPLRGPRARRSASPHdvdlCLVSPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAE 780
Cdd:pfam05109  571 --IPTLGKTSPTSAVTTPTPNATSPTVGETSPQ----ANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSM 644

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    781 ETPPTSVSESL-PTLSDSDP--VPLAPGAadsdEDTEGFGVPRHDPLPDP---LKVPPPLPDPSSICMVD-PEMLPPKTA 853
Cdd:pfam05109  645 SLRPSSISETLsPSTSDNSTshMPLLTSA----HPTGGENITQVTPASTSthhVSTSSPAPRPGTTSQASgPGNSSTSTK 720

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    854 RQTENVSR------TRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRG 927
Cdd:pfam05109  721 PGEVNVTKgtppknATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATTYLP 800

                          410       420
                   ....*....|....*....|....*...
gi 50428935    928 PSGSASSRPGVSATPPksPVYLDLAYLP 955
Cdd:pfam05109  801 PSTSSKLRPRWTFTSP--PVTTAQATVP 826
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 575-706 1.80e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.24  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   575 PVANGPRS----PPSLRCGEASPPSAACGSPASQLVATPSLELGPIPAGeekaleLPLAASSIPRPRTPSPESHRSPAEG 650
Cdd:PRK14954  384 PAGSPDVKkkapEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQ------QPPVARSAPLPPSPQASAPRNVASG 457

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 50428935   651 SERLSLSPLRGGEAGPDASPTVTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVL 706
Cdd:PRK14954  458 KPGVDLGSWQGKFMNFTRNGSRKQPVQASSSDAAQTGVFEGVAELEKLRMEWNQFL 513
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
709-946 2.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   709 SAPTSEAGLSLP--LRGPRARRSASPHDVDLCLVSPCEFEhrKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTS 786
Cdd:PRK07003  366 GAPGGGVPARVAgaVPAPGARAAAAVGASAVPAVTAVTGA--AGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAA 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   787 VSESLPTLSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKP- 865
Cdd:PRK07003  444 DGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPa 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   866 -LARPNSRAAAPKAtpvAAAKTKGLAGGDRAS----RPLSARSEpSEKGGRAPLSRKSSTPKTATRGPsgsASSRPGVSA 940
Cdd:PRK07003  524 aAAPPAPEARPPTP---AAAAPAARAGGAAAAldvlRNAGMRVS-SDRGARAAAAAKPAAAPAAAPKP---AAPRVAVQV 596


                  ....*.
gi 50428935   941 TPPKSP 946
Cdd:PRK07003  597 PTPRAR 602
dnaA PRK14086
chromosomal replication initiator protein DnaA;
525-758 2.73e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.73  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   525 LKKDPKPSVSRTQPREVRRAASSVPNLKKTNAQAAPKPRKAPSTS-----HSGFPPVANGPRSPPSLRCGEASPPSAACG 599
Cdd:PRK14086   62 LEGRLAPIISETLSRELGRPIRIAITVDPSAGEPAPPPPHARRTSepelpRPGRRPYEGYGGPRADDRPPGLPRQDQLPT 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   600 SPASQLVATPSLELGPIPAGEEKALELPLAASSIPRPRTPSPESHRSPAE------GSERLSLSPLRGG--EAGPDASPT 671
Cdd:PRK14086  142 ARPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQErdrepyDAGRPEYDQRRRDydHPRPDWDRP 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   672 VTTPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPPSAPTSEAGLSLPLRGP---RARRSASPHDVDLCLVSPCEFEHR 748
Cdd:PRK14086  222 RRDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGPgepTARLNPKYTFDTFVIGASNRFAHA 301

                         250
                  ....*....|
gi 50428935   749 KAVPMAPAPA 758
Cdd:PRK14086  302 AAVAVAEAPA 311
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 549-642 2.90e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935    549 PNLKKTNAQAAPKPRKAPSTSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQ------------LVATPSLELGPI 616
Cdd:pfam03154  438 QSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQppssasvsssgpVPAAVSCPLPPV 517

                           90       100
                   ....*....|....*....|....*.
gi 50428935    617 PAGEEKALELPLAASSIPRPRTPSPE 642
Cdd:pfam03154  518 QIKEEALDEAEEPESPPPPPRSPSPE 543
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 533-956 3.53e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   533 VSRTQ-----PREVRRAASSVPNLKKTNAQAAPKPRKAPSTShsGFPPVANGPRSPPSLRCGEA--SPPSAACGSPASql 605
Cdd:PTZ00449  476 ISKIQftqeiKKLIKKSKKKLAPIEEEDSDKHDEPPEGPEAS--GLPPKAPGDKEGEEGEHEDSkeSDEPKEGGKPGE-- 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   606 vaTPSLELG--PIPAGEEKALELPLAASsipRPRTPS-PESHRSPAEgsERLSLSPLRggeagpdasptvttptvttpsl 682
Cdd:PTZ00449  552 --TKEGEVGkkPGPAKEHKPSKIPTLSK---KPEFPKdPKHPKDPEE--PKKPKRPRS---------------------- 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   683 PAEVGSPHSTEVDESLSVsfeqvlpPSAPTSEAGLSLPLRGPRARRSASPHdvdlclvSPcefEHRKAVPMAPAPASP-- 760
Cdd:PTZ00449  603 AQRPTRPKSPKLPELLDI-------PKSPKRPESPKSPKRPPPPQRPSSPE-------RP---EGPKIIKSPKPPKSPkp 665

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   761 -----------GSSNDSSARSQERAGGLGAEE------------------TPPTSVSESLPTLSDSDPVPLAPGAADSDE 811
Cdd:PTZ00449  666 pfdpkfkekfyDDYLDAAAKSKETKTTVVLDEsfesilketlpetpgtpfTTPRPLPPKLPRDEEFPFEPIGDPDAEQPD 745

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   812 DTEGFGVPRHD-----------PLPDPL----------------KVPPPLPD-PSSICMVDPEMLP--PKTARQTENVSR 861
Cdd:PTZ00449  746 DIEFFTPPEEErtffhetpadtPLPDILaeefkeedihaetgepDEAMKRPDsPSEHEDKPPGDHPslPKKRHRLDGLAL 825

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50428935   862 TRKPL-ARPNSRAAAPKATPVAAAKTKGL----------AGGDRASRPL---------SARSEPSEKGGRAPLSRKSStP 921
Cdd:PTZ00449  826 STTDLeSDAGRIAKDASGKIVKLKRSKSFddlttveeaeEMGAEARKIVvdddgteadDEDTHPPEEKHKSEVRRRRP-P 904

                         490       500       510
                  ....*....|....*....|....*....|....*
gi 50428935   922 KTATRGPSGSASSRpgvsatpPKSPvylDLAYLPS 956
Cdd:PTZ00449  905 KKPSKPKKPSKPKK-------PKKP---DSAFIPS 929
Lactamase_B_6 pfam16661
Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase ...
 258-304 7.51e-03

Metallo-beta-lactamase superfamily domain; This family is part of the metallo-beta-lactamase superfamily.


Pssm-ID: 406948  Cd Length: 192  Bit Score: 38.73  E-value: 7.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 50428935    258 VNGFTVLVNGGSNPKSSFWKLV----RHLDRVDAVLVTHPGADSLPGLNSL 304
Cdd:pfam16661    4 FDNVRILLDPGWDGSFSYESDLkyleKILPEVDLILLSHPTLEHLGAYPLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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