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Conserved domains on  [gi|4758112|ref|NP_004631|]
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spliceosome RNA helicase DDX39B [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13028696)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as Bacillus cereus ATP-dependent RNA helicase DbpA that is involved in the assembly of the 50S ribosomal subunit

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
44-251 9.02e-167

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 466.44  E-value: 9.02e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   44 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTR 123
Cdd:cd17950   1 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  124 ELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLE 203
Cdd:cd17950  81 ELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLE 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 4758112  204 QLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV 251
Cdd:cd17950 161 QLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
262-391 2.72e-50

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 166.14  E-value: 2.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  262 LQQYYVKLKDNEKNRKLF-DLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRI 340
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4758112  341 LVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFV 391
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
 
Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
44-251 9.02e-167

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 466.44  E-value: 9.02e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   44 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTR 123
Cdd:cd17950   1 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  124 ELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLE 203
Cdd:cd17950  81 ELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLE 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 4758112  204 QLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV 251
Cdd:cd17950 161 QLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
47-422 2.25e-128

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 377.18  E-value: 2.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEP-VTGQVSVLVMCHTREL 125
Cdd:COG0513   4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPTREL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLeql 205
Cdd:COG0513  84 ALQVAEELRKLAKYL-GLRVATVYGGVSIGRQIRALKRG-VDIVVATPGRLLDLIERGALDLSGVETLVLDEADRML--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  206 DM--RRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKlTLHGLQQYYVKLKDNEKNRKLFDLLD 283
Cdd:COG0513 159 DMgfIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENA-TAETIEQRYYLVDKRDKLELLRRLLR 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  284 VLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYD 363
Cdd:COG0513 238 DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYD 317
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758112  364 MPEDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKILNDVQDRFEVNI--SELPDEIDISS 422
Cdd:COG0513 318 LPEDPEDYVHRIGRTGRAGAEGTAISLVTPD-ERRLLRAIEKLIGQKIeeEELPGFEPVEE 377
PTZ00424 PTZ00424
helicase 45; Provisional
47-418 7.93e-83

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 259.76  E-value: 7.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   127 FQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlD 206
Cdd:PTZ00424 110 QQIQKVVLALGDYL-KVRCHACVGGTVVRDDINKLKAGV-HMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSR-G 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDEtKLTLHGLQQYYVKL-KDNEKNRKLFDLLDVL 285
Cdd:PTZ00424 187 FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKD-ELTLEGIRQFYVAVeKEEWKFDTLCDLYETL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   286 EFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMP 365
Cdd:PTZ00424 266 TITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLP 345
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4758112   366 EDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKILNDVQDRFEVNISELPDEI 418
Cdd:PTZ00424 346 ASPENYIHRIGRSGRFGRKGVAINFVTPD-DIEQLKEIERHYNTQIEEMPMEV 397
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
262-391 2.72e-50

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 166.14  E-value: 2.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  262 LQQYYVKLKDNEKNRKLF-DLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRI 340
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4758112  341 LVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFV 391
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
69-236 2.68e-48

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 162.41  E-value: 2.68e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     69 SEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMpNVKVAVF 148
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    149 FGGLSIKKDEEVLKKncPHIVVGTPGRILALARNKSLnLKHIKHFILDECDKMLEQlDMRRDVQEIFRMTPHEKQVMMFS 228
Cdd:pfam00270  80 LGGDSRKEQLEKLKG--PDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLS 155

                  ....*...
gi 4758112    229 ATLSKEIR 236
Cdd:pfam00270 156 ATLPRNLE 163
DEXDc smart00487
DEAD-like helicases superfamily;
60-265 1.98e-47

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 161.51  E-value: 1.98e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112      60 IVDCGFEHPSEVQHECIPQAILG-MDVLCQAKSGMGKTAVFVLATLQQLEPVTGQvSVLVMCHTRELAFQISKEYERFSK 138
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG-RVLVLVPTRELAEQWAEELKKLGP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     139 YMpNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlDMRRDVQEIFRMT 218
Cdd:smart00487  80 SL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLL 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 4758112     219 PHEKQVMMFSATLSKEIRPVCRKFMQDPMEIfvdDETKLTLHGLQQY 265
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDPVFI---DVGFTPLEPIEQF 201
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
273-382 1.17e-27

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 105.76  E-value: 1.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    273 EKNRKLFDLLDVLEFNQVVIFVKSVQRCiALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMD 352
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 4758112    353 IERVNIAFNYDMPEDSDTYLHRVARAGRFG 382
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
303-382 2.59e-22

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 90.35  E-value: 2.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     303 LAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFG 382
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
267-400 3.28e-12

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 67.86  E-value: 3.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  267 VKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNL 346
Cdd:COG0514 210 VPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIA 289
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4758112  347 FgrGMDIERVNIAF--NYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKIL 400
Cdd:COG0514 290 F--GMGIDKPDVRFviHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPE-DVAIQ 342
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
291-390 1.09e-04

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 44.32  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   291 VIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERlSRYQQfkDFQR---RILVATNLFgrGMDIERVNIAF--NYDMP 365
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVR-ADVQE--AFQRddlQIVVATVAF--GMGINKPNVRFvvHFDIP 314
                         90       100
                 ....*....|....*....|....*
gi 4758112   366 EDSDTYLHRVARAGRFGTKGLAITF 390
Cdd:PRK11057 315 RNIESYYQETGRAGRDGLPAEAMLF 339
 
Name Accession Description Interval E-value
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
44-251 9.02e-167

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 466.44  E-value: 9.02e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   44 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTR 123
Cdd:cd17950   1 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  124 ELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLE 203
Cdd:cd17950  81 ELAFQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLE 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 4758112  204 QLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV 251
Cdd:cd17950 161 QLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
47-422 2.25e-128

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 377.18  E-value: 2.25e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEP-VTGQVSVLVMCHTREL 125
Cdd:COG0513   4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPTREL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLeql 205
Cdd:COG0513  84 ALQVAEELRKLAKYL-GLRVATVYGGVSIGRQIRALKRG-VDIVVATPGRLLDLIERGALDLSGVETLVLDEADRML--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  206 DM--RRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKlTLHGLQQYYVKLKDNEKNRKLFDLLD 283
Cdd:COG0513 159 DMgfIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENA-TAETIEQRYYLVDKRDKLELLRRLLR 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  284 VLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYD 363
Cdd:COG0513 238 DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYD 317
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758112  364 MPEDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKILNDVQDRFEVNI--SELPDEIDISS 422
Cdd:COG0513 318 LPEDPEDYVHRIGRTGRAGAEGTAISLVTPD-ERRLLRAIEKLIGQKIeeEELPGFEPVEE 377
PTZ00424 PTZ00424
helicase 45; Provisional
47-418 7.93e-83

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 259.76  E-value: 7.93e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   127 FQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlD 206
Cdd:PTZ00424 110 QQIQKVVLALGDYL-KVRCHACVGGTVVRDDINKLKAGV-HMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSR-G 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDEtKLTLHGLQQYYVKL-KDNEKNRKLFDLLDVL 285
Cdd:PTZ00424 187 FKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKD-ELTLEGIRQFYVAVeKEEWKFDTLCDLYETL 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   286 EFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMP 365
Cdd:PTZ00424 266 TITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLP 345
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4758112   366 EDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKILNDVQDRFEVNISELPDEI 418
Cdd:PTZ00424 346 ASPENYIHRIGRSGRFGRKGVAINFVTPD-DIEQLKEIERHYNTQIEEMPMEV 397
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
52-415 1.42e-80

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 255.88  E-value: 1.42e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    52 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISK 131
Cdd:PRK11776  11 LPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTRELADQVAK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   132 EYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMleqLDM--RR 209
Cdd:PRK11776  91 EIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHG-AHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRM---LDMgfQD 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   210 DVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTlhGLQQYYVKLKDNEKNRKLFDLLDVLEFNQ 289
Cdd:PRK11776 167 AIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLP--AIEQRFYEVSPDERLPALQRLLLHHQPES 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   290 VVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSD 369
Cdd:PRK11776 245 CVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPE 324
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 4758112   370 TYLHRVARAGRFGTKGLAITFVSDENDAKI--LNDVQDRfEVNISELP 415
Cdd:PRK11776 325 VHVHRIGRTGRAGSKGLALSLVAPEEMQRAnaIEDYLGR-KLNWEPLP 371
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
56-249 2.12e-78

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 241.19  E-value: 2.12e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEP----VTGQVSVLVMCHTRELAFQISK 131
Cdd:cd00268   1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPepkkKGRGPQALVLAPTRELAMQIAE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  132 EYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEqLDMRRDV 211
Cdd:cd00268  81 VARKLGKGT-GLKVAAIYGGAPIKKQIEALKKG-PDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLD-MGFEEDV 157
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 4758112  212 QEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd00268 158 EKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
47-416 8.01e-76

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 248.22  E-value: 8.01e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:PRK11634   8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   127 FQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLeQLD 206
Cdd:PRK11634  88 VQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQG-PQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEML-RMG 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKlTLHGLQQYYVKLKDNEKNRKLFDLLDVLE 286
Cdd:PRK11634 166 FIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVT-TRPDISQSYWTVWGMRKNEALVRFLEAED 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   287 FNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPE 366
Cdd:PRK11634 245 FDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPM 324
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4758112   367 DSDTYLHRVARAGRFGTKGLAITFVsDENDAKILNDVQDRFEVNISE--LPD 416
Cdd:PRK11634 325 DSESYVHRIGRTGRAGRAGRALLFV-ENRERRLLRNIERTMKLTIPEveLPN 375
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
47-400 4.01e-70

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 227.90  E-value: 4.01e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL------EPvtGQVSVLVMC 120
Cdd:PRK11192   3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLldfprrKS--GPPRILILT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   121 HTRELAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDK 200
Cdd:PRK11192  81 PTRELAMQVADQARELAKHT-HLDIATITGGVAYMNHAEVFSEN-QDIVVATPGRLLQYIKEENFDCRAVETLILDEADR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   201 MLeqlDM--RRDVQEIFRMTPHEKQVMMFSATL-SKEIRPVCRKFMQDPMEIFVD---DETKltlhGLQQYYVKLKDNEK 274
Cdd:PRK11192 159 ML---DMgfAQDIETIAAETRWRKQTLLFSATLeGDAVQDFAERLLNDPVEVEAEpsrRERK----KIHQWYYRADDLEH 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   275 NRKLfdLLDVLEFNQV---VIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGM 351
Cdd:PRK11192 232 KTAL--LCHLLKQPEVtrsIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGI 309
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 4758112   352 DIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVsDENDAKIL 400
Cdd:PRK11192 310 DIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV-EAHDHLLL 357
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
45-397 2.74e-62

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 208.61  E-value: 2.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    45 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL-------EPVTGQVSVL 117
Cdd:PRK01297  87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLlqtpppkERYMGEPRAL 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   118 VMCHTRELAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDE 197
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKYT-GLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDE 245
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   198 CDKMLEqLDMRRDVQEIFRMTPH--EKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKlTLHGLQQYYVKLKDNEKN 275
Cdd:PRK01297 246 ADRMLD-MGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENV-ASDTVEQHVYAVAGSDKY 323
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   276 RKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIER 355
Cdd:PRK01297 324 KLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDG 403
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 4758112   356 VNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSdENDA 397
Cdd:PRK01297 404 ISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAG-EDDA 444
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
49-250 1.07e-60

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 195.62  E-value: 1.07e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   49 DFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQ 128
Cdd:cd17939   1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  129 ISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlDMR 208
Cdd:cd17939  81 IQKVVKALGDYM-GVKVHACIGGTSVREDRRKLQYG-PHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR-GFK 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4758112  209 RDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIF 250
Cdd:cd17939 158 DQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
47-249 1.92e-60

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 195.21  E-value: 1.92e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:cd17940   1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  127 FQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLkKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlD 206
Cdd:cd17940  81 LQTSQVCKELGKHM-GVKVMVTTGGTSLRDDIMRL-YQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQ-D 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17940 158 FQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
56-249 1.16e-56

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 185.16  E-value: 1.16e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYER 135
Cdd:cd17943   1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  136 FSKYMPNVKVAVFFGGLSIKKDEEVLKknCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlDMRRDVQEIF 215
Cdd:cd17943  81 IGKKLEGLKCEVFIGGTPVKEDKKKLK--GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEG-SFQKDVNWIF 157
                       170       180       190
                ....*....|....*....|....*....|....
gi 4758112  216 RMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17943 158 SSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
52-404 4.86e-56

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 191.56  E-value: 4.86e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    52 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLE----PVTGQ--VSVLVMCHTREL 125
Cdd:PRK10590   8 LSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLItrqpHAKGRrpVRALILTPTREL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   126 AFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLeql 205
Cdd:PRK10590  88 AAQIGENVRDYSKYL-NIRSLVVFGGVSINPQMMKLRGGV-DVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRML--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   206 DMR--RDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQqyYVKLKDNEKNRKLF-DLL 282
Cdd:PRK10590 163 DMGfiHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQ--HVHFVDKKRKRELLsQMI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   283 DVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNY 362
Cdd:PRK10590 241 GKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNY 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 4758112   363 DMPEDSDTYLHRVARAGRFGTKGLAITFVS-DENdaKILNDVQ 404
Cdd:PRK10590 321 ELPNVPEDYVHRIGRTGRAAATGEALSLVCvDEH--KLLRDIE 361
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
47-394 1.20e-55

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 189.80  E-value: 1.20e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL--EPV-----TGQVSVLVM 119
Cdd:PRK04837  10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLlsHPApedrkVNQPRALIM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   120 CHTRELAFQISKEYERFSKyMPNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECD 199
Cdd:PRK04837  90 APTRELAVQIHADAEPLAQ-ATGLKLGLAYGGDGYDKQLKVLESG-VDILIGTTGRLIDYAKQNHINLGAIQVVVLDEAD 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   200 KMLEqLDMRRDVQEIFRMTPHEKQ--VMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKlTLHGLQQYYVKLKDNEKNRK 277
Cdd:PRK04837 168 RMFD-LGFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQK-TGHRIKEELFYPSNEEKMRL 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   278 LFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNfpaiaiHR-GM-----PQEERLSRYQQFKDFQRRILVATNLFGRGM 351
Cdd:PRK04837 246 LQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADG------HRvGLltgdvAQKKRLRILEEFTRGDLDILVATDVAARGL 319
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 4758112   352 DIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDE 394
Cdd:PRK04837 320 HIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEE 362
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
47-426 2.67e-52

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 184.38  E-value: 2.67e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVS-------VLVM 119
Cdd:PRK04537  11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADrkpedprALIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   120 CHTRELAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILA-LARNKSLNLKHIKHFILDEC 198
Cdd:PRK04537  91 APTRELAIQIHKDAVKFGADL-GLRFALVYGGVDYDKQRELLQQGV-DVIIATPGRLIDyVKQHKVVSLHACEICVLDEA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   199 DKMLEqLDMRRDVQEIFRMTPHE--KQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKlKDNEKNR 276
Cdd:PRK04537 169 DRMFD-LGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFP-ADEEKQT 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   277 KLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERV 356
Cdd:PRK04537 247 LLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGV 326
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   357 NIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSdendakilndvqDRFEVNiseLPdeiDISSYIEQ 426
Cdd:PRK04537 327 KYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFAC------------ERYAMS---LP---DIEAYIEQ 378
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
47-249 8.78e-52

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 172.63  E-value: 8.78e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  127 FQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlD 206
Cdd:cd18046  81 QQIQKVVMALGDYM-GIKCHACIGGTSVRDDAQKLQAG-PHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSR-G 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd18046 158 FKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
PTZ00110 PTZ00110
helicase; Provisional
31-392 2.09e-51

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 181.12  E-value: 2.09e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    31 AKKDVKGSYVSIHSSGFRDFLLKpellrAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATL------ 104
Cdd:PTZ00110 121 AGENVPKPVVSFEYTSFPDYILK-----SLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIvhinaq 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   105 QQLEPVTGQVsVLVMCHTRELAFQISKEYERFSKyMPNVKVAVFFGGLSiKKDEEVLKKNCPHIVVGTPGRILALARNKS 184
Cdd:PTZ00110 196 PLLRYGDGPI-VLVLAPTRELAEQIREQCNKFGA-SSKIRNTVAYGGVP-KRGQIYALRRGVEILIACPGRLIDFLESNV 272
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   185 LNLKHIKHFILDECDKMLE---QLDMRRDVQEIfrmTPhEKQVMMFSATLSKEI----RPVCRkfmQDPMEIFVDDETKL 257
Cdd:PTZ00110 273 TNLRRVTYLVLDEADRMLDmgfEPQIRKIVSQI---RP-DRQTLMWSATWPKEVqslaRDLCK---EEPVHVNVGSLDLT 345
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   258 TLHGLQQYYVKLKDNEKNRKLFDLLDVL--EFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKD 335
Cdd:PTZ00110 346 ACHNIKQEVFVVEEHEKRGKLKMLLQRImrDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKT 425
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4758112   336 FQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVS 392
Cdd:PTZ00110 426 GKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT 482
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
262-391 2.72e-50

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 166.14  E-value: 2.72e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  262 LQQYYVKLKDNEKNRKLF-DLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRI 340
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4758112  341 LVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFV 391
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
56-250 2.82e-50

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 168.59  E-value: 2.82e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL---EPVTGQVSVLVMCHTRELAFQISKE 132
Cdd:cd17947   1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCFSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  133 YERFSKYMpNVKVAVFFGGLSIKKDEEVLKKnCPHIVVGTPGRILALARN-KSLNLKHIKHFILDECDKMLEqLDMRRDV 211
Cdd:cd17947  81 LQQLAQFT-DITFALAVGGLSLKAQEAALRA-RPDIVIATPGRLIDHLRNsPSFDLDSIEILVLDEADRMLE-EGFADEL 157
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4758112  212 QEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIF 250
Cdd:cd17947 158 KEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
47-249 7.27e-49

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 165.18  E-value: 7.27e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:cd17954   2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  127 FQISKEYERFSKyMPNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRIL-ALARNKSLNLKHIKHFILDECDKMLEqL 205
Cdd:cd17954  82 QQISEQFEALGS-SIGLKSAVLVGGMDMMAQAIALAKK-PHVIVATPGRLVdHLENTKGFSLKSLKFLVMDEADRLLN-M 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4758112  206 DMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17954 159 DFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
52-243 2.29e-48

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 164.29  E-value: 2.29e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   52 LKPELLRAIVDCGFEHPSEVQHECIPQAI-LGMDVLCQAKSGMGKTAVFVLATLQQL-----EPVTGQVSVLVMCHTREL 125
Cdd:cd17964   1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTREL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSL--NLKHIKHFILDECDKMle 203
Cdd:cd17964  81 ALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRL-- 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4758112  204 qLDM--RRDVQEIFRMTPHEK----QVMMFSATLSKEIRPVCRKFM 243
Cdd:cd17964 159 -LDMgfRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTL 203
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
69-236 2.68e-48

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 162.41  E-value: 2.68e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     69 SEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMpNVKVAVF 148
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    149 FGGLSIKKDEEVLKKncPHIVVGTPGRILALARNKSLnLKHIKHFILDECDKMLEQlDMRRDVQEIFRMTPHEKQVMMFS 228
Cdd:pfam00270  80 LGGDSRKEQLEKLKG--PDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLS 155

                  ....*...
gi 4758112    229 ATLSKEIR 236
Cdd:pfam00270 156 ATLPRNLE 163
DEXDc smart00487
DEAD-like helicases superfamily;
60-265 1.98e-47

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 161.51  E-value: 1.98e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112      60 IVDCGFEHPSEVQHECIPQAILG-MDVLCQAKSGMGKTAVFVLATLQQLEPVTGQvSVLVMCHTRELAFQISKEYERFSK 138
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG-RVLVLVPTRELAEQWAEELKKLGP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     139 YMpNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlDMRRDVQEIFRMT 218
Cdd:smart00487  80 SL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDG-GFGDQLEKLLKLL 157
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 4758112     219 PHEKQVMMFSATLSKEIRPVCRKFMQDPMEIfvdDETKLTLHGLQQY 265
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDPVFI---DVGFTPLEPIEQF 201
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
47-250 2.05e-47

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 161.24  E-value: 2.05e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL--EPVTgqVSVLVMCHTRE 124
Cdd:cd17955   1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLseDPYG--IFALVLTPTRE 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  125 LAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKnCPHIVVGTPGRILALARNKSL---NLKHIKHFILDECDKM 201
Cdd:cd17955  79 LAYQIAEQFRALGAPL-GLRCCVIVGGMDMVKQALELSK-RPHIVVATPGRLADHLRSSDDttkVLSRVKFLVLDEADRL 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 4758112  202 LEQlDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIF 250
Cdd:cd17955 157 LTG-SFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
52-249 2.54e-47

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 160.82  E-value: 2.54e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   52 LKPELLRAIVDCGFEHPSEVQHECIPqaILGMDV----LCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAF 127
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALP--LILSDPpenlIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELAR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  128 QISKEYERFSKYmPNVKVAVFFGGLSIKKDEEVLKkncpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDM 207
Cdd:cd17963  79 QIGEVVEKMGKF-TGVKVALAVPGNDVPRGKKITA----QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTQGH 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4758112  208 RRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17963 154 GDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
47-249 3.26e-46

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 158.01  E-value: 3.26e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 126
Cdd:cd18045   1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  127 FQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlD 206
Cdd:cd18045  81 VQIQKVLLALGDYM-NVQCHACIGGTSVGDDIRKLDYGQ-HIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNK-G 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd18045 158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
35-397 1.68e-45

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 164.96  E-value: 1.68e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    35 VKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQV 114
Cdd:PLN00206 111 VKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGH 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   115 S-------VLVMCHTRELAFQISKEYERFSKYMPnVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNL 187
Cdd:PLN00206 191 PseqrnplAMVLTPTRELCVQVEDQAKVLGKGLP-FKTALVVGGDAMPQQLYRIQQGV-ELIVGTPGRLIDLLSKHDIEL 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   188 KHIKHFILDECDKMLEQlDMRRDVQEIFRMTPhEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTlHGLQQYYV 267
Cdd:PLN00206 269 DNVSVLVLDEVDCMLER-GFRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPN-KAVKQLAI 345
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   268 KLKDNEKNRKLFDLLDVLEFNQ--VVIFVKSVQRCIALAQLL-VEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVAT 344
Cdd:PLN00206 346 WVETKQKKQKLFDILKSKQHFKppAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVAT 425
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4758112   345 NLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDA 397
Cdd:PLN00206 426 GVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRN 478
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
47-252 1.73e-43

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 150.93  E-value: 1.73e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQqlepvtgQVSVLVMCHTRELA 126
Cdd:cd17938   1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ-------IVVALILEPSRELA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  127 FQISKEYERFSKYM--PNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQ 204
Cdd:cd17938  74 EQTYNCIENFKKYLdnPKLRVALLIGGVKAREQLKRLESGV-DIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQ 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4758112  205 lDMRRDVQEIFRMTPHEK------QVMMFSATL-SKEIRPVCRKFMQDPMeiFVD 252
Cdd:cd17938 153 -GNLETINRIYNRIPKITsdgkrlQVIVCSATLhSFEVKKLADKIMHFPT--WVD 204
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
45-246 1.98e-38

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 137.82  E-value: 1.98e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   45 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL---EPVTGqVSVLVMCH 121
Cdd:cd17959   1 GGFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLkahSPTVG-ARALILSP 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  122 TRELAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKM 201
Cdd:cd17959  80 TRELALQTLKVTKELGKFT-DLRTALLVGGDSLEEQFEALASN-PDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRL 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4758112  202 LEqLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 246
Cdd:cd17959 158 FE-MGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEP 201
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
56-251 2.78e-38

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 136.95  E-value: 2.78e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEP--VTGQVSVLVMCHTRELAFQISKEY 133
Cdd:cd17957   1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKprKKKGLRALILAPTRELASQIYREL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  134 ERFSKYMPnVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLdMRRDVQE 213
Cdd:cd17957  81 LKLSKGTG-LRIVLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPG-FREQTDE 158
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4758112  214 IFR-MTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV 251
Cdd:cd17957 159 ILAaCTNPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
52-251 1.13e-37

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 136.08  E-value: 1.13e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   52 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL-----EPVTG-----QVSVLVMCH 121
Cdd:cd17967   7 LRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgpPSVGRgrrkaYPSALILAP 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  122 TRELAFQISKEYERFSKYMPnVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILAL-ARNKsLNLKHIKHFILDECDK 200
Cdd:cd17967  87 TRELAIQIYEEARKFSYRSG-VRSVVVYGGADVVHQQLQLLRGC-DILVATPGRLVDFiERGR-ISLSSIKFLVLDEADR 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4758112  201 MLEQ---LDMRRDVQEiFRMTP-HEKQVMMFSATLSKEIRPVCRKFMQDpmEIFV 251
Cdd:cd17967 164 MLDMgfePQIRKIVEH-PDMPPkGERQTLMFSATFPREIQRLAADFLKN--YIFL 215
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
52-246 2.34e-37

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 135.02  E-value: 2.34e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   52 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL------EPVTGQVSVLVMCHTREL 125
Cdd:cd17961   1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTREL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYM-PNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSL-NLKHIKHFILDECDKML- 202
Cdd:cd17961  81 AQQVSKVLEQLTAYCrKDVRVVNLSASSSDSVQRALLAEK-PDIVVSTPARLLSHLESGSLlLLSTLKYLVIDEADLVLs 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 4758112  203 ---EQldmrrDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 246
Cdd:cd17961 160 ygyEE-----DLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNP 201
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
56-233 3.24e-37

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 135.44  E-value: 3.24e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAIL-GMDVLCQAKSGMGKTAVF-------VLATLQQLEPVTGQ--VSVLVMCHTREL 125
Cdd:cd17946   1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFgipilerLLSQKSSNGVGGKQkpLRALILTPTREL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYmPNVKVAVFFGGLSIKKDEEVLKKnCPHIVVGTPGRILAL--ARNKSL-NLKHIKHFILDECDKML 202
Cdd:cd17946  81 AVQVKDHLKAIAKY-TNIKIASIVGGLAVQKQERLLKK-RPEIVVATPGRLWELiqEGNEHLaNLKSLRFLVLDEADRML 158
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 4758112  203 EQLDMrRDVQEIFRMTP-------HEKQVMMFSATLSK 233
Cdd:cd17946 159 EKGHF-AELEKILELLNkdragkkRKRQTFVFSATLTL 195
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
56-249 1.04e-35

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 130.23  E-value: 1.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATL------QQLEPVTGQVsVLVMCHTRELAFQI 129
Cdd:cd17952   1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvhimdqRELEKGEGPI-AVIVAPTRELAQQI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEqLDMRR 209
Cdd:cd17952  80 YLEAKKFGKAY-NLRVVAVYGGGSKWEQAKALQEGA-EIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFD-MGFEY 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 4758112  210 DVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17952 157 QVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
56-246 1.43e-35

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 130.52  E-value: 1.43e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFV---LATLQQLEPVTGQVS-----VLVMCHTRELAF 127
Cdd:cd17945   1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLiplLVYISRLPPLDEETKddgpyALILAPTRELAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  128 QISKEYERFSKYmPNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMleqLDM 207
Cdd:cd17945  81 QIEEETQKFAKP-LGIRVVSIVGGHSIEEQAFSLRNGC-EILIATPGRLLDCLERRLLVLNQCTYVVLDEADRM---IDM 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758112  208 --RRDVQEIF-RMTPHEK-------------------QVMMFSATLSKEIRPVCRKFMQDP 246
Cdd:cd17945 156 gfEPQVTKILdAMPVSNKkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRP 216
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
56-249 4.91e-34

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 125.74  E-value: 4.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYER 135
Cdd:cd17962   1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  136 FSKYMPNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLeQLDMRRDVQEIF 215
Cdd:cd17962  81 LMKGLPPMKTALLVGGLPLPPQLYRLQQGV-KVIIATPGRLLDILKQSSVELDNIKIVVVDEADTML-KMGFQQQVLDIL 158
                       170       180       190
                ....*....|....*....|....*....|....
gi 4758112  216 RMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17962 159 ENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
52-249 9.04e-34

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 125.95  E-value: 9.04e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   52 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQ------LEPVTGQVSvLVMCHTREL 125
Cdd:cd17953  19 LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHikdqrpVKPGEGPIG-LIMAPTREL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  126 AFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGR---ILALARNKSLNLKHIKHFILDECDKML 202
Cdd:cd17953  98 ALQIYVECKKFSKAL-GLRVVCVYGGSGISEQIAELKRGA-EIVVCTPGRmidILTANNGRVTNLRRVTYVVLDEADRMF 175
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 4758112  203 EqLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17953 176 D-MGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
56-249 4.67e-33

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 123.46  E-value: 4.67e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL-----EPVTGQVSVLVMCHTRELAFQIS 130
Cdd:cd17960   1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILlkrkaNLKKGQVGALIISPTRELATQIY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  131 KEYERF-SKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILAL--ARNKSLNLKHIKHFILDECDKMLEqLDM 207
Cdd:cd17960  81 EVLQSFlEHHLPKLKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELlsRKADKVKVKSLEVLVLDEADRLLD-LGF 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4758112  208 RRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
57-251 2.75e-32

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 121.24  E-value: 2.75e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   57 LRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL-----EPVTGqVSVLVMCHTRELAFQISK 131
Cdd:cd17941   2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyrerwTPEDG-LGALIISPTRELAMQIFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  132 EYERFSKYMpNVKVAVFFGGLSIKkdEEVLKKNCPHIVVGTPGRILA-LARNKSLNLKHIKHFILDECDKMLEqLDMRRD 210
Cdd:cd17941  81 VLRKVGKYH-SFSAGLIIGGKDVK--EEKERINRMNILVCTPGRLLQhMDETPGFDTSNLQMLVLDEADRILD-MGFKET 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4758112  211 VQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFV 251
Cdd:cd17941 157 LDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
34-243 6.33e-32

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 122.00  E-value: 6.33e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   34 DVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL--EPVT 111
Cdd:cd18052  32 EVTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMmkEGLT 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  112 GQVS-------VLVMCHTRELAFQISKEYERFSkYMPNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKS 184
Cdd:cd18052 112 ASSFsevqepqALIVAPTRELANQIFLEARKFS-YGTCIRPVVVYGGVSVGHQIRQIEKGC-HILVATPGRLLDFIGRGK 189
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4758112  185 LNLKHIKHFILDECDKMLE---QLDMRRDVQEiFRMTPHEK-QVMMFSATLSKEIRPVCRKFM 243
Cdd:cd18052 190 ISLSKLKYLILDEADRMLDmgfGPEIRKLVSE-PGMPSKEDrQTLMFSATFPEEIQRLAAEFL 251
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
56-249 3.02e-30

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 115.54  E-value: 3.02e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATL------QQLEPVTGQVsVLVMCHTRELAFQI 129
Cdd:cd17966   1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhinaqPPLERGDGPI-VLVLAPTRELAQQI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SKEYERFSKyMPNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMleqLDM-- 207
Cdd:cd17966  80 QQEANKFGG-SSRLRNTCVYGGAPKGPQIRDLRRGV-EICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRM---LDMgf 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4758112  208 ----RRDVQEIfrmTPhEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17966 155 epqiRKIVDQI---RP-DRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
13-245 4.31e-30

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 116.68  E-value: 4.31e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   13 YEDDEVEtAAGGDGAEapakkdvkgsyvsiHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSG 92
Cdd:cd18051   4 YEDIPVE-ATGENCPP--------------HIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTG 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   93 MGKTAVFVLATLQQ---------LEPVTGQVS-------VLVMCHTRELAFQISKEYERFSkYMPNVKVAVFFGGLSIKK 156
Cdd:cd18051  69 SGKTAAFLLPILSQiyeqgpgesLPSESGYYGrrkqyplALVLAPTRELASQIYDEARKFA-YRSRVRPCVVYGGADIGQ 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  157 DEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMleqLDM------RRDVQEIFRMTPHEKQVMMFSAT 230
Cdd:cd18051 148 QMRDLERGC-HLLVATPGRLVDMLERGKIGLDYCKYLVLDEADRM---LDMgfepqiRRIVEQDTMPPTGERQTLMFSAT 223
                       250
                ....*....|....*
gi 4758112  231 LSKEIRPVCRKFMQD 245
Cdd:cd18051 224 FPKEIQMLARDFLDN 238
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
47-246 9.20e-29

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 112.12  E-value: 9.20e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   47 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILG--MDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRE 124
Cdd:cd18047   3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  125 LAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKncphIVVGTPGRILALA-RNKSLNLKHIKHFILDECDKMLE 203
Cdd:cd18047  83 LALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQ----IVIGTPGTVLDWCsKLKFIDPKKIKVFVLDEADVMIA 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  204 QLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 246
Cdd:cd18047 159 TQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
56-249 1.20e-28

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 111.66  E-value: 1.20e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVL-ATLQQLE-----PVTGQVSV--LVMCHTRELAF 127
Cdd:cd17951   1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLpLIMFALEqekklPFIKGEGPygLIVCPSRELAR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  128 QISKEYERFSKY-----MPNVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKML 202
Cdd:cd17951  81 QTHEVIEYYCKAlqeggYPQLRCLLCIGGMSVKEQLEVIRKGV-HIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMI 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 4758112  203 EqLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17951 160 D-MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
64-249 2.68e-28

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 110.75  E-value: 2.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   64 GFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVS------VLVMCHTRELAFQISKEYERFS 137
Cdd:cd17949  10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDrsdgtlALVLVPTRELALQIYEVLEKLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  138 KYMPNVKVAVFFGGLSIKKDEEVLKKNCPhIVVGTPGRILALARN-KSLNLKHIKHFILDECDKMLEQ------------ 204
Cdd:cd17949  90 KPFHWIVPGYLIGGEKRKSEKARLRKGVN-ILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMgfekditkilel 168
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4758112  205 LDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd17949 169 LDDKRSKAGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
56-250 7.02e-28

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 109.09  E-value: 7.02e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLA----TLQQLEPVTGQV--SVLVMCHTRELAFQI 129
Cdd:cd17958   1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgfihLDLQPIPREQRNgpGVLVLTPTRELALQI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SKEYERFSkyMPNVKVAVFFGGLSIKKDEEVLKKNcPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMleqLDMRR 209
Cdd:cd17958  81 EAECSKYS--YKGLKSVCVYGGGNRNEQIEDLSKG-VDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRM---LDMGF 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  210 DVQ--EIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIF 250
Cdd:cd17958 155 EPQirKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
273-382 1.17e-27

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 105.76  E-value: 1.17e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    273 EKNRKLFDLLDVLEFNQVVIFVKSVQRCiALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMD 352
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
                          90       100       110
                  ....*....|....*....|....*....|
gi 4758112    353 IERVNIAFNYDMPEDSDTYLHRVARAGRFG 382
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
57-240 4.82e-27

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 107.06  E-value: 4.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   57 LRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPV-------TGqvsVLVMCHTRELAFQI 129
Cdd:cd17942   2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLkfkprngTG---VIIISPTRELALQI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKKNCPhIVVGTPGRILALARNKS-LNLKHIKHFILDECDKMLEQlDMR 208
Cdd:cd17942  79 YGVAKELLKYH-SQTFGIVIGGANRKAEAEKLGKGVN-ILVATPGRLLDHLQNTKgFLYKNLQCLIIDEADRILEI-GFE 155
                       170       180       190
                ....*....|....*....|....*....|..
gi 4758112  209 RDVQEIFRMTPHEKQVMMFSATLSKEIRPVCR 240
Cdd:cd17942 156 EEMRQIIKLLPKRRQTMLFSATQTRKVEDLAR 187
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
32-246 1.18e-26

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 107.03  E-value: 1.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   32 KKDVKGSYVSIHSsgFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILG--MDVLCQAKSGMGKTAVFVLATLQQLEP 109
Cdd:cd18048   7 QRDPTSPLFSVKS--FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  110 VTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKncphIVVGTPGRILALA-RNKSLNLK 188
Cdd:cd18048  85 LKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEAQ----IVIGTPGTVLDWCfKLRLIDVT 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758112  189 HIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 246
Cdd:cd18048 161 NISVFVLDEADVMINVQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
82-248 1.53e-22

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 94.53  E-value: 1.53e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   82 GMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVS------VLVMCHTRELAFQISKEYERFSKympNVKVAVFFGGLSIK 155
Cdd:cd17944  27 GKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKrgrapkVLVLAPTRELANQVTKDFKDITR---KLSVACFYGGTPYQ 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  156 KDEEVLKkNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEqLDMRRDVQEIFRMT----PHEK-QVMMFSAT 230
Cdd:cd17944 104 QQIFAIR-NGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLD-MGFAEQVEEILSVSykkdSEDNpQTLLFSAT 181
                       170
                ....*....|....*...
gi 4758112  231 LSKEIRPVCRKFMQDPME 248
Cdd:cd17944 182 CPDWVYNVAKKYMKSQYE 199
HELICc smart00490
helicase superfamily c-terminal domain;
303-382 2.59e-22

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 90.35  E-value: 2.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112     303 LAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFG 382
Cdd:smart00490   3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
56-233 3.80e-20

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 88.84  E-value: 3.80e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAI---------LGMDVLCQAKSGMGKTAVFVLATLQQL--EPVTgQVSVLVMCHTRE 124
Cdd:cd17956   1 LLKNLQNNGITSAFPVQAAVIPWLLpsskstppyRPGDLCVSAPTGSGKTLAYVLPIVQALskRVVP-RLRALIVVPTKE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  125 LAFQISKEYERFSKYMpNVKVAVFFGGLSIKKDEEVLKK-------NCPHIVVGTPGRILA-LARNKSLNLKHIKHFILD 196
Cdd:cd17956  80 LVQQVYKVFESLCKGT-GLKVVSLSGQKSFKKEQKLLLVdtsgrylSRVDILVATPGRLVDhLNSTPGFTLKHLRFLVID 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758112  197 ECDKMLEQldMRRD-----VQEIFRMT--------------PHEKQV--MMFSATLSK 233
Cdd:cd17956 159 EADRLLNQ--SFQDwletvMKALGRPTapdlgsfgdanlleRSVRPLqkLLFSATLTR 214
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
14-249 1.92e-19

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 87.76  E-value: 1.92e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   14 EDDEVETAAGGDGAEAPAKKD--VKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKS 91
Cdd:cd18050  29 EHPEVARMTQYDVEELRRKKEitIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQT 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   92 GMGKTAVFVLATLQQ------LEPVTGQVsVLVMCHTRELAFQISKEYERFSKyMPNVKVAVFFGGLSIKKDEEVLKKNC 165
Cdd:cd18050 109 GSGKTLAYLLPAIVHinhqpyLERGDGPI-CLVLAPTRELAQQVQQVADDYGK-SSRLKSTCIYGGAPKGPQIRDLERGV 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  166 pHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEqLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQD 245
Cdd:cd18050 187 -EICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLD-MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD 264

                ....
gi 4758112  246 PMEI 249
Cdd:cd18050 265 YVQI 268
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
56-249 2.60e-18

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 83.52  E-value: 2.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQ------LEPVTGQVsVLVMCHTRELAFQI 129
Cdd:cd18049  35 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHinhqpfLERGDGPI-CLVLAPTRELAQQV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SK---EYERFSKympnVKVAVFFGGLSIKKDEEVLKKNCpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEqLD 206
Cdd:cd18049 114 QQvaaEYGRACR----LKSTCIYGGAPKGPQIRDLERGV-EICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLD-MG 187
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 4758112  207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEI 249
Cdd:cd18049 188 FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHI 230
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
56-238 1.16e-17

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 81.64  E-value: 1.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   56 LLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQL----EPVTGQVS---VLVMCHTRELAFQ 128
Cdd:cd17948   1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLlrykLLAEGPFNaprGLVITPSRELAEQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  129 ISKEYERFSKYMPnVKVAVFFGGLSIKK-----DEEVlkkncpHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLE 203
Cdd:cd17948  81 IGSVAQSLTEGLG-LKVKVITGGRTKRQirnphFEEV------DILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLD 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 4758112  204 --------------QLDMRRDVQEIFRmtPHEKQVMMFSATLSKEIRPV 238
Cdd:cd17948 154 dsfneklshflrrfPLASRRSENTDGL--DPGTQLVLVSATMPSGVGEV 200
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
82-230 1.17e-16

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 76.67  E-value: 1.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   82 GMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVsvLVMCHTRELAFQISKEYERFSKymPNVKVAVFFGGLSiKKDEEVL 161
Cdd:cd00046   1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKV--LVLVPTKALALQTAERLRELFG--PGIRVAVLVGGSS-AEEREKN 75
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758112  162 KKNCPHIVVGTPGRIL-ALARNKSLNLKHIKHFILDECDKMLEQLD-MRRDVQEIFRMTPHEKQVMMFSAT 230
Cdd:cd00046  76 KLGDADIIIATPDMLLnLLLREDRLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
84-428 3.61e-15

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 77.37  E-value: 3.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   84 DVLCQAKSGMGKTAVFVLATLQQLEPVTgqvsVLVMCHTRELAFQISKEYERFSKympnvkvAVFFGGLSIKKDEevlkk 163
Cdd:COG1061 102 RGLVVAPTGTGKTVLALALAAELLRGKR----VLVLVPRRELLEQWAEELRRFLG-------DPLAGGGKKDSDA----- 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  164 ncpHIVVGTpgrILALARNKSLNL--KHIKHFILDEC--------DKMLEQLDMRRdvqeI-------FRMTPHEKQVMM 226
Cdd:COG1061 166 ---PITVAT---YQSLARRAHLDElgDRFGLVIIDEAhhagapsyRRILEAFPAAY----RlgltatpFRSDGREILLFL 235
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  227 F-----SATLSKEIR-PVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKnRKLFDLLDVLEFN----QVVIFVKS 296
Cdd:COG1061 236 FdgivyEYSLKEAIEdGYLAPPEYYGIRVDLTDERAEYDALSERLREALAADAE-RKDKILRELLREHpddrKTLVFCSS 314
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  297 VQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFnYDMPEDSDTYLH--- 373
Cdd:COG1061 315 VDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI-LLRPTGSPREFIqrl 393
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758112  374 -RVARAGRFGTKGLAITFVSD--ENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR 428
Cdd:COG1061 394 gRGLRPAPGKEDALVYDFVGNdvPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAV 451
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
267-400 3.28e-12

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 67.86  E-value: 3.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  267 VKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNL 346
Cdd:COG0514 210 VPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIA 289
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4758112  347 FgrGMDIERVNIAF--NYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDEnDAKIL 400
Cdd:COG0514 290 F--GMGIDKPDVRFviHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPE-DVAIQ 342
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
265-390 2.43e-10

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 57.99  E-value: 2.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  265 YYVKLKDNEKNRKLFDLLDVLEFNQ--VVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILV 342
Cdd:cd18794   6 YSVRPKDKKDEKLDLLKRIKVEHLGgsGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIV 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 4758112  343 ATNLFgrGMDIERVNIAF--NYDMPEDSDTYLHRVARAGRFGTKGLAITF 390
Cdd:cd18794  86 ATVAF--GMGIDKPDVRFviHYSLPKSMESYYQESGRAGRDGLPSECILF 133
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
89-245 1.69e-07

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 51.99  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   89 AKSGMGKTAVFVLATLQQL-----------------EPVTGQVSVLVMCHTRELAFQISKEYERFSKYMpNVKVAVF--- 148
Cdd:cd17965  68 AETGSGKTLAYLAPLLDYLkrqeqepfeeaeeeyesAKDTGRPRSVILVPTHELVEQVYSVLKKLSHTV-KLGIKTFssg 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  149 FGGLSIKKDEevLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQlDMRRDVQEIFRMTPHEKQVMMFS 228
Cdd:cd17965 147 FGPSYQRLQL--AFKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDR-SFLQDTTSIIKRAPKLKHLILCS 223
                       170
                ....*....|....*..
gi 4758112  229 ATLSKEIRPVCRKFMQD 245
Cdd:cd17965 224 ATIPKEFDKTLRKLFPD 240
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
85-232 1.31e-06

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 48.41  E-value: 1.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   85 VLCqAKSGMGKTAVFVLATLQQLEpvTGQVSVLVMCHTRELAFQISKE-YERFSKYMpnVKVAVFFGGLSIKKDEEVLkk 163
Cdd:cd17921  21 LVS-APTSSGKTLIAELAILRALA--TSGGKAVYIAPTRALVNQKEADlRERFGPLG--KNVGLLTGDPSVNKLLLAE-- 93
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758112  164 ncPHIVVGTPGRILALARN-KSLNLKHIKHFILDECDKM--------LEQLdmrrdVQEIFRMTPHEKQVMMfSATLS 232
Cdd:cd17921  94 --ADILVATPEKLDLLLRNgGERLIQDVRLVVVDEAHLIgdgergvvLELL-----LSRLLRINKNARFVGL-SATLP 163
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
340-391 1.55e-06

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 45.77  E-value: 1.55e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 4758112  340 ILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTK-GLAITFV 391
Cdd:cd18785  25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDeGEVILFV 77
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
51-305 6.02e-06

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 48.35  E-value: 6.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   51 LLKPELLRAIVDCGFEHPSEVQHECIPQAIL-GMDVLCQAKSGMGKTAVFVLATLQQLEpvTGQvSVLVMCHTRELAFQI 129
Cdd:COG1204   6 LPLEKVIEFLKERGIEELYPPQAEALEAGLLeGKNLVVSAPTASGKTLIAELAILKALL--NGG-KALYIVPLRALASEK 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  130 SKEYER-FSKYmpNVKVAVFFGGlsIKKDEEVLKKNcpHIVVGTPGRILALARNKSLNLKHIKHFILDECdKMLEqlDMR 208
Cdd:COG1204  83 YREFKRdFEEL--GIKVGVSTGD--YDSDDEWLGRY--DILVATPEKLDSLLRNGPSWLRDVDLVVVDEA-HLID--DES 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  209 R-----DVQEIFRMTPHEKQVMMFSATLS--KEI-------------RPVCRK--FMQDPMEIFVDDETKltlhglqqyy 266
Cdd:COG1204 154 RgptleVLLARLRRLNPEAQIVALSATIGnaEEIaewldaelvksdwRPVPLNegVLYDGVLRFDDGSRR---------- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4758112  267 vklkdnEKNRKLFDLLDVLEFN-QVVIFVKSVQRCIALAQ 305
Cdd:COG1204 224 ------SKDPTLALALDLLEEGgQVLVFVSSRRDAESLAK 257
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
68-201 1.18e-05

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 45.48  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   68 PSEVQHECIpQAILG-------MDVLCQAKSGMGKTAVFVLATLQQLEpvtGQVSVLVMCHTRELAFQIskeYERFSKYM 140
Cdd:cd17918  16 LTKDQAQAI-KDIEKdlhspepMDRLLSGDVGSGKTLVALGAALLAYK---NGKQVAILVPTEILAHQH---YEEARKFL 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758112  141 PNVKVAVFFGGLSIKKDEEvlkkncPHIVVGTPGRILALARNKSLNLkhikhFILDECDKM 201
Cdd:cd17918  89 PFINVELVTGGTKAQILSG------ISLLVGTHALLHLDVKFKNLDL-----VIVDEQHRF 138
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
92-198 1.64e-05

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 47.03  E-value: 1.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   92 GMGKTAVFVLATLQQLEPVTGQvsVLVMCHTRELAFQISKEYERFSKyMPNVKVAVFFGGLSIKKDEEVLKKNcpHIVVG 171
Cdd:COG1111  27 GLGKTAVALLVIAERLHKKGGK--VLFLAPTKPLVEQHAEFFKEALN-IPEDEIVVFTGEVSPEKRKELWEKA--RIIVA 101
                        90       100
                ....*....|....*....|....*..
gi 4758112  172 TPGRILALARNKSLNLKHIKHFILDEC 198
Cdd:COG1111 102 TPQVIENDLIAGRIDLDDVSLLIFDEA 128
CMS1 pfam14617
U3-containing 90S pre-ribosomal complex subunit; This is a family of fungal and plant ...
102-217 3.55e-05

U3-containing 90S pre-ribosomal complex subunit; This is a family of fungal and plant CMS1-like proteins. The family has similarity to the DEAD-box helicases.


Pssm-ID: 373164  Cd Length: 250  Bit Score: 45.24  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    102 ATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKymPNVKVAVFFGGlSIKKDEEV--LKKNCPHIVVGTPGRILAL 179
Cdd:pfam14617 113 KKLSQRPKSNGSPHTLVLTIAALRAADVLRPLKKLQT--KGFKVAKLFAK-HIKLEEHItyCKASRIGIGVGTPGRIADL 189
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4758112    180 ARNKSLNLKHIKHFILDEC---DKMLEQLDMRRDVQEIFRM 217
Cdd:pfam14617 190 LENESLSVDNLKYIILDASfrdIKNRGILDIRETRKAVIKF 230
DEXHc_HFM1 cd18023
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ...
70-197 3.99e-05

DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350781 [Multi-domain]  Cd Length: 206  Bit Score: 44.27  E-value: 3.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   70 EVQHECIPqAILGMD---VLCqAKSGMGKTAVFVLATLQQL----EPVTGQVSVLVMCHTRELAFQISKEY-ERFSKymP 141
Cdd:cd18023   4 RIQSEVFP-DLLYSDknfVVS-APTGSGKTVLFELAILRLLkernPLPWGNRKVVYIAPIKALCSEKYDDWkEKFGP--L 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  142 NVKVAVFFGGLSIKKDEEVlkKNCpHIVVGTPGRILALAR----NKSLnLKHIKHFILDE 197
Cdd:cd18023  80 GLSCAELTGDTEMDDTFEI--QDA-DIILTTPEKWDSMTRrwrdNGNL-VQLVALVLIDE 135
DEXHc_dicer cd18034
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ...
92-198 4.42e-05

DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350792 [Multi-domain]  Cd Length: 200  Bit Score: 44.18  E-value: 4.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   92 GMGKTAVFVLATLQQLEPVTGQVS----VLVMCHTRELAFQISKEYERFSkympNVKVAVFFGGLSI------KKDEEVL 161
Cdd:cd18034  26 GSGKTLIAVMLIKEMGELNRKEKNpkkrAVFLVPTVPLVAQQAEAIRSHT----DLKVGEYSGEMGVdkwtkeRWKEELE 101
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4758112  162 KKncpHIVVGTPGRILALARNKSLNLKHIKHFILDEC 198
Cdd:cd18034 102 KY---DVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
291-390 1.09e-04

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 44.32  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   291 VIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERlSRYQQfkDFQR---RILVATNLFgrGMDIERVNIAF--NYDMP 365
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVR-ADVQE--AFQRddlQIVVATVAF--GMGINKPNVRFvvHFDIP 314
                         90       100
                 ....*....|....*....|....*
gi 4758112   366 EDSDTYLHRVARAGRFGTKGLAITF 390
Cdd:PRK11057 315 RNIESYYQETGRAGRDGLPAEAMLF 339
PRK13766 PRK13766
Hef nuclease; Provisional
86-198 1.73e-04

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 44.09  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112    86 LCQAKSGMGKTAVFVLATLQQLEPVTGQvsVLVMCHTRELAFQiskEYERFSKYM--PNVKVAVFFGGLSIKKDEEVLKK 163
Cdd:PRK13766  33 LVVLPTGLGKTAIALLVIAERLHKKGGK--VLILAPTKPLVEQ---HAEFFRKFLniPEEKIVVFTGEVSPEKRAELWEK 107
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 4758112   164 NcpHIVVGTP---------GRIlalarnkslNLKHIKHFILDEC 198
Cdd:PRK13766 108 A--KVIVATPqviendliaGRI---------SLEDVSLLIFDEA 140
DEXHc_RecG cd17992
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ...
83-172 6.30e-04

DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350750 [Multi-domain]  Cd Length: 225  Bit Score: 40.98  E-value: 6.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   83 MDVLCQAKSGMGKTAVFVLATLQqlePVTGQVSVLVMCHTRELAFQiskEYERFSKYMP--NVKVAVFFGGLSIKKDEEV 160
Cdd:cd17992  67 MNRLLQGDVGSGKTVVAALAMLA---AVENGYQVALMAPTEILAEQ---HYDSLKKLLEplGIRVALLTGSTKAKEKREI 140
                        90
                ....*....|....*
gi 4758112  161 LKK---NCPHIVVGT 172
Cdd:cd17992 141 LEKiasGEIDIVIGT 155
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
92-198 7.24e-04

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 39.60  E-value: 7.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   92 GMGKTAVFVLATLQqlepvTGQVSVLVMCHTRELAFQISKEYERFSkymPNVKVAVFFGGLSIKKDEEVlkkncphIVVG 171
Cdd:cd17926  28 GSGKTLTALALIAY-----LKELRTLIVVPTDALLDQWKERFEDFL---GDSSIGLIGGGKKKDFDDAN-------VVVA 92
                        90       100
                ....*....|....*....|....*..
gi 4758112  172 TPGRILALARNKSLNLKHIKHFILDEC 198
Cdd:cd17926  93 TYQSLSNLAEEEKDLFDQFGLLIVDEA 119
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
236-391 1.08e-03

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 39.46  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  236 RPVcrkfmqdPMEIFVDDETKLTLHGLQQyyVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVeqnfpAI 315
Cdd:cd18795   1 RPV-------PLEEYVLGFNGLGIKLRVD--VMNKFDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA-----GI 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  316 AIHR-GMPQEERLSRYQQFKDFQRRILVAT-------NLFGRGMDIERVNIAFNYDMPE-DSDTYLHRVARAGR--FGTK 384
Cdd:cd18795  67 AFHHaGLTREDRELVEELFREGLIKVLVATstlaagvNLPARTVIIKGTQRYDGKGYRElSPLEYLQMIGRAGRpgFDTR 146

                ....*..
gi 4758112  385 GLAITFV 391
Cdd:cd18795 147 GEAIIMT 153
Cas3_I cd09639
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ...
224-384 1.22e-03

CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I


Pssm-ID: 187770 [Multi-domain]  Cd Length: 353  Bit Score: 40.88  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  224 VMMFSATLSKEIRpvcrKFMQDpMEIFVDDETKLTLHGLQQYYVKL--KDNEKNRKLFDLLD-VLEFNQVVIFVKSVQRC 300
Cdd:cd09639 157 ILLMSATLPKFLK----EYAEK-IGYVEENEPLDLKPNERAPFIKIesDKVGEISSLERLLEfIKKGGSVAIIVNTVDRA 231
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112  301 IALAQLLVEQN--FPAIAIHRGMPQEERLSRYQQ----FKDFQRRILVATNLFGRGMDIErVNIAFNYDMPEDSdtYLHR 374
Cdd:cd09639 232 QEFYQQLKEKGpeEEIMLIHSRFTEKDRAKKEAEllleFKKSEKFVIVATQVIEASLDIS-VDVMITELAPIDS--LIQR 308
                       170
                ....*....|
gi 4758112  375 VARAGRFGTK 384
Cdd:cd09639 309 LGRLHRYGEK 318
DEXHc_Hef cd18035
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ...
86-198 1.40e-03

DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350793 [Multi-domain]  Cd Length: 181  Bit Score: 39.42  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758112   86 LCQAKSGMGKTAVFVLATLQQLEPVTGQvsVLVMCHTRELAFQiskEYERFSKYM-PNVKVAVFFGGLSIKKDEEVLKKN 164
Cdd:cd18035  20 LIVLPTGLGKTIIAILVAADRLTKKGGK--VLILAPSRPLVEQ---HAENLKRVLnIPDKITSLTGEVKPEERAERWDAS 94
                        90       100       110
                ....*....|....*....|....*....|....
gi 4758112  165 cpHIVVGTPGRILALARNKSLNLKHIKHFILDEC 198
Cdd:cd18035  95 --KIIVATPQVIENDLLAGRITLDDVSLLIFDEA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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