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Conserved domains on  [gi|38045915|ref|NP_002572|]
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pappalysin-1 preproprotein [Homo sapiens]

Protein Classification

LamGL and ZnMc_pappalysin_like domain-containing protein( domain architecture ID 10651285)

protein containing domains LamGL, ZnMc_pappalysin_like, myxo_disulf_rpt, and CCP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 424-660 4.93e-66

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


:

Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 222.99  E-value: 4.93e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  424 CDPECNHTLTGHDGgdcrhlrhPAFVKKQHNGVCDMDCNYERFNFD----GGECCDPEITNVTqTCFDPDSPHRA-YLDV 498
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGlnagVDLGIEFVLAGTT-RTVNSAWPVFAgSGTE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  499 NELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGMPG-----HTHTMIHEIGHSLGLYH 572
Cdd:cd04275   74 DAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYH 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  573 VFRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkSCGDPGpGNDTCGFHSFFnTPYNNFMSYADDDCTDSFTPNQV 652
Cdd:cd04275  154 TFQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQV 217


                 ....*...
gi 38045915  653 ARMHCYLD 660
Cdd:cd04275  218 TRMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
117-266 2.12e-37

LamG-like jellyroll fold domain;


:

Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 137.55  E-value: 2.12e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915     117 DAFTLQVWLRAEGGQRSPAVITGlydkcsyisrdrgWVVGIHTISdqdNKDPRYFFSLKTDRarQVTTINAHRSYLP-GQ 195
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915     196 WVYLAATYDG--QFMKLYVNGAQVATSGEQVGGIFSPLTQKCkvLMLGGSALNHNYRGYIEHFSLWKVARTQR 266
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 944-983 5.27e-14

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 67.40  E-value: 5.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 38045915    944 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 983
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1415-1471 1.06e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 1.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38045915   1415 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 1471
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1547-1583 6.59e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 50.02  E-value: 6.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 38045915    1547 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1583
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1346-1421 1.23e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38045915 1346 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegacvpvtcDPPPPK 1421
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1296-1343 4.45e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 4.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 38045915 1296 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 1343
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1215-1275 1.29e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.60  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915 1215 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtGPSvTVTCTE-GKWN 1275
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV------------GSS-TITCTEnGGWS 50
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 424-660 4.93e-66

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 222.99  E-value: 4.93e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  424 CDPECNHTLTGHDGgdcrhlrhPAFVKKQHNGVCDMDCNYERFNFD----GGECCDPEITNVTqTCFDPDSPHRA-YLDV 498
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGlnagVDLGIEFVLAGTT-RTVNSAWPVFAgSGTE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  499 NELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGMPG-----HTHTMIHEIGHSLGLYH 572
Cdd:cd04275   74 DAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYH 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  573 VFRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkSCGDPGpGNDTCGFHSFFnTPYNNFMSYADDDCTDSFTPNQV 652
Cdd:cd04275  154 TFQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQV 217


                 ....*...
gi 38045915  653 ARMHCYLD 660
Cdd:cd04275  218 TRMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
117-266 2.12e-37

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 137.55  E-value: 2.12e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915     117 DAFTLQVWLRAEGGQRSPAVITGlydkcsyisrdrgWVVGIHTISdqdNKDPRYFFSLKTDRarQVTTINAHRSYLP-GQ 195
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915     196 WVYLAATYDG--QFMKLYVNGAQVATSGEQVGGIFSPLTQKCkvLMLGGSALNHNYRGYIEHFSLWKVARTQR 266
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 110-268 1.98e-18

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 83.59  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    110 ADLELPRDAFTLQVWLR-AEGGQRSPAVITGlydkcsyiSRDRGWVVGIhtisdqdNKDPRYFFSLKTDRArQVTTINAH 188
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKpDSLPGWARAIISS--------SGGGGYSLGL-------DGDGRLRFAVNGGNG-GWDTVTSG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    189 RSYLPGQWVYLAATYDGQFMKLYVNGAQVATSgEQVGGIFSPLTqkcKVLMLGGSA-LNHNYRGYIEHFSLWKVARTQRE 267
Cdd:pfam13385   74 ASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSS-TLTGGPPPGTG---GPLYIGRSPgGDDYFNGLIDEVRIYDRALSAAE 149


                   .
gi 38045915    268 I 268
Cdd:pfam13385  150 I 150
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 944-983 5.27e-14

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 67.40  E-value: 5.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 38045915    944 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 983
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1415-1471 1.06e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 1.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38045915   1415 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 1471
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1547-1583 6.59e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 50.02  E-value: 6.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 38045915    1547 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1583
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1346-1421 1.23e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38045915 1346 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegacvpvtcDPPPPK 1421
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
Sushi pfam00084
Sushi repeat (SCR repeat);
1346-1405 1.67e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 1.67e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915   1346 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSW 1405
Cdd:pfam00084    1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTW 49
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1415-1472 1.04e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38045915 1415 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEdsdasQG---LGSNVIHCRKDGTWNGSFHVCQ 1472
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCN-----EGytlVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1346-1405 1.21e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.21e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    1346 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW 1405
Cdd:smart00032    1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTW 49
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 559-660 2.65e-05

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 46.07  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    559 TMIHEIGHSLGLYHVFRGiseiqSCSDPcmetepsfeTGDLCNDTnPAPKHKSCGDPGPGNDTCGFHSFFNTpynNFMSY 638
Cdd:pfam05572   71 TLTHEFGHFLGLIHTFEG-----GCERG---------EGDKVPDT-PSYTGGEVSLRNKDLFNCNGEPINSQ---NQMDY 132

                           90       100
                   ....*....|....*....|..
gi 38045915    639 adDDCTDSFTPNQVARMHCYLD 660
Cdd:pfam05572  133 --NGCYAMFTQDQVDRMVEVLA 152
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 410-440 3.47e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.31  E-value: 3.47e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 38045915     410 ILANCDI----SKIGDENCDPECNHTLTGHDGGDC 440
Cdd:smart00004    4 PWSRCEDaqcwDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1415-1471 2.04e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.59  E-value: 2.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 38045915    1415 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGLGSNVIHCRKDGTWNGSFHVC 1471
Cdd:smart00032    1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1296-1343 4.45e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 4.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 38045915 1296 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 1343
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1285-1342 9.30e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 9.30e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 38045915    1285 CSIPDhhQVYAASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALC 1342
Cdd:smart00032    1 CPPPP--DIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTI-TCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1215-1275 1.29e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.60  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915 1215 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtGPSvTVTCTE-GKWN 1275
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV------------GSS-TITCTEnGGWS 50
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1342-1551 1.36e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1342 CELMCLAPPPVP-NADLQTA--RCRENKHKVGSFCKYKCKPGYhvpgssRKSKKRAFKTQCTQDGSWQEGACVPVTCDPP 1418
Cdd:PHA02927   16 CVLSCCTIPSRPiNMKFKNSveTDANANYNIGDTIEYLCLPGY------RKQKMGPIYAKCTGTGWTLFNQCIKRRCPSP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1419 PPKFHG-------------LYQCTNGFQFNSECRIKCEdsdasqgLGSNvihcrKDGTWNGSFHVCQEMqgQCSVPNELN 1485
Cdd:PHA02927   90 RDIDNGqldiggvdfgssiTYSCNSGYQLIGESKSYCE-------LGST-----GSMVWNPEAPICESV--KCQSPPSIS 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38045915  1486 SNLKLQCPDGYAIGSECATSCldhNSESIILPMNVTVRDIPHWLNPTRVERVVCtaglkwyPHPAL 1551
Cdd:PHA02927  156 NGRHNGYEDFYTDGSVVTYSC---NSGYSLIGNSGVLCSGGEWSDPPTCQIVKC-------PHPTI 211
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1215-1275 4.50e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 4.50e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915    1215 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 1275
Cdd:smart00032    1 CPPPpDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI-------------GSSTITCLEnGTWS 50
DUF4215 pfam13948
Domain of unknown function (DUF4215); The function of this family is unknown.
 946-972 5.83e-03

Domain of unknown function (DUF4215); The function of this family is unknown.


Pssm-ID: 290659  Cd Length: 47  Bit Score: 36.23  E-value: 5.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 38045915    946 YCGDGIIQKDqgEQCDDMNKINGDGCS 972
Cdd:pfam13948   20 ICGDGIIVNN--EQCDDGNNLQFDGCY 44
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 424-660 4.93e-66

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 222.99  E-value: 4.93e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  424 CDPECNHTLTGHDGgdcrhlrhPAFVKKQHNGVCDMDCNYERFNFD----GGECCDPEITNVTqTCFDPDSPHRA-YLDV 498
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGlnagVDLGIEFVLAGTT-RTVNSAWPVFAgSGTE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  499 NELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGMPG-----HTHTMIHEIGHSLGLYH 572
Cdd:cd04275   74 DAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYH 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  573 VFRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkSCGDPGpGNDTCGFHSFFnTPYNNFMSYADDDCTDSFTPNQV 652
Cdd:cd04275  154 TFQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQV 217


                 ....*...
gi 38045915  653 ARMHCYLD 660
Cdd:cd04275  218 TRMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
117-266 2.12e-37

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 137.55  E-value: 2.12e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915     117 DAFTLQVWLRAEGGQRSPAVITGlydkcsyisrdrgWVVGIHTISdqdNKDPRYFFSLKTDRarQVTTINAHRSYLP-GQ 195
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915     196 WVYLAATYDG--QFMKLYVNGAQVATSGEQVGGIFSPLTQKCkvLMLGGSALNHNYRGYIEHFSLWKVARTQR 266
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 110-268 1.98e-18

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 83.59  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    110 ADLELPRDAFTLQVWLR-AEGGQRSPAVITGlydkcsyiSRDRGWVVGIhtisdqdNKDPRYFFSLKTDRArQVTTINAH 188
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKpDSLPGWARAIISS--------SGGGGYSLGL-------DGDGRLRFAVNGGNG-GWDTVTSG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    189 RSYLPGQWVYLAATYDGQFMKLYVNGAQVATSgEQVGGIFSPLTqkcKVLMLGGSA-LNHNYRGYIEHFSLWKVARTQRE 267
Cdd:pfam13385   74 ASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSS-TLTGGPPPGTG---GPLYIGRSPgGDDYFNGLIDEVRIYDRALSAAE 149


                   .
gi 38045915    268 I 268
Cdd:pfam13385  150 I 150
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 944-983 5.27e-14

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 67.40  E-value: 5.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 38045915    944 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 983
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1415-1471 1.06e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.66  E-value: 1.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 38045915   1415 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 1471
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1547-1583 6.59e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 50.02  E-value: 6.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 38045915    1547 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1583
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1346-1421 1.23e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.23e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38045915 1346 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegacvpvtcDPPPPK 1421
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
Sushi pfam00084
Sushi repeat (SCR repeat);
1346-1405 1.67e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 1.67e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915   1346 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSW 1405
Cdd:pfam00084    1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTW 49
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 510-572 8.63e-06

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 48.18  E-value: 8.63e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  510 STHLNIFFAKSSEEEL--AGVATWPWDKEALMHLGGIVLNPSFYG---MPG--HTHTMIHEIGHSLGLYH 572
Cdd:cd04277   60 NSGADIRFGNSSDPDGntAGYAYYPGSGSGTAYGGDIWFNSSYDTnsdSPGsyGYQTIIHEIGHALGLEH 129
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1415-1472 1.04e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 38045915 1415 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEdsdasQG---LGSNVIHCRKDGTWNGSFHVCQ 1472
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCN-----EGytlVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1346-1405 1.21e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.21e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    1346 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW 1405
Cdd:smart00032    1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTW 49
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 559-660 2.65e-05

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 46.07  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915    559 TMIHEIGHSLGLYHVFRGiseiqSCSDPcmetepsfeTGDLCNDTnPAPKHKSCGDPGPGNDTCGFHSFFNTpynNFMSY 638
Cdd:pfam05572   71 TLTHEFGHFLGLIHTFEG-----GCERG---------EGDKVPDT-PSYTGGEVSLRNKDLFNCNGEPINSQ---NQMDY 132

                           90       100
                   ....*....|....*....|..
gi 38045915    639 adDDCTDSFTPNQVARMHCYLD 660
Cdd:pfam05572  133 --NGCYAMFTQDQVDRMVEVLA 152
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 410-440 3.47e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.31  E-value: 3.47e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 38045915     410 ILANCDI----SKIGDENCDPECNHTLTGHDGGDC 440
Cdd:smart00004    4 PWSRCEDaqcwDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1415-1471 2.04e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.59  E-value: 2.04e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 38045915    1415 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGLGSNVIHCRKDGTWNGSFHVC 1471
Cdd:smart00032    1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1296-1343 4.45e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 4.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 38045915 1296 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 1343
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1285-1342 9.30e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 9.30e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 38045915    1285 CSIPDhhQVYAASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALC 1342
Cdd:smart00032    1 CPPPP--DIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTI-TCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1215-1275 1.29e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.60  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915 1215 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtGPSvTVTCTE-GKWN 1275
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV------------GSS-TITCTEnGGWS 50
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1342-1551 1.36e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1342 CELMCLAPPPVP-NADLQTA--RCRENKHKVGSFCKYKCKPGYhvpgssRKSKKRAFKTQCTQDGSWQEGACVPVTCDPP 1418
Cdd:PHA02927   16 CVLSCCTIPSRPiNMKFKNSveTDANANYNIGDTIEYLCLPGY------RKQKMGPIYAKCTGTGWTLFNQCIKRRCPSP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1419 PPKFHG-------------LYQCTNGFQFNSECRIKCEdsdasqgLGSNvihcrKDGTWNGSFHVCQEMqgQCSVPNELN 1485
Cdd:PHA02927   90 RDIDNGqldiggvdfgssiTYSCNSGYQLIGESKSYCE-------LGST-----GSMVWNPEAPICESV--KCQSPPSIS 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38045915  1486 SNLKLQCPDGYAIGSECATSCldhNSESIILPMNVTVRDIPHWLNPTRVERVVCtaglkwyPHPAL 1551
Cdd:PHA02927  156 NGRHNGYEDFYTDGSVVTYSC---NSGYSLIGNSGVLCSGGEWSDPPTCQIVKC-------PHPTI 211
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 539-576 1.47e-03

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.33  E-value: 1.47e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 38045915  539 MHLGGIVLNPSFYGMPGH--THTMIHEIGHSLGLYHVFRG 576
Cdd:cd04268   75 ILLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAA 114
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1258-1471 2.30e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 41.56  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1258 KSQTGPsVTVTCTEGKWNKQVACEPVDCSIP---DHHQVYAAsfscpeGTTFGSQCSFQCRHPAQLKGNNSL---LTCME 1331
Cdd:PHA02927   60 KQKMGP-IYAKCTGTGWTLFNQCIKRRCPSPrdiDNGQLDIG------GVDFGSSITYSCNSGYQLIGESKSyceLGSTG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1332 DGLWSfPEA-LCE-LMCLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTqDGSWQE-G 1408
Cdd:PHA02927  133 SMVWN-PEApICEsVKCQSPPSISNG---RHNGYEDFYTDGSVVTYSCNSGYSLIGNS--------GVLCS-GGEWSDpP 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38045915  1409 ACVPVTCdpPPPKFHGLYqCTNGFQ----FNSECRIKCEDSDASQGLGSNVihCRKDGTWNGSFHVC 1471
Cdd:PHA02927  200 TCQIVKC--PHPTISNGY-LSSGFKrsysYNDNVDFKCKYGYKLSGSSSST--CSPGNTWQPELPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1210-1339 4.40e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38045915  1210 CEKTDCPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLqirrddeliksqTGPSvTVTCTEGKWNKQVACEPVDCSIP 1288
Cdd:PHA02927  143 CESVKCQSPpSISNGRHNGYEDFYTDGSVVTYSCNSGYSL------------IGNS-GVLCSGGEWSDPPTCQIVKCPHP 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 38045915  1289 DHHQVYAASfSCPEGTTFGSQCSFQCRHPAQLKGNNSlLTCMEDGLWSfPE 1339
Cdd:PHA02927  210 TISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSS-STCSPGNTWQ-PE 257
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1215-1275 4.50e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 4.50e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38045915    1215 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 1275
Cdd:smart00032    1 CPPPpDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI-------------GSSTITCLEnGTWS 50
DUF4215 pfam13948
Domain of unknown function (DUF4215); The function of this family is unknown.
 946-972 5.83e-03

Domain of unknown function (DUF4215); The function of this family is unknown.


Pssm-ID: 290659  Cd Length: 47  Bit Score: 36.23  E-value: 5.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 38045915    946 YCGDGIIQKDqgEQCDDMNKINGDGCS 972
Cdd:pfam13948   20 ICGDGIIVNN--EQCDDGNNLQFDGCY 44
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 549-572 9.25e-03

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 38.10  E-value: 9.25e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 38045915     549 SFYGMPG------------HTHTMIHEIGHSLGLYH 572
Cdd:smart00235   65 SHAGRPGgdqhlslgngciNTGVAAHELGHALGLYH 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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