NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2522518531|ref|NP_001409583|]
View 

sodium/calcium exchanger 3 isoform 1 precursor [Mus musculus]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1693.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531   1 MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAgdSGDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNFTpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 394 FASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 474 FEEDEHFFVRLSNVRVEEEQlaeGMLPAILNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISEV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 632 -------TDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 705 GGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2522518531 865 FAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1693.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531   1 MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAgdSGDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNFTpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 394 FASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 474 FEEDEHFFVRLSNVRVEEEQlaeGMLPAILNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISEV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 632 -------TDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 705 GGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2522518531 865 FAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 253-379 1.65e-82

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 261.86  E-value: 1.65e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 253 KRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG----IEMDGKMMNSHF----LDGNFTPLEGKEVDESRREMIRILKDLK 324
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2522518531 325 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKK 379
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARK 135
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 395-485 1.03e-32

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 121.59  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  395 ASKVFFDPCSYQCLENCGAVLLTVVRKGGDiSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIF 474
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 2522518531  475 EEDEHFFVRLS 485
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
756-909 4.81e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 756 ILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYaDASIGNVTGSNAVNVFLGI 830
Cdd:COG0530   156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIGSNIFNILLVL 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2522518531 831 GLAWSVAAIywamqgqefHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRphlggeLGGPRGcklattWLFVSLWLLYILF 909
Cdd:COG0530   235 GIGALITPI---------PVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 753-909 1.37e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 753 VVSILIIGMLTAIIGD----LASHFGC---TIGLkdsvtavVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVN 825
Cdd:PRK10734  180 GIALIIMPMATRMVIDnatvLANYFAIselTIGL-------TVIAIGTSLPELATAIAGARKG-ENDIAVGNIIGSNIFN 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 826 VFLGIGL-------AWSVAAI---YWAMqgqefhvsagtLAFSVtlftIFAFVCLsvllyrRRPHLGGELGGPRGCKLAT 895
Cdd:PRK10734  252 IVIVLGLpalispgEINPLAFsrdYWVM-----------LLVSV----IFALLCW------RRKRRIGRGAGALLLGGFI 310

                         170
                  ....*....|....
gi 2522518531 896 TWLFVSLWLLYILF 909
Cdd:PRK10734  311 VWLAMLYWLSPILV 324
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1693.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531   1 MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAgdSGDVPSAGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNFTpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTSSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 394 FASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 474 FEEDEHFFVRLSNVRVEEEQlaeGMLPAILNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISEV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 632 -------TDRKLTVEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 705 GGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2522518531 865 FAFVCLSVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 253-379 1.65e-82

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 261.86  E-value: 1.65e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 253 KRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG----IEMDGKMMNSHF----LDGNFTPLEGKEVDESRREMIRILKDLK 324
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2522518531 325 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKK 379
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARK 135
Calx-beta pfam03160
Calx-beta domain;
395-485 3.73e-40

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 142.77  E-value: 3.73e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 395 ASKVFFDPCSYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIF 474
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 2522518531 475 EEDEHFFVRLS 485
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
529-619 1.60e-33

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 123.90  E-value: 1.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 529 AGIFTFECDTIHVSESIGVMEVKVLRTSGA-RGTVIVPFRTVEGTAKGGgEDFEDAYGELEFKNDETVKTIRVKIVDEEE 607
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 2522518531 608 YERQENFFIALG 619
Cdd:pfam03160  80 YEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 395-485 1.03e-32

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 121.59  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  395 ASKVFFDPCSYQCLENCGAVLLTVVRKGGDiSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIF 474
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 2522518531  475 EEDEHFFVRLS 485
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 529-619 7.11e-31

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 116.20  E-value: 7.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  529 AGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKgGGEDFEDAYGELEFKNDETVKTIRVKIVDEEEY 608
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 2522518531  609 ERQENFFIALG 619
Cdd:smart00237  80 EKDETFYVRLS 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 747-912 8.59e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 98.06  E-value: 8.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 747 HGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNV 826
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRG-EPDLALGNVIGSNIFNI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 827 FLGIGLAWSVAAIYWAMQGQEFHvsagtlaFSVTLFTIFAFVCLSVLLYRRRphlggelggPRGCKLATTWLFVSLWLLY 906
Cdd:pfam01699  80 LLVLGLSALIGPVKVDSLLLKLD-------LGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVY 143


                  ....*.
gi 2522518531 907 ILFATL 912
Cdd:pfam01699 144 LVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 79-250 4.04e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 84.96  E-value: 4.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  79 VYFVALIYMFLGVSIIADRFMASIEVITsqerevtikkpngetsttTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGH 158
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 159 GfiaGDLGPSTIVGSAAFNMFIIIGICVYV--IPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILavfsPGVVQVWEGLL 236
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 2522518531 237 TLFFFPVCVLLAWV 250
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
756-909 4.81e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 756 ILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYaDASIGNVTGSNAVNVFLGI 830
Cdd:COG0530   156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIGSNIFNILLVL 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2522518531 831 GLAWSVAAIywamqgqefHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRphlggeLGGPRGcklattWLFVSLWLLYILF 909
Cdd:COG0530   235 GIGALITPI---------PVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLAYLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 77-249 1.15e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 68.87  E-value: 1.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531   77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQereVTIkkpngetstttirvwNETVSNLTLMALGSSAPEILLSLIEV 155
Cdd:TIGR00927  457 VVLHIFGMMYVFVALAIVCDEyFVPALGVITDK---LQI---------------SEDVAGATFMAAGGSAPELFTSLIGV 518

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  156 cghgFIA-GDLGPSTIVGSAAFNMFIIIGICVYVipdgeTRKIKHLrvffvtAAWSIFAYIWLY-----MILAVFSPGVV 229
Cdd:TIGR00927  519 ----FIShSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNL------TWWPLFRDVSFYildlmMLILFFLDSLI 583

                          170       180
                   ....*....|....*....|.
gi 2522518531  230 QVWEGLLTLFFFPVCVL-LAW 249
Cdd:TIGR00927  584 AWWESLLLLLAYALYVFtMKW 604
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
768-910 3.43e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.99  E-value: 3.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 768 DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNVFLGIGLAWSVAAIywamqgqe 847
Cdd:COG0530     6 RGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDG-SPDIAVGNVVGSNIANILLILGLAALIRPL-------- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2522518531 848 fHVSAGTLAFSVTLFTIFAFVCLSVLlyrrrphLGGELGGPRGcklattWLFVSLWLLYILFA 910
Cdd:COG0530    77 -AVDRRVLRRDLPFLLLASLLLLALL-------LDGTLSRIDG------VILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
136-254 8.68e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 54.75  E-value: 8.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 136 LTLMALGSSAPEILLSLIEVCGHgfiAGDLGPSTIVGSAAFNMFIIIGICVYVIPdgetRKIKHlRVFFVTAAWSIFAYI 215
Cdd:COG0530    24 LTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRP----LAVDR-RVLRRDLPFLLLASL 95

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2522518531 216 WLymiLAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Cdd:COG0530    96 LL---LALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 82-243 2.94e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 50.02  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  82 VALIYMFLGVSII-ADRFMASIEVITSqerevTIKKPNgetstttirvwneTVSNLTLMALGSSAPEILLSLIEVCGHgf 160
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMG-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 161 iAGDLGPSTIVGSAAFNMFIIIGICVYVIPdgetrkikhlrvfFVTAAWSIF----AYIWLYMILAVFS-PGVVQVWEGL 235
Cdd:TIGR00367  64 -QPDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdilFYLLVSILLLFFGlDGQISRIDGV 129


                  ....*...
gi 2522518531 236 LTLFFFPV 243
Cdd:TIGR00367 130 VLLILYIV 137
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 753-839 6.05e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.24  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 753 VVSILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNVF 827
Cdd:TIGR00367   3 LIGYLILGLILLIYGadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMG-QPDIGVGNVIGSNIFNIL 81

                          90
                  ....*....|..
gi 2522518531 828 LGIGLAWSVAAI 839
Cdd:TIGR00367  82 LILGLSAIFSPI 93
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 752-834 5.86e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.16  E-value: 5.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 752 FVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVyADASIGNVTGSNAVNVFLGIG 831
Cdd:TIGR00367 175 LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGL-GDIAVGNVIGSNIFNILVGLG 253


                  ...
gi 2522518531 832 LAW 834
Cdd:TIGR00367 254 VPS 256
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 753-909 1.37e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 753 VVSILIIGMLTAIIGD----LASHFGC---TIGLkdsvtavVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVN 825
Cdd:PRK10734  180 GIALIIMPMATRMVIDnatvLANYFAIselTIGL-------TVIAIGTSLPELATAIAGARKG-ENDIAVGNIIGSNIFN 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 826 VFLGIGL-------AWSVAAI---YWAMqgqefhvsagtLAFSVtlftIFAFVCLsvllyrRRPHLGGELGGPRGCKLAT 895
Cdd:PRK10734  252 IVIVLGLpalispgEINPLAFsrdYWVM-----------LLVSV----IFALLCW------RRKRRIGRGAGALLLGGFI 310

                         170
                  ....*....|....
gi 2522518531 896 TWLFVSLWLLYILF 909
Cdd:PRK10734  311 VWLAMLYWLSPILV 324
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 752-833 1.82e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.64  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 752 FVVSILIIGMLTAIIGD-----LASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNV 826
Cdd:PRK10734    3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHG-QRDLAVGTALGSNITNI 81


                  ....*..
gi 2522518531 827 FLGIGLA 833
Cdd:PRK10734   82 LLILGLA 88
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 79-232 6.48e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.60  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531  79 VYFVALIYMfLGvSIIADRFMASIEVITSqerevTIKKPngetstttirvwnETVSNLTLMALGSSAPEILLSLIEVCGH 158
Cdd:PLN03151  145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2522518531 159 GfiAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKhlRVFFVTAAWSIFAYIWLYMILAVfspGVVQVW 232
Cdd:PLN03151  205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVG 271
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
129-247 3.50e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.50  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2522518531 129 WNETVSNLTLMALGSSAPEILLSLIEVC-GHGFIAgdLGpsTIVGSAAFNMFIIIGICVYVIPdgetrkikhLRVFFVTA 207
Cdd:COG0530   184 VSELVIGLTIVAIGTSLPELATSIVAARkGEDDLA--VG--NIIGSNIFNILLVLGIGALITP---------IPVDPAVL 250

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2522518531 208 AWSIFAYI--WLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Cdd:COG0530   251 SFDLPVMLaaTLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH