|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-474 |
6.27e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.14 E-value: 6.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 106 EQPRHRGQRKRASRDQDSSDDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYEACGARVF------VQRFRL 179
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASasadgtVRLWDL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 180 QHG-----LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFeSGHKSNVFQAKFLPNSgdSTLAMCARDG 254
Cdd:COG2319 108 ATGlllrtLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDG--KLLASGSDDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 255 QVRVAELSATQCcknTKRVAQHKGASHKLALEPDSpCTFLSAGEDAVVFTIDLRQDRPASKLvvtkeKEKKVGLYTIYVN 334
Cdd:COG2319 185 TVRLWDLATGKL---LRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTL-----TGHSGSVRSVAFS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 335 PANTHqFAVGGRDQYVRIYDQrkideneNNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNsshSD 414
Cdd:COG2319 256 PDGRL-LASGSADGTVRLWDL-------ATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVRLWD---LA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 415 GAQYIKRYKGHrnNATVKGVNFyGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGV 474
Cdd:COG2319 319 TGKLLRTLTGH--TGAVRSVAF-SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
183-465 |
3.53e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.94 E-value: 3.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 183 LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNSgdSTLAMCARDGQVRVAELS 262
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADG--TYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 263 ATQCcknTKRVAQHKGASHKLALEPDSPCtFLSAGEDAVVFTIDLRQDRPaskLVVTKEKEKKVglYTIYVNPanTHQFA 342
Cdd:cd00200 82 TGEC---VRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKC---LTTLRGHTDWV--NSVAFSP--DGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 343 VGG-RDQYVRIYDqrkidenENNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNssHSDGAQyIKR 421
Cdd:cd00200 151 ASSsQDGTIKLWD-------LRTGKCVATLTGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWD--LSTGKC-LGT 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2504581670 422 YKGHRNNATvkGVNFyGPKSEFVVSGSDCGHIFLWEKSSCQIIQ 465
Cdd:cd00200 215 LRGHENGVN--SVAF-SPDGYLLASGSEDGTIRVWDLRTGECVQ 255
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
177-215 |
7.47e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.80 E-value: 7.47e-07
10 20 30
....*....|....*....|....*....|....*....
gi 2504581670 177 FRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWD 215
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
183-215 |
1.19e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.19e-06
10 20 30
....*....|....*....|....*....|...
gi 2504581670 183 LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWD 215
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
17-177 |
1.88e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 41.13 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 17 NGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGpnRTSTESRGTDTESSGEEKDSDSMEDTGhysinDESRG 96
Cdd:TIGR00927 788 DGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEV--KDETGEQELNAENQGEAKQDEKGVDGG-----GGSDG 860
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 97 HGHSDEEDEEQPRHRGQRKRASRDQDSSDDERALE-DWVSSETTA------LP--RPRWQALPALRERElgSSARFVYEA 167
Cdd:TIGR00927 861 GDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSlEWPETRQKQaiylflLPivFPLWLTVPDVRRQE--ARKFFVITF 938
|
170
....*....|
gi 2504581670 168 CGARVFVQRF 177
Cdd:TIGR00927 939 LGSIMWIAMF 948
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
106-474 |
6.27e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 101.14 E-value: 6.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 106 EQPRHRGQRKRASRDQDSSDDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYEACGARVF------VQRFRL 179
Cdd:COG2319 28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASasadgtVRLWDL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 180 QHG-----LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFeSGHKSNVFQAKFLPNSgdSTLAMCARDG 254
Cdd:COG2319 108 ATGlllrtLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDG--KLLASGSDDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 255 QVRVAELSATQCcknTKRVAQHKGASHKLALEPDSpCTFLSAGEDAVVFTIDLRQDRPASKLvvtkeKEKKVGLYTIYVN 334
Cdd:COG2319 185 TVRLWDLATGKL---LRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTL-----TGHSGSVRSVAFS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 335 PANTHqFAVGGRDQYVRIYDQrkideneNNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNsshSD 414
Cdd:COG2319 256 PDGRL-LASGSADGTVRLWDL-------ATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVRLWD---LA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 415 GAQYIKRYKGHrnNATVKGVNFyGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGV 474
Cdd:COG2319 319 TGKLLRTLTGH--TGAVRSVAF-SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
178-456 |
2.28e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.22 E-value: 2.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 178 RLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNSgdSTLAMCARDGQVR 257
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDG--KLLASGSADGTVR 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 258 VAELSATQCcknTKRVAQHKGASHKLALEPDSPcTFLSAGEDAVVFTIDLRQDRPASKLvvtkeKEKKVGLYTIYVNPaN 337
Cdd:COG2319 230 LWDLATGKL---LRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTL-----TGHSGGVNSVAFSP-D 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 338 THQFAVGGRDQYVRIYDqrkIDENEnngVLKKFCPHHlvnseskANITCLVYSHDGTELLASYNDEDIYLFNsshSDGAQ 417
Cdd:COG2319 300 GKLLASGSDDGTVRLWD---LATGK---LLRTLTGHT-------GAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGE 363
|
250 260 270
....*....|....*....|....*....|....*....
gi 2504581670 418 YIKRYKGHRNnaTVKGVNFyGPKSEFVVSGSDCGHIFLW 456
Cdd:COG2319 364 LLRTLTGHTG--AVTSVAF-SPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
183-465 |
3.53e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.94 E-value: 3.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 183 LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNSgdSTLAMCARDGQVRVAELS 262
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADG--TYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 263 ATQCcknTKRVAQHKGASHKLALEPDSPCtFLSAGEDAVVFTIDLRQDRPaskLVVTKEKEKKVglYTIYVNPanTHQFA 342
Cdd:cd00200 82 TGEC---VRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKC---LTTLRGHTDWV--NSVAFSP--DGTFV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 343 VGG-RDQYVRIYDqrkidenENNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNssHSDGAQyIKR 421
Cdd:cd00200 151 ASSsQDGTIKLWD-------LRTGKCVATLTGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWD--LSTGKC-LGT 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2504581670 422 YKGHRNNATvkGVNFyGPKSEFVVSGSDCGHIFLWEKSSCQIIQ 465
Cdd:cd00200 215 LRGHENGVN--SVAF-SPDGYLLASGSEDGTIRVWDLRTGECVQ 255
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
109-474 |
1.00e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 91.51 E-value: 1.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 109 RHRGQRKRASRDQDSSDDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYeacGARVFVQRFRLQHGLEGHTG 188
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLT---LLLLDAAAGALLATLLGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 189 CVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNSgdSTLAMCARDGQVRVAELSATQCck 268
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG--KTLASGSADGTVRLWDLATGKL-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 269 nTKRVAQHKGASHKLALEPDSPcTFLSAGEDAVVFTIDLRQDRPASKLvvtkeKEKKVGLYTIYVNPaNTHQFAVGGRDQ 348
Cdd:COG2319 155 -LRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVAFSP-DGKLLASGSADG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 349 YVRIYDqrkidenENNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNsshSDGAQYIKRYKGHrnN 428
Cdd:COG2319 227 TVRLWD-------LATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGH--S 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 2504581670 429 ATVKGVNFyGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGV 474
Cdd:COG2319 289 GGVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
174-409 |
6.99e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.73 E-value: 6.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 174 VQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNSgdSTLAMCARD 253
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDG--RLLASGSAD 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 254 GQVRVAELSATQCcknTKRVAQHKGASHKLALEPDSPcTFLSAGEDAVVFTIDLRQDRPASKLvvtkeKEKKVGLYTIYV 333
Cdd:COG2319 268 GTVRLWDLATGEL---LRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVAF 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2504581670 334 NPaNTHQFAVGGRDQYVRIYDqrkideNENNGVLKKFCPHhlvnsesKANITCLVYSHDGTELLASYNDEDIYLFN 409
Cdd:COG2319 339 SP-DGKTLASGSDDGTVRLWD------LATGELLRTLTGH-------TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
183-409 |
4.14e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.14 E-value: 4.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 183 LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFEsGHKSNVFQAKFLPNsgDSTLAMCARDGQVRVAELS 262
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR-GHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 263 ATQCCKNTKrvaQHKGASHKLALEPDSPcTFLSAGEDAVVFTIDLRqdrpASKLVVTKEkEKKVGLYTIYVNPaNTHQFA 342
Cdd:cd00200 166 TGKCVATLT---GHTGEVNSVAFSPDGE-KLLSSSSDGTIKLWDLS----TGKCLGTLR-GHENGVNSVAFSP-DGYLLA 235
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2504581670 343 VGGRDQYVRIYDqrkidenENNGVLKKFCPHHlvnsesKANITCLVYSHDGTELLASYNDEDIYLFN 409
Cdd:cd00200 236 SGSEDGTIRVWD-------LRTGECVQTLSGH------TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
283-474 |
5.35e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 60.43 E-value: 5.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 283 LALEPDSPcTFLSAGEDAVVFTIDLRQDRPASKLvvtKEKEKKVGLYTIYvnpANTHQFAVGGRDQYVRIYDQrkidenE 362
Cdd:cd00200 15 VAFSPDGK-LLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAAS---ADGTYLASGSSDKTIRLWDL------E 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 363 NNGVLKKFCPHhlvnsesKANITCLVYSHDGTELLASYNDEDIYLFNSshsDGAQYIKRYKGHrnNATVKGVNFyGPKSE 442
Cdd:cd00200 82 TGECVRTLTGH-------TSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGH--TDWVNSVAF-SPDGT 148
|
170 180 190
....*....|....*....|....*....|..
gi 2504581670 443 FVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGV 474
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
177-258 |
1.21e-09 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 59.66 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 177 FRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFeSGHKSNVFQAKFLPNSgdSTLAMCARDGQV 256
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTNSVTSLAWSPDG--KRLASGSADGTI 285
|
..
gi 2504581670 257 RV 258
Cdd:cd00200 286 RI 287
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
177-215 |
7.47e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.80 E-value: 7.47e-07
10 20 30
....*....|....*....|....*....|....*....
gi 2504581670 177 FRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWD 215
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
183-215 |
1.19e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.19e-06
10 20 30
....*....|....*....|....*....|...
gi 2504581670 183 LEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWD 215
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
17-177 |
1.88e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 41.13 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 17 NGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGpnRTSTESRGTDTESSGEEKDSDSMEDTGhysinDESRG 96
Cdd:TIGR00927 788 DGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEV--KDETGEQELNAENQGEAKQDEKGVDGG-----GGSDG 860
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2504581670 97 HGHSDEEDEEQPRHRGQRKRASRDQDSSDDERALE-DWVSSETTA------LP--RPRWQALPALRERElgSSARFVYEA 167
Cdd:TIGR00927 861 GDSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSlEWPETRQKQaiylflLPivFPLWLTVPDVRRQE--ARKFFVITF 938
|
170
....*....|
gi 2504581670 168 CGARVFVQRF 177
Cdd:TIGR00927 939 LGSIMWIAMF 948
|
|
| |
