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Conserved domains on  [gi|2503047558|ref|NP_001408079|]
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protein-glutamine gamma-glutamyltransferase E isoform 2 [Mus musculus]

Protein Classification

TGc and Transglut_C domain-containing protein( domain architecture ID 10648757)

TGc and Transglut_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
280-376 3.33e-24

Transglutaminase family, C-terminal ig like domain;


:

Pssm-ID: 460002  Cd Length: 106  Bit Score: 95.49  E-value: 3.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 280 PALTLEVLEQAHVRKPVNVQMLFSNPLDQPVNNCVLL-----VEGSGLLRGSLKID--VPSLRPKEKSRIRFEIFPTRSG 352
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPLKDVVLSlsaqtVEYNGVLGAEFKKKslELTLEPGEEKSVPIKITPSKYG 80

                          90       100
                  ....*....|....*....|....
gi 2503047558 353 TKQLLADFSCNKFPAIKAMLPIDV 376
Cdd:pfam00927  81 PRQLLVEFSSDALAKVKGYRNVLV 104
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
168-273 2.91e-22

Transglutaminase family, C-terminal ig like domain;


:

Pssm-ID: 460002  Cd Length: 106  Bit Score: 90.48  E-value: 2.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 168 ISGKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQY- 245
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPlKDVVLSLSAQTVEYNGVLGAEFKKKSLELTLEPGEEKSVPIKITPSKYg 80

                          90       100
                  ....*....|....*....|....*....
gi 2503047558 246 -ERYLKAdnmIRITAVCKVPDEAEVVVER 273
Cdd:pfam00927  81 pRQLLVE---FSSDALAKVKGYRNVLVAQ 106
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 8-42 1.92e-04

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


:

Pssm-ID: 214673  Cd Length: 68  Bit Score: 39.29  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2503047558    8 GSDSVWNFHVWNEGWFVrtdlgptyNGWQVLDATP 42
Cdd:smart00460  42 GLRSIWEAHAWAEVYLE--------GGWVPVDPTP 68
 
Name Accession Description Interval E-value
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
280-376 3.33e-24

Transglutaminase family, C-terminal ig like domain;


Pssm-ID: 460002  Cd Length: 106  Bit Score: 95.49  E-value: 3.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 280 PALTLEVLEQAHVRKPVNVQMLFSNPLDQPVNNCVLL-----VEGSGLLRGSLKID--VPSLRPKEKSRIRFEIFPTRSG 352
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPLKDVVLSlsaqtVEYNGVLGAEFKKKslELTLEPGEEKSVPIKITPSKYG 80

                          90       100
                  ....*....|....*....|....
gi 2503047558 353 TKQLLADFSCNKFPAIKAMLPIDV 376
Cdd:pfam00927  81 PRQLLVEFSSDALAKVKGYRNVLV 104
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
168-273 2.91e-22

Transglutaminase family, C-terminal ig like domain;


Pssm-ID: 460002  Cd Length: 106  Bit Score: 90.48  E-value: 2.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 168 ISGKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQY- 245
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPlKDVVLSLSAQTVEYNGVLGAEFKKKSLELTLEPGEEKSVPIKITPSKYg 80

                          90       100
                  ....*....|....*....|....*....
gi 2503047558 246 -ERYLKAdnmIRITAVCKVPDEAEVVVER 273
Cdd:pfam00927  81 pRQLLVE---FSSDALAKVKGYRNVLVAQ 106
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 8-42 1.92e-04

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 39.29  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2503047558    8 GSDSVWNFHVWNEGWFVrtdlgptyNGWQVLDATP 42
Cdd:smart00460  42 GLRSIWEAHAWAEVYLE--------GGWVPVDPTP 68
 
Name Accession Description Interval E-value
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
280-376 3.33e-24

Transglutaminase family, C-terminal ig like domain;


Pssm-ID: 460002  Cd Length: 106  Bit Score: 95.49  E-value: 3.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 280 PALTLEVLEQAHVRKPVNVQMLFSNPLDQPVNNCVLL-----VEGSGLLRGSLKID--VPSLRPKEKSRIRFEIFPTRSG 352
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPLKDVVLSlsaqtVEYNGVLGAEFKKKslELTLEPGEEKSVPIKITPSKYG 80

                          90       100
                  ....*....|....*....|....
gi 2503047558 353 TKQLLADFSCNKFPAIKAMLPIDV 376
Cdd:pfam00927  81 PRQLLVEFSSDALAKVKGYRNVLV 104
Transglut_C pfam00927
Transglutaminase family, C-terminal ig like domain;
168-273 2.91e-22

Transglutaminase family, C-terminal ig like domain;


Pssm-ID: 460002  Cd Length: 106  Bit Score: 90.48  E-value: 2.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2503047558 168 ISGKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQY- 245
Cdd:pfam00927   1 PEMKIEVLGSAVVGQDLTVSVTLSNPLSEPlKDVVLSLSAQTVEYNGVLGAEFKKKSLELTLEPGEEKSVPIKITPSKYg 80

                          90       100
                  ....*....|....*....|....*....
gi 2503047558 246 -ERYLKAdnmIRITAVCKVPDEAEVVVER 273
Cdd:pfam00927  81 pRQLLVE---FSSDALAKVKGYRNVLVAQ 106
TGc smart00460
Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish ...
 8-42 1.92e-04

Transglutaminase/protease-like homologues; Transglutaminases are enzymes that establish covalent links between proteins. A subset of transglutaminase homologues appear to catalyse the reverse reaction, the hydrolysis of peptide bonds. Proteins with this domain are both extracellular and intracellular, and it is likely that the eukaryotic intracellular proteins are involved in signalling events.


Pssm-ID: 214673  Cd Length: 68  Bit Score: 39.29  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2503047558    8 GSDSVWNFHVWNEGWFVrtdlgptyNGWQVLDATP 42
Cdd:smart00460  42 GLRSIWEAHAWAEVYLE--------GGWVPVDPTP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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