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Conserved domains on  [gi|2496213823|ref|NP_001406917|]
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C4b-binding protein isoform 6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 43-149 2.53e-08

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 51.58  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2496213823  43 QMTFTAALWVAVFGKCGPPPAIPNALPASDVNRTDFESH----TTLKYECLPGYgRGISRMMVYCKPSGE-WEISVSCAK 117
Cdd:PHA02927    5 SVTFLTLLGIGCVLSCCTIPSRPINMKFKNSVETDANANynigDTIEYLCLPGY-RKQKMGPIYAKCTGTgWTLFNQCIK 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2496213823 118 KHCRNPGYLDNGYVNGETITFGSQIEFSCQEG 149
Cdd:PHA02927   84 RRCPSPRDIDNGQLDIGGVDFGSSITYSCNSG 115
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 43-149 2.53e-08

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 51.58  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2496213823  43 QMTFTAALWVAVFGKCGPPPAIPNALPASDVNRTDFESH----TTLKYECLPGYgRGISRMMVYCKPSGE-WEISVSCAK 117
Cdd:PHA02927    5 SVTFLTLLGIGCVLSCCTIPSRPINMKFKNSVETDANANynigDTIEYLCLPGY-RKQKMGPIYAKCTGTgWTLFNQCIK 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2496213823 118 KHCRNPGYLDNGYVNGETITFGSQIEFSCQEG 149
Cdd:PHA02927   84 RRCPSPRDIDNGQLDIGGVDFGSSITYSCNSG 115
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 58-113 8.67e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 8.67e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2496213823   58 CGPPPAIPNALPASDvnRTDFESHTTLKYECLPGYgRGISRMMVYCKPSGEWEISV 113
Cdd:smart00032   1 CPPPPDIENGTVTSS--SGTYSYGDTVTYSCDPGY-TLIGSSTITCLENGTWSPPP 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 58-109 2.13e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 2.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2496213823  58 CGPPPAIPNALpaSDVNRTDFESHTTLKYECLPGYgRGISRMMVYCKPSGEW 109
Cdd:cd00033     1 CPPPPVPENGT--VTGSKGSYSYGSTVTYSCNEGY-TLVGSSTITCTENGGW 49
Sushi pfam00084
Sushi repeat (SCR repeat);
58-110 1.40e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.17  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2496213823  58 CGPPPAIPNALPASdvNRTDFESHTTLKYECLPGYGR-GISRMMvyCKPSGEWE 110
Cdd:pfam00084   1 CPPPPDIPNGKVSA--TKNEYNYGASVSYECDPGYRLvGSPTIT--CQEDGTWS 50
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 43-149 2.53e-08

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 51.58  E-value: 2.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2496213823  43 QMTFTAALWVAVFGKCGPPPAIPNALPASDVNRTDFESH----TTLKYECLPGYgRGISRMMVYCKPSGE-WEISVSCAK 117
Cdd:PHA02927    5 SVTFLTLLGIGCVLSCCTIPSRPINMKFKNSVETDANANynigDTIEYLCLPGY-RKQKMGPIYAKCTGTgWTLFNQCIK 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2496213823 118 KHCRNPGYLDNGYVNGETITFGSQIEFSCQEG 149
Cdd:PHA02927   84 RRCPSPRDIDNGQLDIGGVDFGSSITYSCNSG 115
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 58-113 8.67e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 8.67e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2496213823   58 CGPPPAIPNALPASDvnRTDFESHTTLKYECLPGYgRGISRMMVYCKPSGEWEISV 113
Cdd:smart00032   1 CPPPPDIENGTVTSS--SGTYSYGDTVTYSCDPGY-TLIGSSTITCLENGTWSPPP 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 58-109 2.13e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 2.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2496213823  58 CGPPPAIPNALpaSDVNRTDFESHTTLKYECLPGYgRGISRMMVYCKPSGEW 109
Cdd:cd00033     1 CPPPPVPENGT--VTGSKGSYSYGSTVTYSCNEGY-TLVGSSTITCTENGGW 49
Sushi pfam00084
Sushi repeat (SCR repeat);
58-110 1.40e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 35.17  E-value: 1.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2496213823  58 CGPPPAIPNALPASdvNRTDFESHTTLKYECLPGYGR-GISRMMvyCKPSGEWE 110
Cdd:pfam00084   1 CPPPPDIPNGKVSA--TKNEYNYGASVSYECDPGYRLvGSPTIT--CQEDGTWS 50
PHA02831 PHA02831
EEV host range protein; Provisional
 74-151 2.79e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 36.89  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2496213823  74 NRTdFESHTTLKYEClpgyGRGISRMMVYCKpSGEWEISVSC-AKKHCRNPGYLDNGYVNG--ETITFGSQIEFSCQEGS 150
Cdd:PHA02831   37 NKV-YEENENLEYKC----NNNFDKVFVTCN-NGSWSTKNMCiGKRNCKDPVTILNGYIKNkkDQYSFGDSVTYACKVNK 110


                  .
gi 2496213823 151 L 151
Cdd:PHA02831  111 L 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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