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Conserved domains on  [gi|2472930972|ref|NP_001406342|]
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leptin receptor gene-related protein isoform 2 [Mus musculus]

Protein Classification

Vps55 family protein( domain architecture ID 10514166)

Vps55 family protein such as vacuolar protein sorting-associated protein 55 (Vps55) from budding yeasts and obesity receptor gene-related protein (OB-RGRP or LEPROT) from animals; both proteins are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 7-101 1.69e-25

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


:

Pssm-ID: 461188  Cd Length: 118  Bit Score: 91.80  E-value: 1.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472930972   7 LVALSFSGAIGLTFLMLGCALED-----------------------YGVTYDSDATSSACRELAYFFTTGIVVSAFGLPV 63
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCALYKnwwpllvvlfyvlaplpnliasrSSSSSDDSSSGSAWVDFGRFLTGFLVVSGIALPI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2472930972  64 VLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGD 101
Cdd:pfam04133  81 VLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 7-101 1.69e-25

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


Pssm-ID: 461188  Cd Length: 118  Bit Score: 91.80  E-value: 1.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472930972   7 LVALSFSGAIGLTFLMLGCALED-----------------------YGVTYDSDATSSACRELAYFFTTGIVVSAFGLPV 63
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCALYKnwwpllvvlfyvlaplpnliasrSSSSSDDSSSGSAWVDFGRFLTGFLVVSGIALPI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2472930972  64 VLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGD 101
Cdd:pfam04133  81 VLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Name Accession Description Interval E-value
Vps55 pfam04133
Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the ...
 7-101 1.69e-25

Vacuolar protein sorting 55; Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase. Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.


Pssm-ID: 461188  Cd Length: 118  Bit Score: 91.80  E-value: 1.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2472930972   7 LVALSFSGAIGLTFLMLGCALED-----------------------YGVTYDSDATSSACRELAYFFTTGIVVSAFGLPV 63
Cdd:pfam04133   1 IIGLSFFLAIGFLLVILSCALYKnwwpllvvlfyvlaplpnliasrSSSSSDDSSSGSAWVDFGRFLTGFLVVSGIALPI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2472930972  64 VLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGD 101
Cdd:pfam04133  81 VLAHAGIITWGACGLSIAGGVIIYGTIIAFSWFFDEEE 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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