Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
542-893
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
:
Pssm-ID: 464302 Cd Length: 352 Bit Score: 635.95 E-value: 0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
148-533
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
:
Pssm-ID: 464301 Cd Length: 385 Bit Score: 606.31 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
1-105
6.74e-42
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
The actual alignment was detected with superfamily member pfam14761:
Pssm-ID: 464300 Cd Length: 211 Bit Score: 152.45 E-value: 6.74e-42
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
542-893
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464302 Cd Length: 352 Bit Score: 635.95 E-value: 0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
148-533
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464301 Cd Length: 385 Bit Score: 606.31 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
1-105
6.74e-42
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464300 Cd Length: 211 Bit Score: 152.45 E-value: 6.74e-42
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, ...
542-893
0e+00
Hermansky-Pudlak syndrome 3, C-terminal; This domain is downstream of the mid domain family, pfam14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464302 Cd Length: 352 Bit Score: 635.95 E-value: 0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of ...
148-533
0e+00
Hermansky-Pudlak syndrome 3, middle region; This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464301 Cd Length: 385 Bit Score: 606.31 E-value: 0e+00
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. ...
1-105
6.74e-42
Hermansky-Pudlak syndrome 3; This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072.
Pssm-ID: 464300 Cd Length: 211 Bit Score: 152.45 E-value: 6.74e-42
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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