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Conserved domains on  [gi|2273809815|ref|NP_001396375|]
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annexin A4 isoform e [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446049)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity; similar to Spironucleus barkhanus annexin 5 which localizes to a cytoskeletal structure in the anterior of the cell possibly involved in cell adherence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-155 1.05e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.16  E-value: 1.05e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2273809815  90 YDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSL 155
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-83 4.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2273809815  19 DAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGL 83
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin super family cl02574
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 173-206 7.82e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


The actual alignment was detected with superfamily member pfam00191:

Pssm-ID: 413385  Cd Length: 66  Bit Score: 47.47  E-value: 7.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2273809815 173 QDAQELYEAgEKRWGTDEVKFLSILCSRNRNHLL 206
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQ 33
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-155 1.05e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.16  E-value: 1.05e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2273809815  90 YDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSL 155
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-83 4.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2273809815  19 DAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGL 83
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
103-155 9.88e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.30  E-value: 9.88e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2273809815  103 GTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSL 155
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
31-83 3.72e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 74.75  E-value: 3.72e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2273809815   31 GTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGL 83
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 173-206 7.82e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 47.47  E-value: 7.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2273809815 173 QDAQELYEAgEKRWGTDEVKFLSILCSRNRNHLL 206
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQ 33
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 90-155 1.05e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 97.16  E-value: 1.05e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2273809815  90 YDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSL 155
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-83 4.53e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 92.92  E-value: 4.53e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2273809815  19 DAQTLRKAMKGLGTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGL 83
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
103-155 9.88e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.30  E-value: 9.88e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2273809815  103 GTDEGCLIEILASRTPEEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSL 155
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
31-83 3.72e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 74.75  E-value: 3.72e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2273809815   31 GTDEDAIIGILAYRNTAQRQEIRSAYKSTIGRDLIEDLKSELSSNFEQVILGL 83
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 173-206 7.82e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 47.47  E-value: 7.82e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2273809815 173 QDAQELYEAgEKRWGTDEVKFLSILCSRNRNHLL 206
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQ 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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