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Conserved domains on  [gi|2248185598|ref|NP_001394471|]
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zinc finger protein 26 isoform b [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
113-171 7.34e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 7.34e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2248185598  113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 171
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-760 3.09e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.98  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 325 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 402
Cdd:COG5048     9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 403 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 479
Cdd:COG5048    89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 480 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 558
Cdd:COG5048   168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 559 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 629
Cdd:COG5048   242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 630 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 698
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2248185598 699 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 760
Cdd:COG5048   402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
600-956 4.65e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 600 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 675
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 676 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 755
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 756 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 827
Cdd:COG5048   183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 828 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 900
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 901 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 956
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
113-171 7.34e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 7.34e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2248185598  113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 171
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 113-153 3.00e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.00  E-value: 3.00e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2248185598 113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVG 153
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 113-150 4.30e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 4.30e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2248185598 113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLA 150
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-760 3.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.98  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 325 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 402
Cdd:COG5048     9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 403 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 479
Cdd:COG5048    89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 480 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 558
Cdd:COG5048   168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 559 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 629
Cdd:COG5048   242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 630 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 698
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2248185598 699 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 760
Cdd:COG5048   402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
600-956 4.65e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 600 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 675
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 676 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 755
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 756 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 827
Cdd:COG5048   183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 828 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 900
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 901 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 956
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
896-920 4.31e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.31e-05
                          10        20
                  ....*....|....*....|....*
gi 2248185598 896 YLRVHMRIHTGEKPYVCQYCGKAFT 920
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
672-695 4.71e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.71e-05
                          10        20
                  ....*....|....*....|....
gi 2248185598 672 YLRIHMRTHTGEKPYECKECGKTF 695
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 768-821 2.87e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2248185598 768 KPYkCSYCGKAFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 821
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
transpos_ISL3 NF033550
ISL3 family transposase;
326-402 9.21e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.49  E-value: 9.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2248185598 326 EECGQASTHPISHGGHVIPTEKkyyeckkcekFFTHPVYLNihmqshtVEKP-YDCKECGKAFTERSSLIVHLRQHTR 402
Cdd:NF033550   14 PECGKPSRRVHDTGKRRIRHLP----------IFGRPVYLE-------LRVRrFKCPECGKTFTEELPWARKRSRITL 74
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
113-171 7.34e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 106.91  E-value: 7.34e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2248185598  113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVGGQMFKPSLISWLEKKVEL 171
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 113-153 3.00e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 96.00  E-value: 3.00e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2248185598 113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLATVG 153
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 113-150 4.30e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 4.30e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2248185598 113 VTFEDVAVDFTQEEWTSLDPVQRNLYRDVMLENYQNLA 150
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-760 3.09e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.98  E-value: 3.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 325 SEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHMQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTR 402
Cdd:COG5048     9 SSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 403 EKSYEC-KECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLG 479
Cdd:COG5048    89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 480 HIRTHTGEKpyeckvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNS 558
Cdd:COG5048   168 HPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 559 SCLKTH----FRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KP 629
Cdd:COG5048   242 SQSPSSlsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 630 FEC--YQCGKALAHSSSLVGHLRTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPER 698
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRD 401

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2248185598 699 SCLTKHIRTHTGERPYECK--ECGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 760
Cdd:COG5048   402 SNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
460-891 3.33e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 3.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 460 KPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGkafsgrswltihlrkhtgerpypcteCEKAFTSFAQLTEHIKT 539
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 540 HTGEKPFRC--KVCARTFRNSSCLKTHFrIHTGIKPYKCNYCGKAFTARSGLTKHVL--IHNGEKPYE-CKECGKAFSTS 614
Cdd:COG5048    86 HHNNPSDLNskSLPLSNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPgNNSSSVNTPQS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 615 SGLveHIRIHTGEKPFECYQCGKALAHSSslvghlrTHTGEKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKT 694
Cdd:COG5048   165 NSL--HPPLPANSLSKDPSSNLSLLISSN-------VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 695 FPERSCLTKHIRTHTGERPYECKECGKGFISFA--QLTVHIKTHSSER-----PFQCKVCTKSFRNSSSLETHFR--IHT 765
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 766 G--VKPYKC--SYCGKAFTARSGLTIHLRNHTGEKSYAC--QECGKAFSTSS-----GLIAHIRSHKGEKPFECDH--CG 832
Cdd:COG5048   316 GesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCI 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2248185598 833 KAFASSSYLNVHLKIHTGEKP--FQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSF 891
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
432-844 1.84e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 432 KPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECN--ICGKAFTRSSYLLGHIRTHTGEKPYEC-KVCGKAFSGRSWLTIH 508
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 509 LRKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNS-SCLKTHFRIHTGIKpykcnyCGKAFTARS 587
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 588 GLTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIH--TGEKPFECYQCGKALAHS---SSLVGHLRTHTGEKPFECNQ 662
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKSLLSqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 663 CDKTFTRSSYLRIHMRTHTG-EKPYECKECGKTFPERSCLTKHIRT--HTGE--RPYECKE--CGKGFISFAQLTVHIKT 735
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 736 HSSERPFQCKVCTKSFRNSSSL----ETHFRIHTGVKPYK---CSY--CGKAFTARSGLTIHLRNHTGEKSYACQ--ECG 804
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKkseTLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2248185598 805 KAFSTSSGLIAHIRSHKGEKPFECDHCGKAFASSSYLNVH 844
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
600-956 4.65e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 600 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 675
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 676 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQltvhikthSSERPFQCKVCTKSFRNSS 755
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--------SNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 756 --SLETHFRIHTGVKPYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTS------SGLIAHIRSHKGEKPFE 827
Cdd:COG5048   183 nlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 828 CDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRVH 900
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 901 MRIHTGEKPYVCQYCGKAFTEHSGLNK----HLRKHTGEKPYEYKECGENFTTSADANEH 956
Cdd:COG5048   343 ILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDS 402
zf-H2C2_2 pfam13465
Zinc-finger double domain;
896-920 4.31e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.31e-05
                          10        20
                  ....*....|....*....|....*
gi 2248185598 896 YLRVHMRIHTGEKPYVCQYCGKAFT 920
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
672-695 4.71e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.71e-05
                          10        20
                  ....*....|....*....|....
gi 2248185598 672 YLRIHMRTHTGEKPYECKECGKTF 695
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 542-621 8.96e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 8.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 542 GEKPFRCKV--CARTFRNSSCLKTHfRIHtgikpykcNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVE 619
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2248185598 620 HI 621
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-445 2.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 2248185598 420 RLTEHMRSHTGEKPYQCDQCGNAFAS 445
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 768-821 2.87e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2248185598 768 KPYkCSYCGKAFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 821
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-473 3.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 2248185598 448 YLTTHLRTHTGEKPFECNICGKAFTR 473
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
840-865 3.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 2248185598 840 YLNVHLKIHTGEKPFQCTVCGKTFTC 865
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
756-780 3.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.66e-04
                          10        20
                  ....*....|....*....|....*
gi 2248185598 756 SLETHFRIHTGVKPYKCSYCGKAFT 780
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-584 3.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|....
gi 2248185598 561 LKTHFRIHTGIKPYKCNYCGKAFT 584
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
872-891 5.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.00e-04
                          10        20
                  ....*....|....*....|
gi 2248185598 872 HMRTHTGEKPFQCIICGKSF 891
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
701-725 7.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.56e-04
                          10        20
                  ....*....|....*....|....*
gi 2248185598 701 LTKHIRTHTGERPYECKECGKGFIS 725
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 658-680 7.68e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 7.68e-04
                          10        20
                  ....*....|....*....|...
gi 2248185598 658 FECNQCDKTFTRSSYLRIHMRTH 680
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 486-564 7.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 486 GEKPYECKV--CGKAFSGRSWLTIH-LRKHTGERPYPcTECEKAFTSFAqltehikthTGEKPFRCKVCARTFRNSSCLK 562
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGHQNQKLHE-NPSPEKMNIFS---------AKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 2248185598 563 TH 564
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
648-669 7.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|..
gi 2248185598 648 HLRTHTGEKPFECNQCDKTFTR 669
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-500 8.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.02e-04
                          10        20
                  ....*....|....*....|.
gi 2248185598 480 HIRTHTGEKPYECKVCGKAFS 500
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 830-933 9.40e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2248185598 830 HCGKAFASSSYLNVHLKihtGEKPFQCTV--CGKTFTCSSYLPVHMRT-HTGEKpfqciicgksfLWSSYLRVHMRIHTG 906
Cdd:COG5189   329 HGGERNIDTPSRMLKVK---DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSA 394

                          90       100
                  ....*....|....*....|....*...
gi 2248185598 907 E-KPYVCQYCGKAFTEHSGLNKHlRKHT 933
Cdd:COG5189   395 KdKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-529 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*
gi 2248185598 505 LTIHLRKHTGERPYPCTECEKAFTS 529
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-388 2.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.53e-03
                          10        20
                  ....*....|....*....|....*
gi 2248185598 364 YLNIHMQSHTVEKPYDCKECGKAFT 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
816-837 2.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.71e-03
                          10        20
                  ....*....|....*....|..
gi 2248185598 816 HIRSHKGEKPFECDHCGKAFAS 837
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-613 4.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....*
gi 2248185598 589 LTKHVLIHNGEKPYECKECGKAFST 613
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
617-638 4.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|..
gi 2248185598 617 LVEHIRIHTGEKPFECYQCGKA 638
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 462-484 5.74e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|...
gi 2248185598 462 FECNICGKAFTRSSYLLGHIRTH 484
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 686-708 5.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.85e-03
                          10        20
                  ....*....|....*....|...
gi 2248185598 686 YECKECGKTFPERSCLTKHIRTH 708
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
785-809 6.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*
gi 2248185598 785 LTIHLRNHTGEKSYACQECGKAFST 809
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 406-428 6.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.91e-03
                          10        20
                  ....*....|....*....|...
gi 2248185598 406 YECKECGKTFIQPSRLTEHMRSH 428
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 602-624 8.92e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.92e-03
                          10        20
                  ....*....|....*....|...
gi 2248185598 602 YECKECGKAFSTSSGLVEHIRIH 624
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
transpos_ISL3 NF033550
ISL3 family transposase;
326-402 9.21e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 39.49  E-value: 9.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2248185598 326 EECGQASTHPISHGGHVIPTEKkyyeckkcekFFTHPVYLNihmqshtVEKP-YDCKECGKAFTERSSLIVHLRQHTR 402
Cdd:NF033550   14 PECGKPSRRVHDTGKRRIRHLP----------IFGRPVYLE-------LRVRrFKCPECGKTFTEELPWARKRSRITL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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