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Conserved domains on  [gi|2237445299|ref|NP_001393200|]
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F-box/WD repeat-containing protein 2 isoform 3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 1.48e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  84 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEV 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 238 ANLALLGFGDVFALLFDNHYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2237445299 318 L 318
Cdd:cd00200   287 I 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 1.48e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  84 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEV 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 238 ANLALLGFGDVFALLFDNHYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2237445299 318 L 318
Cdd:cd00200   287 I 287
WD40 COG2319
WD40 repeat [General function prediction only];
11-318 9.63e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 9.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  11 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 84
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  85 SSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 164
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 165 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEVANL 240
Cdd:COG2319   262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2237445299 241 ALLGFGDVFALLFDNHYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAFSPD-GRTLASGSADGTVRL 398
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 18-139 1.42e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  18 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 90
Cdd:PLN00181  574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2237445299  91 Q-HFRGHTGAVFSVDYSDElDILVSGSADFAVKVWALSAG------TCLNTLTGHT 139
Cdd:PLN00181  654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 31-132 3.34e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  31 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSG---------ARTQHFR--- 94
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrnTQTEFPRkdh 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2237445299  95 -----------GHTGAVFSVDYSDELDILVSGSADfavkvwalsaGTCL 132
Cdd:pfam20426 176 viaetpfhilcGHDDIITCLYVSVELDIVISGSKD----------GTCI 214
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-124 3.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2237445299   86 SGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 124
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-318 1.48e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  11 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 83
Cdd:cd00200     1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  84 WSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYI 163
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF----------SPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 164 LLSA--DKYeIKIWPIGreiNCKCLKTLSVSED--RSICLQPRLhfdGKYIVCSSALGLYQWDFASYDILRVI--KTPEV 237
Cdd:cd00200   150 VASSsqDGT-IKLWDLR---TGKCVATLTGHTGevNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCLGTLrgHENGV 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 238 ANLALLGFGDVFALLFDNHYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDTGLVFATSMpDHSIH 317
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---------------LSGHTNSVTSLAWSPDGKRLASGSA-DGTIR 286


                  .
gi 2237445299 318 L 318
Cdd:cd00200   287 I 287
WD40 COG2319
WD40 repeat [General function prediction only];
11-318 9.63e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 9.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  11 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 84
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  85 SSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSPGDYIL 164
Cdd:COG2319   192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 165 LSADKY-EIKIWPIGREincKCLKTLSVSEDRSICLqpRLHFDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEVANL 240
Cdd:COG2319   262 ASGSADgTVRLWDLATG---ELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2237445299 241 ALLGFGDVFALLFDNHYLYIMDLRTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVAFSPD-GRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
14-273 3.04e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 3.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  14 SLIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319    73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvrSVAFspDGKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  88 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 166
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPdGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 167 ADKYEIKIWPIGREincKCLKTLSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIKTPE--VANLA 241
Cdd:COG2319   223 SADGTVRLWDLATG---KLLRTLTGHSGsvRSVAFSP----DGRLLASGSADGtVRLWDLATGELLRTLTGHSggVNSVA 295

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2237445299 242 LLGFGDVFALLFDNHYLYIMDLRTESLISRWP 273
Cdd:COG2319   296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
14-177 1.64e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.64e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  14 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319   241 TLTGHSGSVRSVAFsPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGvnSVAFspDGKLLASGSDDGTVRLWDLATG 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  88 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLS 166
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF----------SPdGRTLASG 390

                         170
                  ....*....|.
gi 2237445299 167 ADKYEIKIWPI 177
Cdd:COG2319   391 SADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
34-318 9.77e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 9.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  34 TGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDEL 109
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTaavlSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 110 DILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGreiNCKCLKT 188
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF----------SPdGKLLASGSDDGTVRLWDLA---TGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 189 LSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEVANLALLGFGDVFALLFDNHYLYIMDL 263
Cdd:COG2319   200 LTGHTGavRSVAFSP----DGKLLASGSADGtVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2237445299 264 RTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   276 ATGELLRT---------------LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
14-127 1.16e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  14 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 87
Cdd:COG2319   283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2237445299  88 ARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALS 127
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
34-318 1.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 1.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  34 TGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSDEL 109
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAaavaSLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 110 DILVSGSADFAVKVWALSAGTCLNTLTGHTEWVTKVVLqkckvksllhSP-GDYILLSADKYEIKIWPIGREincKCLKT 188
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF----------SPdGKTLASGSADGTVRLWDLATG---KLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299 189 LSVSED--RSICLQPrlhfDGKYIVCSSALG-LYQWDFASYDILRVIK--TPEVANLALLGFGDVFALLFDNHYLYIMDL 263
Cdd:COG2319   158 LTGHSGavTSVAFSP----DGKLLASGSDDGtVRLWDLATGKLLRTLTghTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2237445299 264 RTESLISRwplpeyrkskrgssfLAGEASWLNGLDGHNDtGLVFATSMPDHSIHL 318
Cdd:COG2319   234 ATGKLLRT---------------LTGHSGSVRSVAFSPD-GRLLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
14-86 1.38e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.38e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2237445299  14 SLIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSS 86
Cdd:COG2319   325 TLTGHTGAVRSVaFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAvtSVAFspDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 18-139 1.42e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  18 HSARVYALYYKDG---LLCTGSDDLSAKLWDVSTGQCVYGIQTH-TCAAVKFDE---QKLVTGSFDNTVACWEWSSGART 90
Cdd:PLN00181  574 HEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIGTIKTKaNICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLP 653

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2237445299  91 Q-HFRGHTGAVFSVDYSDElDILVSGSADFAVKVWALSAG------TCLNTLTGHT 139
Cdd:PLN00181  654 LcTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHT 708
PTZ00421 PTZ00421
coronin; Provisional
 65-143 1.94e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.12  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  65 FDEQKLVTGSFDNTVACWEWSSGARTQ-------HFRGHTGAVFSVDY-SDELDILVSGSADFAVKVWALSAGTCLNTLT 136
Cdd:PTZ00421   86 FDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFhPSAMNVLASAGADMVVNVWDVERGKAVEVIK 165


                  ....*..
gi 2237445299 137 GHTEWVT 143
Cdd:PTZ00421  166 CHSDQIT 172
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 31-132 3.34e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  31 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWEWSSG---------ARTQHFR--- 94
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrnTQTEFPRkdh 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2237445299  95 -----------GHTGAVFSVDYSDELDILVSGSADfavkvwalsaGTCL 132
Cdd:pfam20426 176 viaetpfhilcGHDDIITCLYVSVELDIVISGSKD----------GTCI 214
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-124 3.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2237445299   86 SGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 124
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
87-124 8.95e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 8.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2237445299  87 GARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVW 124
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 67-135 6.80e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 6.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2237445299  67 EQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYSD-ELDILVSGSADFAVKVWALSAGTCLNTL 135
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI 614
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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