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Conserved domains on  [gi|2227679096|ref|NP_001392090|]
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nuclear receptor coactivator 3 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 252-365 5.15e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


:

Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.25  E-value: 5.15e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  252 YGLSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGP-----SGNTGSHSFSSSSLSALQAISEGV 326
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2227679096  327 GTSLLSTLSSPGPKLDNSPNMNISQPSKVSGQDSKSPLG 365
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 515-602 3.91e-34

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


:

Pssm-ID: 465083  Cd Length: 87  Bit Score: 126.07  E-value: 3.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  515 RQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADSGDSKLSQCSCSTNPSSGQEK-DPKIKTETNEEVSgdLDNLD 593
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKeESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 2227679096  594 AILGDLTSS 602
Cdd:pfam16279   79 AILGDLRNS 87
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 409-497 2.36e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


:

Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 106.71  E-value: 2.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  409 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSstsNVHGSLLQEKHRILHKLLQNGNS 487
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 2227679096  488 PAEVAKITAE 497
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 super family cl37882
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 63-173 2.28e-24

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


The actual alignment was detected with superfamily member pfam14598:

Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 98.91  E-value: 2.28e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096   63 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRHYQEAYVHGHAETPVYRFSLADGTI 140
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLREIIQTRGRATSPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2227679096  141 VSAQTKSKLFRNPVTNDRHGFISTHFLQREQNG 173
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 857-903 2.57e-20

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


:

Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 85.15  E-value: 2.57e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2227679096  857 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALESK 903
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1070-1127 3.84e-11

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 59.40  E-value: 3.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2227679096 1070 SMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 1127
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 1033-1201 1.03e-06

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 52.89  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1033 QKRELMSHHLQQQRMAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSampQAPPQQFPYPANYGMGQPPEPAFGRGSSPPS 1112
Cdd:TIGR01628  362 QRKEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQ---QFNGQPLGWPRMSMMPTPMGPGGPLRPNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1113 AMMSSRMGPS--QNAMVQHPQPTPMYQPSdmkgwpsgnlarngsfPQQQFAPQGNPAAynmvhmNSSGGHLGQMAMTPMP 1190
Cdd:TIGR01628  439 PMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------------YQSLPLSQDLPQP------QSTASQGGQNKKLAQV 496

                          170
                   ....*....|.
gi 2227679096 1191 MSGMPMGpDQK 1201
Cdd:TIGR01628  497 LASATPQ-MQK 506
 
Name Accession Description Interval E-value
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 252-365 5.15e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.25  E-value: 5.15e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  252 YGLSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGP-----SGNTGSHSFSSSSLSALQAISEGV 326
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2227679096  327 GTSLLSTLSSPGPKLDNSPNMNISQPSKVSGQDSKSPLG 365
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 515-602 3.91e-34

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 126.07  E-value: 3.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  515 RQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADSGDSKLSQCSCSTNPSSGQEK-DPKIKTETNEEVSgdLDNLD 593
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKeESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 2227679096  594 AILGDLTSS 602
Cdd:pfam16279   79 AILGDLRNS 87
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 409-497 2.36e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 106.71  E-value: 2.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  409 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSstsNVHGSLLQEKHRILHKLLQNGNS 487
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 2227679096  488 PAEVAKITAE 497
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 63-173 2.28e-24

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 98.91  E-value: 2.28e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096   63 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRHYQEAYVHGHAETPVYRFSLADGTI 140
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLREIIQTRGRATSPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2227679096  141 VSAQTKSKLFRNPVTNDRHGFISTHFLQREQNG 173
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 857-903 2.57e-20

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 85.15  E-value: 2.57e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2227679096  857 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALESK 903
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1070-1127 3.84e-11

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 59.40  E-value: 3.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2227679096 1070 SMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 1127
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 1033-1201 1.03e-06

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 52.89  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1033 QKRELMSHHLQQQRMAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSampQAPPQQFPYPANYGMGQPPEPAFGRGSSPPS 1112
Cdd:TIGR01628  362 QRKEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQ---QFNGQPLGWPRMSMMPTPMGPGGPLRPNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1113 AMMSSRMGPS--QNAMVQHPQPTPMYQPSdmkgwpsgnlarngsfPQQQFAPQGNPAAynmvhmNSSGGHLGQMAMTPMP 1190
Cdd:TIGR01628  439 PMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------------YQSLPLSQDLPQP------QSTASQGGQNKKLAQV 496

                          170
                   ....*....|.
gi 2227679096 1191 MSGMPMGpDQK 1201
Cdd:TIGR01628  497 LASATPQ-MQK 506
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 895-1198 6.10e-06

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 50.78  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  895 NQGQALESKQDVFQGQEAAVMMDQKAALygQTYPAQG--PPLQGGFNLQGQSPSFNSM--MGQISQQGSFPLQGMHPRAG 970
Cdd:pfam09606   59 QQQQPQGGQGNGGMGGGQQGMPDPINAL--QNLAGQGtrPQMMGPMGPGPGGPMGQQMggPGTASNLLASLGRPQMPMGG 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  971 LVRPrtntpkqlrmqlqqrlqgqqflNQSRQALEMKMENPAGtAVMRPMMPQAFF---NAQMAAQQKRELMSHHLQQQRM 1047
Cdd:pfam09606  137 AGFP----------------------SQMSRVGRMQPGGQAG-GMMQPSSGQPGSgtpNQMGPNGGPGQGQAGGMNGGQQ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1048 AMMMSQPQPQAFSPPPNVTASPsmdgvlaGSAMPQAPPQQFPYPANYGMGQPPEPAFgRGSSPPSAMMSSRMGPSQNAMV 1127
Cdd:pfam09606  194 GPMGGQMPPQMGVPGMPGPADA-------GAQMGQQAQANGGMNPQQMGGAPNQVAM-QQQQPQQQGQQSQLGMGINQMQ 265

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2227679096 1128 QHPQPTPMYQPSDMKGWPSGNLARNGSFPQQQFAPQGNPAAYNMVHMNSSGGHLGQMAMTPMPMSGMPMGP 1198
Cdd:pfam09606  266 QMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQ 336
 
Name Accession Description Interval E-value
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 252-365 5.15e-37

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 135.25  E-value: 5.15e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  252 YGLSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGP-----SGNTGSHSFSSSSLSALQAISEGV 326
Cdd:pfam16665    1 YGLNMNSPPQGSPGMTPPQQNLMMSPRHRGSPKMPANQFSPGMGLHSPMGSvssggSGGGGSRTYSSSSLNALQAISEGV 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2227679096  327 GTSLLSTLSSPGPKLDNSPNMNISQPSKVSGQDSKSPLG 365
Cdd:pfam16665   81 GNSLGSSLTSPVPKQDSSPNINSTQQKKEGSSDSKSPSS 119
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 515-602 3.91e-34

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 126.07  E-value: 3.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  515 RQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADSGDSKLSQCSCSTNPSSGQEK-DPKIKTETNEEVSgdLDNLD 593
Cdd:pfam16279    1 KQEQLSPKKKKNNALLRYLLDKDDSKDPLSKDIKPKLEGLDGKTGPCSSSKIPTSKSEKeESKIKTEPPDELS--LDNLD 78


                   ....*....
gi 2227679096  594 AILGDLTSS 602
Cdd:pfam16279   79 AILGDLRNS 87
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 409-497 2.36e-27

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 106.71  E-value: 2.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  409 KGHKKLLQLLTCSSDDRG-HSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSstsNVHGSLLQEKHRILHKLLQNGNS 487
Cdd:pfam08832    1 KGHKKLLQLLTTPTEQLGpSPLRSHADADTDCKDSLAGVTSPSSGVSSSSGSSC---PSHHSSLQEKHKILHRLLQNGNS 77

                           90
                   ....*....|
gi 2227679096  488 PAEVAKITAE 497
Cdd:pfam08832   78 PDDVAKLTAE 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 63-173 2.28e-24

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 98.91  E-value: 2.28e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096   63 ESFITRHDLSGKVVNIDTnslRSSMRPGFED--IIRRCIQRFFSLNDgQSWSQKRHYQEAYVHGHAETPVYRFSLADGTI 140
Cdd:pfam14598    2 EQFTTRHDIDGKIISCDT---RAPFSLGYEKdeLVGRSIYDLVHPQD-LRTAKSHLREIIQTRGRATSPSYRLRLRDGDF 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2227679096  141 VSAQTKSKLFRNPVTNDRHGFISTHFLQREQNG 173
Cdd:pfam14598   78 LSVHTKSKLFLNQNSNQQPFIMCTHTILREENA 110
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 857-903 2.57e-20

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 85.15  E-value: 2.57e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2227679096  857 EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALESK 903
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVGQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 1070-1127 3.84e-11

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 59.40  E-value: 3.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2227679096 1070 SMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 1127
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 1033-1201 1.03e-06

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 52.89  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1033 QKRELMSHHLQQQRMAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSampQAPPQQFPYPANYGMGQPPEPAFGRGSSPPS 1112
Cdd:TIGR01628  362 QRKEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQ---QFNGQPLGWPRMSMMPTPMGPGGPLRPNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1113 AMMSSRMGPS--QNAMVQHPQPTPMYQPSdmkgwpsgnlarngsfPQQQFAPQGNPAAynmvhmNSSGGHLGQMAMTPMP 1190
Cdd:TIGR01628  439 PMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------------YQSLPLSQDLPQP------QSTASQGGQNKKLAQV 496

                          170
                   ....*....|.
gi 2227679096 1191 MSGMPMGpDQK 1201
Cdd:TIGR01628  497 LASATPQ-MQK 506
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 895-1198 6.10e-06

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 50.78  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  895 NQGQALESKQDVFQGQEAAVMMDQKAALygQTYPAQG--PPLQGGFNLQGQSPSFNSM--MGQISQQGSFPLQGMHPRAG 970
Cdd:pfam09606   59 QQQQPQGGQGNGGMGGGQQGMPDPINAL--QNLAGQGtrPQMMGPMGPGPGGPMGQQMggPGTASNLLASLGRPQMPMGG 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  971 LVRPrtntpkqlrmqlqqrlqgqqflNQSRQALEMKMENPAGtAVMRPMMPQAFF---NAQMAAQQKRELMSHHLQQQRM 1047
Cdd:pfam09606  137 AGFP----------------------SQMSRVGRMQPGGQAG-GMMQPSSGQPGSgtpNQMGPNGGPGQGQAGGMNGGQQ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1048 AMMMSQPQPQAFSPPPNVTASPsmdgvlaGSAMPQAPPQQFPYPANYGMGQPPEPAFgRGSSPPSAMMSSRMGPSQNAMV 1127
Cdd:pfam09606  194 GPMGGQMPPQMGVPGMPGPADA-------GAQMGQQAQANGGMNPQQMGGAPNQVAM-QQQQPQQQGQQSQLGMGINQMQ 265

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2227679096 1128 QHPQPTPMYQPSDMKGWPSGNLARNGSFPQQQFAPQGNPAAYNMVHMNSSGGHLGQMAMTPMPMSGMPMGP 1198
Cdd:pfam09606  266 QMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQ 336
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 1010-1195 7.10e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 50.42  E-value: 7.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1010 PAGTAVMRPMMPQAFFNAQMAAQQKRELMShhLQQQRmAMMMSQPQPQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQFP 1089
Cdd:pfam09770  166 APKKAAAPAPAPQPAAQPASLPAPSRKMMS--LEEVE-AAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQ 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096 1090 YPANYGMGQPPEPAFGRGS--------SPPSAMMSSRMGPSQNAMVQHPQPTPMYQPSDMKGWPS-GNLARNGSFPQQQF 1160
Cdd:pfam09770  243 QQQPQQQPQQPQQHPGQGHpvtilqrpQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNrLSAARVGYPQNPQP 322

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2227679096 1161 APQGNPAAYnMVHMNSSGGHLGQMAMTPMPMSGMP 1195
Cdd:pfam09770  323 GVQPAPAHQ-AHRQQGSFGRQAPIITHPQQLAQLS 356
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 997-1102 1.27e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2227679096  997 NQSR-QALEMKMENPAGTAVMRPMMPQAFFNAQMAAQQKRelmsHHLQQQRM--AMMMSQPQPQAFsPPPNVTASPSMDG 1073
Cdd:TIGR01628  376 MQLQpRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLG----WPRMSMMPtpMGPGGPLRPNGL-APMNAVRAPSRNA 450

                           90       100
                   ....*....|....*....|....*....
gi 2227679096 1074 VlagSAMPQAPPQQFPYPANYGMGQPPEP 1102
Cdd:TIGR01628  451 Q---NAAQKPPMQPVMYPPNYQSLPLSQD 476
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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