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Conserved domains on  [gi|2224094954|ref|NP_001391877|]
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complement decay-accelerating factor transmembrane isoform isoform 3 precursor [Mus musculus]

Protein Classification

CCP domain-containing protein( domain architecture ID 12867676)

CCP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 92-279 7.30e-35

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 129.00  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  92 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 167
Cdd:PHA02927   16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 168 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 245
Cdd:PHA02927   93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2224094954 246 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 279
Cdd:PHA02927  171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 34-93 1.03e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  34 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 93
Cdd:cd00033     1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-279 7.30e-35

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 129.00  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  92 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 167
Cdd:PHA02927   16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 168 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 245
Cdd:PHA02927   93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2224094954 246 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 279
Cdd:PHA02927  171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 223-283 5.20e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 68.64  E-value: 5.20e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2224094954 223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQCI 283
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 223-282 1.29e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 62.16  E-value: 1.29e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 282
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
223-282 1.02e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 59.44  E-value: 1.02e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 282
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 34-93 1.03e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  34 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 93
Cdd:cd00033     1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 34-92 3.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 3.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954   34 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 92
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
34-92 3.52e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 3.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954  34 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 92
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 92-279 7.30e-35

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 129.00  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  92 CEKSCDT----PERLSFASLKKEYFNMNFfPVGTIVEYECRPGFRKQPSLSGKSTCLEDlVWSPVAQfCKKKSCPNPKDL 167
Cdd:PHA02927   16 CVLSCCTipsrPINMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 168 DNGHINIpTGILFGSEINFSCNPGYRLVGITSILCTI--IGNTVdWDDEFPVCTEIFCPDPPKINNGIMRGESDSYKYSQ 245
Cdd:PHA02927   93 DNGQLDI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGS 170

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2224094954 246 VVIYSCDKGFILFGNSTIYCTvsksdVGQWSSPP 279
Cdd:PHA02927  171 VVTYSCNSGYSLIGNSGVLCS-----GGEWSDPP 199
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 223-283 5.20e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 68.64  E-value: 5.20e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2224094954 223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQCI 283
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 223-282 1.29e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 62.16  E-value: 1.29e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 282
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 96-288 1.33e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 67.77  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  96 CDTPERLSFASLKKEyfnMNFFPVGTIVEYECRPGFrkqpSLSGKS--TCLED---LVWSPVAQFCKKKSCPNPKDLDNG 170
Cdd:PHA02639   22 CDKPDDISNGFITEL---MEKYEIGKLIEYTCNTDY----ALIGDRfrTCIKDknnAIWSNKAPFCMLKECNDPPSIING 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 171 HI-NIPTGILFGSEINFSCNP----GYRLVGITSILCTiigNTVDWDDEFPVCTEIFCpDPPKINNGIMRG--ESDSYKY 243
Cdd:PHA02639   95 KIyNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI---QDKSWKPDPPICKMINC-RFPALQNGYINGipSNKKFYY 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2224094954 244 SQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSSPPPQCIEESKV 288
Cdd:PHA02639  171 KTRVGFSCKSGFDLVGEKYSTCNINAT----WFPSIPTCVRNKPI 211
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 34-283 5.15e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 65.44  E-value: 5.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  34 CGPPPDIPNARPILGrHSKFAeqSKVAYSCNNGFKQVpdksnivvclenGQWSSHetfcekscdtperlsfaslkkeyfn 113
Cdd:PHA02927   86 CPSPRDIDNGQLDIG-GVDFG--SSITYSCNSGYQLI------------GESKSY------------------------- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 114 mnffpvgtiveyeCRPGFRKQpslsgkstcledLVWSPVAQFCKKKSCPNPKDLDNG-HINIPTGILFGSEINFSCNPGY 192
Cdd:PHA02927  126 -------------CELGSTGS------------MVWNPEAPICESVKCQSPPSISNGrHNGYEDFYTDGSVVTYSCNSGY 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 193 RLVGITSILCTiignTVDWDDEfPVCTEIFCPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSdv 272
Cdd:PHA02927  181 SLIGNSGVLCS----GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNT-- 253

                         250
                  ....*....|.
gi 2224094954 273 gqWSSPPPQCI 283
Cdd:PHA02927  254 --WQPELPKCV 262
Sushi pfam00084
Sushi repeat (SCR repeat);
223-282 1.02e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 59.44  E-value: 1.02e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 223 CPDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSksdvGQWSSPPPQC 282
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 157-282 1.47e-11

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 64.69  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 157 KKKSCPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGITSILCTIIGNTVDWDDEFPVCTEIFCPDPPKINNGIMR 235
Cdd:PHA02639   18 KSIYCDKPDDISNGFITeLMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGKIY 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2224094954 236 GESDSYKYSQVVIYSCD--KG--FILFGNSTIYCTVSKSdvgqWSSPPPQC 282
Cdd:PHA02639   98 NKREMYKVGDEIYYVCNehKGvqYSLVGNEKITCIQDKS----WKPDPPIC 144
PHA02831 PHA02831
EEV host range protein; Provisional
 123-286 1.96e-11

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 63.86  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 123 VEYECRPGFRKQPSLSGKSTcledlvWSPVAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG----YRLVGI 197
Cdd:PHA02831   46 LEYKCNNNFDKVFVTCNNGS------WSTKNMCIGKRNCKDPVTILNGYIkNKKDQYSFGDSVTYACKVNklekYSIVGN 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 198 TSILCTiignTVDWDDEFPVCTEIFCpDPPKINNGIMRGESDSYKYSQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSS 277
Cdd:PHA02831  120 ETVKCI----NKQWVPKYPVCKLIRC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYP 190


                  ....*....
gi 2224094954 278 PPPQCIEES 286
Cdd:PHA02831  191 GIPKCVKDK 199
PHA02817 PHA02817
EEV Host range protein; Provisional
 152-287 2.63e-10

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 59.95  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 152 VAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG-----YRLVGITSILCTIIGNtvdWDDEFPVCTEIFCpD 225
Cdd:PHA02817   15 VYSLCDLNKCCYPPSIKNGYIyNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGK---WNKEFPVCKIIRC-R 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2224094954 226 PPKINNGIMRGESDSYK--YSQVVIYSCDKGFILFGNSTIYCTVSKSdvgqWSSPPPQCIEESK 287
Cdd:PHA02817   91 FPALQNGFVNGIPDSKKfyYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPICSRDNI 150
PHA02831 PHA02831
EEV host range protein; Provisional
 53-220 5.07e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 59.62  E-value: 5.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  53 FAEQSKVAYSCNNGFKQVpdksnIVVClENGQWSShETFC--EKSCDTPERLSFASLKKEyfnMNFFPVGTIVEYECRPG 130
Cdd:PHA02831   40 YEENENLEYKCNNNFDKV-----FVTC-NNGSWST-KNMCigKRNCKDPVTILNGYIKNK---KDQYSFGDSVTYACKVN 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 131 FRKQPSLSGKST--CLeDLVWSPVAQFCKKKSCPNPKdLDNGHINI-PTGILFGSEINFSCNPGYRLVGITSILCTIigN 207
Cdd:PHA02831  110 KLEKYSIVGNETvkCI-NKQWVPKYPVCKLIRCKYPA-LQNGFLNVfEKKFYYGDIVNFKCKKGFILLGSSVSTCDI--N 185

                         170
                  ....*....|...
gi 2224094954 208 TVdWDDEFPVCTE 220
Cdd:PHA02831  186 SI-WYPGIPKCVK 197
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 34-93 1.03e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.03e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  34 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 93
Cdd:cd00033     1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 161-218 9.19e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.31  E-value: 9.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954 161 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGITSILCTIIGNtvdWDDEFPVC 218
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 161-218 9.19e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.37  E-value: 9.19e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954  161 CPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGITSILCTiigNTVDWDDEFPVC 218
Cdd:smart00032   1 CPPPPDIENGTVTsSSGTYSYGDTVTYSCDPGYTLIGSSTITCL---ENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 34-92 3.84e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 3.84e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954   34 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 92
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 38-287 4.73e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 53.94  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  38 PDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPDKSnivVClENGQWSsHETFCEKSCDTPERLSfaslkkEYFNMNFF 117
Cdd:PHA02954   24 PTMNNAK-LTSTETSFNDKQKVTFTCDSGYYSLDPNA---VC-ETDKWK-YENPCKKMCTVSDYVS------ELYDKPLY 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 118 PVGTIVEYECRPG---FRKQPSlsGKSTCLEDLVWSPVAQfCKkkscpnPKDLDNGHIN-IPTGILFGSEINFSCNPGYR 193
Cdd:PHA02954   92 EVNSTITLICKDEtkyFRCEEK--NGNTSWNDTVTCPNAE-CQ------PLQLEHGSCQpVKEKYSFGEHITINCDVGYE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 194 LVGITSILCTIIGNTVdwddeFPVCTEIFcpDPPKINNGIMRGEsdSYKYSQVVIYSCDKGFILFGNSTIYCTvsksdVG 273
Cdd:PHA02954  163 VIGASYISCTANSWNV-----IPSCQQKC--DIPSLSNGLISGS--TFSIGGVIHLSCKSGFTLTGSPSSTCI-----DG 228

                         250
                  ....*....|....
gi 2224094954 274 QWSSPPPQCIEESK 287
Cdd:PHA02954  229 KWNPVLPICVRSNE 242
Sushi pfam00084
Sushi repeat (SCR repeat);
161-218 1.56e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 1.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954 161 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGITSILCTIIGNtvdWDDEFPVC 218
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
96-156 2.09e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 2.09e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2224094954  96 CDTPERLSFASLkkeYFNMNFFPVGTIVEYECRPGFRKQPSLsgKSTCLEDLVWSPVAQFC 156
Cdd:pfam00084   1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
34-92 3.52e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 3.52e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2224094954  34 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 92
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 96-157 1.56e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.76  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2224094954  96 CDTPERLSFASLKkeyFNMNFFPVGTIVEYECRPGFRKQPslSGKSTCLEDLVWSPVAQFCK 157
Cdd:cd00033     1 CPPPPVPENGTVT---GSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 96-156 9.23e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.82  E-value: 9.23e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2224094954   96 CDTPERLSFASLKKEYFNmnfFPVGTIVEYECRPGFRKQPSLSgkSTCLEDLVWSPVAQFC 156
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIGSST--ITCLENGTWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 108-220 2.68e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.85  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954 108 KKEYFNmnffpVGTIVEYECRPGFRKQP-SLSGKS--TCLEDLVWSPVAQFCKKKSCPNPKdLDNGHIN-IPTGILF--G 181
Cdd:PHA02817   38 KKTEYN-----IGSNVTFFCGNNTRGVRyTLVGEKniICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVNgIPDSKKFyyE 111

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2224094954 182 SEINFSCNPGYRLVGITSILCTIignTVDWDDEFPVCTE 220
Cdd:PHA02817  112 SEVSFSCKPGFVLIGTKYSVCGI---NSSWIPKVPICSR 147
PHA02831 PHA02831
EEV host range protein; Provisional
 33-163 2.83e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 39.21  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2224094954  33 DCGPPPDIPNARpILGRHSKFAEQSKVAYSCN-NGFKQVPDKSNIVVCLENGQWSSHETFCEKScdtpeRLSFASLKK-- 109
Cdd:PHA02831   77 NCKDPVTILNGY-IKNKKDQYSFGDSVTYACKvNKLEKYSIVGNETVKCINKQWVPKYPVCKLI-----RCKYPALQNgf 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2224094954 110 -EYFNMNFFpVGTIVEYECRPGFRKQPSLSgkSTCLEDLVWSPVAQFCKKKSCPN 163
Cdd:PHA02831  151 lNVFEKKFY-YGDIVNFKCKKGFILLGSSV--STCDINSIWYPGIPKCVKDKVHN 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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