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Conserved domains on  [gi|2217262553|ref|NP_001390745|]
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histone-lysine N-methyltransferase EZH1 isoform 10 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRC2_HTH_1 super family cl39506
Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb ...
 146-221 6.93e-23

Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.


The actual alignment was detected with superfamily member pfam18118:

Pssm-ID: 436286  Cd Length: 101  Bit Score: 93.22  E-value: 6.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262553 146 DETFIEeLIN----NYD----------GKQDDSKEDLPVTRKRKRH--AIEGNKKSSKKQFPNDMIFSAIASMFPENGVP 209
Cdd:pfam18118  11 DDIFVE-LVNalmqYYDdddesepessEKMSQAKKDERKTEEDERTekKDGDEKSESKKPFPSDIIFQAISSMFPDKGTP 89

                          90
                  ....*....|..
gi 2217262553 210 DDMKERYRELTE 221
Cdd:pfam18118  90 EELKEKYKELTE 101
EZH2_WD-Binding pfam11616
WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, ...
 42-71 3.88e-12

WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.


:

Pssm-ID: 463308  Cd Length: 30  Bit Score: 60.54  E-value: 3.88e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217262553  42 KALYVANFAKVQEKTQILNEEWKKLRVQPV 71
Cdd:pfam11616   1 KSLFVSNRQKIQERTELLNEEWKKLRIQPI 30
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 392-433 5.24e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 40.64  E-value: 5.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217262553 392 EWTGAEESLFRVFHGTY-FNNFCSIARLLGTKTCKQVFQFAVK 433
Cdd:cd00167     1 PWTEEEDELLLEAVKKYgKNNWEKIAKELPGRTPKQCRERWRN 43
 
Name Accession Description Interval E-value
PRC2_HTH_1 pfam18118
Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb ...
 146-221 6.93e-23

Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.


Pssm-ID: 436286  Cd Length: 101  Bit Score: 93.22  E-value: 6.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262553 146 DETFIEeLIN----NYD----------GKQDDSKEDLPVTRKRKRH--AIEGNKKSSKKQFPNDMIFSAIASMFPENGVP 209
Cdd:pfam18118  11 DDIFVE-LVNalmqYYDdddesepessEKMSQAKKDERKTEEDERTekKDGDEKSESKKPFPSDIIFQAISSMFPDKGTP 89

                          90
                  ....*....|..
gi 2217262553 210 DDMKERYRELTE 221
Cdd:pfam18118  90 EELKEKYKELTE 101
EZH2_WD-Binding pfam11616
WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, ...
 42-71 3.88e-12

WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.


Pssm-ID: 463308  Cd Length: 30  Bit Score: 60.54  E-value: 3.88e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217262553  42 KALYVANFAKVQEKTQILNEEWKKLRVQPV 71
Cdd:pfam11616   1 KSLFVSNRQKIQERTELLNEEWKKLRIQPI 30
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 392-433 5.24e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 40.64  E-value: 5.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217262553 392 EWTGAEESLFRVFHGTY-FNNFCSIARLLGTKTCKQVFQFAVK 433
Cdd:cd00167     1 PWTEEEDELLLEAVKKYgKNNWEKIAKELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
392-433 4.07e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217262553  392 EWTGAEESLFRVFHGTY-FNNFCSIARLLGTKTCKQVFQFAVK 433
Cdd:smart00717   3 EWTEEEDELLIELVKKYgKNNWEKIAKELPGRTAEQCRERWRN 45
 
Name Accession Description Interval E-value
PRC2_HTH_1 pfam18118
Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb ...
 146-221 6.93e-23

Polycomb repressive complex 2 tri-helical domain; This domain can be found in the Polycomb repressive complex 2 (PRC2) present in Homo sapiens. Polycomb complexes maintain repressive chromatin states by silencing gene expression. PRC2 does this by methylating lysine 27 of histone H3. This domain makes up part of the N-lobe which is involved in regulation.


Pssm-ID: 436286  Cd Length: 101  Bit Score: 93.22  E-value: 6.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217262553 146 DETFIEeLIN----NYD----------GKQDDSKEDLPVTRKRKRH--AIEGNKKSSKKQFPNDMIFSAIASMFPENGVP 209
Cdd:pfam18118  11 DDIFVE-LVNalmqYYDdddesepessEKMSQAKKDERKTEEDERTekKDGDEKSESKKPFPSDIIFQAISSMFPDKGTP 89

                          90
                  ....*....|..
gi 2217262553 210 DDMKERYRELTE 221
Cdd:pfam18118  90 EELKEKYKELTE 101
EZH2_WD-Binding pfam11616
WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, ...
 42-71 3.88e-12

WD repeat binding protein EZH2; This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.


Pssm-ID: 463308  Cd Length: 30  Bit Score: 60.54  E-value: 3.88e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 2217262553  42 KALYVANFAKVQEKTQILNEEWKKLRVQPV 71
Cdd:pfam11616   1 KSLFVSNRQKIQERTELLNEEWKKLRIQPI 30
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 392-433 5.24e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 40.64  E-value: 5.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217262553 392 EWTGAEESLFRVFHGTY-FNNFCSIARLLGTKTCKQVFQFAVK 433
Cdd:cd00167     1 PWTEEEDELLLEAVKKYgKNNWEKIAKELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
392-433 4.07e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2217262553  392 EWTGAEESLFRVFHGTY-FNNFCSIARLLGTKTCKQVFQFAVK 433
Cdd:smart00717   3 EWTEEEDELLIELVKKYgKNNWEKIAKELPGRTAEQCRERWRN 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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