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Conserved domains on  [gi|1821010147|ref|NP_001365844|]
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splicing factor, suppressor of white-apricot homolog isoform 3 [Mus musculus]

Protein Classification

DRY_EERY and SWAP domain-containing protein( domain architecture ID 10560971)

DRY_EERY and SWAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 4.59e-44

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 155.55  E-value: 4.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821010147  35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDPKILIDRYDGRGHLHDLSAYDAEYAtwNRDYQLSEEEARVEALCDEER 114
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1821010147 115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGNYSAVGFTYGS 155
Cdd:pfam09750  79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 1.08e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1821010147  209 HAIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 460-507 2.35e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 65.30  E-value: 2.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1821010147  460 DKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 507
Cdd:smart00648   5 DKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 4.59e-44

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 155.55  E-value: 4.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821010147  35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDPKILIDRYDGRGHLHDLSAYDAEYAtwNRDYQLSEEEARVEALCDEER 114
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1821010147 115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGNYSAVGFTYGS 155
Cdd:pfam09750  79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 1.08e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1821010147  209 HAIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 210-254 1.66e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.66e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1821010147 210 AIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLR-FDHYLNPYYK 254
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYR 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 460-507 2.35e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 65.30  E-value: 2.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1821010147  460 DKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 507
Cdd:smart00648   5 DKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 460-501 1.22e-10

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 57.53  E-value: 1.22e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1821010147 460 DKLAEYVARNGLKFETSVRAK--NDQRFEFL-QPWHQYNAYYEFK 501
Cdd:pfam01805   4 KKTAQFVARNGPEFEALLMEReeRNPQFDFLfDPDDPLHAYYRWK 48
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 4.59e-44

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 155.55  E-value: 4.59e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821010147  35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDPKILIDRYDGRGHLHDLSAYDAEYAtwNRDYQLSEEEARVEALCDEER 114
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1821010147 115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGNYSAVGFTYGS 155
Cdd:pfam09750  79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 1.08e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1821010147  209 HAIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 210-254 1.66e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.66e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1821010147 210 AIIERTANFVCKQGAQFEIMLKAKQARNSQFDFLR-FDHYLNPYYK 254
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYR 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 460-507 2.35e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 65.30  E-value: 2.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1821010147  460 DKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 507
Cdd:smart00648   5 DKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 460-501 1.22e-10

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 57.53  E-value: 1.22e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1821010147 460 DKLAEYVARNGLKFETSVRAK--NDQRFEFL-QPWHQYNAYYEFK 501
Cdd:pfam01805   4 KKTAQFVARNGPEFEALLMEReeRNPQFDFLfDPDDPLHAYYRWK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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