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Conserved domains on  [gi|1569289672|ref|NP_001355320|]
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SURP and G-patch domain-containing protein 1 [Mus musculus]

Protein Classification

Surp and G-patch domain-containing protein( domain architecture ID 10485244)

protein containing domains Surp, kgd, and G-patch

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 186-237 4.69e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 77.94  E-value: 4.69e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 186 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 237
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 261-312 1.29e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.29e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 261 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 312
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 561-605 8.39e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 8.39e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1569289672 561 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 605
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 293-416 1.45e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672  293 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 367
Cdd:PRK12270    18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1569289672  368 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 416
Cdd:PRK12270    89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 186-237 4.69e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 77.94  E-value: 4.69e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 186 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 237
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 185-239 2.58e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 2.58e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1569289672  185 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 239
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 261-312 1.29e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.29e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 261 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 312
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 561-605 8.39e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 8.39e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1569289672 561 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 605
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 558-604 2.55e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 64.49  E-value: 2.55e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1569289672  558 LTVENIGYQMLMKMGWKEGEGLGTEGQGIKNPVnKGATTIDGAGFGI 604
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPI-SAEIKKDRKGLGA 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 260-314 4.74e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 63.76  E-value: 4.74e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1569289672  260 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 314
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 293-416 1.45e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672  293 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 367
Cdd:PRK12270    18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1569289672  368 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 416
Cdd:PRK12270    89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 186-237 4.69e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 77.94  E-value: 4.69e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 186 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 237
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 185-239 2.58e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 2.58e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1569289672  185 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 239
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 261-312 1.29e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.29e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1569289672 261 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 312
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 561-605 8.39e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 8.39e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1569289672 561 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 605
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 558-604 2.55e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 64.49  E-value: 2.55e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1569289672  558 LTVENIGYQMLMKMGWKEGEGLGTEGQGIKNPVnKGATTIDGAGFGI 604
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPI-SAEIKKDRKGLGA 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 260-314 4.74e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 63.76  E-value: 4.74e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1569289672  260 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 314
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 293-416 1.45e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672  293 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 367
Cdd:PRK12270    18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1569289672  368 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 416
Cdd:PRK12270    89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 560-590 2.55e-04

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 39.57  E-value: 2.55e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1569289672 560 VENIGYQMLMKMGWKEGEGLGTEGQGIKNPV 590
Cdd:pfam12656  14 VEEFGAAMLRGMGWKPGQGIGKNKKGDVKPK 44
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
313-410 1.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672 313 RKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKV 392
Cdd:PRK12323  417 RAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496

                          90       100
                  ....*....|....*....|....
gi 1569289672 393 ----ELPP--AELAQRDIDASPSP 410
Cdd:PRK12323  497 ppweELPPefASPAPAQPDAAPAG 520
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 315-410 1.61e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672 315 AKAGSTGSFPAPAPNPSLRRKSAPEAlsgAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKVEL 394
Cdd:PRK14951  378 KKTPARPEAAAPAAAPVAQAAAAPAP---AAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ 454

                          90
                  ....*....|....*.
gi 1569289672 395 PPAELAQRDIDASPSP 410
Cdd:PRK14951  455 AAPETVAIPVRVAPEP 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 324-410 4.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 4.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672  324 PAPAPNP---SLRRKSAPEALSGAVPPITACPTPVAPA--PAVNPTPSIPGKPTATAAVKRKR--KSRWGPEEDKVELPP 396
Cdd:PHA03247  2708 PEPAPHAlvsATPLPPGPAAARQASPALPAAPAPPAVPagPATPGGPARPARPPTTAGPPAPAppAAPAAGPPRRLTRPA 2787

                           90
                   ....*....|....
gi 1569289672  397 AELAQRDIDASPSP 410
Cdd:PHA03247  2788 VASLSESRESLPSP 2801
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 316-410 9.35e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.93  E-value: 9.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672 316 KAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKrksrwgPEEDKVELP 395
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAP------AAAAPAAAP 438

                          90
                  ....*....|....*
gi 1569289672 396 PAELAQRDIDASPSP 410
Cdd:PRK14951  439 AAAPAAVALAPAPPA 453
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 314-410 9.92e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.93  E-value: 9.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1569289672 314 KAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTP-SIPGKPTATAAVKRKRKSrwgpEEDKV 392
Cdd:PRK14951  391 AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPaAVALAPAPPAQAAPETVA----IPVRV 466

                          90
                  ....*....|....*...
gi 1569289672 393 ELPPAELAQRDIDASPSP 410
Cdd:PRK14951  467 APEPAVASAAPAPAAAPA 484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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