|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
95-273 |
6.73e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 214823 Cd Length: 183 Bit Score: 211.29 E-value: 6.73e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 95 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 169
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1386876223 250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
9-91 |
7.99e-23 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 214824 Cd Length: 89 Bit Score: 93.55 E-value: 7.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800 1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80
|
....*....
gi 1386876223 83 RFGFCRLSS 91
Cdd:smart00800 81 RYGFCLRFY 89
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
305-371 |
1.92e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.92e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
692-1018 |
1.78e-14 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 692 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 771
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 772 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 846
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 847 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 921
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 922 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 992
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1386876223 993 GESPLLPPRPPQSLQPTPQPSVPTQA 1018
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
95-273 |
6.73e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 211.29 E-value: 6.73e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 95 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 169
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1386876223 250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
96-273 |
5.68e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 157.73 E-value: 5.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 96 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 165
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 166 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 245
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1386876223 246 LIGIHLSLMEKVRNmALDDVVILNVDTN 273
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
9-91 |
7.99e-23 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 93.55 E-value: 7.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800 1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80
|
....*....
gi 1386876223 83 RFGFCRLSS 91
Cdd:smart00800 81 RYGFCLRFY 89
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
305-371 |
1.92e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.92e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
692-1018 |
1.78e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 692 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 771
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 772 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 846
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 847 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 921
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 922 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 992
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1386876223 993 GESPLLPPRPPQSLQPTPQPSVPTQA 1018
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
31-89 |
3.82e-11 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 59.16 E-value: 3.82e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 31 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 89
Cdd:pfam03456 1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
693-1016 |
8.29e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 8.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 693 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 766
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 767 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 840
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 841 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 914
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 915 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 972
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1386876223 973 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 1016
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
337-388 |
1.09e-06 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.42 E-value: 1.09e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1386876223 337 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 388
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
758-968 |
2.37e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.97 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 758 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 834
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 835 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 910
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1386876223 911 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 968
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
95-273 |
6.73e-63 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 211.29 E-value: 6.73e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 95 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 169
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 170 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 249
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1386876223 250 HLSLMEKVRNMALDDVVILNVDTN 273
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
96-273 |
5.68e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 157.73 E-value: 5.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 96 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 165
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 166 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 245
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1386876223 246 LIGIHLSLMEKVRNmALDDVVILNVDTN 273
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
9-91 |
7.99e-23 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 93.55 E-value: 7.99e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 9 PETTFEVYVEVAYPRTGGTLS---DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQ 82
Cdd:smart00800 1 PSRLFDYFVVVGLDSDTGPLGrsyKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSR 80
|
....*....
gi 1386876223 83 RFGFCRLSS 91
Cdd:smart00800 81 RYGFCLRFY 89
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
305-371 |
1.92e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.92e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 305 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 371
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
692-1018 |
1.78e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 692 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 771
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 772 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 846
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 847 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 921
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 922 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 992
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1386876223 993 GESPLLPPRPPQSLQPTPQPSVPTQA 1018
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
692-1017 |
5.20e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 73.82 E-value: 5.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 692 PSKPSITSPE-KPSAllgtsPALPLRPQnqegilspsikeeTPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAA 770
Cdd:PHA03247 2577 PSEPAVTSRArRPDA-----PPQSARPR-------------APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 771 GGPLGDFSSEPLQMD------RERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW-SG 843
Cdd:PHA03247 2639 DPHPPPTVPPPERPRddpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvSA 2718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 844 STIPSHPATPSAATPFIPQLSFPPTVTPTPfvQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSS 923
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 924 GFYAPHRSQPNLSALSMPNlfgqIPMGAHTSPLQPLGPPavaPSRIRTLPLARSSARAAEAKQGLALRPG---------- 993
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPA----AALPPAASPAGPLPPP---TSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrppsr 2869
|
330 340
....*....|....*....|....*..
gi 1386876223 994 ---ESPLLPPRPPQSLQPTPQPSVPTQ 1017
Cdd:PHA03247 2870 spaAKPAAPARPPVRRLARPAVSRSTE 2896
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
31-89 |
3.82e-11 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 59.16 E-value: 3.82e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 31 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 89
Cdd:pfam03456 1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
688-1019 |
5.64e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.27 E-value: 5.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 688 DMAIPSKPSITSPEKPSAllgTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPElgivPPPPTARPAKL 767
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHA---LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA----RPPTTAGPPAP 2769
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 768 QAAGGPLGdfsSEPLQMDRERQAALSPALLSGLLPRAvPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIP 847
Cdd:PHA03247 2770 APPAAPAA---GPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 848 SHPATP--SAATPFIPQLSFPPTVTPTPFVQTPLNPfvpsvPVVPPSMPLSSTPARPFGTPPASLGPAYAPSIllsssgf 925
Cdd:PHA03247 2846 PPPSLPlgGSVAPGGDVRRRPPSRSPAAKPAAPARP-----PVRRLARPAVSRSTESFALPPDQPERPPQPQA------- 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 926 YAPHRSQPNLSALSMPNLFGQIPmGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeAKQGLALRPGESPLLPPRPPQS 1005
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPTTDPAGAGEPSGAVP----------QPWLGALVPGRVAVPRFRVPQP 2982
|
330
....*....|....
gi 1386876223 1006 LQPTPQPSVPTQAR 1019
Cdd:PHA03247 2983 APSREAPASSTPPL 2996
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
693-1016 |
8.29e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.23 E-value: 8.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 693 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 766
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 767 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 840
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 841 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 914
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 915 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 972
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1386876223 973 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 1016
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
337-388 |
1.09e-06 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.42 E-value: 1.09e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1386876223 337 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 388
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
691-1014 |
4.27e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.92 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 691 IPSKPSITSPEKPSALLGTSPALPLRPQNQEGILS-PSIKEETPIPTPGSITIPRPQGRKTPelgiVPPPPTARPAKLQA 769
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHGQMPPMPHSLQTGPSHMQHP----VPPQPFPLTPQSSQ 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 770 AGGPLGDFSSEPLQM-DRERQAALSPALLSGLLPRAVPQGPTEL----LQPP--SPAPGAAGTGSDallalldplntaws 842
Cdd:pfam03154 307 SQVPPGPSPAAPGQSqQRIHTPPSQSQLQSQQPPREQPLPPAPLsmphIKPPptTPIPQLPNPQSH-------------- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 843 gstipSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFG-------TPPASLG 911
Cdd:pfam03154 373 -----KHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPqsqqLPPPPAQPPVltqsqslPPPAASH 447
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 912 PAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPlgPPAVAPSRIRTLPLARSSARAAEAKQGLALR 991
Cdd:pfam03154 448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP--PSSASVSSSGPVPAAVSCPLPPVQIKEEALD 525
|
330 340
....*....|....*....|...
gi 1386876223 992 PGESPLLPPRPPQSlqPTPQPSV 1014
Cdd:pfam03154 526 EAEEPESPPPPPRS--PSPEPTV 546
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
683-1026 |
4.94e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.09 E-value: 4.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 683 SLGQDDMAIPSKPSITSPekpSALLGTSPALPLRPQNQEGI--LSPSIKEETPIPTPGSITIPRPqgrKTPELGIVPPPP 760
Cdd:PHA03247 2500 GGGPPDPDAPPAPSRLAP---AILPDEPVGEPVHPRMLTWIrgLEELASDDAGDPPPPLPPAAPP---AAPDRSVPPPRP 2573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 761 TARPaklqaaggplgdfsSEPLQMDRERQAALSPALLSGLLPRAVPQGP------------TELLQPPSPAPGAAGT--- 825
Cdd:PHA03247 2574 APRP--------------SEPAVTSRARRPDAPPQSARPRAPVDDRGDPrgpappsplppdTHAPDPPPPSPSPAANepd 2639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 826 -GSDALLALLDPLNTAWSGSTI--------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLS 896
Cdd:PHA03247 2640 pHPPPTVPPPERPRDDPAPGRVsrprrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 897 STPARPFGTPPASLGPAYAPSILLSSSGFYAP--HRSQPNLSALSMPNLfGQIPMGAHTSPLQPLGPPAVAPSRIRTLPL 974
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVASLSESRESL 2798
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1386876223 975 ARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLL 1026
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
713-959 |
7.72e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 49.87 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 713 LPLRPQNQEGILSPsikeetpiPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGgplgdfSSEPLQMDRERQAAL 792
Cdd:PRK12323 361 LAFRPGQSGGGAGP--------ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA------AAAAARAVAAAPARR 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 793 SPAL--LSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVT 870
Cdd:PRK12323 427 SPAPeaLAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 871 PTPFVQtPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRsqPNLSALSMPNLF-GQIPM 949
Cdd:PRK12323 507 ASPAPA-QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP--PRASASGLPDMFdGDWPA 583
|
250
....*....|
gi 1386876223 950 GAHTSPLQPL 959
Cdd:PRK12323 584 LAARLPVRGL 593
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
758-968 |
2.37e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.97 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 758 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 834
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 835 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 910
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1386876223 911 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 968
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
689-1033 |
2.93e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.24 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 689 MAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQ 768
Cdd:PHA03307 60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 769 AAG--GPLGDFSSEPLQMDRERQAA-----LSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW 841
Cdd:PHA03307 140 PVGspGPPPAASPPAAGASPAAVASdaassRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 842 SGSTIPSHPATPSAATPFIPQLSFPP-------TVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASlGPAY 914
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSgcgwgpeNECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-SPSP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 915 APSillSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeakqglalrPGE 994
Cdd:PHA03307 299 SPS---SPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS------------------RPP 357
|
330 340 350
....*....|....*....|....*....|....*....
gi 1386876223 995 SPLLPPRPPQSlqPTPQPSVPTQARDPFEDLLRKTKQDV 1033
Cdd:PHA03307 358 PPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAV 394
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
691-961 |
1.65e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 45.69 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 691 IPSKPsiTSPEKPSALLGTSPAlPLRPQNQEGILSPSIKEetpiPTPGSITIPRPQGRKTPELGIVPPpptARPAKLQAA 770
Cdd:PLN03209 323 IPSQR--VPPKESDAADGPKPV-PTKPVTPEAPSPPIEEE----PPQPKAVVPRPLSPYTAYEDLKPP---TSPIPTPPS 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 771 GGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPApgaagtgsdallalldplnTAWSGSTIPSHP 850
Cdd:PLN03209 393 SSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPY-------------------ARYEDLKPPTSP 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 851 aTPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAyapsillSSSGFYAPHR 930
Cdd:PLN03209 454 -SPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-------APVGKVAPSS 525
|
250 260 270
....*....|....*....|....*....|..
gi 1386876223 931 SQPNLSALSMPNLFGQIPMGAHTSPLQ-PLGP 961
Cdd:PLN03209 526 TNEVVKVGNSAPPTALADEQHHAQPKPrPLSP 557
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
461-873 |
9.28e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 9.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 461 SSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHV------VRRPKsNITVEGRRTSVSSPEHlvKPLRHY 534
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgrVSRPR-RARRLGRAAQASSPPQ--RPRRRA 2687
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 535 A------VFLSEDSSDEECRREEAPSTGFTESLLFSAPFEWPQ--PYRTLKESDSAEGDETESPEQLVREPWGPTPAPPD 606
Cdd:PHA03247 2688 ArptvgsLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 607 RAASIDLLEDVFSSLDVEAPLQPLgqAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPytklwslgq 686
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP--------- 2836
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 687 ddmAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGilSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 766
Cdd:PHA03247 2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR--SPAAKPAAP-ARPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 767 LQAAGGPLGDFSSEPlqmdrerqaalspallsglLPRAVPQGPTellQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 846
Cdd:PHA03247 2911 PQAPPPPQPQPQPPP-------------------PPQPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
410 420
....*....|....*....|....*..
gi 1386876223 847 PSHPATPSAATPfIPQLSFPPTVTPTP 873
Cdd:PHA03247 2969 PGRVAVPRFRVP-QPAPSREAPASSTP 2994
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
538-858 |
1.14e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.24 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 538 LSEDSSDEECRREEAPSTGFT--ESLLFSAPFEWPQPYRtlkESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLE 615
Cdd:PHA03307 10 LIEAAAEGGEFFPRPPATPGDaaDDLLSGSQGQLVSDSA---ELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 616 DVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSfdyqrLDLCRSERGLSMAAALKLAHPYTklwSLGQDDMAIPSKP 695
Cdd:PHA03307 87 TPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-----PASPPPSPAPDLSEMLRPVGSPG---PPPAASPPAAGAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 696 SITSPEKPSALLGTSPALPLRPQNQEGILSPSikEETPIPTPGSITIPRPQGRKTPeLGIVPPPPTARPAKLQAAGGPLG 775
Cdd:PHA03307 159 PAAVASDAASSRQAALPLSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSP-ISASASSPAPAPGRSAADDAGAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 776 DFSSEPLQM----DRERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALlalldplntawSGSTIPSHPA 851
Cdd:PHA03307 236 SSDSSSSESsgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-----------SPSPSPSSPG 304
|
....*..
gi 1386876223 852 TPSAATP 858
Cdd:PHA03307 305 SGPAPSS 311
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
686-1025 |
3.82e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 41.20 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 686 QDDMAIPSKPSITSPEKPsallgTSPALPLRPQNQEGILSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPA 765
Cdd:PHA03379 429 QSLETATSHGSAQVPEPP-----PVHDLEPGPLHDQHSMAPCPVAQLP-PGPLQDLEPGDQLPGVVQDGRPACAPVPAPA 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 766 klqaaGGPLGDFSSEPLQMDRERQAALSPALLSGllpRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGST 845
Cdd:PHA03379 503 -----GPIVRPWEASLSQVPGVAFAPVMPQPMPV---EPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAP 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 846 IPSHPATPSAATPFIPQLS----------FPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA 915
Cdd:PHA03379 575 WTPNPPRSPSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQ 654
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 916 PsillsssgfyaPHRSQPnlsaLSMPNLFGQ--IPMGAHTSPLQPLgpPAVAPSRIRtLPLARSSARAAEAKQGLALRPG 993
Cdd:PHA03379 655 P-----------QYFDLP----LQQPISQGAplAPLRASMGPVPPV--PATQPQYFD-IPLTEPINQGASAAHFLPQQPM 716
|
330 340 350
....*....|....*....|....*....|..
gi 1386876223 994 ESPLLPPRPPQSLQPTPQPSVPTQARDPFEDL 1025
Cdd:PHA03379 717 EGPLVPERWMFQGATLSQSVRPGVAQSQYFDL 748
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
748-923 |
6.06e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 40.36 E-value: 6.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 748 RKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGL-------LPRAVPQG-PTELLQPPSPA 819
Cdd:PRK12727 60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMalrqpvsVPRQAPAAaPVRAASIPSPA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1386876223 820 PGAAGTGSDALLALLDPLNTAWSGSTI-------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPS 892
Cdd:PRK12727 140 AQALAHAAAVRTAPRQEHALSAVPEQLfadflttAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDGFD 219
|
170 180 190
....*....|....*....|....*....|..
gi 1386876223 893 MPLSSTPA-RPFGTPPASLGPAyAPSILLSSS 923
Cdd:PRK12727 220 LDDALPQIlPPAALPPIVVAPA-APAALAAVA 250
|
|
| |
