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Conserved domains on  [gi|1252414565|ref|NP_001343474|]
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preferentially expressed antigen in melanoma like 6 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
201-415 2.71e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 201 KLVDLNCILELQLSQWWPEVLEELDPYLEGMNNLHTLMLEGLKPF-RFTACEE-DQEDEWQSTLPSLLSNFGSLQNLYLN 278
Cdd:COG4886    65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESlDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 279 DIYLleDSLDKWLGCLKTpLKTLSITDCPrlLQSDFECLPNCPNickLKHLNLNALFLSDVGYEIPGLilekvtSTLQIL 358
Cdd:COG4886   145 NNQL--TDLPEPLGNLTN-LKSLDLSNNQ--LTDLPEELGNLTN---LKELDLSNNQITDLPEPLGNL------TNLEEL 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1252414565 359 ELERCGMTDphfkaLMPALSKCSQLLKVSFCHNDIS-------LRVLKTLLCHTAKLSQLTQEL 415
Cdd:COG4886   211 DLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTdlpelgnLTNLEELDLSNNQLTDLPPLA 269
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-415 2.71e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 201 KLVDLNCILELQLSQWWPEVLEELDPYLEGMNNLHTLMLEGLKPF-RFTACEE-DQEDEWQSTLPSLLSNFGSLQNLYLN 278
Cdd:COG4886    65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESlDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 279 DIYLleDSLDKWLGCLKTpLKTLSITDCPrlLQSDFECLPNCPNickLKHLNLNALFLSDVGYEIPGLilekvtSTLQIL 358
Cdd:COG4886   145 NNQL--TDLPEPLGNLTN-LKSLDLSNNQ--LTDLPEELGNLTN---LKELDLSNNQITDLPEPLGNL------TNLEEL 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1252414565 359 ELERCGMTDphfkaLMPALSKCSQLLKVSFCHNDIS-------LRVLKTLLCHTAKLSQLTQEL 415
Cdd:COG4886   211 DLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTdlpelgnLTNLEELDLSNNQLTDLPPLA 269
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-415 2.71e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 201 KLVDLNCILELQLSQWWPEVLEELDPYLEGMNNLHTLMLEGLKPF-RFTACEE-DQEDEWQSTLPSLLSNFGSLQNLYLN 278
Cdd:COG4886    65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESlDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 279 DIYLleDSLDKWLGCLKTpLKTLSITDCPrlLQSDFECLPNCPNickLKHLNLNALFLSDVGYEIPGLilekvtSTLQIL 358
Cdd:COG4886   145 NNQL--TDLPEPLGNLTN-LKSLDLSNNQ--LTDLPEELGNLTN---LKELDLSNNQITDLPEPLGNL------TNLEEL 210

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1252414565 359 ELERCGMTDphfkaLMPALSKCSQLLKVSFCHNDIS-------LRVLKTLLCHTAKLSQLTQEL 415
Cdd:COG4886   211 DLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTdlpelgnLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
221-416 7.65e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 7.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 221 LEELDPYLEGMNNLHTLMLEGLKPFRFTACEEDQEDEWQSTLPSLLSNFGSLQNLYLNDIYLLEDSLDKWLGCLKTPLKT 300
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1252414565 301 LSITDCPRLLQSDFECLPNCPNickLKHLNLNALFLSDVGYEIPGLilekvtSTLQILELERCGMTDphfkaLMPALSKC 380
Cdd:COG4886    93 GDLTNLTELDLSGNEELSNLTN---LESLDLSGNQLTDLPEELANL------TNLKELDLSNNQLTD-----LPEPLGNL 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1252414565 381 SQLLKVSFCHNDIS--------LRVLKTLLCHTAKLSQLTQELY 416
Cdd:COG4886   159 TNLKSLDLSNNQLTdlpeelgnLTNLKELDLSNNQITDLPEPLG 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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