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Conserved domains on  [gi|620597332|ref|NP_001278733|]
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desmocollin-1 isoform 1 preproprotein [Mus musculus]

Protein Classification

Cadherin_pro and Cadherin_repeat domain-containing protein( domain architecture ID 11279598)

protein containing domains Cadherin_pro, Cadherin_repeat, and CADH_Y-type_LIR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 8.56e-33

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 121.62  E-value: 8.56e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332    29 ACQKVSLHVPSHLKAETPVGKVNLEECLKSPSL-ILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKL 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 620597332   108 EV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-350 6.04e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 6.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 248 VFSVPENCRSGTSVGQVTAIDKDEPgtLHTRLKYKILQqiPDQPKHFSIHPDTGVITTTTPlLDREKCDTYKLVMEVRDM 327
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 620597332 328 GGQPfgLFTTGTITISLEDENDN 350
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
477-568 2.28e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 2.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  477 VIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESkfvkNNQYNISVVATD-- 553
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDsg 77

                          90
                  ....*....|....*
gi 620597332  554 TAGRSCTGTLVVLLE 568
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-462 3.26e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  359 YTTEVEEN-RIDVEILRMVVHDQDLPntPHSKAVYTILKGNENGNFKITTDPntneGVLCVVKPLNYEVSRQVTLQIGVL 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 620597332  438 NeaqftnaaNAQPPTMCTTTVTVKI 462
Cdd:pfam00028  75 D--------SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
139-233 5.79e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  139 IPCSLMENSL-GPFPQHIQQIQSDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 620597332  218 DGYAPDYPLPLLFKVE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 837-880 1.01e-04

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 40.98  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 620597332  837 DYVRPYNYEGKGSMAG---SVGCCSDrQEEEGLEFLDQLEPKFRTLA 880
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTS-DSDQDYDYLSDWGPRFKKLA 56
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 8.56e-33

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 121.62  E-value: 8.56e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332    29 ACQKVSLHVPSHLKAETPVGKVNLEECLKSPSL-ILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKL 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 620597332   108 EV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-350 6.04e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 6.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 248 VFSVPENCRSGTSVGQVTAIDKDEPgtLHTRLKYKILQqiPDQPKHFSIHPDTGVITTTTPlLDREKCDTYKLVMEVRDM 327
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 620597332 328 GGQPfgLFTTGTITISLEDENDN 350
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-345 6.08e-27

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 105.08  E-value: 6.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  248 VFSVPENCRSGTSVGQVTAIDKDEPgtLHTRLKYKILQQIPDQpkHFSIHPDTGVITTTTPlLDREKCDTYKLVMEVRDM 327
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 620597332  328 GGQPfgLFTTGTITISLE 345
Cdd:pfam00028  77 GGPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-352 1.82e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 1.82e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   265 TAIDKDEPgtLHTRLKYKILQQIPDQpkHFSIHPDTGVITTTTPLlDREKCDTYKLVMEVRDMGGQPfgLFTTGTITISL 344
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDG--LFSIDPETGEITTTKPL-DREEQPEYTLTVEATDGGGPP--LSSTATVTITV 73


                   ....*...
gi 620597332   345 EDENDNSP 352
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
477-568 2.28e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 2.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  477 VIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESkfvkNNQYNISVVATD-- 553
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDsg 77

                          90
                  ....*....|....*
gi 620597332  554 TAGRSCTGTLVVLLE 568
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-462 3.26e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  359 YTTEVEEN-RIDVEILRMVVHDQDLPntPHSKAVYTILKGNENGNFKITTDPntneGVLCVVKPLNYEVSRQVTLQIGVL 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 620597332  438 NeaqftnaaNAQPPTMCTTTVTVKI 462
Cdd:pfam00028  75 D--------SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 483-573 4.52e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 4.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 483 GLPAGQELLGYKAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESKfvknNQYNISVVATDTAG--RSC 559
Cdd:cd11304    9 NAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGppLSS 84

                         90
                 ....*....|....
gi 620597332 560 TGTLVVLLEDFNDH 573
Cdd:cd11304   85 TATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
139-233 5.79e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  139 IPCSLMENSL-GPFPQHIQQIQSDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 620597332  218 DGYAPDYPLPLLFKVE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.00e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   494 KAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESKfvknNQYNISVVATDTAG--RSCTGTLVVLLEDF 570
Cdd:smart00112   1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 620597332   571 NDHPP 575
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 358-464 1.07e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 358 SYTTEVEEN-RIDVEILRMVVHDQDLPntPHSKAVYTILKGNENGNFKIttDPNTneGVLCVVKPLNYEVSRQVTLQIGV 436
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 620597332 437 LNeaqftnaaNAQPPTMCTTTVTVKIKD 464
Cdd:cd11304   75 TD--------GGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-240 7.85e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 7.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   160 SDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNA 239
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 620597332   240 P 240
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 376-469 1.80e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   376 VVHDQDLPntPHSKAVYTILKGNENGNFKIttDPNTneGVLCVVKPLNYEVSRQVTLQIGVLNeaqftnaaNAQPPTMCT 455
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD--------GGGPPLSST 66

                           90
                   ....*....|....
gi 620597332   456 TTVTVKIKDRDEGP 469
Cdd:smart00112  67 ATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 142-238 2.17e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 142 SLMENSlgPFPQHIQQIQ---SDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTAD 218
Cdd:cd11304    5 SVPENA--PPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 620597332 219 GYAPDYPLPLLFKVEDDNDN 238
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 34-111 2.10e-07

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 49.63  E-value: 2.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 620597332   34 SLHVPSHLKAETPVGKVNLEECLKSPSLIL-SSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVL 111
Cdd:pfam08758  12 TFSVPRRLEEGQPLLNVKFNDCTGRKKTLYeSSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 837-880 1.01e-04

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 40.98  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 620597332  837 DYVRPYNYEGKGSMAG---SVGCCSDrQEEEGLEFLDQLEPKFRTLA 880
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTS-DSDQDYDYLSDWGPRFKKLA 56
 
Name Accession Description Interval E-value
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-109 8.56e-33

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 121.62  E-value: 8.56e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332    29 ACQKVSLHVPSHLKAETPVGKVNLEECLKSPSL-ILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKL 107
Cdd:smart01055   6 SEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLqFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQGQEKKEI 85


                   ..
gi 620597332   108 EV 109
Cdd:smart01055  86 KV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 248-350 6.04e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 6.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 248 VFSVPENCRSGTSVGQVTAIDKDEPgtLHTRLKYKILQqiPDQPKHFSIHPDTGVITTTTPlLDREKCDTYKLVMEVRDM 327
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 620597332 328 GGQPfgLFTTGTITISLEDENDN 350
Cdd:cd11304   78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
248-345 6.08e-27

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 105.08  E-value: 6.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  248 VFSVPENCRSGTSVGQVTAIDKDEPgtLHTRLKYKILQQIPDQpkHFSIHPDTGVITTTTPlLDREKCDTYKLVMEVRDM 327
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 620597332  328 GGQPfgLFTTGTITISLE 345
Cdd:pfam00028  77 GGPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-352 1.82e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 1.82e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   265 TAIDKDEPgtLHTRLKYKILQQIPDQpkHFSIHPDTGVITTTTPLlDREKCDTYKLVMEVRDMGGQPfgLFTTGTITISL 344
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDG--LFSIDPETGEITTTKPL-DREEQPEYTLTVEATDGGGPP--LSSTATVTITV 73


                   ....*...
gi 620597332   345 EDENDNSP 352
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
477-568 2.28e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 2.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  477 VIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESkfvkNNQYNISVVATD-- 553
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDsg 77

                          90
                  ....*....|....*
gi 620597332  554 TAGRSCTGTLVVLLE 568
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
359-462 3.26e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 3.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  359 YTTEVEEN-RIDVEILRMVVHDQDLPntPHSKAVYTILKGNENGNFKITTDPntneGVLCVVKPLNYEVSRQVTLQIGVL 437
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 620597332  438 NeaqftnaaNAQPPTMCTTTVTVKI 462
Cdd:pfam00028  75 D--------SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 483-573 4.52e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 4.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 483 GLPAGQELLGYKAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESKfvknNQYNISVVATDTAG--RSC 559
Cdd:cd11304    9 NAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGppLSS 84

                         90
                 ....*....|....
gi 620597332 560 TGTLVVLLEDFNDH 573
Cdd:cd11304   85 TATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
139-233 5.79e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332  139 IPCSLMENSL-GPFPQHIQQIQSDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTA 217
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 620597332  218 DGYAPDYPLPLLFKVE 233
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 494-575 1.00e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   494 KAVDPETSSGEGLRYEMV-GDEDNWFEINKITGDLRTVKVLDRESKfvknNQYNISVVATDTAG--RSCTGTLVVLLEDF 570
Cdd:smart00112   1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 620597332   571 NDHPP 575
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 358-464 1.07e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 358 SYTTEVEEN-RIDVEILRMVVHDQDLPntPHSKAVYTILKGNENGNFKIttDPNTneGVLCVVKPLNYEVSRQVTLQIGV 436
Cdd:cd11304    1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 620597332 437 LNeaqftnaaNAQPPTMCTTTVTVKIKD 464
Cdd:cd11304   75 TD--------GGGPPLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 160-240 7.85e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 7.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   160 SDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNA 239
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 620597332   240 P 240
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 376-469 1.80e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332   376 VVHDQDLPntPHSKAVYTILKGNENGNFKIttDPNTneGVLCVVKPLNYEVSRQVTLQIGVLNeaqftnaaNAQPPTMCT 455
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD--------GGGPPLSST 66

                           90
                   ....*....|....
gi 620597332   456 TTVTVKIKDRDEGP 469
Cdd:smart00112  67 ATVTITVLDVNDNA 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 142-238 2.17e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 142 SLMENSlgPFPQHIQQIQ---SDAAQNYTIFYSISGPGVDkepyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTAD 218
Cdd:cd11304    5 SVPENA--PPGTVVLTVSatdPDSGENGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 620597332 219 GYAPDYPLPLLFKVEDDNDN 238
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 34-111 2.10e-07

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 49.63  E-value: 2.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 620597332   34 SLHVPSHLKAETPVGKVNLEECLKSPSLIL-SSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVL 111
Cdd:pfam08758  12 TFSVPRRLEEGQPLLNVKFNDCTGRKKTLYeSSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSHGEKMASVKVTV 90
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 4.07e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.88  E-value: 4.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 139 IPCSLMENSLGPfpQHIQQIQSDAAQNYTIFYSISGPGVDKEPyNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTAD 218
Cdd:cd00031    2 PDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|
gi 620597332 219 GYAPDYPLPLLFKVEDDNDN 238
Cdd:cd00031   79 ANVPQTSSVFSIEVYDENDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 837-880 1.01e-04

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 40.98  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 620597332  837 DYVRPYNYEGKGSMAG---SVGCCSDrQEEEGLEFLDQLEPKFRTLA 880
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTS-DSDQDYDYLSDWGPRFKKLA 56
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-350 7.19e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.63  E-value: 7.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597332 249 FSVPENCRSGTSVGQVtAIDKDEpgtlHTRLKYKILQQIPDQPKH-FSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDM 327
Cdd:cd00031    4 GSAVEGRSRGSFRVSI-PTDLIA----SSGEIIKISAAGKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|...
gi 620597332 328 GGQPfglFTTGTITISLEDENDN 350
Cdd:cd00031   79 ANVP---QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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