CUE domain-containing protein 1 [Homo sapiens]
Protein Classification
CUE domain-containing protein 1( domain architecture ID 10198889)
CUE domain-containing protein 1 (CUEDC1) is a primary target of ERa essential for the growth of breast cancer cells
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED1 | cd14366 | CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The ... |
46-87 | 2.17e-22 | ||
CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The subfamily includes a group of uncharacterized CUE domain-containing protein termed CUED1. Their biological function remains unknown. : Pssm-ID: 270549 Cd Length: 42 Bit Score: 88.82 E-value: 2.17e-22
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| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED1 | cd14366 | CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The ... |
46-87 | 2.17e-22 | ||
CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The subfamily includes a group of uncharacterized CUE domain-containing protein termed CUED1. Their biological function remains unknown. Pssm-ID: 270549 Cd Length: 42 Bit Score: 88.82 E-value: 2.17e-22
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
46-88 | 1.31e-14 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 67.13 E-value: 1.31e-14
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
47-88 | 1.74e-11 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 58.26 E-value: 1.74e-11
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| Name | Accession | Description | Interval | E-value | ||
| CUE_CUED1 | cd14366 | CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The ... |
46-87 | 2.17e-22 | ||
CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins; The subfamily includes a group of uncharacterized CUE domain-containing protein termed CUED1. Their biological function remains unknown. Pssm-ID: 270549 Cd Length: 42 Bit Score: 88.82 E-value: 2.17e-22
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| CUE | smart00546 | Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ... |
46-88 | 1.31e-14 | ||
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press) Pssm-ID: 214715 Cd Length: 43 Bit Score: 67.13 E-value: 1.31e-14
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| CUE | pfam02845 | CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ... |
47-88 | 1.74e-11 | ||
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Pssm-ID: 427018 Cd Length: 42 Bit Score: 58.26 E-value: 1.74e-11
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| CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
48-85 | 7.97e-09 | ||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. Pssm-ID: 270465 Cd Length: 38 Bit Score: 50.93 E-value: 7.97e-09
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| CUE_TOLIP | cd14363 | CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins; ... |
52-87 | 1.24e-08 | ||
CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins; Tollip is a new component of the IL-1RI pathway which contains an N-terminal C2 domain and a C-terminal CUE domain. Tollip binds to the cytoplasmic TIR domain of IL-1Rs after IL-1 stimulation. It is sufficient for recruitment of IRAK to IL-1Rs and negatively regulates IL-1-induced signaling by inhibiting IRAK phosphorylation. In addition, Tollip directly interacts with toll-like receptors TLR2 and TLR4, and plays an inhibitory role in TLR-mediated cell activation through suppressing phosphorylation and kinase activity of IRAK. Moreover, Tollip can associate with GAT domains of Tom1 and its related proteins Tom1L1 and Tom1L2, and facilitate the recruitment of clathrin onto endosomes. Pssm-ID: 270546 Cd Length: 41 Bit Score: 50.40 E-value: 1.24e-08
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| CUE_VPS9_like | cd14369 | CUE domain found in vacuolar protein sorting-associated protein 9 (VPS9) and similar proteins; ... |
50-87 | 2.42e-06 | ||
CUE domain found in vacuolar protein sorting-associated protein 9 (VPS9) and similar proteins; VPS9, also called vacuolar protein-targeting protein 9, is a cytosolic yeast protein required for localization of vacuolar proteins, such as the soluble vacuolar hydrolases CPY and PrA. It may bind and act as an effector of a rab GTPase and plays a role in vacuolar protein sorting (VPS) pathway. VPS9 contains a region called GBH domain that is related to mammalian Ras-binding proteins, Rin1 and JC265, and may negatively regulate Ras-mediated signaling in yeast Saccharomyces cerevisiae. This model corresponds to the N-terminal CUE domain that interacts specifically with monoubiquitin and regulates intramolecular monoubiquitylation. Pssm-ID: 270552 Cd Length: 42 Bit Score: 43.75 E-value: 2.42e-06
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| CUE_CID7_like | cd14371 | CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; ... |
55-90 | 2.42e-04 | ||
CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; CID7 is encoded by ubiquitously expressed gene CID7. It contains an N-terminal PABC-interacting domain (PAM2 or PABP-interacting motif 2) which is also found in the human Paip1 and Paip2. At this point, it functions as an interaction partner of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins. It also harbors an ubiquitin-associated (UBA)-like CUE domain and a C-terminal small MutS-related (SMR) domain. CID5 and CID6 are encoded by gene CID5, CID6, respectively. CID5 is only expressed in immature siliques. The biological function of CID5 and CID6 remain unclear. Pssm-ID: 270554 Cd Length: 43 Bit Score: 38.39 E-value: 2.42e-04
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| CUE2_Cue2p_like | cd14375 | CUE2 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins; Cue2p, ... |
51-85 | 1.62e-03 | ||
CUE2 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins; Cue2p, also called coupling of ubiquitin conjugation to ER degradation protein 2, is encoded by the open reading frame (ORF) YKL090W. It is involved in the intramolecular monoubiquitination that serves as a regulatory signal in a variety of cellular processes in yeast. Cue2p contains two tandem CUE domains at the N-terminus. Both of them can bind monoubiquitin independently. This model corresponds to the second CUE domain. Pssm-ID: 270558 Cd Length: 38 Bit Score: 35.86 E-value: 1.62e-03
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