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Conserved domains on  [gi|359718971|ref|NP_001240789|]
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sodium channel protein type 5 subunit alpha isoform 2 [Mus musculus]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.84e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.54  E-value: 2.84e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1207 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1286 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1365
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1366 CINQTEGDlplnytivnnksecesfnvtgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwed 1445
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 359718971  1446 NLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
955-1203 1.62e-66

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 223.37  E-value: 1.62e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   955 DGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALAT-----HSQLPSCIAAPRSPpppevEKAPPARKETr 1029
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTelkdaRSKLTNQIANHTSL-----KKAPGGKYEL- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1030 feeDKRPGQGTPGDTEPVCVPIAVAesdtddqeedeenslgteeeesskqqesqvvsggheppqEprawsqvSETTSSEA 1109
Cdd:pfam06512   75 ---DEDHMDFITNPNLTVCVPIAEG---------------------------------------E-------SDLENEED 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1110 EASTSQADWQQEREAEPRApgcgETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQA 1189
Cdd:pfam06512  106 DDESSQSSDEEKSKQQEQL----EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKG 181
                          250
                   ....*....|....
gi 359718971  1190 PGKVWWRLRKTCYR 1203
Cdd:pfam06512  182 PWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
509-667 4.93e-66

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 220.76  E-value: 4.93e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   509 LSLTHGLSRTsmrPRSSRGSIFTFRRR--DQGSEADFADDENSTAGESESHRTSLLVPWP--LRRPSTQGQPGFG-TSAP 583
Cdd:pfam11933    3 LSIPGSPFSP---RRSSRGSIFSFRGRgrDVGSENDFADDENSTFEDSESRRGSLFVPRRhlERRSSYQSQASRSsRSHP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   584 GHVLNGKRNSTVDCNGVVSLLGaGDAEATSPGSHLLRPIVLDRP-PDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRA 662
Cdd:pfam11933   80 GLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGQLLPEVILDKPaTGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRA 158

                   ....*
gi 359718971   663 LSAVS 667
Cdd:pfam11933  159 VSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1785 3.60e-59

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 204.04  E-value: 3.60e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1531 QAFDVTIMFLICLNMVTMMVETDDQSPEKVN-ILAKINLLFVAIFTGECIVKMAALR--HYYFTNSWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1608 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1685
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1686 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdpnlpnsngsrgncgsPAVGILFFTTYIIISFLI 1765
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 359718971  1766 VVNMYIAIILENFSVATEES 1785
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-929 2.59e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.59e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   716 DPFADLTITMCIVLNTLFMALEHYNMTAE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   794 MELGLSRM---GNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYselrh 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   871 RISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 929
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 8.70e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.93  E-value: 8.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   130 HSLFSMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVIV 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   203 MAYTT----EFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   279 kcvrnftelngtngsveadgivwnsldvylndpanyllkngttdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 359718971   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 7.37e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 7.37e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 359718971 1474 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1526
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.84e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.54  E-value: 2.84e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1207 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1286 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1365
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1366 CINQTEGDlplnytivnnksecesfnvtgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwed 1445
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 359718971  1446 NLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
955-1203 1.62e-66

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 223.37  E-value: 1.62e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   955 DGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALAT-----HSQLPSCIAAPRSPpppevEKAPPARKETr 1029
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTelkdaRSKLTNQIANHTSL-----KKAPGGKYEL- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1030 feeDKRPGQGTPGDTEPVCVPIAVAesdtddqeedeenslgteeeesskqqesqvvsggheppqEprawsqvSETTSSEA 1109
Cdd:pfam06512   75 ---DEDHMDFITNPNLTVCVPIAEG---------------------------------------E-------SDLENEED 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1110 EASTSQADWQQEREAEPRApgcgETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQA 1189
Cdd:pfam06512  106 DDESSQSSDEEKSKQQEQL----EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKG 181
                          250
                   ....*....|....
gi 359718971  1190 PGKVWWRLRKTCYR 1203
Cdd:pfam06512  182 PWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
509-667 4.93e-66

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 220.76  E-value: 4.93e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   509 LSLTHGLSRTsmrPRSSRGSIFTFRRR--DQGSEADFADDENSTAGESESHRTSLLVPWP--LRRPSTQGQPGFG-TSAP 583
Cdd:pfam11933    3 LSIPGSPFSP---RRSSRGSIFSFRGRgrDVGSENDFADDENSTFEDSESRRGSLFVPRRhlERRSSYQSQASRSsRSHP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   584 GHVLNGKRNSTVDCNGVVSLLGaGDAEATSPGSHLLRPIVLDRP-PDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRA 662
Cdd:pfam11933   80 GLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGQLLPEVILDKPaTGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRA 158

                   ....*
gi 359718971   663 LSAVS 667
Cdd:pfam11933  159 VSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1785 3.60e-59

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 204.04  E-value: 3.60e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1531 QAFDVTIMFLICLNMVTMMVETDDQSPEKVN-ILAKINLLFVAIFTGECIVKMAALR--HYYFTNSWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1608 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1685
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1686 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdpnlpnsngsrgncgsPAVGILFFTTYIIISFLI 1765
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 359718971  1766 VVNMYIAIILENFSVATEES 1785
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-929 2.59e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.59e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   716 DPFADLTITMCIVLNTLFMALEHYNMTAE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   794 MELGLSRM---GNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYselrh 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   871 RISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 929
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 8.70e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.93  E-value: 8.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   130 HSLFSMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVIV 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   203 MAYTT----EFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   279 kcvrnftelngtngsveadgivwnsldvylndpanyllkngttdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 359718971   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 7.37e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 7.37e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 359718971 1474 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1526
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1611-1790 7.66e-04

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 44.93  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971 1611 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1690
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971 1691 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPNLPNSNGSRGncgspAVGILFFTTYIIISFLIVVNMY 1770
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 359718971 1771 IAIILENFSVATEESTEPLS 1790
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.84e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 227.54  E-value: 2.84e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1207 HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLlEYADKMFTYVFVLEMLLKWVAYGFKK-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1286 LVSLVANTLGfaEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1365
Cdd:pfam00520   80 LISLVLSSVG--SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1366 CINQTEGDlplnytivnnksecesfnvtgelywtkvkVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGyeeqpqwed 1445
Cdd:pfam00520  158 WENPDNGR-----------------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------- 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 359718971  1446 NLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
955-1203 1.62e-66

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 223.37  E-value: 1.62e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   955 DGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALAT-----HSQLPSCIAAPRSPpppevEKAPPARKETr 1029
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPKKKPLTelkdaRSKLTNQIANHTSL-----KKAPGGKYEL- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1030 feeDKRPGQGTPGDTEPVCVPIAVAesdtddqeedeenslgteeeesskqqesqvvsggheppqEprawsqvSETTSSEA 1109
Cdd:pfam06512   75 ---DEDHMDFITNPNLTVCVPIAEG---------------------------------------E-------SDLENEED 105
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1110 EASTSQADWQQEREAEPRApgcgETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQA 1189
Cdd:pfam06512  106 DDESSQSSDEEKSKQQEQL----EDDDSSSSEGSTVDLQDPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKG 181
                          250
                   ....*....|....
gi 359718971  1190 PGKVWWRLRKTCYR 1203
Cdd:pfam06512  182 PWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
509-667 4.93e-66

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 220.76  E-value: 4.93e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   509 LSLTHGLSRTsmrPRSSRGSIFTFRRR--DQGSEADFADDENSTAGESESHRTSLLVPWP--LRRPSTQGQPGFG-TSAP 583
Cdd:pfam11933    3 LSIPGSPFSP---RRSSRGSIFSFRGRgrDVGSENDFADDENSTFEDSESRRGSLFVPRRhlERRSSYQSQASRSsRSHP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   584 GHVLNGKRNSTVDCNGVVSLLGaGDAEATSPGSHLLRPIVLDRP-PDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRA 662
Cdd:pfam11933   80 GLPQNGKRHSTVDCNGVVSLVG-GGPEPTSPGGQLLPEVILDKPaTGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRA 158

                   ....*
gi 359718971   663 LSAVS 667
Cdd:pfam11933  159 VSAAS 163
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1785 3.60e-59

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 204.04  E-value: 3.60e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1531 QAFDVTIMFLICLNMVTMMVETDDQSPEKVN-ILAKINLLFVAIFTGECIVKMAALR--HYYFTNSWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1608 gtvlsDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYV-- 1685
Cdd:pfam00520   82 -----SLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1686 KWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPpycdpnlpnsngsrgncgsPAVGILFFTTYIIISFLI 1765
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 359718971  1766 VVNMYIAIILENFSVATEES 1785
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
716-929 2.59e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.59e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   716 DPFADLTITMCIVLNTLFMALEHYNMTAE-FEEMLQVGNLVFTGIFTAEMTFKIIALDP-YYYFQQGWNIFDSIIVILSL 793
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   794 MELGLSRM---GNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYselrh 870
Cdd:pfam00520   81 ISLVLSSVgslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   871 RISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGN 929
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-423 8.70e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.93  E-value: 8.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   130 HSLFSMLIMCTILTNCVFMAQHDPPP-------WTKYVEYTFTAIYTFESLVKILARGFCLHaftFLRDPWNWLDFSVIV 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   203 MAYTT----EFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGnlrh 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971   279 kcvrnftelngtngsveadgivwnsldvylndpanyllkngttdvllcgnssdagtcpegyrCLKAGENPDHGYTSFDSF 358
Cdd:pfam00520  154 --------------------------------------------------------------KLKTWENPDNGRTNFDNF 171
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 359718971   359 AWAFLALFRLMTQDCWERLYQQTLRSAG-KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQAT 423
Cdd:pfam00520  172 PNAFLWLFQTMTTEGWGDIMYDTIDGKGeFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 7.37e-33

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 121.52  E-value: 7.37e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 359718971 1474 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFD 1526
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1568-1779 7.41e-09

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 58.06  E-value: 7.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1568 LLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLS--------DIIQKYFFSPTLF----RVIRLARIGR 1635
Cdd:pfam08016   18 VVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLNiyrdfladRLIKSVEASPVTFidfdRVAQLDNLYR 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971  1636 I-------------LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWeagiddmfNFQTFAN 1702
Cdd:pfam08016   98 IilaflvfltwlklFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAP--------NFSNFVK 169
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 359718971  1703 SMLCLFQITTSA-GWDGLLSpilntgppycdpnlpnsngsrgncGSPAVGILFFTTYIIISFLIVVNMYIAIILENFS 1779
Cdd:pfam08016  170 SILTLFRTILGDfGYNEIFS------------------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
1611-1790 7.66e-04

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 44.93  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971 1611 LSDIIQKYFfspTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVkweag 1690
Cdd:PLN03223 1284 LVDYFQWYM---TLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNA----- 1355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359718971 1691 iddMFNFQTFANSMLCLFQIttsagwdgLLSPIlntgpPYCDPNLPNSNGSRGncgspAVGILFFTTYIIISFLIVVNMY 1770
Cdd:PLN03223 1356 ---SVHFSDMTDSINSLFEN--------LLGDI-----TYFNEDLKNLTGLQF-----VVGMIYFYSYNIFVFMILFNFL 1414
                         170       180
                  ....*....|....*....|
gi 359718971 1771 IAIILENFSVATEESTEPLS 1790
Cdd:PLN03223 1415 LAIICDAFGEVKANAAETVS 1434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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