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Conserved domains on  [gi|258614007|ref|NP_001158244|]
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F-box/WD repeat-containing protein 2 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 7.35e-21

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438903  Cd Length: 40  Bit Score: 82.37  E-value: 7.35e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
WD40 COG2319
WD40 repeat [General function prediction only];
143-228 7.81e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                         90
                 ....*....|..
gi 258614007 217 ARTQHFRGHTGA 228
Cdd:COG2319  363 ELLRTLTGHTGA 374
 
Name Accession Description Interval E-value
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 7.35e-21

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 82.37  E-value: 7.35e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
WD40 COG2319
WD40 repeat [General function prediction only];
143-228 7.81e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                         90
                 ....*....|..
gi 258614007 217 ARTQHFRGHTGA 228
Cdd:COG2319  363 ELLRTLTGHTGA 374
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-232 1.34e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 140 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                         90       100
                 ....*....|....*....|
gi 258614007 213 WSSGARTQHFRGHTGAgVFS 232
Cdd:cd00200   80 LETGECVRTLTGHTSY-VSS 98
FBOX smart00256
A Receptor for Ubiquitination Targets;
60-94 2.30e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.19  E-value: 2.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258614007    60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 60-102 2.16e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 258614007   60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISaCTEVWQTAC 102
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRLC 45
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 160-212 9.44e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 36.59  E-value: 9.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 258614007  160 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWE 212
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWE 152
 
Name Accession Description Interval E-value
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 55-94 7.35e-21

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 82.37  E-value: 7.35e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVISSC 40
WD40 COG2319
WD40 repeat [General function prediction only];
143-228 7.81e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 7.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  283 TLTGHSGGVNSVAFsPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTgavrSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                         90
                 ....*....|..
gi 258614007 217 ARTQHFRGHTGA 228
Cdd:COG2319  363 ELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
143-228 3.16e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 3.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 143 SLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319  199 TLTGHTGAVRSVAFsPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFspDGRLLASGSADGTVRLWDLATG 278

                         90
                 ....*....|..
gi 258614007 217 ARTQHFRGHTGA 228
Cdd:COG2319  279 ELLRTLTGHSGG 290
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-232 1.34e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 140 ETSSLIGHSARVYAL--YYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT-----CAAVKFDEQkLVTGSFDNTVACWE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgpvrdVAASADGTY-LASGSSDKTIRLWD 79

                         90       100
                 ....*....|....*....|
gi 258614007 213 WSSGARTQHFRGHTGAgVFS 232
Cdd:cd00200   80 LETGECVRTLTGHTSY-VSS 98
WD40 COG2319
WD40 repeat [General function prediction only];
140-228 3.53e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 3.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 140 ETSSLIGHSARVYALYY-KDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEW 213
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFsPDGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAvtSVAFspDGKLLASGSDDGTVRLWDL 191

                         90
                 ....*....|....*
gi 258614007 214 SSGARTQHFRGHTGA 228
Cdd:COG2319  192 ATGKLLRTLTGHTGA 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-228 7.96e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 7.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 144 LIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQK--LVTGSFDNTVACWEWSSGA 217
Cdd:cd00200  173 LTGHTGEVNSVaFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHEngVNSVAFSPDGylLASGSEDGTIRVWDLRTGE 252

                         90
                 ....*....|.
gi 258614007 218 RTQHFRGHTGA 228
Cdd:cd00200  253 CVQTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
143-228 1.70e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.31  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 143 SLIGHSARVYALYYK--DGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSSG 216
Cdd:COG2319   73 TLLGHTAAVLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAvrSVAFspDGKTLASGSADGTVRLWDLATG 152

                         90
                 ....*....|..
gi 258614007 217 ARTQHFRGHTGA 228
Cdd:COG2319  153 KLLRTLTGHSGA 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 140-227 3.85e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 3.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 140 ETSSLIGHSARVYALYY--KDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQK--LVTGSFDNTVACWEW 213
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvnSVAFSPDGtfVASSSQDGTIKLWDL 164

                         90
                 ....*....|....
gi 258614007 214 SSGARTQHFRGHTG 227
Cdd:cd00200  165 RTGKCVATLTGHTG 178
WD40 COG2319
WD40 repeat [General function prediction only];
143-215 3.25e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 3.25e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 258614007 143 SLIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKF--DEQKLVTGSFDNTVACWEWSS 215
Cdd:COG2319  325 TLTGHTGAVRSVaFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAvtSVAFspDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-212 7.78e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 7.78e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258614007 143 SLIGHSARVYAL-YYKDG-LLCTGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWE 212
Cdd:cd00200  214 TLRGHENGVNSVaFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTnsvtSLAWSPDGKRLASGSADGTIRIWD 289
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 56-100 3.67e-07

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 45.74  E-value: 3.67e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 258614007  56 FLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQT 100
Cdd:cd22148    1 FISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASS-NELWKA 44
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 56-102 1.69e-06

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 43.84  E-value: 1.69e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 258614007  56 FLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQTAC 102
Cdd:cd22147    1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADD-DELWKRMC 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
60-94 2.30e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.19  E-value: 2.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 258614007    60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAC 94
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSH 35
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 40-87 5.80e-06

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 42.80  E-value: 5.80e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 258614007  40 QLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQW 87
Cdd:cd22133    1 QVRHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYW 48
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 55-107 7.05e-06

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 42.27  E-value: 7.05e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTACKNLGW 107
Cdd:cd22172    4 DFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYW-KYLTELDQLWMPKCLRFGW 55
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 55-107 1.89e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 41.24  E-value: 1.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTACKNLGW 107
Cdd:cd22173    1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHW-KFLAEQDCLWMPKCVKFGW 52
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 60-102 2.16e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.54  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 258614007   60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISaCTEVWQTAC 102
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 60-92 2.96e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 40.12  E-value: 2.96e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 258614007  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:cd09917    3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 57-102 8.05e-05

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 39.22  E-value: 8.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 258614007  57 LKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTAC 102
Cdd:cd22113    1 IELLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENSDYLWRPHC 46
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 60-92 3.45e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 37.06  E-value: 3.45e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 258614007  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:cd22157    3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLIS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 57-92 5.64e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.75  E-value: 5.64e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 258614007   57 LKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVIS 92
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
WD40 COG2319
WD40 repeat [General function prediction only];
163-228 6.04e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 6.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258614007 163 TGSDDLSAKLWDVSTGQCVYGIQTHT----CAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGA 228
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGHTaavlSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA 122
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 60-103 1.39e-03

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 35.62  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 258614007  60 LPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISAcTEVWQTACK 103
Cdd:cd22141    4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRN-TALWKKLLI 46
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 55-102 1.81e-03

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 35.50  E-value: 1.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 258614007  55 DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWnKVISACTEVWQTAC 102
Cdd:cd22094    1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYW-KFLCESDELWLPKC 47
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 160-212 9.44e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 36.59  E-value: 9.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 258614007  160 LLCTGSDDLSAKLWDVSTGQCVYGIQTH----TCAAVKFDEQKLVTGSFDNTVACWE 212
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHkdvvSCVAVTSDGSILATGSYDTTVMVWE 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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