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Conserved domains on  [gi|347658943|ref|NP_001073370|]
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replication initiator 1 isoform a [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-571 1.03e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 300 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRLEVSaqaapHPESHQIA 379
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS-----SASESPRS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 380 AEPMAQPALGVPLGSPRTPAEAPALLHSCSDCGRSFRLERFLRLHQRQ--HTGE--RPFACTE--CGKNFGKKTHLVAHS 453
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 454 RVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPERPFVC--PDCGKAFRHKPYLAAHRRIHTGEKPYVC--PD 522
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347658943 523 CGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 571
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-571 1.03e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 300 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRLEVSaqaapHPESHQIA 379
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS-----SASESPRS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 380 AEPMAQPALGVPLGSPRTPAEAPALLHSCSDCGRSFRLERFLRLHQRQ--HTGE--RPFACTE--CGKNFGKKTHLVAHS 453
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 454 RVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPERPFVC--PDCGKAFRHKPYLAAHRRIHTGEKPYVC--PD 522
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347658943 523 CGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 571
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-557 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 347658943  532 NLVSHRRIHTGERPYACPDCDRSFSQ 557
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-571 1.03e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 300 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRLEVSaqaapHPESHQIA 379
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS-----SASESPRS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 380 AEPMAQPALGVPLGSPRTPAEAPALLHSCSDCGRSFRLERFLRLHQRQ--HTGE--RPFACTE--CGKNFGKKTHLVAHS 453
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 454 RVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPERPFVC--PDCGKAFRHKPYLAAHRRIHTGEKPYVC--PD 522
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347658943 523 CGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 571
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-571 4.17e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 279 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHK------ 350
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 351 --------------PNLLSHSKIHK-----RLEVSAQAAPHPESHQIAAEPMAQPALGVPLGSPRTPAEAPALL------ 405
Cdd:COG5048  111 sssssnsndnnllsSHSLPPSSRDPqlpdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLslliss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 406 --------HSCSDCGRSFRLERFLRLHQRQHTGERPFACTECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 469
Cdd:COG5048  191 nvstsipsSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 470 RFSQGSHLAAHRRDH-APERPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 542
Cdd:COG5048  269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                        330       340
                 ....*....|....*....|....*....
gi 347658943 543 ERPYACPDCDRSFSQKSNLITHRKSHIRD 571
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-483 6.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 281 PFQCACCGKRFRHKPNLIAHRR--VHTGE--RPHQCPE--CGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLL 354
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347658943 355 ShskihkrlEVSAQAAPHPESHQIaaepmaqpalgvplgsprtpAEAPALLHSCSdcgRSFRLERFLRLHQRQHTGERP- 433
Cdd:COG5048  369 N--------EPPQSLQQYKDLKND--------------------KKSETLSNSCI---RNFKRDSNLSLHIITHLSFRPy 417

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347658943 434 -FACTECGKNFGKKTHLVAHSRVHSGERPFACEECgRRFSQGSHLAAHRRD 483
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-557 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 347658943  532 NLVSHRRIHTGERPYACPDCDRSFSQ 557
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-529 3.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 347658943  504 YLAAHRRIHTGEKPYVCPDCGKAFSQ 529
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-321 6.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 347658943  296 NLIAHRRVHTGERPHQCPECGKRFTN 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 6.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 347658943  324 YLTSHRRIHTGEKPYPCTECGRRFRH 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 518-540 9.92e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.92e-04
                          10        20
                  ....*....|....*....|...
gi 347658943  518 YVCPDCGKAFSQKSNLVSHRRIH 540
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 546-568 3.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|...
gi 347658943  546 YACPDCDRSFSQKSNLITHRKSH 568
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 310-332 7.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.20e-03
                          10        20
                  ....*....|....*....|...
gi 347658943  310 HQCPECGKRFTNKPYLTSHRRIH 332
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-443 7.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 347658943  421 LRLHQRQHTGERPFACTECGKNF 443
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 9.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|...
gi 347658943  490 FVCPDCGKAFRHKPYLAAHRRIH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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