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Conserved domains on  [gi|115495559|ref|NP_001069386|]
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T-lymphocyte surface antigen Ly-9 [Bos taurus]

Protein Classification

Ig_3 and Ig_SLAM-like_N domain-containing protein( domain architecture ID 11617256)

Ig_3 and Ig_SLAM-like_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 253-354 3.62e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.13  E-value: 3.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559 253 KTVLGVLGESITLSLALLDSQHIDNVVWIFNTSIISKEWrEEATANQLIEFKDPDQNTVWVSSQDYSLKIVQLKMEHAGL 332
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 115495559 333 YQAYLCS-NARVASVKHINLRIY 354
Cdd:cd16842   80 YRARINTkNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-149 1.60e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.21  E-value: 1.60e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559  53 TVVKAIVGGSVILSLNISVDAEIEQITWSGPKDALVLAF---PSGEILFLDKSYKGRINIPKNN-SLSINKLTLKDAGSY 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPgegGAPEIIITDKSYKERLNISQNDySLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 115495559 129 KARINQKGS-EDFNERFILYIY 149
Cdd:cd16842   81 RARINTKNSrVTITKEFTLHIY 102
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 155-224 3.62e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 3.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115495559  155 PQVTIQSVNVSENASCTITLVCSVEGaGGDIQYKWT--------SRDPHASESWGHPTLTISWL-PCDADlPYTCTAKN 224
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATG-SPPPTITWYkngepissGSTRSRSLSGSNSTLTISNVtRSDAG-TYTCVASN 78
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 253-354 3.62e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.13  E-value: 3.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559 253 KTVLGVLGESITLSLALLDSQHIDNVVWIFNTSIISKEWrEEATANQLIEFKDPDQNTVWVSSQDYSLKIVQLKMEHAGL 332
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 115495559 333 YQAYLCS-NARVASVKHINLRIY 354
Cdd:cd16842   80 YRARINTkNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-149 1.60e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.21  E-value: 1.60e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559  53 TVVKAIVGGSVILSLNISVDAEIEQITWSGPKDALVLAF---PSGEILFLDKSYKGRINIPKNN-SLSINKLTLKDAGSY 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPgegGAPEIIITDKSYKERLNISQNDySLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 115495559 129 KARINQKGS-EDFNERFILYIY 149
Cdd:cd16842   81 RARINTKNSrVTITKEFTLHIY 102
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 155-224 3.62e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 3.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115495559  155 PQVTIQSVNVSENASCTITLVCSVEGaGGDIQYKWT--------SRDPHASESWGHPTLTISWL-PCDADlPYTCTAKN 224
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATG-SPPPTITWYkngepissGSTRSRSLSGSNSTLTISNVtRSDAG-TYTCVASN 78
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 253-354 3.62e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 130.13  E-value: 3.62e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559 253 KTVLGVLGESITLSLALLDSQHIDNVVWIFNTSIISKEWrEEATANQLIEFKDPDQNTVWVSSQDYSLKIVQLKMEHAGL 332
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAP-GEGGAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAGS 79

                         90       100
                 ....*....|....*....|...
gi 115495559 333 YQAYLCS-NARVASVKHINLRIY 354
Cdd:cd16842   80 YRARINTkNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-149 1.60e-35

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 128.21  E-value: 1.60e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559  53 TVVKAIVGGSVILSLNISVDAEIEQITWSGPKDALVLAF---PSGEILFLDKSYKGRINIPKNN-SLSINKLTLKDAGSY 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPgegGAPEIIITDKSYKERLNISQNDySLQISNLTMEDAGSY 80

                         90       100
                 ....*....|....*....|..
gi 115495559 129 KARINQKGS-EDFNERFILYIY 149
Cdd:cd16842   81 RARINTKNSrVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 55-149 2.43e-06

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 46.19  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559  55 VKAIVGGSVilSLNIS-VDAEIEQITWSGPKDALVLAFPSGEIlFLDKSYKGRINIPKNN-SLSINKLTLKDAGSYKARI 132
Cdd:cd05775    5 VYGALGGNV--TLTISsLQDDIDEIKWKKTKDKIVEWENNIGP-TYFGSFKDRVLLDKESgSLTIKNLTKEDSGTYELEI 81

                         90
                 ....*....|....*..
gi 115495559 133 NQKGSEDFNERFILYIY 149
Cdd:cd05775   82 TSTNGKVLSSKFTLEVL 98
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 57-129 2.53e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 40.41  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559  57 AIVGGSVILSLNISVDAEIEQITWSgpKDALVLafPSGEILF-------LDKSYKGRINI----PKNNSLSINKLTLKDA 125
Cdd:cd05846   10 AVLGGNATLSCNLTLPEEVLQVTWQ--KIKASS--PENIVTYskkygvkIQPSYVRRISFtssgLNSTSITIWNVTLEDE 85


                 ....
gi 115495559 126 GSYK 129
Cdd:cd05846   86 GCYK 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 155-224 3.62e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 3.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115495559  155 PQVTIQSVNVSENASCTITLVCSVEGaGGDIQYKWT--------SRDPHASESWGHPTLTISWL-PCDADlPYTCTAKN 224
Cdd:pfam13927   2 PVITVSPSSVTVREGETVTLTCEATG-SPPPTITWYkngepissGSTRSRSLSGSNSTLTISNVtRSDAG-TYTCVASN 78
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 253-354 3.72e-04

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 40.02  E-value: 3.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115495559 253 KTVLGVLGESITL-SLALLDSqhIDNVVWIFNTSIISkEWREeataNQLIEFKDPDQNTVWVSSQDYSLKIVQLKMEHAG 331
Cdd:cd05775    3 GEVYGALGGNVTLtISSLQDD--IDEIKWKKTKDKIV-EWEN----NIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSG 75

                         90       100
                 ....*....|....*....|...
gi 115495559 332 LYQAYLCSNARVASVKHINLRIY 354
Cdd:cd05775   76 TYELEITSTNGKVLSSKFTLEVL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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