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Conserved domains on  [gi|110347483|ref|NP_001036007|]
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A-kinase anchor protein 4 isoform b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKAP_110 super family cl14906
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
5-840 0e+00

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


The actual alignment was detected with superfamily member smart00807:

Pssm-ID: 449376  Cd Length: 851  Bit Score: 1078.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483     5 IDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDvstlnvedkdskgaagsrsegelnletleekeiivikdtekqdqskt 84
Cdd:smart00807   1 VDWLQSQRGVCKVDVYSPGDQQDQDWKMTEGSV----------------------------------------------- 33
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483    85 egsvCLFKQAPSDPISVLNWLLNDLQKYALGFQHA-LSPSASSCKHKVGDlEGDYSKIPSENCYSVYADqvnfdylnKGP 163
Cdd:smart00807  34 ----CLFKQASSDPVRVLSWLRRDLEKSTAGFQDArFKPGESSCGHEVGD-EGDYHKGFSVDYYNTTAD--------GRP 100
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   164 QNLRLEMAASKNTNnnqspsnpatkspsnQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLEG-GSKCLHHSM 242
Cdd:smart00807 101 QRLHFEMTHKENPN---------------QGPVASPDNECSIDEVSFYANRLTNLVIAMARKEINEKIEGsENKCVHQSL 165
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   243 YTSGDkgkTSPRSAVSKIASEMAHEAV----------------------------------ELTSSEMRGNGEDCRDG-R 287
Cdd:smart00807 166 YMGDE---PSPRKSLSKIASELVNETVsacsknaapdkapgsgdrasgssqspnlkykstlKIKESEKRGTGPDDRPGsK 242
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   288 KTFLYSEMCNKNKCGEKQQ------------MCPKDSKEFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIpACV 355
Cdd:smart00807 243 KSFFYKEVFESRNAGDAQEggrflprerkrfRCQERPDDFADSISKGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATI 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   356 VLKRVLLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGE-------K 428
Cdd:smart00807 322 VLKKVLLKHAKEVVSDLIDSFMKNLHNVTGVLMTDTDFVSAVKRNLFSHGSQKATDIMDAMLKKLYSVLFAKkvpehvrK 401
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   429 KETKSQSLAYATLKAGTNDPKCKNqsLEFSAMKAEMKGKDKCKSkaDPCCKSLTSAERVSEHILKESLTMWNNQKQG--- 505
Cdd:smart00807 402 KEDKSESYSLASMKAGMGDPKCRN--LNFATMKSEMKLREKMKS--DPCSKELTCAETLGEHIIKEGLTMWHNSQQKeaa 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   506 -------------------NQGKVTNKVCcTSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGS 566
Cdd:smart00807 478 feapntqrkpasdisfeypDPCNVSTKLC-PQPPEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGKGDAQSFEEAAGS 556
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   567 SMGYmsqsaqyekcgggqSSKSLSMKHFETRGAPGPSTCMKEnqlESQKMDMSNMVLSLIQKLLSESPFSCDELTES--- 643
Cdd:smart00807 557 TNGY--------------SAKSPSVKHEESLRSPGPSTCDKE---ESEKKDLSSVVFNFIRNLLSETIFKCDDSCESkap 619
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   644 ---DNKRCCDPRSSKAAPMAKRPE--EQCQDNAELDFISGMKQMNRQFIDQLVESVMKLCLIMAKYSNngAALAEL-EEQ 717
Cdd:smart00807 620 eqeENKLCERPRASSAAKLSERDEtgGALQGLTKMDANSGDGQMNGQMVDHLMESVMKLCLIIAKSCD--AALAELgDEK 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   718 AALVG----SGSRCGR-----------DAMMSQNYSE---------------TPGPEVIVNNQCSTTNLQ-KQLQAVLQW 766
Cdd:smart00807 698 AGDASrptsAFPRCLYeclpakgtgtaEAVLQNAYQAihnelrglsgqppegCLGPEVIVSNHNLTDTVQnKQLQAVLQW 777
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110347483   767 IAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL 840
Cdd:smart00807 778 VAASELNVPILYFAGDDEGIQEKLLQLSAKAVEKGYSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL 851
 
Name Accession Description Interval E-value
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
5-840 0e+00

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 1078.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483     5 IDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDvstlnvedkdskgaagsrsegelnletleekeiivikdtekqdqskt 84
Cdd:smart00807   1 VDWLQSQRGVCKVDVYSPGDQQDQDWKMTEGSV----------------------------------------------- 33
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483    85 egsvCLFKQAPSDPISVLNWLLNDLQKYALGFQHA-LSPSASSCKHKVGDlEGDYSKIPSENCYSVYADqvnfdylnKGP 163
Cdd:smart00807  34 ----CLFKQASSDPVRVLSWLRRDLEKSTAGFQDArFKPGESSCGHEVGD-EGDYHKGFSVDYYNTTAD--------GRP 100
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   164 QNLRLEMAASKNTNnnqspsnpatkspsnQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLEG-GSKCLHHSM 242
Cdd:smart00807 101 QRLHFEMTHKENPN---------------QGPVASPDNECSIDEVSFYANRLTNLVIAMARKEINEKIEGsENKCVHQSL 165
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   243 YTSGDkgkTSPRSAVSKIASEMAHEAV----------------------------------ELTSSEMRGNGEDCRDG-R 287
Cdd:smart00807 166 YMGDE---PSPRKSLSKIASELVNETVsacsknaapdkapgsgdrasgssqspnlkykstlKIKESEKRGTGPDDRPGsK 242
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   288 KTFLYSEMCNKNKCGEKQQ------------MCPKDSKEFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIpACV 355
Cdd:smart00807 243 KSFFYKEVFESRNAGDAQEggrflprerkrfRCQERPDDFADSISKGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATI 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   356 VLKRVLLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGE-------K 428
Cdd:smart00807 322 VLKKVLLKHAKEVVSDLIDSFMKNLHNVTGVLMTDTDFVSAVKRNLFSHGSQKATDIMDAMLKKLYSVLFAKkvpehvrK 401
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   429 KETKSQSLAYATLKAGTNDPKCKNqsLEFSAMKAEMKGKDKCKSkaDPCCKSLTSAERVSEHILKESLTMWNNQKQG--- 505
Cdd:smart00807 402 KEDKSESYSLASMKAGMGDPKCRN--LNFATMKSEMKLREKMKS--DPCSKELTCAETLGEHIIKEGLTMWHNSQQKeaa 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   506 -------------------NQGKVTNKVCcTSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGS 566
Cdd:smart00807 478 feapntqrkpasdisfeypDPCNVSTKLC-PQPPEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGKGDAQSFEEAAGS 556
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   567 SMGYmsqsaqyekcgggqSSKSLSMKHFETRGAPGPSTCMKEnqlESQKMDMSNMVLSLIQKLLSESPFSCDELTES--- 643
Cdd:smart00807 557 TNGY--------------SAKSPSVKHEESLRSPGPSTCDKE---ESEKKDLSSVVFNFIRNLLSETIFKCDDSCESkap 619
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   644 ---DNKRCCDPRSSKAAPMAKRPE--EQCQDNAELDFISGMKQMNRQFIDQLVESVMKLCLIMAKYSNngAALAEL-EEQ 717
Cdd:smart00807 620 eqeENKLCERPRASSAAKLSERDEtgGALQGLTKMDANSGDGQMNGQMVDHLMESVMKLCLIIAKSCD--AALAELgDEK 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   718 AALVG----SGSRCGR-----------DAMMSQNYSE---------------TPGPEVIVNNQCSTTNLQ-KQLQAVLQW 766
Cdd:smart00807 698 AGDASrptsAFPRCLYeclpakgtgtaEAVLQNAYQAihnelrglsgqppegCLGPEVIVSNHNLTDTVQnKQLQAVLQW 777
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110347483   767 IAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL 840
Cdd:smart00807 778 VAASELNVPILYFAGDDEGIQEKLLQLSAKAVEKGYSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL 851
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
252-840 1.27e-128

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 401.22  E-value: 1.27e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  252 SPRSAVSKIASEMAHEAV-----ELTSSEMRGNGE---------------------------DCRDGR----KTFLYSEM 295
Cdd:pfam05716   1 TPNKSLSKVASELVNETVsacskNTTPDKAPGSGDrasgssqsppnlkykstlkikestkegKGPDDKpaskKSFFYKEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  296 CNKNKCGEKQQ---MCPKDSK---------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIpACVVLKRVLLK 363
Cdd:pfam05716  81 FESRNAGDAKEggrSLPGERKmfrgqerpdDFTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKVLIK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  364 HTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGEKKET-------KSQSL 436
Cdd:pfam05716 160 HAKEVVSDLIDSFMKNLHSVTGTLMTDTDFVSAVKRSLFSHGSQKATDIMDAMLGKLYSVMFAKKPPEnirktkdKSESY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  437 AYATLKaGTNDPKCKNqsLEFSAMKAEMKGKDKCKSKADPCCKSLTSAERVSEHILKESLTMWNNQKQgNQGK------- 509
Cdd:pfam05716 240 SLVSMK-GMGDPKHRN--VNFASMKSEAKLREKMCSPASKSEKEKTCAETLGEHIIKEGLTLWHKNQQ-KECKspglqra 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  510 ---VTNKVCCTSKD-------------------EKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGSS 567
Cdd:pfam05716 316 tfaTPNRQCKPPPDspfeypldpcnfspppqcpEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAGTT 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  568 MGYMSQSAQYekcgggqsskslsmkHFETRGAPGPSTCMKEnqlESQKMDMSNMVLSLIQKLLSESPFSCDELTES---- 643
Cdd:pfam05716 396 NFPANKSPVV---------------SDESSLKSPPLGGDQE---EAEKKDLMSVFFNFIRNLLSETIFKGDHSCEPkape 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  644 -----DNKRCCDprsskaAPMAKRPEEQCQDNAELDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNngA 709
Cdd:pfam05716 458 qpikeEEGNQCE------RPLTPSPPKLCEDDEAGGAFAGLTKmvanqldghMNGQMVEHLMDSVMKLCLIIAKSCD--S 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  710 ALAELEEQAAlvGSGSR-----------C-------GRDAMMSQNY---------------SETPGPEVIVNNQCSTTNL 756
Cdd:pfam05716 530 PLAELGDEKS--GDASRptsafpdslyeClpvkgtgTAEALLQNAYqaihnelrglsgqppEGCAAPKVIVSNHNLTDTV 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  757 Q-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDW 835
Cdd:pfam05716 608 QnKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDW 687

                  ....*
gi 110347483  836 LLANL 840
Cdd:pfam05716 688 LMVNL 692
 
Name Accession Description Interval E-value
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
5-840 0e+00

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 1078.12  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483     5 IDWLHSRRGVCKVDLYSPKGQQDQDRKVICFVDvstlnvedkdskgaagsrsegelnletleekeiivikdtekqdqskt 84
Cdd:smart00807   1 VDWLQSQRGVCKVDVYSPGDQQDQDWKMTEGSV----------------------------------------------- 33
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483    85 egsvCLFKQAPSDPISVLNWLLNDLQKYALGFQHA-LSPSASSCKHKVGDlEGDYSKIPSENCYSVYADqvnfdylnKGP 163
Cdd:smart00807  34 ----CLFKQASSDPVRVLSWLRRDLEKSTAGFQDArFKPGESSCGHEVGD-EGDYHKGFSVDYYNTTAD--------GRP 100
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   164 QNLRLEMAASKNTNnnqspsnpatkspsnQRSVATPEGECSMDDLSFYVNRLSSLVIQMARKEIKDKLEG-GSKCLHHSM 242
Cdd:smart00807 101 QRLHFEMTHKENPN---------------QGPVASPDNECSIDEVSFYANRLTNLVIAMARKEINEKIEGsENKCVHQSL 165
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   243 YTSGDkgkTSPRSAVSKIASEMAHEAV----------------------------------ELTSSEMRGNGEDCRDG-R 287
Cdd:smart00807 166 YMGDE---PSPRKSLSKIASELVNETVsacsknaapdkapgsgdrasgssqspnlkykstlKIKESEKRGTGPDDRPGsK 242
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   288 KTFLYSEMCNKNKCGEKQQ------------MCPKDSKEFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIpACV 355
Cdd:smart00807 243 KSFFYKEVFESRNAGDAQEggrflprerkrfRCQERPDDFADSISKGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATI 321
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   356 VLKRVLLKHTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGE-------K 428
Cdd:smart00807 322 VLKKVLLKHAKEVVSDLIDSFMKNLHNVTGVLMTDTDFVSAVKRNLFSHGSQKATDIMDAMLKKLYSVLFAKkvpehvrK 401
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   429 KETKSQSLAYATLKAGTNDPKCKNqsLEFSAMKAEMKGKDKCKSkaDPCCKSLTSAERVSEHILKESLTMWNNQKQG--- 505
Cdd:smart00807 402 KEDKSESYSLASMKAGMGDPKCRN--LNFATMKSEMKLREKMKS--DPCSKELTCAETLGEHIIKEGLTMWHNSQQKeaa 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   506 -------------------NQGKVTNKVCcTSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGS 566
Cdd:smart00807 478 feapntqrkpasdisfeypDPCNVSTKLC-PQPPEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGKGDAQSFEEAAGS 556
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   567 SMGYmsqsaqyekcgggqSSKSLSMKHFETRGAPGPSTCMKEnqlESQKMDMSNMVLSLIQKLLSESPFSCDELTES--- 643
Cdd:smart00807 557 TNGY--------------SAKSPSVKHEESLRSPGPSTCDKE---ESEKKDLSSVVFNFIRNLLSETIFKCDDSCESkap 619
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   644 ---DNKRCCDPRSSKAAPMAKRPE--EQCQDNAELDFISGMKQMNRQFIDQLVESVMKLCLIMAKYSNngAALAEL-EEQ 717
Cdd:smart00807 620 eqeENKLCERPRASSAAKLSERDEtgGALQGLTKMDANSGDGQMNGQMVDHLMESVMKLCLIIAKSCD--AALAELgDEK 697
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483   718 AALVG----SGSRCGR-----------DAMMSQNYSE---------------TPGPEVIVNNQCSTTNLQ-KQLQAVLQW 766
Cdd:smart00807 698 AGDASrptsAFPRCLYeclpakgtgtaEAVLQNAYQAihnelrglsgqppegCLGPEVIVSNHNLTDTVQnKQLQAVLQW 777
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110347483   767 IAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL 840
Cdd:smart00807 778 VAASELNVPILYFAGDDEGIQEKLLQLSAKAVEKGYSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL 851
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
252-840 1.27e-128

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 401.22  E-value: 1.27e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  252 SPRSAVSKIASEMAHEAV-----ELTSSEMRGNGE---------------------------DCRDGR----KTFLYSEM 295
Cdd:pfam05716   1 TPNKSLSKVASELVNETVsacskNTTPDKAPGSGDrasgssqsppnlkykstlkikestkegKGPDDKpaskKSFFYKEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  296 CNKNKCGEKQQ---MCPKDSK---------EFADSISKGLMVYANQVASDMMVSVMKTLKVHSCGKPIpACVVLKRVLLK 363
Cdd:pfam05716  81 FESRNAGDAKEggrSLPGERKmfrgqerpdDFTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKDTTI-ATILLKKVLIK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  364 HTKEIVSDLIDSCMKNLHNITGVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGEKKET-------KSQSL 436
Cdd:pfam05716 160 HAKEVVSDLIDSFMKNLHSVTGTLMTDTDFVSAVKRSLFSHGSQKATDIMDAMLGKLYSVMFAKKPPEnirktkdKSESY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  437 AYATLKaGTNDPKCKNqsLEFSAMKAEMKGKDKCKSKADPCCKSLTSAERVSEHILKESLTMWNNQKQgNQGK------- 509
Cdd:pfam05716 240 SLVSMK-GMGDPKHRN--VNFASMKSEAKLREKMCSPASKSEKEKTCAETLGEHIIKEGLTLWHKNQQ-KECKspglqra 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  510 ---VTNKVCCTSKD-------------------EKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPCEEECPGSS 567
Cdd:pfam05716 316 tfaTPNRQCKPPPDspfeypldpcnfspppqcpEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAGTT 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  568 MGYMSQSAQYekcgggqsskslsmkHFETRGAPGPSTCMKEnqlESQKMDMSNMVLSLIQKLLSESPFSCDELTES---- 643
Cdd:pfam05716 396 NFPANKSPVV---------------SDESSLKSPPLGGDQE---EAEKKDLMSVFFNFIRNLLSETIFKGDHSCEPkape 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  644 -----DNKRCCDprsskaAPMAKRPEEQCQDNAELDFISGMKQ---------MNRQFIDQLVESVMKLCLIMAKYSNngA 709
Cdd:pfam05716 458 qpikeEEGNQCE------RPLTPSPPKLCEDDEAGGAFAGLTKmvanqldghMNGQMVEHLMDSVMKLCLIIAKSCD--S 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  710 ALAELEEQAAlvGSGSR-----------C-------GRDAMMSQNY---------------SETPGPEVIVNNQCSTTNL 756
Cdd:pfam05716 530 PLAELGDEKS--GDASRptsafpdslyeClpvkgtgTAEALLQNAYqaihnelrglsgqppEGCAAPKVIVSNHNLTDTV 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347483  757 Q-KQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLPEVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDW 835
Cdd:pfam05716 608 QnKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDW 687

                  ....*
gi 110347483  836 LLANL 840
Cdd:pfam05716 688 LMVNL 692
RII_binding_1 pfam10522
RII binding domain; This domain is found is a wide variety of AKAPs (A kinase anchoring ...
206-224 5.54e-03

RII binding domain; This domain is found is a wide variety of AKAPs (A kinase anchoring proteins). The domain is also found on micro-tubule-associated proteins.


Pssm-ID: 371112  Cd Length: 19  Bit Score: 34.80  E-value: 5.54e-03
                          10
                  ....*....|....*....
gi 110347483  206 DDLSFYVNRLSSLVIQMAR 224
Cdd:pfam10522   1 DEIEEAANRIVSLVIQEAV 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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