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Conserved domains on  [gi|57525896|ref|NP_001003553|]
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COMM domain-containing protein 5 [Danio rerio]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 96-205 1.27e-61

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 187.27  E-value: 1.27e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896  96 ALRISEELLADIVVVVFGNRQTSMNVGDKHQGPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGHTHQFEVPV 175
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 57525896 176 AKFQELRYNVSLILKEMNDIEKRSILKIQD 205
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 96-205 1.27e-61

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 187.27  E-value: 1.27e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896  96 ALRISEELLADIVVVVFGNRQTSMNVGDKHQGPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGHTHQFEVPV 175
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 57525896 176 AKFQELRYNVSLILKEMNDIEKRSILKIQD 205
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 129-188 2.02e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.88  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57525896   129 SLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGH----THQFEVPVAKFQELRYNVSLI 188
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 96-205 1.27e-61

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 187.27  E-value: 1.27e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896  96 ALRISEELLADIVVVVFGNRQTSMNVGDKHQGPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGHTHQFEVPV 175
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 57525896 176 AKFQELRYNVSLILKEMNDIEKRSILKIQD 205
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 129-188 2.02e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.88  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57525896   129 SLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGH----THQFEVPVAKFQELRYNVSLI 188
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDgsseEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 126-205 1.37e-13

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 63.48  E-value: 1.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896 126 QGPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGHTHQFEvpvakfqELRYNVSLILKEmNDIEKRSILKIQD 205
Cdd:cd04748  16 QSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSE-------KICFEMTKEELQ-NFLNKLKKIKAQL 87
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 60-166 4.81e-07

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 47.69  E-value: 4.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896  60 ISEESLNHVMAGLYALLKEAlCQPSLKQEVFSDDLRALRISEELLADIVVVVFGNRQTSMNVgDKHQGPSLAKIEDLKWR 139
Cdd:cd04750  28 VEVETVQHGVEALVYLLIES-TKLKLSERDFQDSIEFLGFSDDLNEILLQLYESNRKEIRNI-LKELSPDLPHYHNLEWR 105

                        90       100
                ....*....|....*....|....*..
gi 57525896 140 VDVAISTSSLSRALQPSILMQMKLSDG 166
Cdd:cd04750 106 LDVQIASRSLRSQVKPVITMKLHLEDE 132
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 102-165 1.77e-06

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 45.25  E-value: 1.77e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57525896 102 ELLADIVVvvfGNRQTSMNVGDKHQgPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSD 165
Cdd:cd04757   7 NLLTKIIL---ENRDKWRSEASENQ-ISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQE 66
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 112-193 4.97e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 36.25  E-value: 4.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525896 112 FGNRQTSMNVGDKHQGPSLAKIEDLKWRVDVAISTSSLSRALQPSILMQMKLSDGHT-----HQFEVPVAKFQELRYNVS 186
Cdd:cd04752  86 YEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTgeitpHPFSVSADKFRVLLAELK 165


                ....*..
gi 57525896 187 LILKEMN 193
Cdd:cd04752 166 QAQTLME 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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