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Conserved domains on  [gi|11067751|ref|NP_000596|]
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interferon alpha-2 precursor [Homo sapiens]

Protein Classification

alpha/beta interferon family protein( domain architecture ID 10444641)

alpha/beta interferon family protein produces antiviral and antiproliferative response in cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
26-184 9.55e-91

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


:

Pssm-ID: 459689  Cd Length: 160  Bit Score: 262.13  E-value: 9.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751    26 LPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLL 104
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILsGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751   105 DKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESL 184
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTERL 160
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
26-184 9.55e-91

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 262.13  E-value: 9.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751    26 LPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLL 104
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILsGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751   105 DKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESL 184
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTERL 160
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
26-177 7.21e-84

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 244.55  E-value: 7.21e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751  26 LPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLL 104
Cdd:cd00095   1 LRHQHRLFNRRCLKLLRQMRRLPPQSCLKDRADFGFPQELLqGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLL 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11067751 105 DKFYTELYQQLNDLEACVIQGVGVTETPlMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLS 177
Cdd:cd00095  81 ESLLNELHQQLNHLETCLEQEMGEEETP-GPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
58-174 1.60e-59

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 181.36  E-value: 1.60e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751     58 DFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMkE 136
Cdd:smart00076   1 DFAFPEEILdGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLT-R 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 11067751    137 DSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSF 174
Cdd:smart00076  80 NTHLALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
26-184 9.55e-91

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 262.13  E-value: 9.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751    26 LPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLL 104
Cdd:pfam00143   1 LPQQLRLSNRENLKLLNQMRRSSPQSCLKDRKDFKFPQEILsGSQLQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751   105 DKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESL 184
Cdd:pfam00143  81 EQLLNGLHQQLEDLETCLGEEMEEEESPLGNEDSRLALKKYFQRIHLYLKEKEYSSCAWEVVRVEIRRCFSFINRLTERL 160
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
26-177 7.21e-84

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 244.55  E-value: 7.21e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751  26 LPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLL 104
Cdd:cd00095   1 LRHQHRLFNRRCLKLLRQMRRLPPQSCLKDRADFGFPQELLqGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLL 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11067751 105 DKFYTELYQQLNDLEACVIQGVGVTETPlMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLS 177
Cdd:cd00095  81 ESLLNELHQQLNHLETCLEQEMGEEETP-GPRNTHLHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIMRNFSSI 152
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
58-174 1.60e-59

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 181.36  E-value: 1.60e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11067751     58 DFGFPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMkE 136
Cdd:smart00076   1 DFAFPEEILdGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQQLNHLEACLKQQMGEEETPLT-R 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 11067751    137 DSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSF 174
Cdd:smart00076  80 NTHLALKKYFQRIQLYLKEKKYSPCAWEVVRVEIRRNF 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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