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Conserved domains on  [gi|1796484856|gb|KAF0873664|]
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CCG5 protein, partial [Crocuta crocuta]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
40-130 1.01e-10

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam00822:

Pssm-ID: 473919  Cd Length: 162  Bit Score: 57.77  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484856  40 LVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDTEtyfNYKYGWSFAFAAI 119
Cdd:pfam00822  74 ILSIILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR---KYSFGYSFILGWV 150

                          90
                  ....*....|.
gi 1796484856 120 SFLLTESAGVM 130
Cdd:pfam00822 151 AFALAFIGGVL 161
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
40-130 1.01e-10

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 57.77  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484856  40 LVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDTEtyfNYKYGWSFAFAAI 119
Cdd:pfam00822  74 ILSIILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR---KYSFGYSFILGWV 150

                          90
                  ....*....|.
gi 1796484856 120 SFLLTESAGVM 130
Cdd:pfam00822 151 AFALAFIGGVL 161
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 37-92 5.81e-03

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 36.41  E-value: 5.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796484856  37 PFPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIffilsgLSLVVGLV------LYISSIN 92
Cdd:NF038305   48 IVPLVGLALLFIGYWIDSGARSRKEGLDLRFLSWI------LSLLLGLLflllipLHLNNTR 103
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
40-130 1.01e-10

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 57.77  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484856  40 LVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDTEtyfNYKYGWSFAFAAI 119
Cdd:pfam00822  74 ILSIILGIISLIVFFFQLFTMRKGGRFKLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNR---KYSFGYSFILGWV 150

                          90
                  ....*....|.
gi 1796484856 120 SFLLTESAGVM 130
Cdd:pfam00822 151 AFALAFIGGVL 161
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 8-130 1.14e-05

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 44.34  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484856   8 FTIEYVMPVNTQLTSEstvnvLKMIRSATPFPLVSLFFMFIGFILSNIGHIRPHRTILAFVsGIFFILSGLSLVVGLVLY 87
Cdd:pfam13903  68 FPTFEEEIVSFSVTSL-----PGLTRFVQAFAILSLVLIVCGVVCGLLALPKQSVFLLLAA-GILFLLSGVLGLLGVIVF 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1796484856  88 ISS--INDEMLNRTKDTETYFN--YKYGWSFAFAAISFLLTESAGVM 130
Cdd:pfam13903 142 GQSvkLVFEEYFRQWMPEHQNNvrISFGWSFALAWAGVVLSLLAGLL 188
HpsJ_fam NF038305
HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the ...
 37-92 5.81e-03

HpsJ family protein; HpsJ (hormogornium polysaccharide J) is thought to be involved in the biosynthesis or secretion of an extracellular polysaccharide shared by many Cyanobacteria.


Pssm-ID: 468465 [Multi-domain]  Cd Length: 230  Bit Score: 36.41  E-value: 5.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796484856  37 PFPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIffilsgLSLVVGLV------LYISSIN 92
Cdd:NF038305   48 IVPLVGLALLFIGYWIDSGARSRKEGLDLRFLSWI------LSLLLGLLflllipLHLNNTR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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