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Conserved domains on  [gi|1796484851|gb|KAF0873659|]
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CY561 protein, partial [Crocuta crocuta]

Protein Classification

Cyt_b561_CYB561 domain-containing protein( domain architecture ID 10171795)

Cyt_b561_CYB561 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 45-186 5.71e-79

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176493  Cd Length: 143  Bit Score: 234.32  E-value: 5.71e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  45 WEGALQFNVHPLCMVIGLIFLQGAALLVYRVFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSW 124
Cdd:cd08763     1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796484851 125 CGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLF 186
Cdd:cd08763    81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
 
Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 45-186 5.71e-79

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 234.32  E-value: 5.71e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  45 WEGALQFNVHPLCMVIGLIFLQGAALLVYRVFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSW 124
Cdd:cd08763     1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796484851 125 CGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLF 186
Cdd:cd08763    81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 53-187 3.77e-51

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 163.16  E-value: 3.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  53 VHPLCMVIGLIFLQGAALLVYRV--FRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTF 130
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1796484851 131 VLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLFK 187
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 53-180 2.02e-40

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 135.82  E-value: 2.02e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851   53 VHPLCMVIGLIFLQGAALLVYR-VFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTFV 131
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1796484851  132 LYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGL 180
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02810 PLN02810
carbon-monoxide oxygenase
 12-186 9.86e-36

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 126.86  E-value: 9.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  12 RALPY-YVAFSqlLGLTAVATTGAWLGLYRGGIAWEGA---LQFNVHPLCMVIGLIFLQGAALLVYRVFRNEtKRTTKVL 87
Cdd:PLN02810    6 NALPLtFVAHA--LAVIGAIMVLVWSIYYRGGLAWEATnknLIFNLHPVLMLIGLIIIGGEAIMSYKSLPLK-KEVKKLI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  88 HGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGAT 167
Cdd:PLN02810   83 HLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLF 162

                         170
                  ....*....|....*....
gi 1796484851 168 IFLLAVGTALLGLKEALLF 186
Cdd:PLN02810  163 VYILAVGNAALGFLEKLTF 181
 
Name Accession Description Interval E-value
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 45-186 5.71e-79

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 234.32  E-value: 5.71e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  45 WEGALQFNVHPLCMVIGLIFLQGAALLVYRVFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSW 124
Cdd:cd08763     1 WSGPLQFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSW 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796484851 125 CGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLF 186
Cdd:cd08763    81 CGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 29-239 1.43e-67

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 207.95  E-value: 1.43e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  29 VATTGAWLGLYRGGIAWEGA-LQFNVHPLCMVIGLIFLQGAALLVYRVFRNETKRTTKVLHGLLHVFAFIIALVGLVAVF 107
Cdd:cd08764     1 VVLVGIWLGKFRGGFSWTGPgLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851 108 DYH--RGKGYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALL 185
Cdd:cd08764    81 DSHnlAKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKAF 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1796484851 186 FKLGaKYSTFEPEGVLGNVLGLLLAGFGVTVLYILTRTDWKR-PPQAEEQALSMD 239
Cdd:cd08764   161 FSLN-KYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPDYKRiELPEEEELLIQN 214
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 53-187 3.77e-51

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 163.16  E-value: 3.77e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  53 VHPLCMVIGLIFLQGAALLVYRV--FRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTF 130
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVnsTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1796484851 131 VLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLFK 187
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 50-180 4.19e-48

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 155.52  E-value: 4.19e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  50 QFNVHPLCMVIGLIFLQGAALLVYRVFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILT 129
Cdd:cd08554     1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1796484851 130 FVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGL 180
Cdd:cd08554    81 VLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 51-186 2.39e-46

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 151.31  E-value: 2.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  51 FNVHPLCMVIGLIFLQGAALLVYRVFRNeTKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTF 130
Cdd:cd08766     8 FNVHPVLMVIGFIFLAGEAILAYKTVPG-SREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLGIGTI 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1796484851 131 VLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLF 186
Cdd:cd08766    87 SLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTF 142
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 19-188 2.18e-43

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 145.01  E-value: 2.18e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  19 AFSQLLGLTAVATTGAWLGLYRGGIAWEGALQ-FNVHPLCMVIGLIFLQGAALLVYRVFRN--ETKRTTKVLHGLLHVFA 95
Cdd:cd08762     2 LLLGILGIACVVLVVHWNQMWRGGFAWDGSSKnFNWHPVLMVTGMVVLYGNAALVYRIPLTwgGPKLPWKLLHAGLLLLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  96 FIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGT 175
Cdd:cd08762    82 FILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLSIAS 161

                         170
                  ....*....|...
gi 1796484851 176 ALLGLKEALLFKL 188
Cdd:cd08762   162 CISGINEKLFFSL 174
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 53-180 2.02e-40

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 135.82  E-value: 2.02e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851   53 VHPLCMVIGLIFLQGAALLVYR-VFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTFV 131
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1796484851  132 LYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGL 180
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 42-188 1.97e-37

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 128.86  E-value: 1.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  42 GIAWEG-ALQFNVHPLCMVIGLIFLQGAALLVYRV--FRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYADL 118
Cdd:cd08765     2 GLGWDGgAAEFNWHPVLMVIGFIFIQGIAIIVYRLpwTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851 119 YSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLKEALLFKL 188
Cdd:cd08765    82 YSLHSWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIFSL 151
PLN02810 PLN02810
carbon-monoxide oxygenase
 12-186 9.86e-36

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 126.86  E-value: 9.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  12 RALPY-YVAFSqlLGLTAVATTGAWLGLYRGGIAWEGA---LQFNVHPLCMVIGLIFLQGAALLVYRVFRNEtKRTTKVL 87
Cdd:PLN02810    6 NALPLtFVAHA--LAVIGAIMVLVWSIYYRGGLAWEATnknLIFNLHPVLMLIGLIIIGGEAIMSYKSLPLK-KEVKKLI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  88 HGLLHVFAFIIALVGLVAVFDYHRGKGYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGAT 167
Cdd:PLN02810   83 HLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFGLF 162

                         170
                  ....*....|....*....
gi 1796484851 168 IFLLAVGTALLGLKEALLF 186
Cdd:PLN02810  163 VYILAVGNAALGFLEKLTF 181
PLN02680 PLN02680
carbon-monoxide oxygenase
 22-194 3.78e-35

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 125.30  E-value: 3.78e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  22 QLLGLTAVATTGAWLGLYRGGIAWEGA---LQFNVHPLCMVIGLIFLQGAALLVYRVFRNeTKRTTKVLHGLLHVFAFII 98
Cdd:PLN02680   15 RLLGVIVAALVLTWTVHYRGGLALSSDnkdLIFNVHPVLMVIGLVLLNGEAMLAYKTVPG-TKNLKKLVHLTLQFLAFCL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  99 ALVGLVAVFDYHRGKGYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALL 178
Cdd:PLN02680   94 SLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFGIYIYALAVATATT 173

                         170       180
                  ....*....|....*....|
gi 1796484851 179 GLKEALLF----KLGAKYST 194
Cdd:PLN02680  174 GILEKATFlqsnKVISRYST 193
PLN02351 PLN02351
cytochromes b561 family protein
 9-186 4.00e-21

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 88.81  E-value: 4.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851   9 ATPRALPYYVAFSQLLGLTAVATTGAWLGLYRGGIAWEGALQFNV-----HPLCMVIGLIFLQGAALLVYRVFRNeTKRT 83
Cdd:PLN02351    4 VDSSSLLPLLLFARLSGLVVAVLVLYWALFFKSSFLPQSTSQEDLvyavlHPLLMVIGFILISGEAILVHRWLPG-SRKT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  84 TKVLHGLLHVFAFIIALVGLVAVFDYHRGKgYADLYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLRSRYRPQHIF 163
Cdd:PLN02351   83 KKSVHLWLQGLALASGVFGIWTKFHGQDGI-VANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVF 161

                         170       180
                  ....*....|....*....|...
gi 1796484851 164 FGATIFLLAVGTALLGLKEALLF 186
Cdd:PLN02351  162 LGLYTYGLAVATAETGLLEKLTF 184
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 41-182 9.43e-14

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 67.31  E-value: 9.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  41 GGIAWEGALQFNVHPLCMVIGLIFLQGAALLVYR---VFRNETKRTTKVLHGLLHVFAFIIALVGLVAVFDYHRGKGYAD 117
Cdd:cd08761    11 LYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQptsSLTKLARKTKVRLHWILQLLALLCILAGLVAIYYNKERNGKPH 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1796484851 118 LYSLHSWCGILTFVLYFVQWLVGFSFFLFPGASFSLR--SRYRPQHIFFGATIFLLAVGTALLGLKE 182
Cdd:cd08761    91 FTSWHGILGLVTVILIVLQALGGLALLYPPGLRRGESkaKKLKKYHRLSGYVAYLLGLATLVLGLET 157
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 32-181 2.02e-09

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 55.43  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851  32 TGAWLGLYRGGIAWEGALQFNVHPLCMVIGLIFLQGAALLVYRVFRNeTKRTTKVLHGLLHVFAFIIALVGLVAVFdYHR 111
Cdd:cd08760    17 GGSPFLLPNGSSVGSSDTLIKAHGVLMAIAWGILMPIGALLARYFLL-GDPVWFYLHAGLQLLAVLLAIAGFVLGI-VLV 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796484851 112 GKGYADLYSLHSWCGILTFVLYFVQWLVGFsffLFPGASFSLRSRYRPQHIFFGATIFLLAVGTALLGLK 181
Cdd:cd08760    95 QGGGGSLNNAHAILGIIVLALAILQPLLGL---LRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLD 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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