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Conserved domains on  [gi|148707183|gb|EDL39130|]
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myelin protein zero, isoform CRA_b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myelin-PO_C super family cl11197
Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin ...
 1-52 6.13e-12

Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65.


The actual alignment was detected with superfamily member pfam10570:

Pssm-ID: 287532  Cd Length: 65  Bit Score: 53.90  E-value: 6.13e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148707183   1 MEKGRFHKSSKDSSKRGRQTPVLYAMLDHSRSTKAASEKKSKGLGESRKDKK 52
Cdd:pfam10570 14 VEKGKLHKPAKDSSKRGRQTPILYAMLDQLRKGKSASEKKSKGTGESRKDKK 65
 
Name Accession Description Interval E-value
Myelin-PO_C pfam10570
Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin ...
 1-52 6.13e-12

Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65.


Pssm-ID: 287532  Cd Length: 65  Bit Score: 53.90  E-value: 6.13e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148707183   1 MEKGRFHKSSKDSSKRGRQTPVLYAMLDHSRSTKAASEKKSKGLGESRKDKK 52
Cdd:pfam10570 14 VEKGKLHKPAKDSSKRGRQTPILYAMLDQLRKGKSASEKKSKGTGESRKDKK 65
 
Name Accession Description Interval E-value
Myelin-PO_C pfam10570
Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin ...
 1-52 6.13e-12

Myelin-PO cytoplasmic C-term p65 binding region; Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65.


Pssm-ID: 287532  Cd Length: 65  Bit Score: 53.90  E-value: 6.13e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148707183   1 MEKGRFHKSSKDSSKRGRQTPVLYAMLDHSRSTKAASEKKSKGLGESRKDKK 52
Cdd:pfam10570 14 VEKGKLHKPAKDSSKRGRQTPILYAMLDQLRKGKSASEKKSKGTGESRKDKK 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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