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Conserved domains on  [gi|148700671|gb|EDL32618|]
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zinc finger protein 184 (Kruppel-like), isoform CRA_a [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-558 5.48e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 5.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671  87 SNLSVSSSFITQTEVaLDQPSTKTRAKQNSHPvkkeKLCKCNECGKAFTYCSALIRHQRTHTGEKPYKCN--ECNKAFSR 164
Cdd:COG5048    1 ATLTSSQSSSSNNSV-LSSTPKSTLKSLSNAP----RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 165 SENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGE-KPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCTECG 243
Cdd:COG5048   76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 244 KSFSqrgHFMEHQKIHtGEKPFKCEECEKTFTRSTHLtqHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYEC 323
Cdd:COG5048  156 SSSV---NTPQSNSLH-PPLPANSLSKDPSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 324 NECGKAFSQHSNLTQHQKTHTGEKPydcaecgkafSYWSSLAQHLKIHTGEKPYKcsdcgkafSYCSSLTQHRRIHTREK 403
Cdd:COG5048  230 TTNSQLSPKSLLSQSPSSLSSSDSS----------SSASESPRSSLPTASSQSSS--------PNESDSSSEKGFSLPIK 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 404 pfeCSECGKAFSYLSNLNQHQKT--HTQE--KAYECKE--CGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSL- 476
Cdd:COG5048  292 ---SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 477 ------IQHKKIHTGERPYKC--NECGRAFNQKIHLTQHKRIHTGAKPYAC--PKCGKTFRHCSSLAQHQKTHTEEKPYQ 546
Cdd:COG5048  369 neppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        490
                 ....*....|..
gi 148700671 547 CNKCEKTFSQNS 558
Cdd:COG5048  449 CSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 5.27e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 148700671  559 RLTQHQRIHTGEKPYKCSECDKCFT 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-558 5.48e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 5.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671  87 SNLSVSSSFITQTEVaLDQPSTKTRAKQNSHPvkkeKLCKCNECGKAFTYCSALIRHQRTHTGEKPYKCN--ECNKAFSR 164
Cdd:COG5048    1 ATLTSSQSSSSNNSV-LSSTPKSTLKSLSNAP----RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 165 SENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGE-KPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCTECG 243
Cdd:COG5048   76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 244 KSFSqrgHFMEHQKIHtGEKPFKCEECEKTFTRSTHLtqHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYEC 323
Cdd:COG5048  156 SSSV---NTPQSNSLH-PPLPANSLSKDPSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 324 NECGKAFSQHSNLTQHQKTHTGEKPydcaecgkafSYWSSLAQHLKIHTGEKPYKcsdcgkafSYCSSLTQHRRIHTREK 403
Cdd:COG5048  230 TTNSQLSPKSLLSQSPSSLSSSDSS----------SSASESPRSSLPTASSQSSS--------PNESDSSSEKGFSLPIK 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 404 pfeCSECGKAFSYLSNLNQHQKT--HTQE--KAYECKE--CGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSL- 476
Cdd:COG5048  292 ---SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 477 ------IQHKKIHTGERPYKC--NECGRAFNQKIHLTQHKRIHTGAKPYAC--PKCGKTFRHCSSLAQHQKTHTEEKPYQ 546
Cdd:COG5048  369 neppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        490
                 ....*....|..
gi 148700671 547 CNKCEKTFSQNS 558
Cdd:COG5048  449 CSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-220 9.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 148700671  195 SLTQHQRIHTGEKPYKCDECGKAFSQ 220
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 5.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 148700671  559 RLTQHQRIHTGEKPYKCSECDKCFT 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 263-303 2.57e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148700671 263 KPFkCEECEKTFTRSTHLTQHQKihtgEKTYKCNECGKAFN 303
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLY 36
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
87-558 5.48e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 5.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671  87 SNLSVSSSFITQTEVaLDQPSTKTRAKQNSHPvkkeKLCKCNECGKAFTYCSALIRHQRTHTGEKPYKCN--ECNKAFSR 164
Cdd:COG5048    1 ATLTSSQSSSSNNSV-LSSTPKSTLKSLSNAP----RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 165 SENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGE-KPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCTECG 243
Cdd:COG5048   76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 244 KSFSqrgHFMEHQKIHtGEKPFKCEECEKTFTRSTHLtqHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYEC 323
Cdd:COG5048  156 SSSV---NTPQSNSLH-PPLPANSLSKDPSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 324 NECGKAFSQHSNLTQHQKTHTGEKPydcaecgkafSYWSSLAQHLKIHTGEKPYKcsdcgkafSYCSSLTQHRRIHTREK 403
Cdd:COG5048  230 TTNSQLSPKSLLSQSPSSLSSSDSS----------SSASESPRSSLPTASSQSSS--------PNESDSSSEKGFSLPIK 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 404 pfeCSECGKAFSYLSNLNQHQKT--HTQE--KAYECKE--CGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSL- 476
Cdd:COG5048  292 ---SKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 477 ------IQHKKIHTGERPYKC--NECGRAFNQKIHLTQHKRIHTGAKPYAC--PKCGKTFRHCSSLAQHQKTHTEEKPYQ 546
Cdd:COG5048  369 neppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        490
                 ....*....|..
gi 148700671 547 CNKCEKTFSQNS 558
Cdd:COG5048  449 CSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-612 1.91e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 207 KPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCT--ECGKSFSQRGHFMEHQKIHTGEKPFKCEECEKTFTRST-HLTQH 283
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAsSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 284 QKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHT---GEKPYECNECGKAFSQhSNLTQHQKTHTgekpydcAECGKAFSY 360
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQ-SNSLHPPLPAN-------SLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 361 WSSLAQHLKIHTGEKPYKCSDCGKAFSYcSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECG- 439
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSI-PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 440 -----KAFIRSSSLAKHERIHTG-EKPYQCHECGKTFSYGSSLIQHK--KIHTGE--RPYKCNE--CGRAFNQKIHLTQH 507
Cdd:COG5048  263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 508 KRIHTGAKPYACP--KCGKTFRHCS-----SLAQHQKTHTEEKPYQC--NKCEKTFSQNSRLTQHQRIHTGEKP--YKCS 576
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 148700671 577 ECDKCFTGSVHLTEHRSTHTGEKPYNSECPQTFSQS 612
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-639 2.27e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 263 KPFKCEECEKTFTRSTHLTQHQKIHTGEKTYKCN--ECGKAFNGPSTFIRHHMIHTGEKPYECN-ECGKAFSQHSNLTQH 339
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 340 QKTHTGEKPYDCAECGKAFSYWSSLAQHLKIHTGEKPYKCSDCGKAF----------------------SYCSSLTQHRR 397
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 398 IHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLI 477
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 478 QHKKIHTGER-------PYKCNECGRAFNQKIHLTQHKR--IHTG--AKPYACPK--CGKTFRHCSSLAQHQKTHTEEKP 544
Cdd:COG5048  272 SSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 545 YQC--NKCEKTFSQ--NSRLTQHQRIHTGEKPYKCSECD-----KCFTGSVHLTEHRSTHTGEKPYN---SECPQTFSQS 612
Cdd:COG5048  352 AKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYNcknPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|....*..
gi 148700671 613 TYLTQHQKIHSGEKLLGCEDCEKAFQC 639
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-312 1.87e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671  70 MLPREVQITEKTAPTCESNLSVSSSFITQTE---VALDQPSTKTRAKQNSHPVKKEKL----CKCNECGKAFTYCSALIR 142
Cdd:COG5048  228 PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASespRSSLPTASSQSSSPNESDSSSEKGfslpIKSKQCNISFSRSSPLTR 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 143 HQRT--HTGE--KPYKCNE--CNKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQhqrihtgekpykcdecgk 216
Cdd:COG5048  308 HLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNN------------------ 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 217 afSQRTHLVQHQRIHTGEKPYTCTECGKSFSQRGHFMEHQKIHT---GEKPFKCEECEKTFTRSTHLTQHQKIHTgEKTY 293
Cdd:COG5048  370 --EPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        250
                 ....*....|....*....
gi 148700671 294 KCNECGKAFNGPSTFIRHH 312
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
195-220 9.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 9.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 148700671  195 SLTQHQRIHTGEKPYKCDECGKAFSQ 220
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-248 1.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  223 HLVQHQRIHTGEKPYTCTECGKSFSQ 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-472 2.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  447 SLAKHERIHTGEKPYQCHECGKTFSY 472
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
139-164 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  139 ALIRHQRTHTGEKPYKCNECNKAFSR 164
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-388 3.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  363 SLAQHLKIHTGEKPYKCSDCGKAFSY 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-583 5.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.27e-04
                          10        20
                  ....*....|....*....|....*
gi 148700671  559 RLTQHQRIHTGEKPYKCSECDKCFT 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-276 5.64e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.64e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  251 HFMEHQKIHTGEKPFKCEECEKTFTR 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 6.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 148700671  335 NLTQHQKTHTGEKPYDCAECGKAFSY 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-500 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 148700671  475 SLIQHKKIHTGERPYKCNECGRAFNQ 500
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 149-227 1.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 149 GEKPYKCN--ECNKAFsRSENLINHQRIHtgdkpykcDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQ 226
Cdd:COG5189  346 DGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 148700671 227 H 227
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-444 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 148700671  419 NLNQHQKTHTQEKAYECKECGKAFIR 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 261-344 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148700671 261 GEKPFKCE--ECEKTFTRSTHLTQHQKI-HTGEKTYKcnecgkafnGPSTfIRHHMIHTGEKPYECNECGKAFSQHSNLT 337
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE---------NPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 148700671 338 QHQKTHT 344
Cdd:COG5189  416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*
gi 148700671  279 HLTQHQKIHTGEKTYKCNECGKAFN 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-190 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....
gi 148700671  167 NLINHQRIHTGDKPYKCDQCGKGF 190
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-528 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 148700671  503 HLTQHKRIHTGAKPYACPKCGKTFRH 528
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-416 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*.
gi 148700671  391 SLTQHRRIHTREKPFECSECGKAFSY 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 263-303 2.57e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148700671 263 KPFkCEECEKTFTRSTHLTQHQKihtgEKTYKCNECGKAFN 303
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLY 36
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 321-343 3.07e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.07e-03
                          10        20
                  ....*....|....*....|...
gi 148700671  321 YECNECGKAFSQHSNLTQHQKTH 343
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-556 3.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 148700671  531 SLAQHQKTHTEEKPYQCNKCEKTFSQ 556
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 153-175 4.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.20e-03
                          10        20
                  ....*....|....*....|...
gi 148700671  153 YKCNECNKAFSRSENLINHQRIH 175
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 4.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.31e-03
                          10        20
                  ....*....|....*....|...
gi 148700671  310 RHHMIHTGEKPYECNECGKAFSQ 332
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 459-509 7.49e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148700671 459 KPYqCHECGKTFSYGSSLIQHKKIHTgerpYKCNECGRAFNQ----KIHLTQ-HKR 509
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTagglAVHCLQvHKE 51
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 209-231 8.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.35e-03
                          10        20
                  ....*....|....*....|...
gi 148700671  209 YKCDECGKAFSQRTHLVQHQRIH 231
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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