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Conserved domains on  [gi|119605307|gb|EAW84901|]
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zinc finger protein 429, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 1.04e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.29  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048  194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048  269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        410       420
                 ....*....|....*....|..
gi 119605307 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCS 450
KRAB super family cl42959
krueppel associated box;
1-31 1.67e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.67e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119605307     1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 1.04e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.29  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048  194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048  269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        410       420
                 ....*....|....*....|..
gi 119605307 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCS 450
KRAB smart00349
krueppel associated box;
1-31 1.67e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.67e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119605307     1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 4.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 119605307  435 HLTSHRRIHTGEKPYKCEECGKAFKQ 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 1.04e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.29  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048  194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048  269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        410       420
                 ....*....|....*....|..
gi 119605307 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-574 2.40e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 2.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 251 KPYKCDECGKTFSISSTFTKHKIIHTEEKPYKC--KECGKAFNRSSTLTSHKRIHTGEKPYKCE-ECGKAFNWSSTLTKH 327
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 328 KVIHTGEKPYKCEECGKAFNQSSRLTRHKKIHTGEEPYKFEKCGRVFTCSStltQDKKIHtgeKPYNCEECGKVFTYSST 407
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLH---PPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 408 LTRHKRIHTEEKPYKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNSHKKIHSGEKPYKCEECGKAFI 487
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 488 LSSRLTQHKKIHTGE-------KPYKCEECGKAFNRSSRLTQHK--KIHTGE--KPYKC--KQCDKAFTHSSNLSSHKKI 554
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340
                 ....*....|....*....|..
gi 119605307 555 HSGEKPYKC--EECGKAFNRSS 574
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLL 367
KRAB smart00349
krueppel associated box;
1-31 1.67e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.67e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119605307     1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-591 7.22e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 7.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 279 KPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKC--EECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRltRHK 356
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 357 KIHTGEEPYKFEKCgrvFTCSSTLTQDKKIHtgEKPYNCEECGKVFTYSSTLTRHKRIHTEEKPYKC---NECGKAFNRS 433
Cdd:COG5048  110 LSSSSSNSNDNNLL---SSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLpanSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 434 SHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNSHKKIHSgEKPYKCEECGKAFILSSRLTQHKKIHTGEKPYKCEECGKA 513
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 514 FNRSSRLTQHKKIHTGE-------KPYKCKQCDKAFTHSSNLSSHK--KIHSGE--KPYKCEE--CGKAFNRSSRLTQHK 580
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|.
gi 119605307 581 KIHTREKPYKC 591
Cdd:COG5048  344 LLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 530-612 7.29e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 530 EKPYKCKQCDKAFTHSSNL----SSHKKIHSGEKPYKCE--ECGKAFNRSSRLTQHKKI-HTREK--PYKCEECAKAFTR 600
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERnidtPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKlhENPSPEKMNIFSA 394

                         90
                 ....*....|..
gi 119605307 601 REKPYKCVECGK 612
Cdd:COG5189  395 KDKPYRCEVCDK 406
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-581 1.71e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 501 GEKPYKCE--ECGKAFNRSSRLTQHKKiHtgekpykcKQCDKAFTHSSNLSSHKKIHSGEKPYKCEECGKAFNRSSRLTQ 578
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 119605307 579 HKK 581
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-497 3.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 405 SSTLTRHKRIHTEEKPYKCNECGKAFNRSSHL---TSHRRIHT-GEKPYKCE--ECGKAFKQSSNLNSHKK--------- 469
Cdd:COG5189  302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklh 381

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 119605307 470 ----------IHSGEKPYKCEECGKAFILSSRLTQHKK 497
Cdd:COG5189  382 enpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 389-472 4.07e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 389 GEKPYNCE--ECGKVFTYSSTLTRHKrihteekpyKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNS 466
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 119605307 467 HKKiHS 472
Cdd:COG5189  417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 4.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 119605307  435 HLTSHRRIHTGEKPYKCEECGKAFKQ 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-544 7.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 119605307  519 RLTQHKKIHTGEKPYKCKQCDKAFTH 544
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 8.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 119605307  547 NLSSHKKIHSGEKPYKCEECGKAFNR 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
491-516 9.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 119605307  491 RLTQHKKIHTGEKPYKCEECGKAFNR 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 119605307  212 LTNHKRIHTGEKPYKCKECGKAFSR 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*
gi 119605307  408 LTRHKRIHTEEKPYKCNECGKAFNR 432
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-319 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....
gi 119605307  296 LTSHKRIHTGEKPYKCEECGKAFN 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-486 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....
gi 119605307  463 NLNSHKKIHSGEKPYKCEECGKAF 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 529-598 2.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119605307 529 GEKPYKCK--QCDKAFTHSSNLSSHKKiHSGEKPYKCEECGKafnrssrlTQHKKIHTREKPYKCEECAKAF 598
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 264-357 2.97e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 264 ISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTL---TSHKRIHT-GEKPYKCE--ECGKAFNWSSTLTKHK--------- 328
Cdd:COG5189  301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqkl 380

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 119605307 329 ----------VIHTGEKPYKCEECGKAFNQSSRLTRHKK 357
Cdd:COG5189  381 henpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 4.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.93e-03
                          10        20
                  ....*....|....*....|....*
gi 119605307  324 LTKHKVIHTGEKPYKCEECGKAFNQ 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-263 4.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.98e-03
                          10        20
                  ....*....|....*....|....
gi 119605307  240 LTTHKRIHSGEKPYKCDECGKTFS 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 5.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119605307 221 GEKPYKCK--ECGKAFSRYSTLTTHKrihsgekpyKCDECGKTFSISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTLTS 298
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 119605307 299 HK 300
Cdd:COG5189  417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 421-443 7.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.06e-03
                          10        20
                  ....*....|....*....|...
gi 119605307  421 YKCNECGKAFNRSSHLTSHRRIH 443
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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