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Conserved domains on  [gi|119581359|gb|EAW60955|]
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transmembrane protein 106A, isoform CRA_b, partial [Homo sapiens]

Protein Classification

TMEM106 family protein( domain architecture ID 3241)

TMEM106 family protein is a DUF1356 domain-containing protein; similar to Homo sapiens transmembrane protein 106C

Gene Ontology:  GO:0005789

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1356 super family cl06221
Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian ...
 25-223 1.42e-127

Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.


The actual alignment was detected with superfamily member pfam07092:

Pssm-ID: 462088  Cd Length: 232  Bit Score: 360.98  E-value: 1.42e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359   25 AIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICL 104
Cdd:pfam07092   1 AMGSKAASYLSTDNSKPDISQFPYVEFTGRDSVTCPTCQGTGEIPREQENQLVALIPYSDQRLKPRRTKLYVFLSVLICL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359  105 VTSSFIVFFLFPRSVIVQPAGLNSSTVAFD--EADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLH 182
Cdd:pfam07092  81 LTSGLIVFFLFPRSIAVQPVGLNSSTVAFDkeERIVYLNITNTLNISNSNYYPVTVTQLTAQVQHMSTVVGQVTLSNLLH 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 119581359  183 IGPLASEQMFYAVATKIRDENTY--KICTWLEIKVHHVLLHIQ 223
Cdd:pfam07092 161 IGPLDSEQMFYTVASRIGDENTYmyKFCTLPKIKVHNIVLHMQ 203
 
Name Accession Description Interval E-value
DUF1356 pfam07092
Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian ...
 25-223 1.42e-127

Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.


Pssm-ID: 462088  Cd Length: 232  Bit Score: 360.98  E-value: 1.42e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359   25 AIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICL 104
Cdd:pfam07092   1 AMGSKAASYLSTDNSKPDISQFPYVEFTGRDSVTCPTCQGTGEIPREQENQLVALIPYSDQRLKPRRTKLYVFLSVLICL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359  105 VTSSFIVFFLFPRSVIVQPAGLNSSTVAFD--EADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLH 182
Cdd:pfam07092  81 LTSGLIVFFLFPRSIAVQPVGLNSSTVAFDkeERIVYLNITNTLNISNSNYYPVTVTQLTAQVQHMSTVVGQVTLSNLLH 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 119581359  183 IGPLASEQMFYAVATKIRDENTY--KICTWLEIKVHHVLLHIQ 223
Cdd:pfam07092 161 IGPLDSEQMFYTVASRIGDENTYmyKFCTLPKIKVHNIVLHMQ 203
PLN03165 PLN03165
chaperone protein dnaJ-related; Provisional
 26-75 5.99e-04

chaperone protein dnaJ-related; Provisional


Pssm-ID: 178709 [Multi-domain]  Cd Length: 111  Bit Score: 38.65  E-value: 5.99e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 119581359  26 IGSKAVNYSSTGSSKSFCSCVPCEGtadASFVTCPTCQGSGKIPQELEKQ 75
Cdd:PLN03165  59 VGSGNVTVELGGGEKEVSKCINCDG---AGSLTCTTCQGSGIQPRYLDRR 105
DnaJ_zf cd10719
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ...
 45-68 9.37e-03

Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.


Pssm-ID: 199908 [Multi-domain]  Cd Length: 65  Bit Score: 33.77  E-value: 9.37e-03
                         10        20
                 ....*....|....*....|....*..
gi 119581359  45 CVPCEGT---ADASFVTCPTCQGSGKI 68
Cdd:cd10719    1 CPTCNGSgakPGTKPKTCPTCGGSGQV 27
 
Name Accession Description Interval E-value
DUF1356 pfam07092
Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian ...
 25-223 1.42e-127

Protein of unknown function (DUF1356); This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.


Pssm-ID: 462088  Cd Length: 232  Bit Score: 360.98  E-value: 1.42e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359   25 AIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICL 104
Cdd:pfam07092   1 AMGSKAASYLSTDNSKPDISQFPYVEFTGRDSVTCPTCQGTGEIPREQENQLVALIPYSDQRLKPRRTKLYVFLSVLICL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119581359  105 VTSSFIVFFLFPRSVIVQPAGLNSSTVAFD--EADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLH 182
Cdd:pfam07092  81 LTSGLIVFFLFPRSIAVQPVGLNSSTVAFDkeERIVYLNITNTLNISNSNYYPVTVTQLTAQVQHMSTVVGQVTLSNLLH 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 119581359  183 IGPLASEQMFYAVATKIRDENTY--KICTWLEIKVHHVLLHIQ 223
Cdd:pfam07092 161 IGPLDSEQMFYTVASRIGDENTYmyKFCTLPKIKVHNIVLHMQ 203
PLN03165 PLN03165
chaperone protein dnaJ-related; Provisional
 26-75 5.99e-04

chaperone protein dnaJ-related; Provisional


Pssm-ID: 178709 [Multi-domain]  Cd Length: 111  Bit Score: 38.65  E-value: 5.99e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 119581359  26 IGSKAVNYSSTGSSKSFCSCVPCEGtadASFVTCPTCQGSGKIPQELEKQ 75
Cdd:PLN03165  59 VGSGNVTVELGGGEKEVSKCINCDG---AGSLTCTTCQGSGIQPRYLDRR 105
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 43-68 5.74e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 37.43  E-value: 5.74e-03
                         10        20
                 ....*....|....*....|....*....
gi 119581359  43 CSCVPCEGT---ADASFVTCPTCQGSGKI 68
Cdd:PRK10767 143 VTCDTCHGSgakPGTSPKTCPTCHGAGQV 171
DnaJ_zf cd10719
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ...
 45-68 9.37e-03

Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.


Pssm-ID: 199908 [Multi-domain]  Cd Length: 65  Bit Score: 33.77  E-value: 9.37e-03
                         10        20
                 ....*....|....*....|....*..
gi 119581359  45 CVPCEGT---ADASFVTCPTCQGSGKI 68
Cdd:cd10719    1 CPTCNGSgakPGTKPKTCPTCGGSGQV 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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