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Conserved domains on  [gi|70887227|gb|EAN99987|]
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phosphatidic acid phosphatase, putative [Trypanosoma cruzi]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Homo sapiens phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 48-240 2.63e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 185.12  E-value: 2.63e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  48 TSISQPPSHTETSPTY-SVLIAVILVIFIYATGEYFTWRehgkhmVAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRP 126
Cdd:cd03390   1 PSISYPFAESETVPTWlLVIISVGIPLLVIILISLFFRR------SLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 127 DFIHRLAKEGITESNFNQF---THDQICGAAREGRLSFPSGHASSSFAGFVPLVLYLLCRTGTLRT-GAFYTAAASLLPL 202
Cdd:cd03390  75 DFLARCFPDGGTPSDTLVGidiCCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPrGSSWRLLLALLPL 154

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 70887227 203 IFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFL 240
Cdd:cd03390 155 LLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 48-240 2.63e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 185.12  E-value: 2.63e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  48 TSISQPPSHTETSPTY-SVLIAVILVIFIYATGEYFTWRehgkhmVAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRP 126
Cdd:cd03390   1 PSISYPFAESETVPTWlLVIISVGIPLLVIILISLFFRR------SLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 127 DFIHRLAKEGITESNFNQF---THDQICGAAREGRLSFPSGHASSSFAGFVPLVLYLLCRTGTLRT-GAFYTAAASLLPL 202
Cdd:cd03390  75 DFLARCFPDGGTPSDTLVGidiCCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPrGSSWRLLLALLPL 154

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 70887227 203 IFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFL 240
Cdd:cd03390 155 LLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
PLN02250 PLN02250
lipid phosphate phosphatase
 54-246 1.08e-19

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 86.90  E-value: 1.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   54 PSHTETSPTYSV-LIAVIL---VIFIYatgeYFTWREhgkhmvAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRPDFI 129
Cdd:PLN02250  60 PLQDNTIPFWAVpLIAILLpfaVILVY----YFIRRD------VYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFF 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  130 HRLAKEGIteSNFNQFTHDQICGAA----REGRLSFPSGHASSSFAGFVPLVLYLlcrTGTLRT----GAFYTAAASLLP 201
Cdd:PLN02250 130 WRCFPDGK--GVFHPVTTDVLCTGAksviKEGHKSFPSGHTSWSFAGLGFLSLYL---SGKIRVfdrrGHVAKLCIVFLP 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 70887227  202 LIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFsVFLSFVVGP 246
Cdd:PLN02250 205 LLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASF-CYLQFFPPP 248
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-242 1.29e-17

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 77.08  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   105 FSVSLDYCIVNLCKLYAGRLRPDFIHRLAKEGITESNFNQFTHdqicgaaregrlSFPSGHASSSFAGFVPLVLYLLcrt 184
Cdd:pfam01569   4 LALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGY------------SFPSGHSATAFALALLLALLLR--- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 70887227   185 gtlRTGAFYTAAASLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFLSF 242
Cdd:pfam01569  69 ---RLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
118-236 6.05e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 66.99  E-value: 6.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227    118 KLYAGRLRPDFIHrlakegITESNFNQFTHDQicgaaREGRLSFPSGHASSSFAGFVPLVLYLLCRTGTLRtgafytaaA 197
Cdd:smart00014  15 KNYFGRPRPFFLS------IGDACCTPNFLLT-----LEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKL--------L 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 70887227    198 SLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALF 236
Cdd:smart00014  76 IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 27-240 1.27e-09

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.59  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  27 LVGALVGILVRPHCRPFVFDDTSISQPPSHTETSPTYSVLIAVILVIFIYATGEYFTWREHGKHMVAKHLNAWILVQSFS 106
Cdd:COG0671   2 LLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 107 VSLDYCIVNLCKLYAGRLRPDFIHRLAKEGITESNFnqfthdqicgaaregrlSFPSGHASSSFAGFvpLVLYLLCRTGT 186
Cdd:COG0671  82 LLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGY-----------------SFPSGHAAAAFALA--LVLALLLPRRW 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 70887227 187 LRTGAFytaaasllplIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFL 240
Cdd:COG0671 143 LAALLL----------ALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 48-240 2.63e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 185.12  E-value: 2.63e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  48 TSISQPPSHTETSPTY-SVLIAVILVIFIYATGEYFTWRehgkhmVAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRP 126
Cdd:cd03390   1 PSISYPFAESETVPTWlLVIISVGIPLLVIILISLFFRR------SLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 127 DFIHRLAKEGITESNFNQF---THDQICGAAREGRLSFPSGHASSSFAGFVPLVLYLLCRTGTLRT-GAFYTAAASLLPL 202
Cdd:cd03390  75 DFLARCFPDGGTPSDTLVGidiCCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPrGSSWRLLLALLPL 154

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 70887227 203 IFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFL 240
Cdd:cd03390 155 LLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQ 192
PLN02250 PLN02250
lipid phosphate phosphatase
 54-246 1.08e-19

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 86.90  E-value: 1.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   54 PSHTETSPTYSV-LIAVIL---VIFIYatgeYFTWREhgkhmvAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRPDFI 129
Cdd:PLN02250  60 PLQDNTIPFWAVpLIAILLpfaVILVY----YFIRRD------VYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFF 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  130 HRLAKEGIteSNFNQFTHDQICGAA----REGRLSFPSGHASSSFAGFVPLVLYLlcrTGTLRT----GAFYTAAASLLP 201
Cdd:PLN02250 130 WRCFPDGK--GVFHPVTTDVLCTGAksviKEGHKSFPSGHTSWSFAGLGFLSLYL---SGKIRVfdrrGHVAKLCIVFLP 204

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 70887227  202 LIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFsVFLSFVVGP 246
Cdd:PLN02250 205 LLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASF-CYLQFFPPP 248
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 113-238 3.03e-19

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 82.29  E-value: 3.03e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 113 IVNLCKLYAGRLRPDFIHR---LAKEGITESNFNQFTHDQICGAA----REGRLSFPSGHASSSFAGFVPLVLYLLCRTG 185
Cdd:cd03384  19 LTDLGKYVTGRLRPHFLDVckpNYTDLTCSLDHQYIADCTCCTGDpdliREARLSFPSGHASLSMYAAVFLALYLQARLK 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 70887227 186 TLRTgAFYTAAASLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSV 238
Cdd:cd03384  99 LRGS-RLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 98-238 5.29e-18

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 77.89  E-value: 5.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  98 AWILVQSFSVSLDYCIVNLCKLYAGRLRPDFIHRlakegitesnfnqFTHDQICGAAREGRLSFPSGHASSSFAGFVPLV 177
Cdd:cd01610   3 LLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLR-------------CGPDGDPLLLTEGGYSFPSGHAAFAFALALFLA 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 70887227 178 LYLLCRTGTLRtgafytaaASLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSV 238
Cdd:cd01610  70 LLLPRRLLRLL--------LGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-242 1.29e-17

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 77.08  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   105 FSVSLDYCIVNLCKLYAGRLRPDFIHRLAKEGITESNFNQFTHdqicgaaregrlSFPSGHASSSFAGFVPLVLYLLcrt 184
Cdd:pfam01569   4 LALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGY------------SFPSGHSATAFALALLLALLLR--- 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 70887227   185 gtlRTGAFYTAAASLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFLSF 242
Cdd:pfam01569  69 ---RLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 11-273 1.03e-15

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 76.22  E-value: 1.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   11 VWRWRVFDYVTCVVFgLVGALVGILVRPHCRpFVFDD--TSISQPPSHTE----TSPTYSVLIAVILVIFIYatgeyFTW 84
Cdd:PLN02731  37 VARTHMHDWIILVLL-VILECVLLIIHPFYR-FVGKDmmTDLSYPLKSNTvpiwSVPVYAMLLPLVIFIFIY-----FRR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   85 REhgkhmvAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRPDFIHRLAKEGitESNFNQFThDQIC----GAAREGRLS 160
Cdd:PLN02731 110 RD------VYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDG--KALYDSLG-DVIChgdkSVIREGHKS 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  161 FPSGHASSSFAGFVPLVLYLLCRTGTLR-TGAFYTAAASLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSaLFSVF 239
Cdd:PLN02731 181 FPSGHTSWSFSGLGFLSLYLSGKIQAFDgKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAI-STICY 259

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 70887227  240 LSFVVGPT-----GDWVIRSESFSTPSAASAVGSVAQNP 273
Cdd:PLN02731 260 LQFFPPPYhtegwGPYAYFQVLEAARVQGAANGAVQQPP 298
PLN02715 PLN02715
lipid phosphate phosphatase
 61-236 1.12e-14

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 73.16  E-value: 1.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227   61 PTYSVLIAVILVIFIYAtgeyftwrehgKHMVAKHLNAWILVQSFSVSLDYCIVNLCKLYAGRLRPDFIHRLAKEG--IT 138
Cdd:PLN02715  97 PVYAVLLPIILFVCFYL-----------KRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGkeLY 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  139 ESNFNQFTHDQiCGAAREGRLSFPSGHASSSFAGFVPLVLYLlcrTGTLRTGAFYTAAASLLPLIFPLV----VSISRTR 214
Cdd:PLN02715 166 DALGGVICHGK-AAEVKEGHKSFPSGHTSWSFAGLTFLSLYL---SGKIKAFNGEGHVAKLCLVIFPLLaaclVGISRVD 241

                        170       180
                 ....*....|....*....|..
gi 70887227  215 DNKHHFSDIVGGAVVGTFSALF 236
Cdd:PLN02715 242 DYWHHWQDVFAGALIGILVAAF 263
acidPPc smart00014
Acid phosphatase homologues;
118-236 6.05e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 66.99  E-value: 6.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227    118 KLYAGRLRPDFIHrlakegITESNFNQFTHDQicgaaREGRLSFPSGHASSSFAGFVPLVLYLLCRTGTLRtgafytaaA 197
Cdd:smart00014  15 KNYFGRPRPFFLS------IGDACCTPNFLLT-----LEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKL--------L 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 70887227    198 SLLPLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALF 236
Cdd:smart00014  76 IFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAV 114
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 59-240 6.63e-10

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 57.27  E-value: 6.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  59 TSPTYSVLIAVILVIFIYATGEYFTWRehgkhmvakhlnaWILVQSFSVSL-DYCIVNLCKLYAGRLRPDFIHRLAkegi 137
Cdd:cd03395  30 TGKKLSVPIFLLLALFILFRKGPIGLL-------------ILLLVLLAVGFaDQLASGFLKPLVARLRPCNALDGV---- 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 138 tesnfnqfthDQICGAAREGRLSFPSGHASSSFAGFVPLVLYllcrtgtlrtgaFYTAAASLLPLIFPLVVSISRTRDNK 217
Cdd:cd03395  93 ----------RLVVLGDQGGSYSFASSHAANSFALALFIWLF------------FRRGLFSPVLLLWALLVGYSRVYVGV 150

                       170       180
                ....*....|....*....|...
gi 70887227 218 HHFSDIVGGAVVGTFSALFSVFL 240
Cdd:cd03395 151 HYPGDVIAGALIGIISGLLFYLL 173
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 27-240 1.27e-09

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 56.59  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  27 LVGALVGILVRPHCRPFVFDDTSISQPPSHTETSPTYSVLIAVILVIFIYATGEYFTWREHGKHMVAKHLNAWILVQSFS 106
Cdd:COG0671   2 LLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 107 VSLDYCIVNLCKLYAGRLRPDFIHRLAKEGITESNFnqfthdqicgaaregrlSFPSGHASSSFAGFvpLVLYLLCRTGT 186
Cdd:COG0671  82 LLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGY-----------------SFPSGHAAAAFALA--LVLALLLPRRW 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 70887227 187 LRTGAFytaaasllplIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVFL 240
Cdd:COG0671 143 LAALLL----------ALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 160-240 5.76e-09

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 54.54  E-value: 5.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 160 SFPSGHASSSFAgFVPLVLYLLCRTGTLRTGAFYTAAASllpLIFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFSVF 239
Cdd:cd03392 102 SFPSGHAMGATV-LYGFLAYLLARRLPRRRVRILLLILA---AILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLIL 177


                .
gi 70887227 240 L 240
Cdd:cd03392 178 L 178
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 95-238 7.48e-08

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 49.64  E-value: 7.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  95 HLNAWILVQSFSVSLdyCIVNLCKLYAGRLRPDfihrlakegitesnfnqfthdqicgAAREGRLSFPSGHASSSFAGFV 174
Cdd:cd03394   2 REGLLILAEAAALTA--AVTEGLKFAVGRARPD-------------------------GSNNGYRSFPSGHTASAFAAAT 54

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 70887227 175 plvlYLLCRTGTLRTG-AFYTAAAsllplifplVVSISRTRDNKHHFSDIVGGAVVGTFSALFSV 238
Cdd:cd03394  55 ----FLQYRYGWRWYGiPAYALAS---------LVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 63-236 3.07e-06

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 46.55  E-value: 3.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227  63 YSVLIAVILVIFIYATGEYFTWREhgkhMVAKHLNAWILVQSfSVSLDYCIVNLCKLYAGRLRPDFIHrlakegitESNF 142
Cdd:cd03389  39 IPSLLLFLLFRFGDLRGLSAPSRA----RFPKAAWAGLFLFA-TVALSGILVNLLKFIIGRARPKLLF--------DDGL 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 143 NQFTHDQICGAAregrLSFPSGHASSSFAGFVPLvLYLLCRtgtlRTGAFYTAAasllplifpLVVSISRTRDNKHHFSD 222
Cdd:cd03389 106 YGFDPFHADYAF----TSFPSGHSATAGAAAAAL-ALLFPR----YRWAFILLA---------LLIAFSRVIVGAHYPSD 167

                       170
                ....*....|....
gi 70887227 223 IVGGAVVGTFSALF 236
Cdd:cd03389 168 VIAGSLLGAVTALA 181
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 109-237 1.40e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 44.23  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 109 LDYCIVNLCKLYAGRLRPDFIHrlakegitESNFNQFTHDqicgaaregRLSFPSGHASSSFagFVPLVLYllcrtgtlr 188
Cdd:cd03391  58 LDIITVAILKALVRRRRPAYNS--------PDMLDYVAVD---------KYSFPSGHASRAA--FVARFLL--------- 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 70887227 189 tgAFYTAAASLLPL--IFPLVVSISRTRDNKHHFSDIVGGAVVGTFSALFS 237
Cdd:cd03391 110 --NHLVLAVPLRVLlvLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 101-244 2.65e-05

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 44.21  E-value: 2.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70887227 101 LVQSFSVSLDYCIVNLCKLYAGRLRPDFIHRLAKEGITESNFNQFTHDqiCGAARegrlSFPSGHASssfAGFVPLVLYL 180
Cdd:cd03396  70 LLLILVIGLGLLVVAILKSHWGRPRPWDLTEFGGDAPYTPLFSGPSNG--CGKGC----SFPSGHAS---AGFALLALYF 140

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 70887227 181 LCRTGTLRTGAFYTAAAsllpLIFPLVVSISRTRDNKHHFSDIVggavvgtFSALFSVFLSFVV 244
Cdd:cd03396 141 LFRRRRPRLARLVLAAG----LALGALMGLARMARGAHFLSDVL-------WSLLLVWLIALLL 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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