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Conserved domains on  [gi|51465225|emb|CAH17959|]
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voltage-gated sodium channel alpha subunit Nav1.1, partial [Mus musculus]

Protein Classification

Na_channel_gate and Ion_trans domain-containing protein( domain architecture ID 11599010)

Na_channel_gate and Ion_trans domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 52-220 7.00e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.52  E-value: 7.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225    52 RQVFDISIMILICLNMVTMMVETDDQSD-YVTSILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 128
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225   129 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 208
Cdd:pfam00520  81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                         170
                  ....*....|....
gi 51465225   209 R--EVGIDDMFNFE 220
Cdd:pfam00520 156 KtwENPDNGRTNFD 169
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
 1-48 1.65e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 99.18  E-value: 1.65e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 51465225   1 QKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 48
Cdd:cd13433   6 LKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 52-220 7.00e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.52  E-value: 7.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225    52 RQVFDISIMILICLNMVTMMVETDDQSD-YVTSILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 128
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225   129 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 208
Cdd:pfam00520  81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                         170
                  ....*....|....
gi 51465225   209 R--EVGIDDMFNFE 220
Cdd:pfam00520 156 KtwENPDNGRTNFD 169
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
 1-48 1.65e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 99.18  E-value: 1.65e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 51465225   1 QKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 48
Cdd:cd13433   6 LKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 52-220 7.00e-31

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 113.52  E-value: 7.00e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225    52 RQVFDISIMILICLNMVTMMVETDDQSD-YVTSILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 128
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51465225   129 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 208
Cdd:pfam00520  81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                         170
                  ....*....|....
gi 51465225   209 R--EVGIDDMFNFE 220
Cdd:pfam00520 156 KtwENPDNGRTNFD 169
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
 1-48 1.65e-27

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 99.18  E-value: 1.65e-27
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 51465225   1 QKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 48
Cdd:cd13433   6 LKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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