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Conserved domains on  [gi|74223120|dbj|BAE40699|]
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unnamed protein product [Mus musculus]

Protein Classification

ETS translocation variant( domain architecture ID 12054215)

ETS translocation variant (ETV) is a transcriptional activator that binds to consensus DNA sequences, such as human ETV1 that binds to the pentanucleotide 5'-CGGA[AT]-3'

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
 1-366 0e+00

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


:

Pssm-ID: 461371  Cd Length: 344  Bit Score: 523.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120     1 MDGFCDQQVPFMVPGKSRSEDCRGRPLIDRKRKFVDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVL 80
Cdd:pfam04621   1 MDGFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTELAQDSEELFQDLSQLQETWLAEAQVPDDEQFVPDFQSENLAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    81 HAPPPTKIKRELHSPSSELSSCSHEQALGAKYGEKCLYNYCAYDRKPPSGFKPLTPPATPLSPTHQ-NSLFPPPQATLPT 159
Cdd:pfam04621  81 HGPPPAKIKREPQSPSSDLSSCSHEQSFKYPYGEQCLYNYSAYDRKPPSGFKPPTPPSTPVSPLQQhSSLKTPPLQRQPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   160 SGLTPgagpvqgvgpaptphslpepgSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDS 239
Cdd:pfam04621 161 PLPLM---------------------RQSPPFAVPRPPRGYMPMPPSQPSNSYPIEHRFQRQLSEPCLPFPPPEGGPRDG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   240 RPSYHRQMSEPIVPAAPpplQGFKQEYHDPLYEHGvPGMPGPPAHGFQSPMGIKQEPRDYCADSEVPNCQSSYMR--GGY 317
Cdd:pfam04621 220 RPPYQRQMSEPLVPYPP---QGFKQEYHDPLYEHG-PPPGGPPPHRFPPPMMIKQEPRDYGYDSEVPNCQSSYGRseGFL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 74223120   318 FSSSHEGFPYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRG 366
Cdd:pfam04621 296 YPNSHDGFSYDKDPRLFYDDTCVVPEKLEGKVKQEPGVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 367-452 4.51e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 166.29  E-value: 4.51e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    367 SLQLWQFLVTLLDDPANAHFIAWTGR-GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVY 445
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*..
gi 74223120    446 KFVCDPD 452
Cdd:smart00413  81 KFVKNPL 87
 
Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
 1-366 0e+00

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


Pssm-ID: 461371  Cd Length: 344  Bit Score: 523.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120     1 MDGFCDQQVPFMVPGKSRSEDCRGRPLIDRKRKFVDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVL 80
Cdd:pfam04621   1 MDGFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTELAQDSEELFQDLSQLQETWLAEAQVPDDEQFVPDFQSENLAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    81 HAPPPTKIKRELHSPSSELSSCSHEQALGAKYGEKCLYNYCAYDRKPPSGFKPLTPPATPLSPTHQ-NSLFPPPQATLPT 159
Cdd:pfam04621  81 HGPPPAKIKREPQSPSSDLSSCSHEQSFKYPYGEQCLYNYSAYDRKPPSGFKPPTPPSTPVSPLQQhSSLKTPPLQRQPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   160 SGLTPgagpvqgvgpaptphslpepgSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDS 239
Cdd:pfam04621 161 PLPLM---------------------RQSPPFAVPRPPRGYMPMPPSQPSNSYPIEHRFQRQLSEPCLPFPPPEGGPRDG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   240 RPSYHRQMSEPIVPAAPpplQGFKQEYHDPLYEHGvPGMPGPPAHGFQSPMGIKQEPRDYCADSEVPNCQSSYMR--GGY 317
Cdd:pfam04621 220 RPPYQRQMSEPLVPYPP---QGFKQEYHDPLYEHG-PPPGGPPPHRFPPPMMIKQEPRDYGYDSEVPNCQSSYGRseGFL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 74223120   318 FSSSHEGFPYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRG 366
Cdd:pfam04621 296 YPNSHDGFSYDKDPRLFYDDTCVVPEKLEGKVKQEPGVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 367-452 4.51e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 166.29  E-value: 4.51e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    367 SLQLWQFLVTLLDDPANAHFIAWTGR-GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVY 445
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*..
gi 74223120    446 KFVCDPD 452
Cdd:smart00413  81 KFVKNPL 87
Ets pfam00178
Ets-domain;
369-447 6.35e-44

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 149.57  E-value: 6.35e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   369 QLWQFLVTLLDDPANAHFIAWTGR-GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF 447
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKeEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
PHA03247 PHA03247
large tegument protein UL36; Provisional
 133-321 2.17e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   133 PLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPA------------PTPHSLPEPGSQQQTFAVPRPPHQP 200
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSrspaakpaaparPPVRRLARPAVSRSTESFALPPDQP 2905

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   201 LQMPKmmPESQYPSEQRFQRQLSEPSHPFPPQSGVPgdsrpsyhrqmSEPIVPAAPPPLQGFKQ-EYHDPLYEHGVPGMP 279
Cdd:PHA03247 2906 ERPPQ--PQAPPPPQPQPQPPPPPQPQPPPPPPPRP-----------QPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRV 2972

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 74223120   280 GPPAHGFQSPmgikQEPRDYCADSEVPNCQSSYMRGGYFSSS 321
Cdd:PHA03247 2973 AVPRFRVPQP----APSREAPASSTPPLTGHSLSRVSSWASS 3010
 
Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
 1-366 0e+00

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


Pssm-ID: 461371  Cd Length: 344  Bit Score: 523.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120     1 MDGFCDQQVPFMVPGKSRSEDCRGRPLIDRKRKFVDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVL 80
Cdd:pfam04621   1 MDGFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTELAQDSEELFQDLSQLQETWLAEAQVPDDEQFVPDFQSENLAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    81 HAPPPTKIKRELHSPSSELSSCSHEQALGAKYGEKCLYNYCAYDRKPPSGFKPLTPPATPLSPTHQ-NSLFPPPQATLPT 159
Cdd:pfam04621  81 HGPPPAKIKREPQSPSSDLSSCSHEQSFKYPYGEQCLYNYSAYDRKPPSGFKPPTPPSTPVSPLQQhSSLKTPPLQRQPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   160 SGLTPgagpvqgvgpaptphslpepgSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDS 239
Cdd:pfam04621 161 PLPLM---------------------RQSPPFAVPRPPRGYMPMPPSQPSNSYPIEHRFQRQLSEPCLPFPPPEGGPRDG 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   240 RPSYHRQMSEPIVPAAPpplQGFKQEYHDPLYEHGvPGMPGPPAHGFQSPMGIKQEPRDYCADSEVPNCQSSYMR--GGY 317
Cdd:pfam04621 220 RPPYQRQMSEPLVPYPP---QGFKQEYHDPLYEHG-PPPGGPPPHRFPPPMMIKQEPRDYGYDSEVPNCQSSYGRseGFL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 74223120   318 FSSSHEGFPYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRG 366
Cdd:pfam04621 296 YPNSHDGFSYDKDPRLFYDDTCVVPEKLEGKVKQEPGVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 367-452 4.51e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 166.29  E-value: 4.51e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120    367 SLQLWQFLVTLLDDPANAHFIAWTGR-GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVY 445
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*..
gi 74223120    446 KFVCDPD 452
Cdd:smart00413  81 KFVKNPL 87
Ets pfam00178
Ets-domain;
369-447 6.35e-44

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 149.57  E-value: 6.35e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   369 QLWQFLVTLLDDPANAHFIAWTGR-GMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF 447
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKeEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 125-260 8.71e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 51.58  E-value: 8.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   125 RKPPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMP 204
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFH 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74223120   205 KMMPESQYPSEQRFQRQlSEPSHPFPPQSGVPGDSRPSYHRQMSEPIVPAAPPPLQ 260
Cdd:pfam09770 290 QQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
 133-321 2.17e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   133 PLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPA------------PTPHSLPEPGSQQQTFAVPRPPHQP 200
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSrspaakpaaparPPVRRLARPAVSRSTESFALPPDQP 2905

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   201 LQMPKmmPESQYPSEQRFQRQLSEPSHPFPPQSGVPgdsrpsyhrqmSEPIVPAAPPPLQGFKQ-EYHDPLYEHGVPGMP 279
Cdd:PHA03247 2906 ERPPQ--PQAPPPPQPQPQPPPPPQPQPPPPPPPRP-----------QPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRV 2972

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 74223120   280 GPPAHGFQSPmgikQEPRDYCADSEVPNCQSSYMRGGYFSSS 321
Cdd:PHA03247 2973 AVPRFRVPQP----APSREAPASSTPPLTGHSLSRVSSWASS 3010
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 197-298 2.21e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.47  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   197 PHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDSRP-SYHRQMSEPIVPAAPPPLQGFKQEYHDPLYEHGV 275
Cdd:PRK10263  740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPvAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQ 819

                          90       100
                  ....*....|....*....|....
gi 74223120   276 PGMPGPPAHGFQSPMG-IKQEPRD 298
Cdd:PRK10263  820 PQQPVAPQPQYQQPQQpVAPQPQD 843
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 123-258 6.31e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   123 YDRKPPSGFKPLTPPATPLSPThQNSLFPPPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPhqplq 202
Cdd:PRK10263  711 YSGEQPAGANPFSLDDFEFSPM-KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQP----- 784

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   203 mpkMMPESQYPSEQR---FQRQLSEPSHPFPPQSGVPGDSRP-SYHRQMSEPIVPAAPPP 258
Cdd:PRK10263  785 ---VAPQPQYQQPQQpvaPQPQYQQPQQPVAPQPQYQQPQQPvAPQPQYQQPQQPVAPQP 841
PHA03247 PHA03247
large tegument protein UL36; Provisional
 127-289 6.87e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   127 PPSGFKPLTPPATPLS--PTHQNSLFP--------------PPQatlPTSGLTPGA------GPVQGVGPAPTPHSL--P 182
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRsvPPPRPAPRPsepavtsrarrpdaPPQ---SARPRAPVDdrgdprGPAPPSPLPPDTHAPdpP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   183 EPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPfPPQSGVPGDSRPSYHRQMSEPIVPAAPPPLQGF 262
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706

                         170       180
                  ....*....|....*....|....*..
gi 74223120   263 KQEYHDPLYEHGVPGMPGPPAHGFQSP 289
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASP 2733
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 163-296 1.18e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   163 TPGAGPVQGVGPAPTPHSLP----EPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGd 238
Cdd:pfam09770 207 AKKPAQQPAPAPAQPPAAPPaqqaQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQA- 285

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 74223120   239 srPSYHRQMSepivPAAPPPLQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEP 296
Cdd:pfam09770 286 --QQFHQQPP----PVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQG 337
PHA03247 PHA03247
large tegument protein UL36; Provisional
 125-242 2.29e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   125 RKPPSGFkpltPPATPLSPTHqnslfpPPQATLPTSgltpgagpvqgvGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMP 204
Cdd:PHA03247 2864 RRPPSRS----PAAKPAAPAR------PPVRRLARP------------AVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 74223120   205 kmmPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDSRPS 242
Cdd:PHA03247 2922 ---QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-279 2.79e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   126 KPPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPA--PTPHSLPEPGSQQQTFAVPRPPHQPLQM 203
Cdd:PHA03247 2706 PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74223120   204 PKMMPESQYPSEQRFQRQLSEPSHPFP-PQSGVPGDSRPSYHRQMSEPIVPAAPPPLQGFKQEYhDPLYEHGVPGMP 279
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADPPAAVLaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS-LPLGGSVAPGGD 2861
dnaA PRK14086
chromosomal replication initiator protein DnaA;
122-283 3.92e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.89  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  122 AYDRKPPSGFKPLTPPATPLSPTHQNSL----FPPPQATLP----TSGLTPGAGPVQGVGPAPTPHSLPEPGSQQ--QTF 191
Cdd:PRK14086 126 ADDRPPGLPRQDQLPTARPAYPAYQQRPepgaWPRAADDYGwqqqRLGFPPRAPYASPASYAPEQERDREPYDAGrpEYD 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  192 AVPRPPHQPlqmpkmMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDSRPSyhrQMSEPIVPAAPPPLQGFKQEyhdply 271
Cdd:PRK14086 206 QRRRDYDHP------RPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDD---APVVPIRPSAPGPLAAQPAP------ 270

                        170
                 ....*....|..
gi 74223120  272 ehgVPGMPGPPA 283
Cdd:PRK14086 271 ---APGPGEPTA 279
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 151-261 5.65e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  151 PPPQATLPTS-GLTPGAGPVQGvGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQRfQRQLSEPSHPF 229
Cdd:PRK07764 392 GAPAAAAPSAaAAAPAAAPAPA-AAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPP-AAAPSAQPAPA 469

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 74223120  230 P----PQSGVPGDSRPSYHRQMSEPIVPAAPPPLQG 261
Cdd:PRK07764 470 PaaapEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 133-298 8.98e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 8.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   133 PLTPPATPLSPTHQNSLFPPPQA-TLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRpPHQPLQ-MPKMMPES 210
Cdd:pfam03154 181 ASPPSPPPPGTTQAATAGPTPSApSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS-PHPPLQpMTQPPPPS 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   211 QYPSEQRFQRQLSEPSHPFPPqsgvPGDSRPSYhrqMSEPIVPAAPPPLQGFKQEYHDPLYEHGVPG----MPGPPAHGF 286
Cdd:pfam03154 260 QVSPQPLPQPSLHGQMPPMPH----SLQTGPSH---MQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGqsqqRIHTPPSQS 332

                         170
                  ....*....|..
gi 74223120   287 QSPMGikQEPRD 298
Cdd:pfam03154 333 QLQSQ--QPPRE 342
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 138-296 1.02e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   138 ATPLSPTHQNSLFPPPQATL--PTSGLTPGAGPVQgvgPAPTPHSLPEPGSQQQTFAVPRPPHQ-PLQMPkmmpesqYPS 214
Cdd:PRK10263  334 AAPVEPVTQTPPVASVDVPPaqPTVAWQPVPGPQT---GEPVIAPAPEGYPQQSQYAQPAVQYNePLQQP-------VQP 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   215 EQRFQRQLSEPShPFPPQSGVPGDSRPSYHRQMSEPIVPAAPPPLQGFKQEY---HDPLYEHGVPGM-PGPPAHGFQSPM 290
Cdd:PRK10263  404 QQPYYAPAAEQP-AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQStfaPQSTYQTEQTYQqPAAQEPLYQQPQ 482


                  ....*.
gi 74223120   291 GIKQEP 296
Cdd:PRK10263  483 PVEQQP 488
PRK04654 PRK04654
sec-independent translocase; Provisional
 135-250 1.03e-03

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 40.57  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  135 TPPATPLSPTHQNsLFPPPQATLPtSGLTPGAGPvqgvgpAPTPHSLPEPGSQQQTFAVPrPPHQPLqMPKmmPESQYPS 214
Cdd:PRK04654 106 TPVATPLELAHAD-LSASAQVDAA-AGAEPGAGQ------AHTPVPAPAPVIAQAQPIAP-APHQTL-VPA--PHDTIVP 173

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 74223120  215 EQRFQRQlsePSHPFPPQSGVPGDSRPSYHRQMSEP 250
Cdd:PRK04654 174 APHAAHL---PSAPATPVSVAPVDAGTSASPTPSEP 206
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 137-250 1.53e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 41.25  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  137 PATPLSPTHQNSLFPPPqATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKMMPESQYPSEQ 216
Cdd:PHA03269  40 PDPAPAPHQAASRAPDP-AVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPKPDAAEAFTS 118

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 74223120  217 RFQRqlsepsHPFPPQSGVPGDSR---PSYHRQMSEP 250
Cdd:PHA03269 119 AAQA------HEAPADAGTSAASKkpdPAAHTQHSPP 149
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
125-258 2.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  125 RKPPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMP 204
Cdd:PRK12323 401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAP 480

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 74223120  205 kmmPESQYPSEQRFQRQLSEPSHPFPPQSGVPG--DSRPSYHRQMSEPIV-PAAPPP 258
Cdd:PRK12323 481 ---ARAAPAAAPAPADDDPPPWEELPPEFASPApaQPDAAPAGWVAESIPdPATADP 534
PHA03247 PHA03247
large tegument protein UL36; Provisional
 125-297 2.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   125 RKPPSGFKPLTP--------PATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGP-------------APTPHSLP- 182
Cdd:PHA03247 2773 AAPAAGPPRRLTrpavaslsESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPptsaqptapppppGPPPPSLPl 2852

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   183 ----EPGSQQQTFAVPRPPHQPLQMPKMMPESQY--PSEQRFQRQLSEPSHPFPPQSGVPGDSRPSYHRQMSEPIVPAAP 256
Cdd:PHA03247 2853 ggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 74223120   257 PPLQGFKQEyhdplyehgvPGMPGPPAHGFQSPMGIKQEPR 297
Cdd:PHA03247 2933 PPPPPRPQP----------PLAPTTDPAGAGEPSGAVPQPW 2963
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 127-284 2.53e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   127 PPSGFKPLTP---PATPLSPTHQNSLFPPPQATLPTSGLTPGA-----GPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPH 198
Cdd:pfam03154 199 PTPSAPSVPPqgsPATSQPPNQTQSTAAPHTLIQQTPTLHPQRlpsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPM 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   199 -QPLQM-PKMMPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDSRPSYHRQMSEPI-----------VPAAPPPLQGFKQE 265
Cdd:pfam03154 279 pHSLQTgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQlqsqqppreqpLPPAPLSMPHIKPP 358

                         170
                  ....*....|....*....
gi 74223120   266 YHDPlyehgVPGMPGPPAH 284
Cdd:pfam03154 359 PTTP-----IPQLPNPQSH 372
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 128-257 2.75e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   128 PSGFKPLTPPATPLSPTHQNSLFP-PPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKM 206
Cdd:PRK10263  377 PEGYPQQSQYAQPAVQYNEPLQQPvQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTF 456

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74223120   207 MPESQYPSEQRFQRQLSEPSHPFPPQSGVPGDSRPSyhRQMSEPIVPAAPP 257
Cdd:PRK10263  457 APQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEP--EPVVEETKPARPP 505
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 140-309 4.31e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 4.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   140 PLSPTHQNSLFPPPQATLPTSGLTPGAGPVQG---VGPAPTPHSLPEPGSQQQtfavPRPPHQPLQMPKMMPESQYPSEQ 216
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSapsVPPQGSPATSQPPNQTQS----TAAPHTLIQQTPTLHPQRLPSPH 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   217 RFQRQLSEPshPFPPQSGVPGDSRPSYHRQMsepivPAAPPPLQGFKQEYHDPLYEHGVPGMP------GPPAHGFQSPM 290
Cdd:pfam03154 247 PPLQPMTQP--PPPSQVSPQPLPQPSLHGQM-----PPMPHSLQTGPSHMQHPVPPQPFPLTPqssqsqVPPGPSPAAPG 319

                         170
                  ....*....|....*....
gi 74223120   291 GIKQEPRDYCADSEVPNCQ 309
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQ 338
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
151-303 5.78e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  151 PPPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPKmMPESQYPSEQRFQRQLSEPSHPFP 230
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQASARGPGGAPAPAP 452

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74223120  231 PQSGVPGDSRPSYHRQMSEPIVPAAPPPLQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYCADS 303
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 126-258 6.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 6.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  126 KPPSGfKPLTPPATPLSPThqnslfpPPQATLPTSglTPGAGPVQGVGPAPTPHSLPEPGSQQQTFAVPRPPHQPLQMPK 205
Cdd:PRK14951 365 KPAAA-AEAAAPAEKKTPA-------RPEAAAPAA--APVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAP 434

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74223120  206 MMPESqyPSEQRFQRQLSEPSHPFPPQSGVPGDSRPSYHRQMSEPIVPAAPPP 258
Cdd:PRK14951 435 AAAPA--AAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
PHA03247 PHA03247
large tegument protein UL36; Provisional
 134-291 6.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   134 LTPPATPLSPTHQNslfpPPQATLPTSgltPGAGPVQGVGPAPTPHSLPEPGSQQQTFAV-------------------- 193
Cdd:PHA03247 2469 LLGELFPGAPVYRR----PAEARFPFA---AGAAPDPGGGGPPDPDAPPAPSRLAPAILPdepvgepvhprmltwirgle 2541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   194 ---------PRPPHQPLQMP----KMMPESQY---PSEQRFQRQLSEPSHPFPPQSG-VPGDSRPSYHRQMSEPIVPAAP 256
Cdd:PHA03247 2542 elasddagdPPPPLPPAAPPaapdRSVPPPRPaprPSEPAVTSRARRPDAPPQSARPrAPVDDRGDPRGPAPPSPLPPDT 2621

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 74223120   257 PPLQgfkqeyhdplyehgvPGMPGPPAHGFQSPMG 291
Cdd:PHA03247 2622 HAPD---------------PPPPSPSPAANEPDPH 2641
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 127-258 6.71e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 6.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  127 PPSGFKPLTPPATPLSPTHQNSLFPPPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQTFA--VPRPPHQPLQMP 204
Cdd:PRK07764 634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAqpAPAPAATPPAGQ 713

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74223120  205 KMMPESQYPSEQRFQRQLSE------PSHPFPPQSGVPGD-SRPSYHRQMSEPIVPAAPPP 258
Cdd:PRK07764 714 ADDPAAQPPQAAQGASAPSPaaddpvPLPPEPDDPPDPAGaPAQPPPPPAPAPAAAPAAAP 774
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 142-306 7.99e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 7.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   142 SPTHQNSLFPPPQATLPTSGLTPGAGPvqgvGPAPTPHSLpEPGSQQqtfaVPRPPHQP---LQMPKMMPE-SQYPSEQR 217
Cdd:pfam03154 382 SPFQMNSNLPPPPALKPLSSLSTHHPP----SAHPPPLQL-MPQSQQ----LPPPPAQPpvlTQSQSLPPPaASHPPTSG 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120   218 FQRQLSEPshPFPPQSGVPGDSRPSYHRQMSEPIVPAAPPPLQgfKQEYHDPLYEHGVPGMPGPPAhgfqSPMGIKQEPR 297
Cdd:pfam03154 453 LHQVPSQS--PFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQ--PPSSASVSSSGPVPAAVSCPL----PPVQIKEEAL 524


                  ....*....
gi 74223120   298 DYCADSEVP 306
Cdd:pfam03154 525 DEAEEPESP 533
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 131-258 9.40e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 38.69  E-value: 9.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74223120  131 FKPLTPPATPLSPthqnslfppPQATLPTSGLTPGAGPVQGVGPAPTPHSLPEPGSQQQtfAVPRPPHQPLQMPKMMPES 210
Cdd:PRK07994 359 FHPAAPLPEPEVP---------PQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQ--QAPAVPLPETTSQLLAARQ 427

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74223120  211 QYPSeqrfQRQLSEPSHPFPPQSGVPGDSRPSYHRQMSEPIVPAAPPP 258
Cdd:PRK07994 428 QLQR----AQGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEK 471
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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