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Conserved domains on  [gi|74177987|dbj|BAE29788|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-270 2.81e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.83  E-value: 2.81e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   4 VWGLAFSPwpsppsrklwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSAS 83
Cdd:COG2319 123 VRSVAFSP--------------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  84 RDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSAL 163
Cdd:COG2319 182 DDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 164 LVTASYDTSVIMWDPYTGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAP 242
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTG 328

                       250       260
                ....*....|....*....|....*....
gi 74177987 243 MTNGLCC-TFFPHGGIIATGTRDGHVQFW 270
Cdd:COG2319 329 HTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 274-312 6.70e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.93  E-value: 6.70e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 74177987 274 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-270 2.81e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.83  E-value: 2.81e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   4 VWGLAFSPwpsppsrklwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSAS 83
Cdd:COG2319 123 VRSVAFSP--------------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  84 RDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSAL 163
Cdd:COG2319 182 DDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 164 LVTASYDTSVIMWDPYTGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAP 242
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTG 328

                       250       260
                ....*....|....*....|....*....
gi 74177987 243 MTNGLCC-TFFPHGGIIATGTRDGHVQFW 270
Cdd:COG2319 329 HTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-270 3.48e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 3.48e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  35 ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 114
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 115 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlep 194
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----- 175

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74177987 195 tmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATGTRDGHVQFW 270
Cdd:cd00200 176 -------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASGSEDGTIRVW 246
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 274-312 6.70e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.93  E-value: 6.70e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 74177987 274 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 270-312 2.25e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 60.77  E-value: 2.25e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 74177987    270 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 36-177 2.78e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.06  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   36 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 108
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74177987  109 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWD 177
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-177 9.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74177987    138 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-177 1.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.41e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 74177987   140 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 278-310 4.69e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 39.84  E-value: 4.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 74177987   278 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 310
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-270 2.81e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.83  E-value: 2.81e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   4 VWGLAFSPwpsppsrklwarhhpqapdvSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSAS 83
Cdd:COG2319 123 VRSVAFSP--------------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  84 RDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSAL 163
Cdd:COG2319 182 DDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 164 LVTASYDTSVIMWDPYTGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAP 242
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTG 328

                       250       260
                ....*....|....*....|....*....
gi 74177987 243 MTNGLCC-TFFPHGGIIATGTRDGHVQFW 270
Cdd:COG2319 329 HTGAVRSvAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
35-280 7.30e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.28  E-value: 7.30e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  35 ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 114
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 115 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlep 194
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 195 tmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFWTA 272
Cdd:COG2319 245 -------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250
                ....*....|
gi 74177987 273 --PRVLSSLK 280
Cdd:COG2319 318 atGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-270 3.48e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.99  E-value: 3.48e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  35 ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 114
Cdd:cd00200  23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTLTGHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 115 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlep 194
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG----- 175

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74177987 195 tmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATGTRDGHVQFW 270
Cdd:cd00200 176 -------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-270 2.02e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.36  E-value: 2.02e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  36 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 115
Cdd:cd00200  66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAF 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 116 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqlept 195
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR------- 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74177987 196 mddsdVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFW 270
Cdd:cd00200 217 -----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
4-233 2.27e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 2.27e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   4 VWGLAFSP----------------WPSPPSRKLWA-RHHPQApdVSCL-------ILATGLNDGQIKIWEVQTGLLLLNL 59
Cdd:COG2319 165 VTSVAFSPdgkllasgsddgtvrlWDLATGKLLRTlTGHTGA--VRSVafspdgkLLASGSADGTVRLWDLATGKLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  60 SGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSY 139
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 140 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqleptmddsDVHMSSLRSVCFSPEGLYLA 219
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRTLA 388

                       250
                ....*....|....
gi 74177987 220 TVADDRLLRIWALE 233
Cdd:COG2319 389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-231 5.87e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 5.87e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  30 DVSCL-------ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLIlVSASRDKTLRIWDLNKhGKQIQV 102
Cdd:cd00200  95 YVSSVafspdgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLRT-GKCVAT 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 103 LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGE 182
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 74177987 183 RLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWA 231
Cdd:cd00200 253 CVQTLSG------------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
34-281 2.15e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 2.15e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  34 LILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCC 113
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSV 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 114 SISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqle 193
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL------ 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 194 ptmddsDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGIIATGTRDGHVQFW- 270
Cdd:COG2319 201 ------TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWd 274

                       250
                ....*....|..
gi 74177987 271 -TAPRVLSSLKH 281
Cdd:COG2319 275 lATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
36-281 9.59e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 9.59e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  36 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGsLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSI 115
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDG-ARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 116 SPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHtqlept 195
Cdd:COG2319  87 SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG------ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 196 mddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVA-FAPMTNGL-CCTFFPHGGIIATGTRDGHVQFW--T 271
Cdd:COG2319 161 ------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVrSVAFSPDGKLLASGSADGTVRLWdlA 234

                       250
                ....*....|
gi 74177987 272 APRVLSSLKH 281
Cdd:COG2319 235 TGKLLRTLTG 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-270 6.89e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.35  E-value: 6.89e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 100 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPY 179
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 180 TGERLRSLHHtqleptmddsdvHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNG--LCCTFFPHGGI 257
Cdd:cd00200  82 TGECVRTLTG------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTF 149

                       170
                ....*....|...
gi 74177987 258 IATGTRDGHVQFW 270
Cdd:cd00200 150 VASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
4-138 1.98e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.98e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   4 VWGLAFSP----------------WpSPPSRKLWARHHPQAPDVSCL-------ILATGLNDGQIKIWEVQTGLLLLNLS 60
Cdd:COG2319 249 VRSVAFSPdgrllasgsadgtvrlW-DLATGELLRTLTGHSGGVNSVafspdgkLLASGSDDGTVRLWDLATGKLLRTLT 327

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74177987  61 GHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRS 138
Cdd:COG2319 328 GHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 274-312 6.70e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 80.93  E-value: 6.70e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 74177987 274 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 274-312 7.90e-20

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 80.71  E-value: 7.90e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 74177987 274 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-270 6.81e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 6.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987 141 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHhtqleptmddsdVHMSSLRSVCFSPEGLYLAT 220
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 74177987 221 VADDRLLRIWALELKAPVA-FAPMTNG-LCCTFFPHGGIIATGTRDGHVQFW 270
Cdd:cd00200  69 GSSDKTIRLWDLETGECVRtLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 270-312 2.25e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 60.77  E-value: 2.25e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 74177987    270 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 274-313 7.88e-12

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 59.05  E-value: 7.88e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 74177987 274 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRT 313
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
PTZ00421 PTZ00421
coronin; Provisional
 36-177 2.78e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.06  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   36 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 108
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74177987  109 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDTS----VIMWD 177
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWD 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-92 6.47e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 6.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   2 QIVWGLAFSPWPsppsrklwarhhpqapdvscLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVS 81
Cdd:cd00200 220 NGVNSVAFSPDG--------------------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLAS 278

                        90
                ....*....|.
gi 74177987  82 ASRDKTLRIWD 92
Cdd:cd00200 279 GSADGTIRIWD 289
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 278-312 1.96e-08

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 49.39  E-value: 1.96e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 74177987 278 SLKHLCRKALRSFL---TTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03587   4 SLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-177 9.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 9.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 74177987    138 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 177
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-177 1.41e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.41e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 74177987   140 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWD 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 42-177 2.38e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   42 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQwvYCCSISPDCS- 120
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKAN--ICCVQFPSESg 630

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74177987  121 -MLCSAAGEKSVFLWSMRSYTL-IRKLEGHQSSVVSCDFSpDSALLVTASYDTSVIMWD 177
Cdd:PLN00181 631 rSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 277-312 4.57e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 45.67  E-value: 4.57e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 74177987 277 SSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 312
Cdd:cd03717   4 RSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-92 6.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.44e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 74177987     52 TGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 92
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 48-136 8.16e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 8.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   48 WEVQTGLLL--------------LNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ-------VLSGH 106
Cdd:PTZ00420  45 WEVEGGGLIgairlenqmrkppvIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGH 124

                         90       100       110
                 ....*....|....*....|....*....|.
gi 74177987  107 LQWVYCCSISP-DCSMLCSAAGEKSVFLWSM 136
Cdd:PTZ00420 125 KKKISIIDWNPmNYYIMCSSGFDSFVNIWDI 155
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 277-312 8.99e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 44.71  E-value: 8.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 74177987    277 SSLKHLCRKALRSFLttYQVLALPIPKKMKEFLTYR 312
Cdd:smart00969   1 RSLQHLCRLAIRRSL--GGIDKLPLPPRLKDYLLYY 34
PTZ00421 PTZ00421
coronin; Provisional
 25-214 1.45e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   25 HPQAPDVscliLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDlNKHGKQIQVLS 104
Cdd:PTZ00421 134 HPSAMNV----LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSL-LCTTSKDKKLNIID-PRDGTIVSSVE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  105 GHL-----QWVYCCSISPDCSMLCSAAGEKSVFLWSmrsytlIRKLEG-------HQSSVVSCD-FSPDSALLVTASYDT 171
Cdd:PTZ00421 208 AHAsaksqRCLWAKRKDLIITLGCSKSQQRQIMLWD------TRKMASpystvdlDQSSALFIPfFDEDTNLLYIGSKGE 281

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 74177987  172 SVIMWDPYTGERLRSLHhtqlepTMDDSDVHmsslRSVCFSPE 214
Cdd:PTZ00421 282 GNIRCFELMNERLTFCS------SYSSVEPH----KGLCMMPK 314
WD40 pfam00400
WD domain, G-beta repeat;
53-92 1.89e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 1.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 74177987    53 GLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 92
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-135 9.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 9.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 74177987     97 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 135
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
97-135 3.40e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 74177987    97 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 135
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 278-310 4.69e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 39.84  E-value: 4.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 74177987   278 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 310
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 278-312 1.34e-04

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 38.63  E-value: 1.34e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 74177987 278 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLTYR 312
Cdd:cd03716   5 SLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
PTZ00421 PTZ00421
coronin; Provisional
 59-178 1.81e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   59 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQ------IQVLSGHLQWVYCCSISPDC-SMLCSAAGEKSV 131
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 74177987  132 FLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDP 178
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP 197
PTZ00420 PTZ00420
coronin; Provisional
 35-109 3.26e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987   35 ILATGLNDGQIKIWE----------VQTGLLLLNlsGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQV-- 102
Cdd:PTZ00420  89 ILASGSEDLTIRVWEiphndesvkeIKDPQCILK--GHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQInm 166

                         90
                 ....*....|
gi 74177987  103 ---LSGhLQW 109
Cdd:PTZ00420 167 pkkLSS-LKW 175
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 35-171 8.84e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 8.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74177987  35 ILATGLNDGQIKIWEVQ-TGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCC 113
Cdd:COG0823   1 LAFTLSRDGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74177987 114 SISPDCSMLCSAAGEKSVF-LWSMRsytlirkLEGHQSSVVSCD-----FSPDSALLVTASYDT 171
Cdd:COG0823  81 SWSPDGKRLAFVSRSDGRFdIYVLD-------LDGGAPRRLTDGpgspsWSPDGRRIVFSSDRG 137
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-230 9.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 9.02e-04
                           10        20
                   ....*....|....*....|....*....
gi 74177987    202 HMSSLRSVCFSPEGLYLATVADDRLLRIW 230
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 278-314 4.16e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.44  E-value: 4.16e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 74177987 278 SLKHLCRKALRSflTTYQVLALPIPKKMKEFLTYRTF 314
Cdd:cd03736   5 SLQHLCRITINK--CTRQIQELPLPTRLKDYLTEYTY 39
WD40 pfam00400
WD domain, G-beta repeat;
202-230 4.79e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|....*....
gi 74177987   202 HMSSLRSVCFSPEGLYLATVADDRLLRIW 230
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 278-309 6.92e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 33.93  E-value: 6.92e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 74177987 278 SLKHLCRKALRSFLTTYQVLALPIPKKMKEFL 309
Cdd:cd03740   5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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