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Conserved domains on  [gi|26333857|dbj|BAC30646|]
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unnamed protein product [Mus musculus]

Protein Classification

MutS_I domain-containing protein( domain architecture ID 10483057)

MutS_I domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MutS_I pfam01624
MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair ...
 1-105 4.62e-37

MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.


:

Pssm-ID: 426350 [Multi-domain]  Cd Length: 113  Bit Score: 124.24  E-value: 4.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857     1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNI-----YCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETA 75
Cdd:pfam01624  10 LKSKYPDAVLFFRVGDFYELFGEDAEIAARELGItltvrKGGSGKRIPMAGVPEHAFERYARRLVNKGYKVAICEQTETP 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 26333857    76 ALkaigdnKSSVFSRKLTALYTKSTLIGED 105
Cdd:pfam01624  90 AE------AKGVVKREVVRVVTPGTLTDDE 113
 
Name Accession Description Interval E-value
MutS_I pfam01624
MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair ...
 1-105 4.62e-37

MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.


Pssm-ID: 426350 [Multi-domain]  Cd Length: 113  Bit Score: 124.24  E-value: 4.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857     1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNI-----YCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETA 75
Cdd:pfam01624  10 LKSKYPDAVLFFRVGDFYELFGEDAEIAARELGItltvrKGGSGKRIPMAGVPEHAFERYARRLVNKGYKVAICEQTETP 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 26333857    76 ALkaigdnKSSVFSRKLTALYTKSTLIGED 105
Cdd:pfam01624  90 AE------AKGVVKREVVRVVTPGTLTDDE 113
MutS COG0249
DNA mismatch repair ATPase MutS [Replication, recombination and repair];
1-140 2.20e-13

DNA mismatch repair ATPase MutS [Replication, recombination and repair];


Pssm-ID: 440019 [Multi-domain]  Cd Length: 861  Bit Score: 67.39  E-value: 2.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857   1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIY-----CHLDHNF-MtASIPTHRLFVHVRRLVAKGYKVGVVKQTET 74
Cdd:COG0249  17 IKAQYPDALLFFRMGDFYELFFEDAEKASRLLDITltkrgKGAGEPIpM-AGVPYHAAEGYLAKLVKAGYKVAICEQVED 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333857  75 AAlKAIGdnkssVFSRKLTALYTKSTLIGEDVnplirLDDSVNidevmtdtstNYLLCIYEEKENI 140
Cdd:COG0249  96 PA-EAKG-----LVKREVVRVVTPGTLTEDAL-----LDAKRN----------NYLAAVARDKGRY 140
PRK05399 PRK05399
DNA mismatch repair protein MutS; Provisional
 1-140 3.49e-13

DNA mismatch repair protein MutS; Provisional


Pssm-ID: 235444 [Multi-domain]  Cd Length: 854  Bit Score: 67.04  E-value: 3.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857    1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIY-----CHLDHNF-MtASIPTHRLFVHVRRLVAKGYKVGVVKQTET 74
Cdd:PRK05399  18 IKAQYPDALLFFRMGDFYELFFEDAKKASRLLDITltkrgKSAGEPIpM-AGVPYHAAEGYLAKLVKKGYKVAICEQVED 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333857   75 AALkaigdNKSSVfSRKLTALYTKSTLIGEDVnplirLDDSVNidevmtdtstNYLLCIYEEKENI 140
Cdd:PRK05399  97 PAT-----AKGPV-KREVVRIVTPGTVTDEAL-----LDEKQN----------NYLAAIAQDGGGY 141
 
Name Accession Description Interval E-value
MutS_I pfam01624
MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair ...
 1-105 4.62e-37

MutS domain I; This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam00488, pfam05188, pfam05192 and pfam05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.


Pssm-ID: 426350 [Multi-domain]  Cd Length: 113  Bit Score: 124.24  E-value: 4.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857     1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNI-----YCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETA 75
Cdd:pfam01624  10 LKSKYPDAVLFFRVGDFYELFGEDAEIAARELGItltvrKGGSGKRIPMAGVPEHAFERYARRLVNKGYKVAICEQTETP 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 26333857    76 ALkaigdnKSSVFSRKLTALYTKSTLIGED 105
Cdd:pfam01624  90 AE------AKGVVKREVVRVVTPGTLTDDE 113
MutS COG0249
DNA mismatch repair ATPase MutS [Replication, recombination and repair];
1-140 2.20e-13

DNA mismatch repair ATPase MutS [Replication, recombination and repair];


Pssm-ID: 440019 [Multi-domain]  Cd Length: 861  Bit Score: 67.39  E-value: 2.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857   1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIY-----CHLDHNF-MtASIPTHRLFVHVRRLVAKGYKVGVVKQTET 74
Cdd:COG0249  17 IKAQYPDALLFFRMGDFYELFFEDAEKASRLLDITltkrgKGAGEPIpM-AGVPYHAAEGYLAKLVKAGYKVAICEQVED 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333857  75 AAlKAIGdnkssVFSRKLTALYTKSTLIGEDVnplirLDDSVNidevmtdtstNYLLCIYEEKENI 140
Cdd:COG0249  96 PA-EAKG-----LVKREVVRVVTPGTLTEDAL-----LDAKRN----------NYLAAVARDKGRY 140
PRK05399 PRK05399
DNA mismatch repair protein MutS; Provisional
 1-140 3.49e-13

DNA mismatch repair protein MutS; Provisional


Pssm-ID: 235444 [Multi-domain]  Cd Length: 854  Bit Score: 67.04  E-value: 3.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333857    1 MKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIY-----CHLDHNF-MtASIPTHRLFVHVRRLVAKGYKVGVVKQTET 74
Cdd:PRK05399  18 IKAQYPDALLFFRMGDFYELFFEDAKKASRLLDITltkrgKSAGEPIpM-AGVPYHAAEGYLAKLVKKGYKVAICEQVED 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333857   75 AALkaigdNKSSVfSRKLTALYTKSTLIGEDVnplirLDDSVNidevmtdtstNYLLCIYEEKENI 140
Cdd:PRK05399  97 PAT-----AKGPV-KREVVRIVTPGTVTDEAL-----LDEKQN----------NYLAAIAQDGGGY 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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