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Conserved domains on  [gi|12848969|dbj|BAB28155|]
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unnamed protein product [Mus musculus]

Protein Classification

PBD and BORG_CEP domain-containing protein( domain architecture ID 10466536)

PBD and BORG_CEP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 5.23e-26

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


:

Pssm-ID: 464403  Cd Length: 121  Bit Score: 98.32  E-value: 5.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848969   102 VLKNAISLPTI--GGSQALMLPLLSPvtfhskqesfgrpKLPRlscEPVMEEKVQEQSSLLENGAVHQGDTSwgssgsgS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKLPP-------------KPPR---EPKSLSSSPEKKSLYEDGPRADSTNS-------A 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12848969   180 QSSQGRDSHSSSLSEQSSDWPADDmfehpascelVKSKTKSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  58 PLESPTEKLSERSFGSLTDLSSES----------PKYSDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 30-86 6.92e-09

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


:

Pssm-ID: 395634  Cd Length: 59  Bit Score: 50.77  E-value: 6.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12848969    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHSGQFPGHNDFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 5.23e-26

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 98.32  E-value: 5.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848969   102 VLKNAISLPTI--GGSQALMLPLLSPvtfhskqesfgrpKLPRlscEPVMEEKVQEQSSLLENGAVHQGDTSwgssgsgS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKLPP-------------KPPR---EPKSLSSSPEKKSLYEDGPRADSTNS-------A 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12848969   180 QSSQGRDSHSSSLSEQSSDWPADDmfehpascelVKSKTKSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  58 PLESPTEKLSERSFGSLTDLSSES----------PKYSDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 30-86 6.92e-09

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 50.77  E-value: 6.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12848969    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHSGQFPGHNDFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 31-67 3.13e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 40.27  E-value: 3.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 12848969     31 ISPPLgDFRHTIHIGKEGQHDVFGDISFLQGNYELLP 67
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 5.23e-26

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 98.32  E-value: 5.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12848969   102 VLKNAISLPTI--GGSQALMLPLLSPvtfhskqesfgrpKLPRlscEPVMEEKVQEQSSLLENGAVHQGDTSwgssgsgS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKLPP-------------KPPR---EPKSLSSSPEKKSLYEDGPRADSTNS-------A 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12848969   180 QSSQGRDSHSSSLSEQSSDWPADDmfehpascelVKSKTKSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  58 PLESPTEKLSERSFGSLTDLSSES----------PKYSDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 30-86 6.92e-09

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 50.77  E-value: 6.92e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12848969    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHSGQFPGHNDFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 31-67 3.13e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 40.27  E-value: 3.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 12848969     31 ISPPLgDFRHTIHIGKEGQHDVFGDISFLQGNYELLP 67
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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