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Conserved domains on  [gi|12844532|dbj|BAB26398|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

RMD1 family protein( domain architecture ID 2147)

RMD1 family protein contains a DUF155 domain; similar to Saccharomyces cerevisiae sporulation protein RMD1 required for sporulation where it is believed to have a role in meiotic nuclear division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF155 super family cl00751
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
 3-111 4.41e-31

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


The actual alignment was detected with superfamily member COG1723:

Pssm-ID: 469904  Cd Length: 261  Bit Score: 110.30  E-value: 4.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12844532   3 KVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 82
Cdd:COG1723 153 KLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEALNRKLEIIHETLETLLDLL 232

                        90       100
                ....*....|....*....|....*....
gi 12844532  83 NEKRALRLEWMIVILITIEVMFELGRVFF 111
Cdd:COG1723 233 QHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
 
Name Accession Description Interval E-value
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
 3-111 4.41e-31

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 110.30  E-value: 4.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12844532   3 KVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 82
Cdd:COG1723 153 KLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEALNRKLEIIHETLETLLDLL 232

                        90       100
                ....*....|....*....|....*....
gi 12844532  83 NEKRALRLEWMIVILITIEVMFELGRVFF 111
Cdd:COG1723 233 QHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
 1-65 2.07e-26

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 96.14  E-value: 2.07e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12844532     1 GKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMN 65
Cdd:pfam02582 109 TGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEPLYEALREYLEIKERIEVLN 173
 
Name Accession Description Interval E-value
Rmd1 COG1723
Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure ...
 3-111 4.41e-31

Mitochondrial translation protein, Rmd1/RMND1/DUF155 family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441329  Cd Length: 261  Bit Score: 110.30  E-value: 4.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12844532   3 KVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 82
Cdd:COG1723 153 KLPLSRKELLKKIGKLLLIKHRIILRVEILDKPEFFWENPELERLYLRLEDEFELKERYEALNRKLEIIHETLETLLDLL 232

                        90       100
                ....*....|....*....|....*....
gi 12844532  83 NEKRALRLEWMIVILITIEVMFELGRVFF 111
Cdd:COG1723 233 QHRHSSRLEWIIIILIVVEIVLTLYEKFF 261
DUF155 pfam02582
RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, ...
 1-65 2.07e-26

RMND1/Sif2-Sif3/Mrx10, DUF155; This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homolog, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.


Pssm-ID: 460604  Cd Length: 173  Bit Score: 96.14  E-value: 2.07e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12844532     1 GKKVKLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMN 65
Cdd:pfam02582 109 TGKLKLSRKELLKKIGELLLLRHDINLNSELLDTPDFFWEEPELEPLYEALREYLEIKERIEVLN 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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