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Conserved domains on  [gi|410698520|gb|AFV77548|]
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pro-opiomelanocortin, partial [Homo sapiens]

Protein Classification

ACTH_domain and Op_neuropeptide domain-containing protein( domain architecture ID 10469886)

ACTH_domain and Op_neuropeptide domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACTH_domain pfam00976
Corticotropin ACTH domain;
57-75 7.23e-09

Corticotropin ACTH domain;


:

Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.49  E-value: 7.23e-09
                         10
                 ....*....|....*....
gi 410698520  57 EGPYRMEHFRWGSPPKDKG 75
Cdd:pfam00976  1 DGKYKMEHFRWGSPPKSKR 19
Op_neuropeptide super family cl06873
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 76-90 4.84e-03

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


The actual alignment was detected with superfamily member pfam08035:

Pssm-ID: 462343  Cd Length: 30  Bit Score: 31.64  E-value: 4.84e-03
                         10
                 ....*....|....*..
gi 410698520  76 YGGFMTS--EKSQTPLV 90
Cdd:pfam08035  1 YGGFMKSwdERSQKPLI 17
 
Name Accession Description Interval E-value
ACTH_domain pfam00976
Corticotropin ACTH domain;
57-75 7.23e-09

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.49  E-value: 7.23e-09
                         10
                 ....*....|....*....
gi 410698520  57 EGPYRMEHFRWGSPPKDKG 75
Cdd:pfam00976  1 DGKYKMEHFRWGSPPKSKR 19
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 76-90 4.84e-03

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 31.64  E-value: 4.84e-03
                         10
                 ....*....|....*..
gi 410698520  76 YGGFMTS--EKSQTPLV 90
Cdd:pfam08035  1 YGGFMKSwdERSQKPLI 17
 
Name Accession Description Interval E-value
ACTH_domain pfam00976
Corticotropin ACTH domain;
57-75 7.23e-09

Corticotropin ACTH domain;


Pssm-ID: 460014  Cd Length: 19  Bit Score: 46.49  E-value: 7.23e-09
                         10
                 ....*....|....*....
gi 410698520  57 EGPYRMEHFRWGSPPKDKG 75
Cdd:pfam00976  1 DGKYKMEHFRWGSPPKSKR 19
Op_neuropeptide pfam08035
Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a ...
 76-90 4.84e-03

Opioids neuropeptide; This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.


Pssm-ID: 462343  Cd Length: 30  Bit Score: 31.64  E-value: 4.84e-03
                         10
                 ....*....|....*..
gi 410698520  76 YGGFMTS--EKSQTPLV 90
Cdd:pfam08035  1 YGGFMKSwdERSQKPLI 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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