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Conserved domains on  [gi|290465913|gb|ADD25301|]
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hemagglutinin, partial [Influenza A virus (A/Rome/663/2009(H1N1))]

Protein Classification

hemagglutinin( domain architecture ID 164)

hemagglutinin is a class I fusion protein, having multifunctional activity as both an attachment factor and membrane fusion protein

CATH:  3.90.20.10|3.90.209.20
Gene Ontology:  GO:0046789|GO:0016020|GO:0019031|GO:0055036|GO:0019062|GO:0019064|GO:0039654
PubMed:  19004788|7464906
SCOP:  4002506

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hemagglutinin super family cl10565
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
 1-127 1.23e-56

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


The actual alignment was detected with superfamily member pfam00509:

Pssm-ID: 395409  Cd Length: 504  Bit Score: 183.23  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290465913    1 SNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGTSRYS 80
Cdd:pfam00509 126 TSSGVSSACPYAGGSSFFRNVVWLIKKNNNYPTIKRSYNNTNGEDLLVLWGIHHPNDAAEQTRLYQNPTTYISVGTSTLN 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 290465913   81 KKFKPEIAIRPKVREQEGRMNYYWTLVEPGDKITFEATGNLVVPRYA 127
Cdd:pfam00509 206 QRLVPEIATRPKVNGQSGRMEFFWTILKPGDTINFESNGNFIAPEYA 252
 
Name Accession Description Interval E-value
Hemagglutinin pfam00509
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
 1-127 1.23e-56

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


Pssm-ID: 395409  Cd Length: 504  Bit Score: 183.23  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290465913    1 SNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGTSRYS 80
Cdd:pfam00509 126 TSSGVSSACPYAGGSSFFRNVVWLIKKNNNYPTIKRSYNNTNGEDLLVLWGIHHPNDAAEQTRLYQNPTTYISVGTSTLN 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 290465913   81 KKFKPEIAIRPKVREQEGRMNYYWTLVEPGDKITFEATGNLVVPRYA 127
Cdd:pfam00509 206 QRLVPEIATRPKVNGQSGRMEFFWTILKPGDTINFESNGNFIAPEYA 252
 
Name Accession Description Interval E-value
Hemagglutinin pfam00509
Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral ...
 1-127 1.23e-56

Haemagglutinin; Haemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalizes the virus by endocytosis. The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.


Pssm-ID: 395409  Cd Length: 504  Bit Score: 183.23  E-value: 1.23e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 290465913    1 SNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGTSRYS 80
Cdd:pfam00509 126 TSSGVSSACPYAGGSSFFRNVVWLIKKNNNYPTIKRSYNNTNGEDLLVLWGIHHPNDAAEQTRLYQNPTTYISVGTSTLN 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 290465913   81 KKFKPEIAIRPKVREQEGRMNYYWTLVEPGDKITFEATGNLVVPRYA 127
Cdd:pfam00509 206 QRLVPEIATRPKVNGQSGRMEFFWTILKPGDTINFESNGNFIAPEYA 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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