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Conserved domains on  [gi|49671085|gb|AAH75209|]
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Commd5-prov protein [Xenopus laevis]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 6.40e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 193.81  E-value: 6.40e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 115 ELRIPEDFIEDFANIVYGNRRPILENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGISHRFEVPV 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 49671085 195 AKFQELRYNIALILKEMNDLEKRSILRIQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 6.40e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 193.81  E-value: 6.40e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 115 ELRIPEDFIEDFANIVYGNRRPILENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGISHRFEVPV 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 49671085 195 AKFQELRYNIALILKEMNDLEKRSILRIQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 149-207 8.41e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.42  E-value: 8.41e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49671085   149 LPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDG----ISHRFEVPVAKFQELRYNIALI 207
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 115-224 6.40e-64

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 193.81  E-value: 6.40e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 115 ELRIPEDFIEDFANIVYGNRRPILENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGISHRFEVPV 194
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 49671085 195 AKFQELRYNIALILKEMNDLEKRSILRIQD 224
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 149-207 8.41e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 66.42  E-value: 8.41e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 49671085   149 LPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDG----ISHRFEVPVAKFQELRYNIALI 207
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 129-224 6.40e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 59.63  E-value: 6.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 129 IVYGNRRPIlENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGISHrfevpvaKFQELRYNIALIL 208
Cdd:cd04748   1 LLTENKAEI-EELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNN-------SSEKICFEMTKEE 72

                        90
                ....*....|....*.
gi 49671085 209 KEmNDLEKRSILRIQD 224
Cdd:cd04748  73 LQ-NFLNKLKKIKAQL 87
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 140-184 1.25e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 40.24  E-value: 1.25e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 49671085 140 NAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSD 184
Cdd:cd04757  22 SEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQE 66
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 130-187 1.26e-04

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 39.64  E-value: 1.26e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 49671085 130 VYGNRRPILENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGIS 187
Cdd:cd04751   6 QYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGEN 63
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 107-192 4.63e-04

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 39.60  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 107 EVFKEDLKELRIPEDFIEDFANIVYGNRRPIlENAALKKGVTLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDGI 186
Cdd:cd04750  55 RDFQDSIEFLGFSDDLNEILLQLYESNRKEI-RNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDEN 133


                ....*.
gi 49671085 187 SHRFEV 192
Cdd:cd04750 134 KKIETH 139
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 132-214 1.84e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 37.79  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49671085 132 GNRRPILENAALKkgvtLPTLEDIRWRVDVAISTSSLSRALQPSILMQLKLSDG-----ISHRFEVPVAKFQELRYNIAL 206
Cdd:cd04752  91 SKLQESLRANSLR----LSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNAdtgeiTPHPFSVSADKFRVLLAELKQ 166


                ....*...
gi 49671085 207 ILKEMNDL 214
Cdd:cd04752 167 AQTLMETL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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