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Conserved domains on  [gi|8809806|gb|AAF79949|]
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KRAB zinc finger protein [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.38e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.38e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 8809806      4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLTCIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-448 1.66e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  254 SNTTEKNYEYNQWGKAFSYPSYLQVHETIHTGKS-PYECNQCGKTFAYKSHFHKHER--IHTGE--KPYEC--NRCGKAF 326
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLF 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  327 SSNSNLQRHERIHTGEKPYEC--SQCGKAF------AYRNSLHIHERNHTGEKPYKCYQ-CGKDFASNSNLQIHRRVHSG 397
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLS 413

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 8809806  398 EKP--YKCFECGKHFSCNSHLQMHERIHTGEKPYKCNQCGKTFAYSSSFHMHE 448
Cdd:COG5048 414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-496 6.62e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    471 HLQRHERCHTGEKPYECNQCGKAFAY 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-468 1.59e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|...
gi 8809806    446 MHERTHTGEKPYECNQCGKAFAY 468
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.38e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.38e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 8809806      4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLTCIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 5.87e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.87e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 8809806    4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
4-46 3.42e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.42e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 8809806       4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLTCIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-448 1.66e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  254 SNTTEKNYEYNQWGKAFSYPSYLQVHETIHTGKS-PYECNQCGKTFAYKSHFHKHER--IHTGE--KPYEC--NRCGKAF 326
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLF 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  327 SSNSNLQRHERIHTGEKPYEC--SQCGKAF------AYRNSLHIHERNHTGEKPYKCYQ-CGKDFASNSNLQIHRRVHSG 397
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLS 413

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 8809806  398 EKP--YKCFECGKHFSCNSHLQMHERIHTGEKPYKCNQCGKTFAYSSSFHMHE 448
Cdd:COG5048 414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 2.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.53e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    331 NLQRHERIHTGEKPYECSQCGKAFAY 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-496 6.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    471 HLQRHERCHTGEKPYECNQCGKAFAY 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-468 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|...
gi 8809806    446 MHERTHTGEKPYECNQCGKAFAY 468
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 2.38e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.38e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 8809806      4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLTCIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 5.87e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.87e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 8809806    4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB smart00349
krueppel associated box;
4-46 3.42e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.42e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 8809806       4 VTYEDVHVNFSREEWVLLDPSQKSLYKDVMLETYWNLTCIGYK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-448 1.66e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  254 SNTTEKNYEYNQWGKAFSYPSYLQVHETIHTGKS-PYECNQCGKTFAYKSHFHKHER--IHTGE--KPYEC--NRCGKAF 326
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLF 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  327 SSNSNLQRHERIHTGEKPYEC--SQCGKAF------AYRNSLHIHERNHTGEKPYKCYQ-CGKDFASNSNLQIHRRVHSG 397
Cdd:COG5048 334 SRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLS 413

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 8809806  398 EKP--YKCFECGKHFSCNSHLQMHERIHTGEKPYKCNQCGKTFAYSSSFHMHE 448
Cdd:COG5048 414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-475 2.46e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  279 HETIHTGKSPYECNQCGKTFAYKSHFHKHERIHTG-EKPYECNRCGKAFSSNSNLQRHER--IHTGE--KPYEC--SQCG 351
Cdd:COG5048 251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  352 KAFAYRNSLHIHERNHTGEKPYKCY--QCGKDF--ASNSNLQIHRRVHSGEKPYKCFECGKHFSC-----NSHLQMHERI 422
Cdd:COG5048 331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKKSETLSNSCIrnfkrDSNLSLHIIT 410

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 8809806  423 HTGEKPY--KCNQCGKTFAYSSSFHMHERTHTGEKPYECNQCGKaFAYCCHLQRH 475
Cdd:COG5048 411 HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-543 8.82e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 8.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  286 KSPYECNQCGKTFAYKSHFHKHERIHTGEKPYECNR--CGKAFSSNSNLQRHERIHTGEKPYE----------------- 346
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLnskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  347 ------------CSQCGKAFAYRNSLHIHERNHTGEKPYKCYQCGKDFA----------------------SNSNLQIHR 392
Cdd:COG5048 111 sssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  393 RVHSGEKPYKCFECGKHFSCNSHLQMHERIHTGEKPYKCNQCGKTFAYS------SSFHMHERTHTGEKPYECNQCGKAF 466
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  467 AYCCHLQRHERCHTG-EKPYECNQCGKAFAYLSSLHKHER--NHTGEKLFEC----NQCGKVFACLSTLQEHKRIHTDKI 539
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSIS 350


                ....
gi 8809806  540 PKET 543
Cdd:COG5048 351 PAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 2.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.53e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    331 NLQRHERIHTGEKPYECSQCGKAFAY 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-496 6.62e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.62e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    471 HLQRHERCHTGEKPYECNQCGKAFAY 496
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 9.33e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 8809806    415 HLQMHERIHTGEKPYKCNQCGKTFAY 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-487 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  214 NQCGKSSLQLHRRTHLEMKYSECNQGDKSFAFYNHHQVGRSNTTEKNYEYNQWGKAFSYPSYLQVHETIHTgKSPYECNQ 293
Cdd:COG5048  72 SFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLS-ISNLRNNP 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  294 C----GKTFAYKSHFHKHERIHTgekpyecNRCGKAFSSNSNLQRHERIHTGEKPYECSQCGKAFAYRNSLHIHERNHTG 369
Cdd:COG5048 151 LpgnnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  370 EKPYKCYQCGKDFASNSNLQIHRRVHSGEKPYKCFECGKHFSCNSHLQMHERIHTGE-------KPYKCNQCGKTFAYSS 442
Cdd:COG5048 224 SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSS 303

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 8809806  443 SFHMHERT--HTGE--KPYEC--NQCGKAFAYCCHLQRHERCHTGEKPYEC 487
Cdd:COG5048 304 PLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-468 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|...
gi 8809806    446 MHERTHTGEKPYECNQCGKAFAY 468
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-384 3.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|..
gi 8809806    363 HERNHTGEKPYKCYQCGKDFAS 384
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-540 4.76e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  160 CGKALSSSCSLQRRDQTHMGKGSDkcepsskSLTHPRYLQIQKTAYNEEDLYVWN------QCGKSSLQLHRRTHLEMKY 233
Cdd:COG5048  69 CDKSFSRPLELSRHLRTHHNNPSD-------LNSKSLPLSNSKASSSSLSSSSSNsndnnlLSSHSLPPSSRDPQLPDLL 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  234 SECNQGDKSFAFYNHHQVGRSNTTEKNYEYNQW--GKAFSYPSYLQVHETIHTGKSPYECNQCGKTFAYKSHFHKHERIH 311
Cdd:COG5048 142 SISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLE 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  312 TGEKPYECNRCGKAFSSNSNLQRH------ERIHTGEKPYECSQCGKAFAYRNSLHIHERNHTG-EKPYKCYQCGKDFAS 384
Cdd:COG5048 222 NSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSR 301

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  385 NSNLQIHRR--VHSGE--KPYKCFE--CGKHFSCNSHLQMHERIHTGEKPYKC--NQCGKTF-----AYSSSFHMHERTH 451
Cdd:COG5048 302 SSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDL 381

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8809806  452 TGEKPYEC--NQCGKAFAYCCHLQRHERCHTGEKPYECNqcgkaFAYLSSLHKHERNhtgeklfecnqcgkvfaclstLQ 529
Cdd:COG5048 382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK-----NPPCSKSFNRHYN---------------------LI 435

                       410
                ....*....|.
gi 8809806  530 EHKRIHTDKIP 540
Cdd:COG5048 436 PHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-412 6.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 8809806    387 NLQIHRRVHSGEKPYKCFECGKHFSC 412
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-328 7.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.89e-03
                          10        20
                  ....*....|....*....|...
gi 8809806    306 KHERIHTGEKPYECNRCGKAFSS 328
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 9.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 8809806    275 YLQVHETIHTGKSPYECNQCGKTFAY 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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