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Conserved domains on  [gi|6649849|gb|AAF21597|]
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tumor RMS cell line RD specific product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 182-225 4.80e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.30  E-value: 4.80e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6649849    182 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 225
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
VWC smart00214
von Willebrand factor (vWF) type C domain;
53-112 7.83e-10

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 7.83e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6649849      53 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 112
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 182-225 4.80e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.30  E-value: 4.80e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6649849    182 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 225
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
VWC smart00214
von Willebrand factor (vWF) type C domain;
53-112 7.83e-10

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 7.83e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6649849      53 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 112
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 53-113 1.10e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 50.89  E-value: 1.10e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6649849     53 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNPRLVKVTGQCCEE 113
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 185-225 3.46e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 3.46e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 6649849     185 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 225
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 182-225 4.80e-19

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 79.30  E-value: 4.80e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 6649849    182 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 225
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
VWC smart00214
von Willebrand factor (vWF) type C domain;
53-112 7.83e-10

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 54.06  E-value: 7.83e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6649849      53 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 112
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 53-113 1.10e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 50.89  E-value: 1.10e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6649849     53 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNPRLVKVTGQCCEE 113
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 187-225 3.27e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.03  E-value: 3.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 6649849    187 TSWSQCSKTCGTGISTRV-------TNDNPECRLVKETRICEVRPC 225
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 185-225 3.46e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 3.46e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 6649849     185 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 225
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 185-225 5.46e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.43  E-value: 5.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6649849    185 QTTSWSQCSKTCGTGISTRV----------TNDNPECRLVK---ETRICEVRPC 225
Cdd:pfam19030   2 VAGPWGECSVTCGGGVQTRLvqcvqkgggsIVPDSECSAQKkppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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